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ES2172697T3 - Metodo y composiciones para la sintesis de nucleosidos de dioxolano que tienen una configuracion beta. - Google Patents

Metodo y composiciones para la sintesis de nucleosidos de dioxolano que tienen una configuracion beta.

Info

Publication number
ES2172697T3
ES2172697T3 ES96941539T ES96941539T ES2172697T3 ES 2172697 T3 ES2172697 T3 ES 2172697T3 ES 96941539 T ES96941539 T ES 96941539T ES 96941539 T ES96941539 T ES 96941539T ES 2172697 T3 ES2172697 T3 ES 2172697T3
Authority
ES
Spain
Prior art keywords
compositions
synthesis
nucleosids
dioxolan
beta configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96941539T
Other languages
English (en)
Inventor
Tarek Mansour
Alex Cimpoia
Krzystof Bednarski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Shire BioChem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire BioChem Inc filed Critical Shire BioChem Inc
Application granted granted Critical
Publication of ES2172697T3 publication Critical patent/ES2172697T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a procedimientos y composiciones para preparar análogos de nucleósidos biológicamente importantes que contienen anillos de azúcar 1,3-dioxolano. En particular, esta invención se refiere a la síntesis estereoselectiva del isómero beta (cis) mediante glucosilación de la base con un intermedio de fórmula (II) *fórmula* por debajo de una temperatura de aproximadamente -10º C, siendo R{sub,1} y L como se definieron anteriormente.
ES96941539T 1995-12-14 1996-12-13 Metodo y composiciones para la sintesis de nucleosidos de dioxolano que tienen una configuracion beta. Expired - Lifetime ES2172697T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration

Publications (1)

Publication Number Publication Date
ES2172697T3 true ES2172697T3 (es) 2002-10-01

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96941539T Expired - Lifetime ES2172697T3 (es) 1995-12-14 1996-12-13 Metodo y composiciones para la sintesis de nucleosidos de dioxolano que tienen una configuracion beta.

Country Status (27)

Country Link
US (4) US5922867A (es)
EP (1) EP0970074B1 (es)
JP (1) JP3229990B2 (es)
KR (1) KR100406159B1 (es)
CN (1) CN1080263C (es)
AP (1) AP879A (es)
AT (1) ATE214699T1 (es)
AU (1) AU706328B2 (es)
BR (1) BR9612351A (es)
CA (1) CA2237730C (es)
DE (1) DE69620042T2 (es)
DK (1) DK0970074T3 (es)
EA (1) EA000844B1 (es)
ES (1) ES2172697T3 (es)
GB (1) GB9525606D0 (es)
HU (1) HU224076B1 (es)
IL (3) IL144155A (es)
IN (1) IN187349B (es)
MX (1) MX9804701A (es)
NO (1) NO309901B1 (es)
NZ (1) NZ323855A (es)
OA (1) OA11094A (es)
PL (1) PL188447B1 (es)
PT (1) PT970074E (es)
TW (1) TW341574B (es)
WO (1) WO1997021706A1 (es)
ZA (1) ZA9610544B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001518899A (ja) 1997-04-07 2001-10-16 トライアングル ファーマシューティカルズ，インコーポレイティド 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用
EP1104415B1 (en) 1998-08-12 2004-11-10 Gilead Sciences, Inc. Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
US6358963B1 (en) * 1998-12-23 2002-03-19 Biochem Pharma Inc. Antiviral nucleoside analogues
WO2000047759A1 (en) * 1999-02-11 2000-08-17 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
CA2385349A1 (en) 1999-09-24 2001-04-05 Francis J. Giles Method for the treatment or prevention of viral infection using nucleoside analogues
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
DE60134196D1 (de) * 2000-02-10 2008-07-10 Mitsui Chemicals Inc Verfahren zur selektiven herstellung eines 1-phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden
WO2001058894A1 (en) 2000-02-11 2001-08-16 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
EP1389207B1 (en) 2001-03-01 2005-12-07 Gilead Sciences, Inc. Polymorphic and other crystalline forms of cis-ftc
WO2003020222A2 (en) * 2001-09-04 2003-03-13 Merck & Co., Inc. PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE
WO2003037344A1 (en) * 2001-11-02 2003-05-08 Shire Biochem Inc. Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs
US7105527B2 (en) * 2001-12-14 2006-09-12 Otto Michael J N4-acylcytosine nucleosides for treatment of viral infections
WO2003062229A1 (en) * 2002-01-25 2003-07-31 Shire Biochem Inc. Process for producing dioxolane nucleoside analogues
WO2004028445A2 (en) 2002-08-06 2004-04-08 Pharmasset Inc. Processes for preparing 1,3-dioxolane nucleosides
BR0315341B1 (pt) 2002-10-15 2014-02-18 Adesivos compreendendo poliolefina.
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
US7785839B2 (en) 2004-02-03 2010-08-31 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
NZ247936A (en) * 1992-06-22 1995-05-26 Lilly Co Eli Stereoselective anion glycosylation process for the preparation of a beta anomer enriched nucleoside

Also Published As

Publication number Publication date
US20020058670A1 (en) 2002-05-16
HK1017886A1 (en) 1999-12-03
US20030060476A1 (en) 2003-03-27
PT970074E (pt) 2002-09-30
TW341574B (en) 1998-10-01
NO982716L (no) 1998-06-12
IL124663A (en) 2001-10-31
KR100406159B1 (ko) 2004-11-16
EA000844B1 (ru) 2000-06-26
DK0970074T3 (da) 2002-07-15
US6069250A (en) 2000-05-30
IN187349B (es) 2002-03-30
NZ323855A (en) 1999-11-29
NO309901B1 (no) 2001-04-17
JP3229990B2 (ja) 2001-11-19
IL124663A0 (en) 1998-12-06
JP2000501714A (ja) 2000-02-15
NO982716D0 (no) 1998-06-12
HUP9901050A2 (hu) 2001-04-28
EP0970074B1 (en) 2002-03-20
DE69620042T2 (de) 2002-10-17
ATE214699T1 (de) 2002-04-15
KR19990072141A (ko) 1999-09-27
CA2237730A1 (en) 1997-06-19
US5922867A (en) 1999-07-13
OA11094A (en) 2003-03-13
EA199800555A1 (ru) 1999-02-25
ZA9610544B (en) 1997-07-29
EP0970074A1 (en) 2000-01-12
HU224076B1 (hu) 2005-05-30
AU706328B2 (en) 1999-06-17
GB9525606D0 (en) 1996-02-14
CN1080263C (zh) 2002-03-06
CA2237730C (en) 2001-12-04
PL327443A1 (en) 1998-12-07
CN1208414A (zh) 1999-02-17
WO1997021706A1 (en) 1997-06-19
PL188447B1 (pl) 2005-02-28
AU1089397A (en) 1997-07-03
IL144155A0 (en) 2002-05-23
BR9612351A (pt) 1999-07-13
HUP9901050A3 (en) 2001-05-28
MX9804701A (es) 1998-10-31
DE69620042D1 (de) 2002-04-25
AP9801252A0 (en) 1998-06-30
AP879A (en) 2000-10-02
IL144155A (en) 2003-07-06

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