ES2183583T3 - Agente con efecto antidepresivo, que contiene pramipexol y sertralina. - Google Patents
Agente con efecto antidepresivo, que contiene pramipexol y sertralina.Info
- Publication number
- ES2183583T3 ES2183583T3 ES99934560T ES99934560T ES2183583T3 ES 2183583 T3 ES2183583 T3 ES 2183583T3 ES 99934560 T ES99934560 T ES 99934560T ES 99934560 T ES99934560 T ES 99934560T ES 2183583 T3 ES2183583 T3 ES 2183583T3
- Authority
- ES
- Spain
- Prior art keywords
- sertraline
- agent
- pramipexol
- antidepressive effect
- antidepressive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 title abstract 2
- 229960002073 sertraline Drugs 0.000 title abstract 2
- 230000001430 anti-depressive effect Effects 0.000 title 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- FASDKYOPVNHBLU-UHFFFAOYSA-N N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine Chemical compound C1C(NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Agente para el tratamiento de depresiones, que contiene 2-amino-4,5,6,7-tetrahidro-6-propilamino- benzotiazol, uno de sus enantiómeros o una de sus sales por adición de ácidos, en combinación con sertralina o una de sus sales farmacológicamente compatibles.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19830201A DE19830201A1 (de) | 1998-07-07 | 1998-07-07 | Mittel mit antidepressiver Wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2183583T3 true ES2183583T3 (es) | 2003-03-16 |
Family
ID=7873155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99934560T Expired - Lifetime ES2183583T3 (es) | 1998-07-07 | 1999-07-02 | Agente con efecto antidepresivo, que contiene pramipexol y sertralina. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6255329B1 (es) |
| EP (1) | EP1093369B1 (es) |
| JP (1) | JP2002520273A (es) |
| KR (1) | KR100557692B1 (es) |
| CN (1) | CN1230168C (es) |
| AR (1) | AR019896A1 (es) |
| AT (1) | ATE228365T1 (es) |
| AU (1) | AU762128B2 (es) |
| BG (1) | BG64972B1 (es) |
| BR (1) | BR9911768A (es) |
| CA (1) | CA2336833C (es) |
| CZ (1) | CZ294087B6 (es) |
| DE (2) | DE19830201A1 (es) |
| DK (1) | DK1093369T3 (es) |
| EA (1) | EA003142B1 (es) |
| EE (1) | EE04296B1 (es) |
| ES (1) | ES2183583T3 (es) |
| HU (1) | HUP0103922A3 (es) |
| ID (1) | ID27776A (es) |
| IL (1) | IL140603A0 (es) |
| MY (1) | MY117969A (es) |
| NO (1) | NO20010064L (es) |
| NZ (1) | NZ509729A (es) |
| PL (1) | PL195043B1 (es) |
| PT (1) | PT1093369E (es) |
| RS (1) | RS49795B (es) |
| SK (1) | SK284923B6 (es) |
| TR (1) | TR200100146T2 (es) |
| TW (1) | TW592698B (es) |
| WO (1) | WO2000002542A2 (es) |
| YU (1) | YU401A (es) |
| ZA (1) | ZA200100090B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000006162A1 (de) * | 1998-07-27 | 2000-02-10 | Boehringer Ingelheim Pharma Kg | Mittel mit antidepressiver wirkung, mit pramipexol und einem weiteren antidepressivum |
| US20020165246A1 (en) * | 2001-03-05 | 2002-11-07 | Andrew Holman | Administration of sleep restorative agents |
| DE10138275A1 (de) * | 2001-08-10 | 2003-02-27 | Boehringer Ingelheim Pharma | Verbindungen zur Beseitigung der Anhedonie |
| AU2002360600B2 (en) * | 2001-12-11 | 2007-11-29 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| DE10334187A1 (de) * | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
| DE10334188B4 (de) * | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
| JP2007518754A (ja) * | 2004-01-22 | 2007-07-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | モノアミン神経伝達物質再取込みインヒビターとドーパミンアゴニストを含む医薬組成物 |
| CA2619217A1 (en) * | 2005-08-15 | 2007-02-22 | University Of Virginia Patent Foundation | Neurorestoration with r(+) pramipexole |
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| ES2379117T3 (es) | 2006-05-16 | 2012-04-20 | Knopp Neurosciences, Inc. | Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas |
| US20080254118A1 (en) * | 2007-04-11 | 2008-10-16 | Hans-Werner Wernersbach | Process for preparing pramipexole dihydrochloride tablets |
| US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| EP2137171A4 (en) | 2007-03-14 | 2010-05-19 | Knopp Neurosciences Inc | SYNTHESIS OF BENZOTHIAZOLE DIAMINES SUBSTITUTED AND PURIFIED FROM THE CHIRAL PERSPECTIVE |
| US20080254117A1 (en) * | 2007-04-10 | 2008-10-16 | Noel Cotton | Process for preparing pramipexole dihydrochloride tablets |
| CA2734491A1 (en) * | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
| ES2459322T3 (es) | 2008-09-05 | 2014-05-09 | Supernus Pharmaceuticals, Inc. | Método de tratamiento de trastorno de déficit de atención con hiperactividad (TDAH) |
| CA2760527A1 (en) * | 2009-04-30 | 2010-11-04 | Supernus Pharmaceuticals, Inc. | Method of treatment of depression |
