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ES2191297T3 - Procedimiento para la desbencilacion de dibencilbiotina. - Google Patents

Procedimiento para la desbencilacion de dibencilbiotina.

Info

Publication number
ES2191297T3
ES2191297T3 ES98916981T ES98916981T ES2191297T3 ES 2191297 T3 ES2191297 T3 ES 2191297T3 ES 98916981 T ES98916981 T ES 98916981T ES 98916981 T ES98916981 T ES 98916981T ES 2191297 T3 ES2191297 T3 ES 2191297T3
Authority
ES
Spain
Prior art keywords
dibencilbiotine
debencilation
procedure
biotin
debylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98916981T
Other languages
English (en)
Inventor
Ulrich Heywang
Heinrich Bollinger
Hans-Rudolf Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2191297T3 publication Critical patent/ES2191297T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La invención se refiere a un nuevo procedimiento para la debencilación selectiva de biotina de dibencilo que se produce como producto intermedio en la síntesis de biotina pero habitualmente no se aísla.
ES98916981T 1997-03-27 1998-03-17 Procedimiento para la desbencilacion de dibencilbiotina. Expired - Lifetime ES2191297T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712952A DE19712952A1 (de) 1997-03-27 1997-03-27 Verfahren zur Entbenzylierung von Dibenzylbiotin

Publications (1)

Publication Number Publication Date
ES2191297T3 true ES2191297T3 (es) 2003-09-01

Family

ID=7824831

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98916981T Expired - Lifetime ES2191297T3 (es) 1997-03-27 1998-03-17 Procedimiento para la desbencilacion de dibencilbiotina.

Country Status (9)

Country Link
US (1) US6140507A (es)
EP (1) EP0971931B1 (es)
JP (1) JP2001516363A (es)
KR (1) KR20010005573A (es)
CN (1) CN1101820C (es)
DE (2) DE19712952A1 (es)
DK (1) DK0971931T3 (es)
ES (1) ES2191297T3 (es)
WO (1) WO1998043979A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3528699B2 (ja) 1998-12-24 2004-05-17 住友化学工業株式会社 ヘキサヒドロ−２−オキソ−１Ｈ−チエノ［３，４−ｄ］イミダゾール−４−ペンタン酸の製造方法
DE19962661B4 (de) * 1998-12-24 2009-07-09 Sumitomo Chemical Co. Ltd. Verfahren zur Herstellung von Hexahydro-2-oxo-1H-thieno[3,4-d]-imidazol-4-pentansäure
AU2003276510A1 (en) * 2002-11-07 2004-06-07 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of biotin
CN100488967C (zh) * 2003-11-10 2009-05-20 浙江医药股份有限公司新昌制药厂 双苄生物素的制备方法
CN101215291B (zh) * 2008-01-10 2010-12-29 复旦大学 (+)-生物素及其衍生物的合成方法
CN103788112B (zh) * 2012-11-02 2016-03-09 菏泽市方明制药有限公司 一种苄基生物素脱苄制备生物素的方法
CN103772409B (zh) * 2013-12-31 2016-06-08 浙江新和成股份有限公司 一种脱苄基合成d-生物素的方法
CN104926828B (zh) * 2014-03-22 2019-02-19 上海创诺制药有限公司 一种由双苄生物素制备d-生物素的方法
WO2020050342A1 (ja) * 2018-09-07 2020-03-12 株式会社トクヤマ Ｎ，ｎ'－ジベンジルビオチンのジシクロへキシルアミン塩及びその製造方法
CN109627254B (zh) * 2018-12-13 2020-04-28 浙江圣达生物药业股份有限公司 一种d-生物素的制备方法
JP7623802B2 (ja) * 2020-07-28 2025-01-29 株式会社トクヤマ ビオチン及びその製造方法、並びに、ビオチン・アミン類塩の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537973A (en) * 1980-03-12 1985-08-27 Sumitomo Chemical Company, Limited Process for preparing biotin
JPS58124791A (ja) * 1982-01-19 1983-07-25 Sumitomo Chem Co Ltd ビオチンの製造法
US5274107A (en) * 1992-04-06 1993-12-28 Council Of Scientific & Industrial Research Process for synthesis of D(+) biotin

Also Published As

Publication number Publication date
WO1998043979A1 (de) 1998-10-08
DK0971931T3 (da) 2003-06-10
DE19712952A1 (de) 1998-10-01
CN1101820C (zh) 2003-02-19
DE59807249D1 (de) 2003-03-27
EP0971931A1 (de) 2000-01-19
JP2001516363A (ja) 2001-09-25
KR20010005573A (ko) 2001-01-15
EP0971931B1 (de) 2003-02-19
CN1251106A (zh) 2000-04-19
US6140507A (en) 2000-10-31
HK1022695A1 (en) 2000-08-18

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