DK0386644T3 - Reagenser til bestemmelse af lægemidler - Google Patents
Reagenser til bestemmelse af lægemidlerInfo
- Publication number
- DK0386644T3 DK0386644T3 DK90104055.0T DK90104055T DK0386644T3 DK 0386644 T3 DK0386644 T3 DK 0386644T3 DK 90104055 T DK90104055 T DK 90104055T DK 0386644 T3 DK0386644 T3 DK 0386644T3
- Authority
- DK
- Denmark
- Prior art keywords
- reagents
- drugs
- determination
- drug
- hydroxysuccinimide
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003118 drug derivative Substances 0.000 abstract 1
- 239000002359 drug metabolite Substances 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 150000002540 isothiocyanates Chemical class 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- -1 poly(amino acid) Polymers 0.000 abstract 1
- 229920001308 poly(aminoacid) Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/816—Alkaloids, amphetamines, and barbiturates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/807—Hapten conjugated with peptide or protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Pyrrole Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32194689A | 1989-03-10 | 1989-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0386644T3 true DK0386644T3 (da) | 1997-10-13 |
Family
ID=23252745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90104055.0T DK0386644T3 (da) | 1989-03-10 | 1990-03-02 | Reagenser til bestemmelse af lægemidler |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5618926A (da) |
| EP (1) | EP0386644B1 (da) |
| JP (1) | JP3009170B2 (da) |
| AT (1) | ATE154135T1 (da) |
| AU (1) | AU624686B2 (da) |
| CA (1) | CA2011722C (da) |
| DE (1) | DE69030829T2 (da) |
| DK (1) | DK0386644T3 (da) |
| ES (1) | ES2104566T3 (da) |
| NO (1) | NO178007C (da) |
| NZ (1) | NZ232854A (da) |
| ZA (1) | ZA901808B (da) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155212A (en) * | 1986-05-21 | 1992-10-13 | Abbott Laboratories | Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit |
| US5612034A (en) * | 1990-10-03 | 1997-03-18 | Redcell, Inc. | Super-globuling for in vivo extended lifetimes |
| ATE140795T1 (de) * | 1990-10-22 | 1996-08-15 | Abbott Lab | Homobifunktionelle agenzien zur kupplung von enzymen un deren analogen an antikörper und deren analoge |
| EP0517327B1 (en) * | 1991-06-07 | 2001-08-16 | Johnson & Johnson Clinical Diagnostics, Inc. | Immunoassay with labeled hapten analogues |
| US5284948A (en) * | 1991-06-07 | 1994-02-08 | Eastman Kodak Company | Drug hapten analogues for immunoassays |
| US5304479A (en) * | 1991-12-06 | 1994-04-19 | Diagnostic Reagents, Inc. | Phencyclidine compounds and assays for its determination |
| US5302715A (en) * | 1992-04-06 | 1994-04-12 | Biosite Diagnostics, Inc. | Benzodiazepine derivatives |
| CA2096495C (en) * | 1992-06-16 | 2002-07-09 | Kathy Palmer Ordonez | Dual analyte immunoassay |
| US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| CA2167362A1 (en) * | 1995-02-10 | 1996-08-11 | Alexei Dmitri Klimov | Apparatus and method for conducting a binding assay on an absorbent carrier material |
| US5840307A (en) * | 1995-03-31 | 1998-11-24 | Immulogic Pharmacuetical Corp. | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation |
| PT814843E (pt) * | 1995-03-31 | 2004-04-30 | Xenova Res Ltd | Conjugados de hapteno-transportador para utilizacao na terapia de abuso de drogas |
| DE19630102A1 (de) * | 1996-07-25 | 1998-01-29 | Boehringer Mannheim Gmbh | Neue aktivierte Amphetamine |
| AU8261098A (en) * | 1997-06-24 | 1999-01-04 | University Of Wyoming | Method and apparatus for detection of a controlled substance |
| US6770488B1 (en) | 1999-03-19 | 2004-08-03 | The University Of Wyoming | Practical method and apparatus for analyte detection with colloidal particles |
| US6262265B1 (en) * | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
| US6372813B1 (en) | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
| US6811998B2 (en) | 1999-06-25 | 2004-11-02 | Roche Diagnostics Operations, Inc. | Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase |
| US6664061B2 (en) | 1999-06-25 | 2003-12-16 | Amersham Biosciences Ab | Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
