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ES2158814A1 - Antagonistas iii del receptor ccr-3. - Google Patents

Antagonistas iii del receptor ccr-3.

Info

Publication number
ES2158814A1
ES2158814A1 ES009902547A ES9902547A ES2158814A1 ES 2158814 A1 ES2158814 A1 ES 2158814A1 ES 009902547 A ES009902547 A ES 009902547A ES 9902547 A ES9902547 A ES 9902547A ES 2158814 A1 ES2158814 A1 ES 2158814A1
Authority
ES
Spain
Prior art keywords
ccr
antagonists
receiver
sup
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009902547A
Other languages
English (en)
Other versions
ES2158814B1 (es
Inventor
Daniel Harry Rogers
John Saunders
John Patrick Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES2158814A1 publication Critical patent/ES2158814A1/es
Application granted granted Critical
Publication of ES2158814B1 publication Critical patent/ES2158814B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Derivados de pirrolidina antagonistas del receptor CCR-3. Estos antagonistas están formados por derivados de pirrolidina, de fórmula (I), en donde los radicales R{sub,1} , Ar{sup,1} , Ar{sup,2}, A, B, Z y Q tienen el significado expresado en las reivindicaciones. La invención se refiere también a composiciones farmacéuticas que contienen a estos antagonistas del receptor CCR-3, a métodos para su uso y a métodos para preparar dichos compuestos. Estos productos se usan para el tratamiento de enfermedades respiratorias, tales como el asma.
ES009902547A 1998-11-20 1999-11-19 Derivados de pirrolidina antagonistas del receptor ccr-3 Expired - Lifetime ES2158814B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10929798P 1998-11-20 1998-11-20

Publications (2)

Publication Number Publication Date
ES2158814A1 true ES2158814A1 (es) 2001-09-01
ES2158814B1 ES2158814B1 (es) 2002-03-16

Family

ID=22326918

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009902547A Expired - Lifetime ES2158814B1 (es) 1998-11-20 1999-11-19 Derivados de pirrolidina antagonistas del receptor ccr-3

Country Status (27)

Country Link
US (1) US6166015A (es)
EP (1) EP1131288A1 (es)
JP (1) JP3593037B2 (es)
KR (1) KR20010086045A (es)
CN (1) CN1158256C (es)
AR (1) AR023707A1 (es)
AU (1) AU763960B2 (es)
BR (1) BR9915520A (es)
CA (1) CA2350903A1 (es)
CO (1) CO5140119A1 (es)
CZ (1) CZ20011760A3 (es)
DE (1) DE19955794A1 (es)
ES (1) ES2158814B1 (es)
FR (1) FR2786185A1 (es)
GB (1) GB2343893B (es)
HU (1) HUP0104364A2 (es)
ID (1) ID29067A (es)
IL (1) IL143226A0 (es)
IT (1) IT1307900B1 (es)
MA (1) MA26762A1 (es)
NO (1) NO20012411L (es)
PE (1) PE20001403A1 (es)
PL (1) PL348375A1 (es)
TR (1) TR200101398T2 (es)
UY (1) UY25811A1 (es)
WO (1) WO2000031032A1 (es)
ZA (1) ZA200103942B (es)

