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ES2176588T3 - Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo. - Google Patents

Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo.

Info

Publication number
ES2176588T3
ES2176588T3 ES97118652T ES97118652T ES2176588T3 ES 2176588 T3 ES2176588 T3 ES 2176588T3 ES 97118652 T ES97118652 T ES 97118652T ES 97118652 T ES97118652 T ES 97118652T ES 2176588 T3 ES2176588 T3 ES 2176588T3
Authority
ES
Spain
Prior art keywords
cell
sample
matrix
head
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97118652T
Other languages
English (en)
Inventor
James A Farmilo
Ronald A Stead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Histaggen Inc
Original Assignee
Histaggen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Histaggen Inc filed Critical Histaggen Inc
Application granted granted Critical
Publication of ES2176588T3 publication Critical patent/ES2176588T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves
    • G01N2035/00267—Meltable plugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Fertilizers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Basic Packing Technique (AREA)
  • Warehouses Or Storage Devices (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • External Artificial Organs (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO AUTOMATICO PARA EL TEÑIDO INMUNOCITOQUIMICO DE MATERIALES BIOLOGICOS UTILIZANDO APAREAMIENTO DE LIGANDO. EL APARATO INCLUYE UNA MATRIZ DE CELDAS DE MUESTRA INTERCONECTADAS CON LINEAS DE SUMINISTRO DE REACTIVO Y DRENAJE. CADA CELDA COMPRENDE UNA CAMARA DE FLUIDO EN LA QUE SE INSERTA UN SUSTRATO DE MUESTRA. LA CARA DEL SUSTRATO EN QUE SE MONTA LA MUESTRA BIOLOGICA ESTA ENCARADA A UN POCILLO DE FLUIDO. LA CELDA INCLUYE UNA CABEZA QUE TIENE UNA CAMARA PARA RECIBIR EN ELLA UNA MATRIZ DE SOPORTE SOLIDA QUE CONTIENE EN FORMA LIBERABLE EL LIGANDO QUE HA DE PONERSE EN CONTACTO CON LA MUESTRA. LA CAMARA DE LA CABEZA DE LA CELDA ESTA COMUNICADA CON EL POCILLO DE FLUIDO DE MANERA QUE CUANDO SE LIBERA EL LIGANDO DE LA MATRIZ ESTE FLUYE DENTRO DEL POCILLO DE FLUIDO PONIENDOSE DE ESTA FORMA EN CONTACTO CON LA MUESTRA BIOLOGICA MONTADA. LA MATRIZ DE SOPORTE DEL LIGANDO PUEDE SER GELATINA O CERA. EL CUERPO DE LA CELDA Y LA CABEZA DE LA CELDA SE CALIENTAN O ENFRIAN DIFERENCIALMENTE DE FORMA QUE LA MUESTRA MONTADA PUEDE SER MANTENIDA A LA TEMPERATURA PREFERENTE PARA LA REACCION DE INTERES Y LA CABEZA DE LA CELDA PUEDE SER CALENTADA A UNA TEMPERATURA SUFICIENTE PARA CAUSAR LA DEGRADACION TERMICA DE LA MATRIZ PARA CAUSAR LA LIBERACION DEL LIGANDO. SE PROPORCIONA EL CONTROL ELECTRONICO PARA LA MEDICION Y CONTROL DE LA TEMPERATURA DE LAS DIVERSAS PARTES DE LA CELDA Y EL CONTROL PROGRAMABLE DEL SUMINISTRO DE REACTIVOS A LAS CELDAS.
ES97118652T 1993-02-03 1994-02-03 Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo. Expired - Lifetime ES2176588T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1285693A 1993-02-03 1993-02-03

Publications (1)

Publication Number Publication Date
ES2176588T3 true ES2176588T3 (es) 2002-12-01

Family

ID=21757058

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97118652T Expired - Lifetime ES2176588T3 (es) 1993-02-03 1994-02-03 Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo.
ES94906107T Expired - Lifetime ES2119166T3 (es) 1993-02-03 1994-02-03 Sistema de encapsulacion y aparato de histocitoquimica automatica destinados al tratamiento de sustancias biologicas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES94906107T Expired - Lifetime ES2119166T3 (es) 1993-02-03 1994-02-03 Sistema de encapsulacion y aparato de histocitoquimica automatica destinados al tratamiento de sustancias biologicas.

Country Status (10)

Country Link
US (1) US5695942A (es)
EP (2) EP0826955B1 (es)
AT (2) ATE217973T1 (es)
AU (1) AU5997194A (es)
CA (1) CA2153677C (es)
DE (2) DE69410084T2 (es)
DK (2) DK0682775T3 (es)
ES (2) ES2176588T3 (es)
PT (1) PT826955E (es)
WO (1) WO1994018539A2 (es)

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US7410753B2 (en) * 1998-09-03 2008-08-12 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6673620B1 (en) 1999-04-20 2004-01-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
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US8869666B2 (en) 2011-03-24 2014-10-28 Sakura Finetek U.S.A., Inc. Microtome with surface orientation sensor to sense orientation of surface of sample
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Also Published As

Publication number Publication date
PT826955E (pt) 2002-09-30
EP0682775B1 (en) 1998-05-06
DK0826955T3 (da) 2002-08-19
DK0682775T3 (da) 1999-02-15
DE69430679D1 (de) 2002-06-27
ES2119166T3 (es) 1998-10-01
DE69430679T2 (de) 2002-12-19
DE69410084D1 (de) 1998-06-10
WO1994018539A2 (en) 1994-08-18
EP0682775A1 (en) 1995-11-22
US5695942A (en) 1997-12-09
EP0826955B1 (en) 2002-05-22
AU5997194A (en) 1994-08-29
ATE165917T1 (de) 1998-05-15
ATE217973T1 (de) 2002-06-15
EP0826955A2 (en) 1998-03-04
WO1994018539A3 (en) 1994-09-29
CA2153677C (en) 2005-01-04
DE69410084T2 (de) 1999-01-21
EP0826955A3 (en) 1999-03-03
CA2153677A1 (en) 1994-08-18

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