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BR9814495A - Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo - Google Patents

Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo

Info

Publication number
BR9814495A
BR9814495A BR9814495-2A BR9814495A BR9814495A BR 9814495 A BR9814495 A BR 9814495A BR 9814495 A BR9814495 A BR 9814495A BR 9814495 A BR9814495 A BR 9814495A
Authority
BR
Brazil
Prior art keywords
compound
prepare
pharmaceutical composition
solvates
salts
Prior art date
Application number
BR9814495-2A
Other languages
English (en)
Inventor
Brian Cox
Mark Patrick Healy
Malcolm Stuart Nobbs
Gita Punjabhai Shah
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR9814495A publication Critical patent/BR9814495A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTO, PROCESSO PARA PREPARá-LO, USO DO MESMO, COMPOSIçãO FARMACêUTICA, E, PROCESSO" Um composto de fórmula (I) e suas prodrogas, sais e solvatos farmaceuticamente aceitáveis.
BR9814495-2A 1997-12-22 1998-12-18 Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo BR9814495A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9726987.2A GB9726987D0 (en) 1997-12-22 1997-12-22 Compounds
PCT/EP1998/008273 WO1999032462A1 (en) 1997-12-22 1998-12-18 Triazine compounds for treatment of cns disorders

Publications (1)

Publication Number Publication Date
BR9814495A true BR9814495A (pt) 2000-10-10

Family

ID=10823992

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814495-2A BR9814495A (pt) 1997-12-22 1998-12-18 Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, processo

Country Status (34)

Country Link
US (2) US6265405B1 (pt)
EP (1) EP1042304A1 (pt)
JP (1) JP2001526275A (pt)
KR (1) KR20010024800A (pt)
CN (1) CN1284951A (pt)
AP (1) AP2000001846A0 (pt)
AR (1) AR014146A1 (pt)
AU (1) AU753874B2 (pt)
BR (1) BR9814495A (pt)
CA (1) CA2315620A1 (pt)
CO (1) CO5011066A1 (pt)
EA (1) EA200000561A1 (pt)
EE (1) EE200000391A (pt)
GB (1) GB9726987D0 (pt)
GT (1) GT199800203A (pt)
HN (1) HN1998000193A (pt)
HR (1) HRP20000419A2 (pt)
HU (1) HUP0100611A3 (pt)
ID (1) ID25449A (pt)
IL (1) IL136867A0 (pt)
IS (1) IS5542A (pt)
JO (1) JO2065B1 (pt)
MA (1) MA26587A1 (pt)
NO (1) NO20003211L (pt)
NZ (1) NZ505254A (pt)
PA (1) PA8465101A1 (pt)
PE (1) PE20000063A1 (pt)
PL (1) PL341392A1 (pt)
SK (1) SK9592000A3 (pt)
SV (1) SV1998000151A (pt)
TR (1) TR200001970T2 (pt)
WO (1) WO1999032462A1 (pt)
YU (1) YU39600A (pt)
ZA (1) ZA9811725B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0002666D0 (en) 2000-02-04 2000-03-29 Univ London Blockade of voltage dependent sodium channels
WO2003057219A1 (en) * 2001-12-27 2003-07-17 Ortho-Mcneil Pharmaceutical Inc. Aroyl pyrrole heteroeryl and methanols useful for treating a central nervous system disorder
ES2323268T3 (es) * 2002-07-29 2009-07-10 Glaxo Group Ltd Formulaciones de liberacion prolongada que contienen lamotrigina.
US20040213842A1 (en) * 2003-01-30 2004-10-28 Dynogen Pharmaceuticals, Inc. Methods of treating gastrointestinal tract disorders using sodium channel modulators
AR044503A1 (es) 2003-03-18 2005-09-14 Merck & Co Inc Triazoles sustituidos con biarilo como bloqueantes del canal de sodio
DE10332472A1 (de) * 2003-07-16 2005-02-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ambroxol für die Behandlung von Tinnitus
PT1658062E (pt) * 2003-08-25 2010-03-31 Newron Pharm Spa Derivados de alfa-amino amida úteis como agentes antiinflamatórios
US20060115865A1 (en) * 2004-10-25 2006-06-01 Anlong Ouyang Lamotrigine analogs
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
TWI651310B (zh) 2014-02-20 2019-02-21 日商日本煙草產業股份有限公司 三化合物及其醫藥用途
CN108137515B (zh) 2015-08-17 2021-07-06 日本烟草产业株式会社 羟基三嗪化合物和其医药用途
ES2770143T3 (es) * 2018-02-13 2020-06-30 Fis Fabbrica Italiana Sintetici Spa Nuevo procedimiento eficiente para la preparación de sitagliptina
CN114796146B (zh) * 2022-04-28 2023-03-28 上海奥科达医药科技股份有限公司 一种拉莫三嗪的缓释制剂及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637688A (en) 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
IL60201A (en) 1979-06-01 1984-05-31 Wellcome Found 3-amino-6-(substituted)phenyl-1,2,4-triazine derivatives,their preparation and pharmaceutical compositions containing them
DE3062603D1 (en) 1979-06-01 1983-05-11 Wellcome Found 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
EP0024351B1 (en) 1979-08-16 1984-10-31 The Wellcome Foundation Limited Solid pharmaceutical formulation containing substitued phenyl-triazines
GB8328757D0 (en) 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
GB9012312D0 (en) 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012311D0 (en) 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012316D0 (en) 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9203483D0 (en) 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
ES2097516T3 (es) 1992-06-12 1997-04-01 Wellcome Found Uso de isetionato de 3,5-diamino-6-(2,3-diclorofenil)-1,2,4-triazina para el tratamiento y prevencion de la dependencia, tolerancia y sensibilidad a los farmacos y drogas.
JPH08504798A (ja) 1992-12-18 1996-05-21 ザ ウエルカム ファウンデーション リミテッド 酵素阻害薬としての，ピリミジン，ピリジン，プテリジノンおよびインダゾール誘導体
GB9305692D0 (en) 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
US5866597A (en) 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
FR2741879A1 (fr) 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament