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WO2000069432A1 (en) 1999-05-18 2000-11-23 Teijin Limited Remedies or preventives for diseases in association with chemokines
WO2001010439A1 (en) * 1999-08-04 2001-02-15 Teijin Limited Cyclic amine ccr3 antagonists
ES2276706T3 (es) * 1999-12-08 2007-07-01 Teijin Limited Antagonistas del receptor ccr5 de aminas ciclicas.
IL155093A0 (en) 2000-09-29 2003-10-31 Glaxo Group Ltd Morpholin-acetamide derivatives for the treatment on inflammatory diseases
HUP0303107A2 (hu) * 2000-09-29 2004-03-01 Glaxo Group Ltd. Gyulladásos betegségek kezelésére alkalmazható vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
BR0116352A (pt) * 2000-12-19 2003-12-02 Hoffmann La Roche Pirrolidinas substituìdas como antagonistas de receptor ccr-3
FR2821356A1 (fr) 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
CN1267412C (zh) * 2001-09-13 2006-08-02 霍夫曼-拉罗奇有限公司 Ccr－3受体拮抗剂v
US7067549B2 (en) * 2001-12-31 2006-06-27 Actelion Pharmaceuticals Ag Pyrrolidone carboxamides
GB0207439D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207443D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207432D0 (en) 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207436D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0212355D0 (en) * 2002-05-29 2002-07-10 Glaxo Group Ltd Novel compounds
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
KR101255356B1 (ko) 2002-06-12 2013-04-17 케모센트릭스, 인크. 염증 및 면역 질병의 치료를 위한 ｃｃｒ１ 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
RU2005102586A (ru) * 2002-07-02 2005-09-20 Ф.Хоффманн-Ля Рош Аг (Ch) 2,5-замещенные производные пиримидина в качестве антагонистов ix рецептора ccr-3
WO2004028530A1 (en) * 2002-09-26 2004-04-08 Bristol-Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
WO2004078749A1 (en) 2003-03-06 2004-09-16 Glaxo Group Limited Heterocyclic urea derivatives for the treatment of pain
US7514562B2 (en) 2003-03-07 2009-04-07 Glaxo Group Limited Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain
GB0305426D0 (en) * 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
TW201018661A (en) 2003-03-14 2010-05-16 Ono Pharmaceutical Co Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
EP1619193A4 (en) 2003-04-18 2010-08-11 Ono Pharmaceutical Co SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
JP2007509095A (ja) * 2003-10-24 2007-04-12 エフ．ホフマン−ラ　ロシュ　アーゲー Ｃｃｒ３受容体アンタゴニスト
CA2558211C (en) 2004-03-03 2013-09-03 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
NZ551196A (en) * 2004-05-14 2010-08-27 Emisphere Tech Inc Compounds and compositions for delivering active agents
RU2530889C2 (ru) * 2004-05-14 2014-10-20 Эмисфире Текнолоджис, Инк. Соединения и составы для доставки активных веществ
TWI400232B (zh) 2004-09-13 2013-07-01 Ono Pharmaceutical Co 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑
WO2006088541A2 (en) * 2005-02-17 2006-08-24 State Of Oregon Acting By & Through The State Board Of Higher Edu. On Behalf Of Portland State Unv. Quinoline derivatives and uses thereof
US20110052612A1 (en) 2005-05-31 2011-03-03 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
WO2007011292A1 (en) * 2005-07-21 2007-01-25 Astrazeneca Ab N-benzyl-morpholine derivatives as modulators of the chemokine receptor
KR100743617B1 (ko) * 2005-08-25 2007-07-27 주식회사 알에스텍 고광학순도를 갖는 키랄 3-히드록시 피롤리딘 및 그유도체를 제조하는 방법
HUP0500879A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
CA2623317A1 (en) * 2005-09-22 2007-03-29 Sanofi-Aventis Amino-alkyl-amide derivatives as ccr3 receptor liquids
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
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CN101906060B (zh) * 2010-05-06 2012-07-04 爱斯医药科技(南京)有限公司 N-取代的3-氨甲基吡咯烷的制备方法

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US3459757A (en) * 1965-10-22 1969-08-05 American Cyanamid Co Imidazolidines
EP0903349A2 (en) * 1997-08-18 1999-03-24 F. Hoffmann-La Roche Ag CCR-3 receptor antagonists
EP0916668A1 (en) * 1996-07-29 1999-05-19 Banyu Pharmaceutical Co., Ltd. Chemokine receptor antagonists
WO1999025686A1 (en) * 1997-11-18 1999-05-27 Teijin Limited Cyclic amine derivatives and their use as drugs

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US3459757A (en) * 1965-10-22 1969-08-05 American Cyanamid Co Imidazolidines
EP0916668A1 (en) * 1996-07-29 1999-05-19 Banyu Pharmaceutical Co., Ltd. Chemokine receptor antagonists
EP0903349A2 (en) * 1997-08-18 1999-03-24 F. Hoffmann-La Roche Ag CCR-3 receptor antagonists
WO1999025686A1 (en) * 1997-11-18 1999-05-27 Teijin Limited Cyclic amine derivatives and their use as drugs

Also Published As

Publication number Publication date
BR9915520A (pt) 2001-07-17
PL348375A1 (en) 2002-05-20
AU1382500A (en) 2000-06-13
AU763960B2 (en) 2003-08-07
GB2343893B (en) 2002-01-09
CO5140119A1 (es) 2002-03-22
WO2000031032A1 (en) 2000-06-02
GB2343893A (en) 2000-05-24
CN1331677A (zh) 2002-01-16
FR2786185A1 (fr) 2000-05-26
CN1158256C (zh) 2004-07-21
JP3593037B2 (ja) 2004-11-24
DE19955794A1 (de) 2000-05-31
GB9927227D0 (en) 2000-01-12
US6166015A (en) 2000-12-26
PE20001403A1 (es) 2000-12-15
EP1131288A1 (en) 2001-09-12
ITTO991009A1 (it) 2001-05-19
IL143226A0 (en) 2002-04-21
ITTO991009A0 (it) 1999-11-19
UY25811A1 (es) 2001-07-31
ZA200103942B (en) 2002-08-15
CA2350903A1 (en) 2000-06-02
TR200101398T2 (tr) 2001-09-21
AR023707A1 (es) 2002-09-04
JP2002530374A (ja) 2002-09-17
HUP0104364A2 (hu) 2002-04-29
ES2158814B1 (es) 2002-03-16
NO20012411D0 (no) 2001-05-16
NO20012411L (no) 2001-05-16
IT1307900B1 (it) 2001-11-19
KR20010086045A (ko) 2001-09-07
MA26762A1 (fr) 2004-12-20
CZ20011760A3 (cs) 2001-12-12
ID29067A (id) 2001-07-26

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