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ES2196380T3 - Procedimiento de purificacion y de separacion de fsh y lh. - Google Patents

Procedimiento de purificacion y de separacion de fsh y lh.

Info

Publication number
ES2196380T3
ES2196380T3 ES97950077T ES97950077T ES2196380T3 ES 2196380 T3 ES2196380 T3 ES 2196380T3 ES 97950077 T ES97950077 T ES 97950077T ES 97950077 T ES97950077 T ES 97950077T ES 2196380 T3 ES2196380 T3 ES 2196380T3
Authority
ES
Spain
Prior art keywords
fsh
purification
basic anion
procedure
ionic exchange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97950077T
Other languages
English (en)
Inventor
Paolo Lualdi
Elisabetta Donati
Irina Rapaport
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IBSA Institut Biochimique SA
Original Assignee
IBSA Institut Biochimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IBSA Institut Biochimique SA filed Critical IBSA Institut Biochimique SA
Application granted granted Critical
Publication of ES2196380T3 publication Critical patent/ES2196380T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Amplifiers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • External Artificial Organs (AREA)
  • Executing Machine-Instructions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCEDIMIENTO, ESPECIALMENTE SENCILLO Y ECONOMICO, DE SEPARACION Y PURIFICACION DE FSH Y LH, PARTIENDO DE HMG BRUTA, PREFERENTEMENTE URINARIA, QUE COMPRENDE LAS SIGUIENTES ETAPAS: (1) ELIMINACION FACULTATIVA DE LA CARGA VIRAL DE HMG BRUTA EN UNA SOLUCION ACUOSA DE ALCOHOL ETILICO; (2) CROMATOGRAFIA DE INTERCAMBIO IONICO SOBRE RESINAS ANIONICAS DEBILMENTE BASICAS DE TIPO DEAE; (3) CROMATOGRAFIA DE AFINIDAD SOBRE UNA RESINA QUE TENGA COMO LIGANDO UN DERIVADO DE ANTRAQUINONA; (4) CROMATOGRAFIA DE INTERCAMBIO IONICO FACULTATIVA SOBRE RESINAS ANIONICAS FUERTEMENTE BASICAS. LAS HORMONAS OBTENIDAS MEDIANTE DICHO PROCEDIMIENTO, ESPECIALMENTE PURAS Y CON UNA ACTIVIDAD ESPECIFICA ELEVADA, PUEDEN SUFRIR ULTERIORMENTE UN PROCESO DE DESPIROGENACION.
ES97950077T 1996-11-07 1997-11-03 Procedimiento de purificacion y de separacion de fsh y lh. Expired - Lifetime ES2196380T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI002313A IT1287138B1 (it) 1996-11-07 1996-11-07 Procedimento per la separazione e purificazione di fsh e lh

Publications (1)

Publication Number Publication Date
ES2196380T3 true ES2196380T3 (es) 2003-12-16

Family

ID=11375168

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97950077T Expired - Lifetime ES2196380T3 (es) 1996-11-07 1997-11-03 Procedimiento de purificacion y de separacion de fsh y lh.

Country Status (10)

Country Link
EP (1) EP0882064B1 (es)
AT (1) ATE236931T1 (es)
AU (1) AU719560B2 (es)
CA (1) CA2242325C (es)
DE (1) DE69720693T2 (es)
ES (1) ES2196380T3 (es)
IL (1) IL125225A (es)
IT (1) IT1287138B1 (es)
PT (1) PT882064E (es)
WO (1) WO1998020039A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
EP1169349B1 (en) * 1999-04-16 2007-03-28 Instituto Massone S.A. Process for preparing gonadotropin compositions
US7022822B1 (en) * 1999-04-16 2006-04-04 Instituto Massone S.A. Highly purified gonadotropin compositions and process for preparing them
KR100806911B1 (ko) * 2000-02-22 2008-02-22 라보라토리스 세로노 에스.에이. ｈＣＧ의 정제 방법 및 이 방법에 의해 정제된 재조합ｈＣＧ
EP1261622B1 (en) * 2000-02-22 2007-03-07 Applied Research Systems ARS Holding N.V. Purified recombinant hlh having a specific bioactivity and process for purification thereof
SI1809663T1 (sl) * 2004-11-09 2009-02-28 Ares Trading Sa Postopek za äśiĺ äśenje fsh
HUE038947T2 (hu) 2005-08-26 2018-12-28 Ares Trading Sa Eljárás glikozilált béta-interferon elõállítására
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
CN101397339B (zh) * 2008-09-24 2012-07-25 上海天伟生物制药有限公司 糖蛋白中去除/灭活病毒的方法
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
CN101792482B (zh) * 2010-03-12 2012-11-21 丽珠医药集团股份有限公司 一种促性腺激素的纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58157720A (ja) * 1982-03-15 1983-09-19 Nippon Chem Res Kk 高純度の胎盤性性腺刺戟ホルモンの製造法

Also Published As

Publication number Publication date
AU719560B2 (en) 2000-05-11
ITMI962313A0 (it) 1996-11-07
PT882064E (pt) 2003-08-29
ITMI962313A1 (it) 1998-05-07
EP0882064B1 (en) 2003-04-09
ATE236931T1 (de) 2003-04-15
IT1287138B1 (it) 1998-08-04
IL125225A (en) 2002-04-21
WO1998020039A1 (en) 1998-05-14
CA2242325A1 (en) 1998-05-14
EP0882064A1 (en) 1998-12-09
IL125225A0 (en) 1999-03-12
DE69720693D1 (de) 2003-05-15
DE69720693T2 (de) 2004-03-04
AU5316298A (en) 1998-05-29
CA2242325C (en) 2008-04-29

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