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ES2193973T3 - Procedimiento para la sintesis de derivados de beta-lactama. - Google Patents

Procedimiento para la sintesis de derivados de beta-lactama.

Info

Publication number
ES2193973T3
ES2193973T3 ES00945949T ES00945949T ES2193973T3 ES 2193973 T3 ES2193973 T3 ES 2193973T3 ES 00945949 T ES00945949 T ES 00945949T ES 00945949 T ES00945949 T ES 00945949T ES 2193973 T3 ES2193973 T3 ES 2193973T3
Authority
ES
Spain
Prior art keywords
lactama
beta
synthesis
derivatives
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00945949T
Other languages
English (en)
Inventor
Walter Cabri
Enrico Siviero
Paola Luigia Daverio
Davide Longoni
Claudio Felisi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olon SpA
Original Assignee
Antibioticos SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SpA filed Critical Antibioticos SpA
Application granted granted Critical
Publication of ES2193973T3 publication Critical patent/ES2193973T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para la preparación de la forma ácida de Cefuroxime o la correspondiente sal o éster farmacológicamente aceptable, que comprende la carbamoilación de un precursor 3-hidroximetil-3-cefem con un isocianato activado, caracterizado porque se usa un alquil éster C1-C4 del ácido carbónico como disolvente para dicha reacción de carbamoilación.
ES00945949T 1999-07-27 2000-07-24 Procedimiento para la sintesis de derivados de beta-lactama. Expired - Lifetime ES2193973T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001655A IT1313569B1 (it) 1999-07-27 1999-07-27 Processo per la sintesi di derivati beta-lattamici.

Publications (1)

Publication Number Publication Date
ES2193973T3 true ES2193973T3 (es) 2003-11-16

Family

ID=11383419

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00945949T Expired - Lifetime ES2193973T3 (es) 1999-07-27 2000-07-24 Procedimiento para la sintesis de derivados de beta-lactama.

Country Status (14)

Country Link
US (1) US6642378B1 (es)
EP (1) EP1196420B1 (es)
KR (1) KR20020031391A (es)
CN (1) CN1364169A (es)
AT (1) ATE234845T1 (es)
AU (1) AU5986700A (es)
CA (1) CA2380183A1 (es)
DE (1) DE60001748T2 (es)
DK (1) DK1196420T3 (es)
ES (1) ES2193973T3 (es)
IT (1) IT1313569B1 (es)
PT (1) PT1196420E (es)
TR (1) TR200200196T2 (es)
WO (1) WO2001007443A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT411996B (de) 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966717A (en) 1971-05-14 1976-06-29 Glaxo Laboratories Limited 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
CA1122972A (en) * 1978-04-07 1982-05-04 Gordon G. Weingarten Cephalosporin compounds
GB2018764B (en) 1978-04-07 1982-09-02 Glaxo Group Ltd Cephalosporin compounds
GB8810394D0 (en) 1988-05-03 1988-06-08 Glaxo Group Ltd Chemical process
DE4321842A1 (de) * 1993-07-01 1995-01-12 Basf Ag Verfahren zur Herstellung von alpha, omega-Dicarbonsäurediestern

Also Published As

Publication number Publication date
ITMI991655A1 (it) 2001-01-27
AU5986700A (en) 2001-02-13
US6642378B1 (en) 2003-11-04
DE60001748T2 (de) 2003-10-16
CN1364169A (zh) 2002-08-14
ATE234845T1 (de) 2003-04-15
PT1196420E (pt) 2003-06-30
ITMI991655A0 (it) 1999-07-27
CA2380183A1 (en) 2001-02-01
DK1196420T3 (da) 2003-07-14
EP1196420B1 (en) 2003-03-19
TR200200196T2 (tr) 2002-07-22
IT1313569B1 (it) 2002-09-09
WO2001007443A1 (en) 2001-02-01
KR20020031391A (ko) 2002-05-01
EP1196420A1 (en) 2002-04-17
DE60001748D1 (de) 2003-04-24

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