| US6921638B2 (en) | 1999-06-25 | 2005-07-26 | Amersham Biosciences Ab | Hydrogel-based microarray signal amplification methods and devices therefor |
| GB2361473C (en) * | 2000-03-08 | 2005-06-28 | Microgenics Corp | Ecstasy-class analogs and use of same in detection of ecstasy-class compounds |
| US6534325B1 (en) | 2000-06-30 | 2003-03-18 | Roche Diagnostics Corporation | Immunoassay for the detection of amphetamines, methamphetamines and methylenedioxy designer amphetamines |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| AU2002241602A1 (en) * | 2000-11-16 | 2002-06-11 | Burstein Technologies, Inc. | Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs |
| US6472228B2 (en) | 2000-12-04 | 2002-10-29 | Lifepoint, Inc. | Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples |
| US6368814B1 (en) * | 2000-12-22 | 2002-04-09 | Roche Diagnostics Corporation | Tricyclic antidepressant derivatives and immunoassay |
| US7141416B2 (en) * | 2001-07-12 | 2006-11-28 | Burstein Technologies, Inc. | Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith |
| US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US20030143637A1 (en) * | 2001-08-31 | 2003-07-31 | Selvan Gowri Pyapali | Capture layer assemblies for cellular assays including related optical analysis discs and methods |
| EP1423699A4 (en) * | 2001-09-07 | 2006-01-18 | Burstein Technologies Inc | CELLULAR MORPHOLOGY BASED IDENTIFICATION AND QUANTIFICATION OF WHITE BLOOD CELL TYPES USING OPTICAL BIO-DISC SYSTEMS |
| PT2939696E (pt) | 2001-10-18 | 2016-06-17 | Nektar Therapeutics | Conjugados poliméricos de antagonistas de opióides |
| EP1448992A4 (en) * | 2001-11-20 | 2005-11-02 | Burstein Technologies Inc | OPTICAL BIODISTICS AND FLUIDIC CIRCUITS FOR CELL ANALYSIS AND CORRESPONDING METHODS |
| US20050003459A1 (en) * | 2002-01-30 | 2005-01-06 | Krutzik Siegfried Richard | Multi-purpose optical analysis disc for conducting assays and related methods for attaching capture agents |
| US6858672B2 (en) * | 2002-06-20 | 2005-02-22 | Basell Poliolefine Italia S.P.A. | Safe process for making polymers containing N-phenylimide groups |
| JP4644192B2 (ja) | 2003-07-01 | 2011-03-02 | エフ.ホフマン−ラ ロシュ アーゲー | 電気化学的アフィニティーバイオセンサーシステム及び方法 |
| US7060847B2 (en) * | 2003-07-18 | 2006-06-13 | Roche Diagnostics Operations, Inc. | Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class drugs |
| RS53279B (sr) * | 2003-12-16 | 2014-08-29 | Nektar Therapeutics | Monodisperzne smeše pegilisanog naloksola |
| US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| US7220842B2 (en) | 2004-04-05 | 2007-05-22 | Dade Behring Inc. | Immunoassays for buprenorphine and norbuprenorphine |
| US20060024748A1 (en) * | 2004-07-29 | 2006-02-02 | Saladax Biomedical Inc. | Cytoxan antibodies and immunoassay |
| US7238791B1 (en) * | 2005-12-16 | 2007-07-03 | Roche Diagnostics Operations, Inc. | 6-monoacetylmorphine derivatives useful in immunoassay |
| EP2584044B1 (en) | 2007-07-26 | 2015-04-22 | Agamatrix, Inc. | Electrochemical analyte detections apparatus and method |
| US8133743B2 (en) * | 2007-10-19 | 2012-03-13 | Roche Diagnostics Operations, Inc. | Phenobarbital derivatives useful in immunoassay |
| BR112013010952B1 (pt) | 2010-10-22 | 2020-08-25 | T2 Biosystems, Inc. | métodos para detectar a presença de um analito de ácido nucleico e uma espécie de candida em uma amostra líquida, para detectar a presença de um patógeno, um vírus e um ácido nucleico alvo em uma amostra de sangue total, e para amplificação de um ácido nucleico de patógeno alvo em uma amostra de sangue total, bem como sistema para a detecção de um ou mais analitos e cartucho removível dimensionado para facilitar inserção e remoção de um sistema |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| CN102621296A (zh) * | 2012-01-06 | 2012-08-01 | 天津医科大学 | 一种带有间隔臂的羧化聚苯乙烯微球上偶联蛋白质的方法 |
| US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
| CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917582A (en) * | 1973-06-13 | 1975-11-04 | Syva Corp | Isothiocyanate and thiourea derivatives of benzoyl ecgonine conjugated to polypeptides |
