[go: up one dir, main page]

ES2169437T3 - Procedimiento para producir compuestos heteroarilicos halogenados. - Google Patents

Procedimiento para producir compuestos heteroarilicos halogenados.

Info

Publication number
ES2169437T3
ES2169437T3 ES97946159T ES97946159T ES2169437T3 ES 2169437 T3 ES2169437 T3 ES 2169437T3 ES 97946159 T ES97946159 T ES 97946159T ES 97946159 T ES97946159 T ES 97946159T ES 2169437 T3 ES2169437 T3 ES 2169437T3
Authority
ES
Spain
Prior art keywords
group
atom
halogen atom
procedure
sup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97946159T
Other languages
English (en)
Inventor
Shigemitsu Okada
Ryosuke Ushijima
Kiyofumi Ishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of ES2169437T3 publication Critical patent/ES2169437T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA OBTENER UN COMPUESTO REPRESENTADO POR LA SIGUIENTE FORMULA GENERAL [II]: EN LA QUE X ES UN ATOMO DE HALOGENO, CADA UNO DE A SUP,1 , A 2 Y A 3 PUEDEN SER IDENTICOS O DIFERENTES, Y SER UN ATOMO DE CARBONO O UN ATOMO DE NITROGENO, A CONDICION DE QUE AL MENOS UNO DE A 1 , A 2 Y A 3 SEA UN ATOMO DE NITROGENO, Y CADA UNO DE R 1 , R 2 , R 3 Y R 4 PUEDEN SER IDENTICOS O DIFERENTES, Y SER UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO INFERIOR, UN GRUPO CIANO, UN GRUPO CARBOXILO, UN GRUPO ALCOXICARBONILO INFERIOR, UN GRUPO CARBAMOILO, UN ATOMO DE HALOGENO, UN GRUPO NITRO, UN GRUPO HIDROXILO O UN GRUPO AMINO (ALQUILO INFERIOR), A CONDICION DE QUE, EN LOS CASOS EN QUE R 1 Y R 2 SE ENCUENTRAN ADYACENTES ENTRE SI, R 1 Y R 2 PODRIAN COMBINARSE ENTRE ELLOS FORM ANDO UN ANILLO DE 5 O 6 MIEMBROS, QUE PODRIA LLEVAR EN SU ANILLO UN SUSTITUYENTE SELECCIONADO DEL GRUPO FORMADO POR UN GRUPO ALQUILO INFERIOR, UN GRUPO NITRILO, UN GRUPO CARBOXILO, UN GRUPO ALCOXICARBONILO INFERIOR, UN GRUPO CARBAMOILO, UN ATOMO DE HALOGENO, UN GRUPO NITRO, UN GRUPO HIDROXILO Y UN GRUPO AMINO - (ALQUILO INFERIOR); CARACTERIZADO POR HACER REACCIONAR UN COMPUESTO REPRESENTADO POR LA SIGUIENTE FORMULA GENERAL [I]: EN LA QUE A 1 , A 2 , A 3 , R 1 , R 2 , R SUP,3 Y R 4 SON TAL COMO SE DEFINEN ANTERIORMENTE, CON UN H ALOGENURO DE AMONIO CUATERNARIO, EN PRESENCIA DE PENTOXIDO DE FOSFORO.
ES97946159T 1996-12-10 1997-12-09 Procedimiento para producir compuestos heteroarilicos halogenados. Expired - Lifetime ES2169437T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34666696 1996-12-10

Publications (1)

Publication Number Publication Date
ES2169437T3 true ES2169437T3 (es) 2002-07-01

Family

ID=18384999

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97946159T Expired - Lifetime ES2169437T3 (es) 1996-12-10 1997-12-09 Procedimiento para producir compuestos heteroarilicos halogenados.