Also Published As

Publication number Publication date
IL136867A0 (en) 2001-06-14
GB9726987D0 (en) 1998-02-18
HUP0100611A3 (en) 2003-03-28
HRP20000419A2 (en) 2000-12-31
MA26587A1 (fr) 2004-12-20
JO2065B1 (en) 2000-05-21
HUP0100611A2 (hu) 2001-09-28
CN1284951A (zh) 2001-02-21
PE20000063A1 (es) 2000-02-16
IS5542A (is) 2000-06-20
NZ505254A (en) 2002-06-28
SK9592000A3 (en) 2001-03-12
EA200000561A1 (ru) 2001-04-23
ID25449A (id) 2000-10-05
CA2315620A1 (en) 1999-07-01
SV1998000151A (es) 1999-07-05
PA8465101A1 (es) 2000-09-29
US6265405B1 (en) 2001-07-24
NO20003211D0 (no) 2000-06-21
CO5011066A1 (es) 2001-02-28
PL341392A1 (en) 2001-04-09
YU39600A (sh) 2002-11-15
AP2000001846A0 (en) 2000-06-30
AU2414799A (en) 1999-07-12
TR200001970T2 (tr) 2001-01-22
WO1999032462A1 (en) 1999-07-01
EE200000391A (et) 2002-02-15
HN1998000193A (es) 2000-04-05
US6465461B1 (en) 2002-10-15
NO20003211L (no) 2000-08-21
ZA9811725B (en) 2000-06-27
EP1042304A1 (en) 2000-10-11
AR014146A1 (es) 2001-02-07
KR20010024800A (ko) 2001-03-26
GT199800203A (es) 2000-06-14
JP2001526275A (ja) 2001-12-18
AU753874B2 (en) 2002-10-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.