| US3888864A (en) * | 1973-06-29 | 1975-06-10 | Hoffmann La Roche | Amino lower alkyl ether derivatives of opium alkaloids |
| US4101549A (en) * | 1976-05-26 | 1978-07-18 | Hoffmann-La Roche Inc. | Aminophenyl esters of 5-carboxyalkyl barbituric acids |
| US4340736A (en) * | 1976-05-26 | 1982-07-20 | Hoffmann-La Roche Inc. | Diagnostic test for barbiturates |
| IL49685A (en) * | 1976-05-31 | 1978-10-31 | Technion Res & Dev Foundation | Specific binding assay method for determining the concentration of materials and reagent means therefor |
| US4196185A (en) * | 1978-06-05 | 1980-04-01 | Hoffmann-La Roche Inc. | Immunoassay for phencyclidine |
| US4223013A (en) * | 1978-12-29 | 1980-09-16 | Syva Company | Amitriptyline conjugates to antigenic proteins and enzymes |
| US4275160A (en) * | 1979-07-06 | 1981-06-23 | Syva Company | Imipramine derivatives and poly(amino acid) conjugates |
| US4351760A (en) * | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
| US4318846A (en) * | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4262089A (en) * | 1980-04-07 | 1981-04-14 | Syva Company | Theophylline antigens and antibodies |
| EP0045334B1 (en) * | 1980-08-04 | 1984-03-14 | Syva Company | Propranolol antigen conjugates and antibodies and method of using them |
| US4366241A (en) * | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4401765A (en) * | 1981-09-01 | 1983-08-30 | E. I. Du Pont De Nemours And Company | Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays |
| US4424150A (en) * | 1982-04-02 | 1984-01-03 | Syva Company | Acetaminophen analogs, antigens, and antibodies |
| AU567433B2 (en) * | 1982-05-18 | 1987-11-19 | University Of Florida | Specific drug delivery |
| US4629691A (en) * | 1983-08-01 | 1986-12-16 | Syntex (U.S.A.) Inc. | Tricyclic antidepressant conjugates with antigens and enzymes |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| CA1332410C (en) * | 1984-06-26 | 1994-10-11 | Roger M. Freidinger | Benzodiazepine analogs |
| EP0199042A1 (en) * | 1985-03-26 | 1986-10-29 | Abbott Laboratories | Procainamide assay, tracers, immunogens and antibodies |
| US4680338A (en) * | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
| EP0279308B1 (en) * | 1987-02-17 | 1996-08-28 | Abbott Laboratories | Fluorescence polarization immunoassay for tetrahydrocannabinoids |
| US4791067A (en) * | 1987-06-25 | 1988-12-13 | Fisher Scientific Co. | Agglutination immunoassay for hapten involving monoclonal antibody of IgA class reagent |
-
1990
- 1990-03-02 EP EP90104055A patent/EP0386644B1/en not_active Expired - Lifetime
- 1990-03-02 AT AT90104055T patent/ATE154135T1/de not_active IP Right Cessation
- 1990-03-02 ES ES90104055T patent/ES2104566T3/es not_active Expired - Lifetime
- 1990-03-02 DK DK90104055.0T patent/DK0386644T3/da active
- 1990-03-02 DE DE69030829T patent/DE69030829T2/de not_active Expired - Lifetime
- 1990-03-08 CA CA002011722A patent/CA2011722C/en not_active Expired - Lifetime
- 1990-03-08 ZA ZA901808A patent/ZA901808B/xx unknown
- 1990-03-08 NZ NZ232854A patent/NZ232854A/en unknown
- 1990-03-09 JP JP2056817A patent/JP3009170B2/ja not_active Expired - Lifetime
- 1990-03-09 NO NO901122A patent/NO178007C/no not_active IP Right Cessation
- 1990-03-09 AU AU51231/90A patent/AU624686B2/en not_active Ceased
-
1994
- 1994-05-26 US US08/249,676 patent/US5618926A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0386644A3 (en) | 1992-10-07 |
| CA2011722C (en) | 2001-06-19 |
| EP0386644B1 (en) | 1997-06-04 |
| NO178007B (no) | 1995-09-25 |
| AU5123190A (en) | 1990-11-22 |
| NO901122D0 (no) | 1990-03-09 |
| NO901122L (no) | 1990-09-11 |
| DE69030829T2 (de) | 1998-01-15 |
| CA2011722A1 (en) | 1990-09-10 |
| US5618926A (en) | 1997-04-08 |
| JP3009170B2 (ja) | 2000-02-14 |
| NZ232854A (en) | 1993-03-26 |
| NO178007C (no) | 1996-01-03 |
| EP0386644A2 (en) | 1990-09-12 |
| AU624686B2 (en) | 1992-06-18 |
| JPH03200763A (ja) | 1991-09-02 |
| ES2104566T3 (es) | 1997-10-16 |
| DE69030829D1 (de) | 1997-07-10 |
| ATE154135T1 (de) | 1997-06-15 |
| ZA901808B (en) | 1990-12-28 |
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