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ES2175337T3 - Compuesto bifenilicos y su utilizacion como agentes estrogenicos. - Google Patents

Compuesto bifenilicos y su utilizacion como agentes estrogenicos.

Info

Publication number
ES2175337T3
ES2175337T3 ES97902408T ES97902408T ES2175337T3 ES 2175337 T3 ES2175337 T3 ES 2175337T3 ES 97902408 T ES97902408 T ES 97902408T ES 97902408 T ES97902408 T ES 97902408T ES 2175337 T3 ES2175337 T3 ES 2175337T3
Authority
ES
Spain
Prior art keywords
pct
bifenilic
compound
estrogen agent
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97902408T
Other languages
English (en)
Inventor
Dominique Lesuisse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2175337T3 publication Critical patent/ES2175337T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/38—Halogenated derivatives with at least one hydroxy group on a condensed ring system containing two rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), EN LA CUAL: (X) REPRESENTA LOS CARBOCICLOS AROMATICOS SIGUIENTES: (A) O (B), DONDE R 1 , R 2 , R 3 , R 4 , R 5 , R 6 Y R 7 SON TAL COMO SE DEFINEN EN LA DESCRIPCION, ASI COMO A SUS SALES, EL PROCEDIMIENTO Y LOS INTERMEDIARIOS PARA SU PREPARACION, SU APLICACION COMO MEDICAMENTO Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES97902408T 1996-02-01 1997-01-30 Compuesto bifenilicos y su utilizacion como agentes estrogenicos. Expired - Lifetime ES2175337T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9601212A FR2744444B1 (fr) 1996-02-01 1996-02-01 Nouveaux composes biphenyles, procede et intermediaires de preparation, application a titre de medicaments et compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ES2175337T3 true ES2175337T3 (es) 2002-11-16

Family

ID=9488725

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97902408T Expired - Lifetime ES2175337T3 (es) 1996-02-01 1997-01-30 Compuesto bifenilicos y su utilizacion como agentes estrogenicos.

Country Status (10)

Country Link
US (2) US6147119A (es)
EP (1) EP0880496B1 (es)
JP (1) JP4143122B2 (es)
AT (1) ATE218122T1 (es)
DE (1) DE69712868T2 (es)
DK (1) DK0880496T3 (es)
ES (1) ES2175337T3 (es)
FR (1) FR2744444B1 (es)
PT (1) PT880496E (es)
WO (1) WO1997028116A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI306450B (en) * 2001-12-13 2009-02-21 Wyeth Corp Substituted phenyl naphthalenes as estrogenic agents
BRPI0519464A2 (pt) * 2004-12-31 2009-01-27 Aventis Pharma Inc uso de certos compostos fenil-naftila que nço tÊm significante afinidade para er alfa ou beta para proteÇço de neurânios e oligodendràcitos no tratamento de esclerose méltipla
JP2008526743A (ja) * 2004-12-31 2008-07-24 アベンティス・ファーマスーティカルズ・インコーポレイテツド 多発性硬化症の治療における神経細胞及び乏突起膠細胞を保護するための選択された化合物の使用
CA2593209A1 (en) * 2005-01-04 2006-07-13 Aventis Pharmaceuticals Inc. Use of certain phenyl napthyl compounds for protection of neurons and oligodendrocytes in the treatment of multiple sclerosis (ms)
JP4590637B2 (ja) * 2006-02-16 2010-12-01 国立大学法人 千葉大学 ベンゼン誘導体の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532579A (ja) * 1991-08-01 1993-02-09 Banyu Pharmaceut Co Ltd エストロゲン物質ｂｅ−２５３２７及びその製造法

Also Published As

Publication number Publication date
FR2744444B1 (fr) 1998-05-29
DK0880496T3 (da) 2002-09-09
EP0880496A1 (fr) 1998-12-02
US6147119A (en) 2000-11-14
WO1997028116A1 (fr) 1997-08-07
US6365775B1 (en) 2002-04-02
ATE218122T1 (de) 2002-06-15
FR2744444A1 (fr) 1997-08-08
DE69712868T2 (de) 2002-11-28
JP4143122B2 (ja) 2008-09-03
EP0880496B1 (fr) 2002-05-29
DE69712868D1 (de) 2002-07-04
JP2000504003A (ja) 2000-04-04
PT880496E (pt) 2002-10-31

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