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ES2151110T3 - Derivados de piridazinona y procedimiento de preparacion. - Google Patents

Derivados de piridazinona y procedimiento de preparacion.

Info

Publication number
ES2151110T3
ES2151110T3 ES96110412T ES96110412T ES2151110T3 ES 2151110 T3 ES2151110 T3 ES 2151110T3 ES 96110412 T ES96110412 T ES 96110412T ES 96110412 T ES96110412 T ES 96110412T ES 2151110 T3 ES2151110 T3 ES 2151110T3
Authority
ES
Spain
Prior art keywords
similar
sup
atomo
group
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96110412T
Other languages
English (en)
Inventor
Akihiko Ishida
Harutami Yamada
Michihisa Yato
Shinsuke Nishiyama
Fumikazu Okumura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2151110T3 publication Critical patent/ES2151110T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Optical Couplings Of Light Guides (AREA)

Abstract

ES EXPUESTO UNA COMPOSICION DE PIRIDACINONA REPRESENTADA POR LA FORMULA (I): EN DONDE X REPRESENTA UN ATOMO DE HALOGENO O SIMILAR; Y REPRESENTA UN BRAZO DE ENLAZAMIENTO SIMPLE, ATOMO DE OXIGENO O AZUFRE; A REPRESENTA UN GRUPO ALQUILENO LINEAL O RAMIFICADO QUE PUEDE TENER UN DOBLE ENLACE; B REPRESENTA UN GRUPO CARBONILO O TIOCARBONILO; Y R{SUP,2} REPRESENTA UN GRUPO ALQUILO QUE TIENE DE 1 A 10 ATOMOS DE CARBONO QUE PUEDE ESTAR SUBSTITUIDO O SIMILAR; O B REPRESENTA UN GRUPO SULFONILO; Y R{SUP,2} REPRESENTA UN GRUPO ALQUENILO INFERIOR O SIMILAR; R{SUP,1} REPRESENTA UN ATOMO DE HIDROGENO O SIMILAR; R{SUP,3} REPRESENTA UN ATOMO DE HIDROGENO O SIMILAR; R{SUP,4} REPRESENTA UN ATOMO DE HIDROGENO O SIMILAR; Y R{SUP,5} REPRESENTA UN ATOMO DE HIDROGENO O SIMILAR, O UNA SAL DEL MISMO ACEPTABLE FARMACEUTICAMENTE.
ES96110412T 1995-06-27 1996-06-27 Derivados de piridazinona y procedimiento de preparacion. Expired - Lifetime ES2151110T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16062095 1995-06-27
JP1985996 1996-02-06

Publications (1)

Publication Number Publication Date
ES2151110T3 true ES2151110T3 (es) 2000-12-16

Family

ID=26356726

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96110412T Expired - Lifetime ES2151110T3 (es) 1995-06-27 1996-06-27 Derivados de piridazinona y procedimiento de preparacion.

Country Status (21)

