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ES2196721T3 - Metodo para producir un derivado de acido fenilpropionico opticamente activo. - Google Patents

Metodo para producir un derivado de acido fenilpropionico opticamente activo.

Info

Publication number
ES2196721T3
ES2196721T3 ES99301004T ES99301004T ES2196721T3 ES 2196721 T3 ES2196721 T3 ES 2196721T3 ES 99301004 T ES99301004 T ES 99301004T ES 99301004 T ES99301004 T ES 99301004T ES 2196721 T3 ES2196721 T3 ES 2196721T3
Authority
ES
Spain
Prior art keywords
group
optically active
producing
acid derivative
phenylpropionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99301004T
Other languages
English (en)
Inventor
Takayuki Suzuki
Takayuki Hamada
Kunisuke Izawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of ES2196721T3 publication Critical patent/ES2196721T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADOS DE ESTERES DE N - [(S) - 2 - (ACETILTIOMETIL) 1 - OXO - 3 - FENILPROPIL] - GLICINA OPTICAMENTE ACTIVOS DE FORMULA (IV) (EN LA QUE R 1 REPRESENTA HIDROGENO, UNA CADENA LATERAL DE AMINOACIDOS OPCIONALMENTE SUSTITUIDA Y UNA CADENA DE AMINOACIDOS PROTEGIDA; R 2 REPRESENTA UN GRUPO ALQUILO C 1 A C 18 , LINEAL O RAMIFICADO, OPCIONALMENTE SUSTITUIDO, O UN GRUPO BENCILO OPCIONALMENTE SUSTITUIDO; Y * REPRESENTA UN ATOMO DE CARBONO OPTICAMENTE ACTIVO) UTILES COMO AGENTES INHIBIDORES DE ENCEFALINA DE AGENTES INHIBIDORES DE ACE QUE SE PUEDEN PRODUCIR A BAJO COSTE A NIVEL INDUSTRIAL SOMETIENDO ESTERES DE ACIDO 2 HIDROXIMETIL - 3 - FENILPROPIONICO Y DE GLICINA OPTICAMENTE ACTIVOS A UNA CONDENSACION TRAS LO CUAL SE CONVIERTE EL GRUPO HIDROXILO EN UN GRUPO DE ELIMINACION Y SE SUSTITUYE EL GRUPO DE ELIMINACION POR UN GRUPO ACETILTIO.
ES99301004T 1998-02-16 1999-02-11 Metodo para producir un derivado de acido fenilpropionico opticamente activo. Expired - Lifetime ES2196721T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3279198 1998-02-16

Publications (1)

Publication Number Publication Date
ES2196721T3 true ES2196721T3 (es) 2003-12-16

Family

ID=12368686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99301004T Expired - Lifetime ES2196721T3 (es) 1998-02-16 1999-02-11 Metodo para producir un derivado de acido fenilpropionico opticamente activo.

Country Status (5)

Country Link
US (3) US6031121A (es)
EP (1) EP0937710B1 (es)
CA (1) CA2262224A1 (es)
DE (1) DE69906849T2 (es)
ES (1) ES2196721T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937710B1 (en) * 1998-02-16 2003-04-16 Ajinomoto Co., Inc. Method for producing an optically active phenylpropionic acid derivative
US6096762A (en) * 1998-06-02 2000-08-01 Bristol-Myers Squibb Company Neurotrophic difluoroamide agents
JP2004530647A (ja) * 2001-01-30 2004-10-07 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧治療用眼薬組成物
WO2003059869A1 (en) * 2002-01-17 2003-07-24 Kaneka Corporation Process for producing 2-aralkylpropionic acid derivative
DE60318188T2 (de) * 2002-03-26 2008-12-11 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung
KR20050036982A (ko) * 2002-08-29 2005-04-20 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 염증, 알러지 및 증식성 질환의 치료에 글루코코르티코이드모사체로 사용하기 위한 3-(설폰아미도에틸)-인돌 유도체
UY28526A1 (es) * 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en) * 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
ES2326907T3 (es) * 2004-12-27 2009-10-21 Boehringer Ingelheim Pharmaceuticals Inc. Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y su uso.
ATE449098T1 (de) * 2005-09-30 2009-12-15 Boehringer Ingelheim Int Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole
BRPI0720131A2 (pt) * 2006-12-06 2014-02-04 Boehringer Ingelheim Int Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos.
KR20110020902A (ko) * 2008-06-06 2011-03-03 베링거 인겔하임 인터내셔날 게엠베하 글루코코르티코이드 유사체, 이의 제조방법, 약제학적 조성물 및 이의 용도
WO2011161646A2 (en) * 2010-06-25 2011-12-29 Ranbaxy Laboratories Limited Process for the preparation of alvimopan or its pharmaceutically acceptable salt or solvate thereof
WO2013021343A1 (en) * 2011-08-05 2013-02-14 Ranbaxy Laboratories Limited Process for the optical resolution of () -3- (2 -benzyloxy- 5 - bromophenyl) - 3 - phenylpropionic
CN107674010B (zh) * 2017-08-29 2020-04-07 陕西汉江药业集团股份有限公司 一种依卡曲尔的制备方法和检测方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798904A (en) * 1983-10-03 1989-01-17 E. R. Squibb & Sons, Inc. Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
US4722810A (en) * 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US5136076A (en) * 1987-11-24 1992-08-04 Societe Civile Bioprojet Process for the preparation of amino acid-derived enatiomeric compounds
FR2623498B1 (fr) 1987-11-24 1990-04-06 Bioprojet Soc Civ Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
FR2707638B1 (fr) * 1993-07-16 1995-08-18 Bioprojet Soc Civ Nouveaux dérivés d'amino-acides, leurs procédés de préparation et leur application thérapeutique.
FR2744446B1 (fr) * 1996-02-05 1998-04-17 Bioprojet Soc Civ Procede de synthese asymetrique des derives s-acyles de l'acide 2-mercaptomethyl 3-phenyl propanoique, application a la synthese de derives n-(mercaptoacyl) amino-acides
JPH11106363A (ja) 1997-10-03 1999-04-20 Ajinomoto Co Inc 光学活性２−ヒドロキシメチル−３−フェニルプロピオン酸の製造方法
EP0937710B1 (en) * 1998-02-16 2003-04-16 Ajinomoto Co., Inc. Method for producing an optically active phenylpropionic acid derivative

Also Published As

Publication number Publication date
US6031121A (en) 2000-02-29
EP0937710B1 (en) 2003-04-16
US20010014754A1 (en) 2001-08-16
CA2262224A1 (en) 1999-08-16
US6239305B1 (en) 2001-05-29
EP0937710A1 (en) 1999-08-25
DE69906849D1 (de) 2003-05-22
DE69906849T2 (de) 2004-01-22
US6339170B2 (en) 2002-01-15

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