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ES2173480T3 - Preparacion de derivados de ciclohexeno carboxilato. - Google Patents

Preparacion de derivados de ciclohexeno carboxilato.

Info

Publication number
ES2173480T3
ES2173480T3 ES97939508T ES97939508T ES2173480T3 ES 2173480 T3 ES2173480 T3 ES 2173480T3 ES 97939508 T ES97939508 T ES 97939508T ES 97939508 T ES97939508 T ES 97939508T ES 2173480 T3 ES2173480 T3 ES 2173480T3
Authority
ES
Spain
Prior art keywords
ciclohexeno
preparation
carboxylate derivatives
useful
formulas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97939508T
Other languages
English (en)
Inventor
Kenneth M Kent
Choung U Kim
Lawrence R Mcgee
John D Munger
Ernest J Prisbe
Michael J Postich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/701,942 external-priority patent/US5859284A/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Application granted granted Critical
Publication of ES2173480T3 publication Critical patent/ES2173480T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA NUEVOS PROCEDIMIENTOS Y COMPOSICIONES SINTETICOS. EN PARTICULAR, NUEVOS PROCEDIMIENTOS PARA PREPARAR INTERMEDIOS, TALES COMO LOS QUE TIENEN LAS FORMULAS (I)-(IV), UTILES EN LA SINTESIS DE LOS INHIBIDORES DE LA NEURAMINIDASA, Y COMPOSICIONES UTILES COMO INTERMEDIOS QUE SON IGUALMENTE UTILES EN LA SINTESIS DE INHIBIDORES DE LA NEURAMINIDASA.
ES97939508T 1996-08-23 1997-08-22 Preparacion de derivados de ciclohexeno carboxilato. Expired - Lifetime ES2173480T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2412296P 1996-08-23 1996-08-23
US08/701,942 US5859284A (en) 1996-08-23 1996-08-23 Preparation of carbocyclic compounds

Publications (1)

Publication Number Publication Date
ES2173480T3 true ES2173480T3 (es) 2002-10-16

Family

ID=26698076

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97939508T Expired - Lifetime ES2173480T3 (es) 1996-08-23 1997-08-22 Preparacion de derivados de ciclohexeno carboxilato.

Country Status (11)

