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ES2186844T3 - Agentes de diagnostico para la diabetes. - Google Patents

Agentes de diagnostico para la diabetes.

Info

Publication number
ES2186844T3
ES2186844T3 ES97306493T ES97306493T ES2186844T3 ES 2186844 T3 ES2186844 T3 ES 2186844T3 ES 97306493 T ES97306493 T ES 97306493T ES 97306493 T ES97306493 T ES 97306493T ES 2186844 T3 ES2186844 T3 ES 2186844T3
Authority
ES
Spain
Prior art keywords
diabetes
marked
diagnostic agents
sup
scrutiny
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97306493T
Other languages
English (en)
Inventor
Tadashi Kohno
Isaburo Hosoi
Junko Ohshima
Kunihiko Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo Gas Co Ltd
Original Assignee
Tokyo Gas Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8225243A external-priority patent/JPH1067689A/ja
Priority claimed from JP25304096A external-priority patent/JP3825098B2/ja
Application filed by Tokyo Gas Co Ltd filed Critical Tokyo Gas Co Ltd
Application granted granted Critical
Publication of ES2186844T3 publication Critical patent/ES2186844T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1206—Administration of radioactive gases, aerosols or breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/90—Breath testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Atmospheric Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN AGENTE DIAGNOSTICO PARA LA DIABETES QUE COMPRENDE GLUCOSA MARCADA CON SUP,13}C EN LA POSICION 1 O 3, O ACIDO PIRUVICO MARCADO CON SUP,13}C EN AL MENOS LA POSICION 3. EL ATOMO MARCADO PUEDE DETECTARSE EN LA RESPIRACION DEL SUJETO A ENSAYAR LO QUE PERMITE LA RECOGIDA DE DATOS PARA DIAGNOSTICO O ESCRUTINIO.
ES97306493T 1996-08-27 1997-08-26 Agentes de diagnostico para la diabetes. Expired - Lifetime ES2186844T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8225243A JPH1067689A (ja) 1996-08-27 1996-08-27 糖尿病診断剤
JP25304096A JP3825098B2 (ja) 1996-09-25 1996-09-25 糖尿病診断剤

Publications (1)

Publication Number Publication Date
ES2186844T3 true ES2186844T3 (es) 2003-05-16

Family

ID=26526522

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97306493T Expired - Lifetime ES2186844T3 (es) 1996-08-27 1997-08-26 Agentes de diagnostico para la diabetes.

Country Status (5)

Country Link
US (2) US5916538A (es)
EP (1) EP0826377B1 (es)
CA (1) CA2213935C (es)
DE (1) DE69716838T2 (es)
ES (1) ES2186844T3 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177283B1 (en) * 1997-05-28 2001-01-23 Flexsite Diagnostics, Inc. Diagnostic assay
US6265223B1 (en) 1997-05-28 2001-07-24 Flexsite Diagnostics, Inc. Diagnostic assay
GB9712524D0 (en) * 1997-06-16 1997-08-20 Nycomed Imaging As Method
CA2249173C (en) * 1997-10-06 2008-12-16 Tokyo Gas Co., Ltd. Diagnostic agent for liver function
CA2250485C (en) * 1997-10-21 2008-04-29 Tokyo Gas Co., Ltd. Diagnostic agent for diabetes
US6461870B2 (en) * 1998-05-06 2002-10-08 Isotechnika Inc. 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
JP2002513911A (ja) * 1998-05-06 2002-05-14 アイソテクニカ、インコーポレーテッド 糖尿病症状の診断及び血糖コントロール監視用１３ｃグルコース呼気試験
US6284219B1 (en) * 1998-06-30 2001-09-04 Phenome Sciences Inc. In vivo determination of metabolic function for use in therapy management
IL161498A0 (en) 2001-10-24 2004-09-27 Univ California Measurement of protein synthesis rates in humans and experimental system by use of isotopically labeled water
WO2003068919A2 (en) 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
US20030180710A1 (en) * 2002-03-22 2003-09-25 Lee Wai-Nang Paul Method of enhancing the efficiency of a pharmaceutical business
US20060100903A1 (en) * 2002-03-22 2006-05-11 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Method of enhancing the efficiency of a pharmaceutical business
US20060094057A1 (en) 2002-07-30 2006-05-04 Maro K. Hellerstein Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
WO2004016156A2 (en) * 2002-08-16 2004-02-26 The Regents Of The University Of California Dynamic hepatic recycling glucose tolerance test
EP1546373B1 (en) 2002-09-13 2008-11-26 The Regents of the University of California Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis
JP4611025B2 (ja) 2002-11-04 2011-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験
US20040137637A1 (en) * 2003-01-13 2004-07-15 Chuji Wang Breath gas analyzer for diagnosing diabetes and method of use thereof
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
TW200711660A (en) 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
JP2014526685A (ja) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
WO2013086070A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
CA2882528A1 (en) * 2012-08-20 2014-02-27 Otsuka Pharmaceutical Co., Ltd. Method for measuring carbohydrate metabolism ability, and composition for use in said method
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
CN105051533B (zh) 2013-03-15 2019-03-26 大塚制药株式会社 基于脂肪酸燃烧的测定胰岛素抵抗性的方法及用于该方法的组合物
WO2018088521A1 (ja) 2016-11-11 2018-05-17 大塚製薬株式会社 肝の糖取込み能評価方法
US11484608B2 (en) * 2017-10-05 2022-11-01 Yale University Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

Also Published As

Publication number Publication date
CA2213935A1 (en) 1998-02-27
EP0826377B1 (en) 2002-11-06
EP0826377A1 (en) 1998-03-04
US6214317B1 (en) 2001-04-10
CA2213935C (en) 2002-10-01
DE69716838D1 (de) 2002-12-12
DE69716838T2 (de) 2003-04-10
US5916538A (en) 1999-06-29

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