Country Status (8)

Country Link
US (1) US6114524A (es)
EP (1) EP0945434B1 (es)
AT (1) ATE213729T1 (es)
AU (1) AU718571B2 (es)
CA (1) CA2274597C (es)
DE (1) DE69710773T2 (es)
ES (1) ES2169437T3 (es)
WO (1) WO1998025906A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080075672A (ko) * 2007-02-13 2008-08-19 삼성전자주식회사 화상독취장치 및 이를 구비하는 화상형성기기
CN113717099B (zh) * 2021-08-03 2023-06-27 四川大学 一种含氮杂环化合物溴代反应的方法及应用
CN113717115A (zh) * 2021-08-27 2021-11-30 湖北石河医药科技有限公司 一种赛乐西帕中间体的制备方法及其在制备赛乐西帕中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404388A (en) * 1981-08-14 1983-09-13 Ciba-Geigy Corporation Process for producing 2-chloropyridines
EP0155911A1 (de) * 1984-03-19 1985-09-25 Ciba-Geigy Ag Purinderivate zur Regulierung des Pflanzenwachstums
US4739057A (en) * 1986-06-30 1988-04-19 Stauffer Chemical Co. Process for converting organo-hydroxyl compounds to halides

Also Published As

Publication number Publication date
WO1998025906A1 (en) 1998-06-18
DE69710773T2 (de) 2002-08-14
AU5139398A (en) 1998-07-03
EP0945434A1 (en) 1999-09-29
EP0945434A4 (en) 2000-02-23
CA2274597C (en) 2003-02-11
EP0945434B1 (en) 2002-02-27
ATE213729T1 (de) 2002-03-15
AU718571B2 (en) 2000-04-13
CA2274597A1 (en) 1998-06-18
DE69710773D1 (de) 2002-04-04
US6114524A (en) 2000-09-05

Similar Documents

Publication Publication Date Title
ES2133610T3 (es) Procedimiento para aumentar la proporcion de beta-modificacion en polipropileno.
ES8300088A1 (es) Procedimiento para preparar acilamilidas.
GT199900056A (es) Nuevas dihidropirimidinas
BR9810953A (pt) "processo para produzir policarbonatos ramificados"
CO4560411A1 (es) Nuevas oxazolidinonas sustituidas
ES2161231T3 (es) Compuestos heterociclicos como antagonistas de bradiquinina.
ATE260907T1 (de) Verfahren zur herstellung von olefinischen epoxiden
ES2033296T3 (es) Nuevas composiciones cataliticas y procedimiento para la copolimerizacion de olefinas/co
MX168653B (es) Catalizador de polimerizacion soportado
ZA200106107B (en) Substituted porphyrins.
ES2190932T3 (es) Procedimiento para la preparacion catalitica de aldehidos a partir de olefinas, utilizando mezclas de ligandos.
IL135949A0 (en) Substituted porphyrins
ES2126062T3 (es) Procedimiento para preparar policarbonatos.
TR199900853A2 (xx) S�bstit�e edilmi� trisiklik bile�ikler.
IT7826837A0 (it) Procedimento per l'unione di cuori di scambi ferroviari, cuori che sono costituiti da acciaio fuso duro al manganese, con rotaie costituite da acciaie al carbonio.
ES2169437T3 (es) Procedimiento para producir compuestos heteroarilicos halogenados.
ES2056146T3 (es) Monopersulfatos de acidos amino-(poli)percarboxilicos.
ES2191675T3 (es) Procedimiento para fabricar oligomeros de policarbonato.
DE69424474D1 (de) Hydrierungsverfahren zur Reinigung einer Mischung von Wasser und Caprolactam
DE69902114D1 (de) Verfahren zur Herstellung von olefinischen Epoxiden
ES2126765T3 (es) Procedimiento para la obtencion de homo- y copolimeros de alqu-1-enos.
BR9510372A (pt) Processo de preparação de alfa ómega-aminonitrilas
ES2157581T3 (es) Procedimiento para la hidroformilacion y catalizadores adecuados para la misma, que contienen como ligandos compuestos de fosforo.
ES541234A0 (es) Procedimiento de preparacion de ligantes dispersables en agua a base de aductos de epoxido-amina modificados
ATE222436T1 (de) Verfahren zum etablieren eines gemeinsamen schlüssels zwischen einer zentrale und einer gruppe von teilnehmern

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 945434

Country of ref document: ES