Country Link
EP (1) EP0920410B1 (es)
JP (3) JP3622983B2 (es)
AT (1) ATE215062T1 (es)
AU (1) AU738577C (es)
DE (1) DE69711395T2 (es)
DK (1) DK0920410T3 (es)
ES (1) ES2173480T3 (es)
MX (1) MXPA99001697A (es)
NZ (2) NZ522535A (es)
PT (1) PT920410E (es)
WO (1) WO1998007685A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100447096B1 (ko) 1995-02-27 2005-10-11 갈리드사이언스인코오퍼레이티드 바이러스성또는세균성뉴라미니다제의신규한선택적저해제
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US5994377A (en) 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
IL134691A0 (en) * 1997-09-17 2001-04-30 Gilead Sciences Inc Compounds containing six-membered rings, processes for their preparation, and their use as medicaments
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
DK0957078T3 (da) * 1998-05-13 2002-04-02 Hoffmann La Roche Fremgangsmåde til fremstilling af shikimisyre og derivater deraf
DE60002949T2 (de) * 1999-06-11 2004-05-19 F. Hoffmann-La Roche Ag Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
AU2039301A (en) * 1999-10-19 2001-04-30 Abbott Laboratories Neuraminidase inhibitors
JP2001131144A (ja) 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6462226B1 (en) 1999-12-03 2002-10-08 Hoffmann-La Roche Inc. Process for the preparation of 4,5-diamino shikimic acid derivatives
AU1552701A (en) 1999-12-27 2001-07-09 Kuraray Co., Ltd. Process for the production of 5-oxy-7-oxabicyclo-(4.1.0)hept-3-E NE-3-carboxylic acid esters
US6403824B2 (en) * 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
US6518048B2 (en) * 2000-04-10 2003-02-11 Hoffmann-La Roche Inc. Stereo-specific synthesis of shimikic acid derivatives with improved efficiency
US7122684B2 (en) * 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
RS51073B (sr) 2003-12-23 2010-10-31 Tibotec Pharmaceuticals Ltd. Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
CN101010289B (zh) 2004-09-02 2011-05-25 弗·哈夫曼-拉罗切有限公司 制备4,5-二氨基莽草酸的方法
ES2366704T3 (es) * 2005-11-25 2011-10-24 Hetero Drugs Limited Procedimiento mejorado para fosfato de oseltamivir.
AU2006331365B2 (en) 2005-12-28 2011-12-22 F. Hoffmann-La Roche Ag Epoxide intermediate in the TAMIFLU synthesis
US7732632B2 (en) 2006-01-02 2010-06-08 Hetero Drugs Limited Process for obtaining pure oseltamivir
KR20080097468A (ko) 2006-02-20 2008-11-05 추가이 세이야쿠 가부시키가이샤 인산 오셀타미비어 함유 의약 조성물
JP2008050336A (ja) 2006-07-28 2008-03-06 Univ Of Tokyo イソキヌクリジン誘導体およびこれを利用した１−シクロヘキセン−１−カルボン酸誘導体の製法
CA2699580C (en) 2007-09-18 2016-07-19 F. Hoffmann-La Roche Ag Process from shikimic acid to oseltamivir phosphate
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
AR073248A1 (es) 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
WO2010143700A1 (ja) 2009-06-09 2010-12-16 国立大学法人 岡山大学 ジヒドロキシヘキセン酸エステル及びその製造方法
JP4496351B1 (ja) * 2009-09-01 2010-07-07 国立大学法人 岡山大学 １，３−ジオキソラン化合物及びその製造方法
SK288218B6 (sk) 2010-05-05 2014-08-05 Synkola, S.R.O. Spôsob prípravy 1-nitro-4-oxobutanylamidov a ich opačných enantiomérov
JP5039236B1 (ja) 2011-04-27 2012-10-03 学校法人東邦大学 抗不整脈剤及び心房細動抑制剤
JP6072247B2 (ja) * 2013-06-28 2017-02-01 富士フイルム株式会社 シキミ酸誘導体の製造法および中間体
TWI481600B (zh) * 2013-07-24 2015-04-21 Nat Applied Res Laboratories 一種奎尼酸衍生物、其製程及其用途
CN105439884A (zh) * 2015-10-27 2016-03-30 沈阳药科大学 一种奥司他韦的制备方法
CN110272381A (zh) * 2019-06-19 2019-09-24 五邑大学 含吡啶片段的奥司他韦类似物及其应用
JP7475578B2 (ja) * 2020-07-01 2024-04-30 信越化学工業株式会社 １，３－ジヒドロキシ－１，１，３，３－テトラ－ｔｅｒｔ－ブトキシジシロキサンの製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100447096B1 (ko) * 1995-02-27 2005-10-11 갈리드사이언스인코오퍼레이티드 바이러스성또는세균성뉴라미니다제의신규한선택적저해제

Also Published As

Publication number Publication date
ATE215062T1 (de) 2002-04-15
JP2009167210A (ja) 2009-07-30
DE69711395T2 (de) 2002-11-07
HK1021815A1 (en) 2000-10-05
EP0920410B1 (en) 2002-03-27
NZ507106A (en) 2003-01-31
AU738577C (en) 2002-04-11
EP0920410A1 (en) 1999-06-09
PT920410E (pt) 2002-07-31
WO1998007685A1 (en) 1998-02-26
JP2000517306A (ja) 2000-12-26
JP2003002888A (ja) 2003-01-08
JP3622983B2 (ja) 2005-02-23
MXPA99001697A (es) 2004-04-05
DE69711395D1 (de) 2002-05-02
AU738577B2 (en) 2001-09-20
AU4157997A (en) 1998-03-06
DK0920410T3 (da) 2002-06-10
NZ522535A (en) 2004-07-30

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