| US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| CA2864088C (en) | 2012-02-08 | 2020-04-28 | Supernus Pharmaceuticals, Inc. | Modified release formulations of viloxazine |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| SMT202100119T1 (it) | 2013-07-12 | 2021-05-07 | Knopp Biosciences Llc | Trattamento dei livelli elevati di eosinofili e/o basofili |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| US9763918B2 (en) | 2013-08-13 | 2017-09-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| WO2015023786A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| IL312486B2 (en) * | 2017-04-10 | 2025-05-01 | Chase Therapeutics Corp | NK1 antagonist combination and method for treating synucleinopathies |
| ES3009607T3 (en) | 2017-06-30 | 2025-03-27 | Chase Therapeutics Corp | Nk-1 antagonist compositions and methods for use in treating depression |
| CN110028464B (zh) * | 2019-04-26 | 2022-11-18 | 浙江海洋大学 | 一种南极真菌次级代谢衍生物BTZ-one及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| EP0186087B1 (de) * | 1984-12-22 | 1989-08-23 | Dr. Karl Thomae GmbH | Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel |
| DE3843227A1 (de) * | 1988-12-22 | 1990-07-05 | Boehringer Ingelheim Kg | Neue verwendung von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzthiazol |
| US4962128A (en) * | 1989-11-02 | 1990-10-09 | Pfizer Inc. | Method of treating anxiety-related disorders using sertraline |
| DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
| US5248699A (en) * | 1992-08-13 | 1993-09-28 | Pfizer Inc. | Sertraline polymorph |
| DE4241013A1 (de) * | 1992-12-05 | 1994-06-09 | Boehringer Ingelheim Kg | Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung |
| JP3947582B2 (ja) * | 1995-08-15 | 2007-07-25 | 中外製薬株式会社 | 不安神経症治療剤 |
| TR199801929T2 (xx) * | 1996-03-29 | 1998-12-21 | Pfizer Inc. | Benzil(iden)-laktam t�revleri, bunlar�n 5-HT1A resept�rlerinin (ant)agonistler olarak kullan�mlar� . |
| CA2273809A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating movement disorders |
| CA2318095C (en) * | 1998-01-13 | 2012-11-20 | Barry S. Fogel | Methods of treating tardive dyskinesia and other movement disorders |
-
1998
- 1998-07-07 DE DE19830201A patent/DE19830201A1/de not_active Withdrawn
-
1999
- 1999-07-02 AU AU50303/99A patent/AU762128B2/en not_active Ceased
- 1999-07-02 PL PL99345842A patent/PL195043B1/pl not_active IP Right Cessation
- 1999-07-02 WO PCT/EP1999/004595 patent/WO2000002542A2/de not_active Ceased
- 1999-07-02 DE DE59903556T patent/DE59903556D1/de not_active Expired - Fee Related
- 1999-07-02 JP JP2000558802A patent/JP2002520273A/ja active Pending
- 1999-07-02 CZ CZ200177A patent/CZ294087B6/cs not_active IP Right Cessation
- 1999-07-02 YU YU401A patent/YU401A/sh unknown
- 1999-07-02 AT AT99934560T patent/ATE228365T1/de not_active IP Right Cessation
- 1999-07-02 EE EEP200100014A patent/EE04296B1/xx not_active IP Right Cessation
- 1999-07-02 EP EP99934560A patent/EP1093369B1/de not_active Expired - Lifetime
- 1999-07-02 KR KR1020017000088A patent/KR100557692B1/ko not_active Expired - Fee Related
- 1999-07-02 ES ES99934560T patent/ES2183583T3/es not_active Expired - Lifetime
- 1999-07-02 CA CA002336833A patent/CA2336833C/en not_active Expired - Fee Related
- 1999-07-02 IL IL14060399A patent/IL140603A0/xx not_active IP Right Cessation
- 1999-07-02 HU HU0103922A patent/HUP0103922A3/hu unknown
- 1999-07-02 EA EA200100084A patent/EA003142B1/ru not_active IP Right Cessation
- 1999-07-02 RS YUP-4/01A patent/RS49795B/sr unknown
- 1999-07-02 ID IDW20010017A patent/ID27776A/id unknown
- 1999-07-02 SK SK11-2001A patent/SK284923B6/sk not_active IP Right Cessation
- 1999-07-02 NZ NZ509729A patent/NZ509729A/xx unknown
- 1999-07-02 TR TR2001/00146T patent/TR200100146T2/xx unknown
- 1999-07-02 BR BR9911768-1A patent/BR9911768A/pt not_active Application Discontinuation
- 1999-07-02 DK DK99934560T patent/DK1093369T3/da active
- 1999-07-02 CN CNB998083038A patent/CN1230168C/zh not_active Expired - Fee Related
- 1999-07-02 PT PT99934560T patent/PT1093369E/pt unknown
- 1999-07-06 TW TW088111454A patent/TW592698B/zh not_active IP Right Cessation
- 1999-07-06 US US09/348,591 patent/US6255329B1/en not_active Expired - Fee Related
- 1999-07-07 AR ARP990103294A patent/AR019896A1/es unknown
- 1999-07-07 MY MYPI99002869A patent/MY117969A/en unknown
-
2001
- 2001-01-03 BG BG105112A patent/BG64972B1/bg unknown
- 2001-01-04 ZA ZA200100090A patent/ZA200100090B/en unknown
- 2001-01-05 NO NO20010064A patent/NO20010064L/no not_active Application Discontinuation
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