Country Link
US (2) US5698554A (es)
EP (1) EP0751132B1 (es)
KR (1) KR970061873A (es)
CN (1) CN1144802A (es)
AR (1) AR002602A1 (es)
AT (1) ATE195937T1 (es)
AU (1) AU694955B2 (es)
BG (1) BG62768B1 (es)
CA (1) CA2179939A1 (es)
DE (1) DE69610036T2 (es)
DK (1) DK0751132T3 (es)
ES (1) ES2151110T3 (es)
GR (1) GR3034910T3 (es)
HU (1) HUP9601766A3 (es)
IL (1) IL118631A (es)
MY (1) MY132263A (es)
NO (1) NO311084B1 (es)
PT (1) PT751132E (es)
RU (1) RU2131419C1 (es)
SG (1) SG46741A1 (es)
TW (1) TW432052B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2235911C (en) * 1997-05-27 2003-07-29 Schneider (Usa) Inc. Stent and stent-graft for treating branched vessels
DOP2000000070A (es) * 1999-09-28 2002-02-28 Bayer Healthcare Llc Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis
KR20030061051A (ko) * 2002-01-07 2003-07-18 대한민국 (경상대학교 총장) 신규한 아렌(혹은 알케인)술폰일피리다진온 유도체, 이의제조방법 및 유기반응에서의 용도
AR050552A1 (es) * 2004-09-02 2006-11-01 Osi Pharm Inc Mercaptoamidas como inhibidores de histona desacetilasa
CN101443317B (zh) * 2006-03-17 2011-07-06 住友化学株式会社 哒嗪酮化合物及其作为除草剂的用途
NZ574873A (en) * 2006-07-25 2012-03-30 Cephalon Inc Pyridazinone derivatives as h3 inhibitors
ES2524787T3 (es) * 2007-11-15 2014-12-12 Msd Italia S.R.L. Derivados de piridazinona como inhibidores de PARP
WO2011116287A1 (en) * 2010-03-19 2011-09-22 Purdue Research Foundation Ccr5 modulators for treating hiv
BR112013011188B1 (pt) 2010-11-05 2022-01-04 Senomyx, Inc Método não-médico para modular canal potencial de receptor transiente de melastina 8 (trpm8), método não-médico para modular a sensação de resfriamento de uma composição, método não-médico para induzir uma sensação de resfriamento em um humano ou animal e composto
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
WO2012177893A2 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
MX389514B (es) 2015-10-01 2025-03-20 Firmenich Incorporated Compuestos útiles como moduladores de canal receptor 8 de potencial transitorio de melastatina (trpm8).
EP3693369A3 (en) 2016-04-15 2020-09-09 AbbVie Inc. Bromodomain inhibitors
AU2019372121A1 (en) * 2018-10-30 2021-05-27 Nuvation Bio Inc. Heterocyclic compounds as BET inhibitors
AU2019374812B2 (en) 2018-11-06 2025-03-06 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
DK3877052T3 (da) 2018-11-06 2023-09-25 Edgewise Therapeutics Inc Pyridazinonforbindelser og anvendelser deraf
EP3877376B1 (en) 2018-11-06 2023-08-23 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
US11584756B2 (en) 2019-07-02 2023-02-21 Nuvation Bio Inc. Heterocyclic compounds as BET inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6053022B2 (ja) * 1977-04-07 1985-11-22 ウェルファイド株式会社 ピリダジノン誘導体
GB8323553D0 (en) * 1983-09-02 1983-10-05 Smith Kline French Lab Pharmaceutical compositions
JPS6193169A (ja) * 1984-10-12 1986-05-12 Sankyo Co Ltd ピリダジノン誘導体及びその製法
KR860007219A (ko) * 1985-03-12 1986-10-08 베쩰, 좀머 설포닐아미노에틸 화합물의 제조방법
EP0194548A3 (de) * 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3508692A1 (de) 1985-03-12 1986-09-18 Dr. Karl Thomae Gmbh, 7950 Biberach 3-(4-(2-benzolsulfonylamino-aethyl)-benzoyl)propionsaeure, diese verbindung enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3623944A1 (de) 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPS63145272A (ja) * 1986-12-09 1988-06-17 Morishita Seiyaku Kk ４，５−ジヒドロ−６−（４−置換フエニル）−３（２ｈ）−ピリダジノン誘導体
SU1486061A3 (ru) * 1987-03-26 1989-06-07 Mitsubishi Chem Ind Способ получения производных пиридазинона или их солей
DE3728491A1 (de) * 1987-08-26 1989-03-09 Heumann Pharma Gmbh & Co Dihydropyridazinon-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4134467A1 (de) * 1991-10-18 1993-04-22 Thomae Gmbh Dr K Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DK0589037T3 (da) * 1991-03-01 1996-09-16 Zeria Pharm Co Ltd Indanderivat og thromboxanantagonist indeholdende samme
CA2099743A1 (en) * 1992-07-02 1994-01-03 Akihiko Ishida Pyridazinone derivatives and processes for preparing the same
JP2616584B2 (ja) * 1992-07-02 1997-06-04 田辺製薬株式会社 ピリダジノン誘導体及びその製法
CA2138812A1 (en) * 1993-12-28 1995-06-29 Akihiko Ishida Indane derivative and processes for preparing the same
JP2757353B2 (ja) * 1993-12-28 1998-05-25 田辺製薬株式会社 インダン誘導体、その製法及びその合成中間体
CA2139088A1 (en) * 1993-12-28 1995-06-29 Akihiko Ishida Indane derivatives, processes for preparing the same and synthetic intermediate of the same

Also Published As

Publication number Publication date
CA2179939A1 (en) 1996-12-28
DK0751132T3 (da) 2000-11-13
BG100684A (bg) 1997-03-31
CN1144802A (zh) 1997-03-12
US5698554A (en) 1997-12-16
US5808065A (en) 1998-09-15
AU694955B2 (en) 1998-08-06
AU5622196A (en) 1997-01-09
NO962643D0 (no) 1996-06-21
NO311084B1 (no) 2001-10-08
IL118631A0 (en) 1996-10-16
HU9601766D0 (en) 1996-08-28
EP0751132B1 (en) 2000-08-30
GR3034910T3 (en) 2001-02-28
HUP9601766A3 (en) 1998-04-28
BG62768B1 (bg) 2000-07-31
ATE195937T1 (de) 2000-09-15
RU2131419C1 (ru) 1999-06-10
DE69610036D1 (de) 2000-10-05
DE69610036T2 (de) 2001-04-12
KR970061873A (ko) 1997-09-12
EP0751132A1 (en) 1997-01-02
HUP9601766A2 (en) 1997-02-28
TW432052B (en) 2001-05-01
IL118631A (en) 2002-05-23
SG46741A1 (en) 1998-02-20
PT751132E (pt) 2000-12-29
MY132263A (en) 2007-09-28
NO962643L (no) 1996-12-30
AR002602A1 (es) 1998-03-25

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