[go: up one dir, main page]

ES2149213T3 - Compuesto de pirimidina. - Google Patents

Compuesto de pirimidina.

Info

Publication number
ES2149213T3
ES2149213T3 ES93921102T ES93921102T ES2149213T3 ES 2149213 T3 ES2149213 T3 ES 2149213T3 ES 93921102 T ES93921102 T ES 93921102T ES 93921102 T ES93921102 T ES 93921102T ES 2149213 T3 ES2149213 T3 ES 2149213T3
Authority
ES
Spain
Prior art keywords
alkoxy
alkyl
halogen
represent
double bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921102T
Other languages
English (en)
Inventor
Tomio Kimura
Yoshiaki Ube Research L Kuroki
Hiroshi Ube Research Fujiwara
Shigeharu Ube Research Anpeiji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ube Corp
Original Assignee
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries Ltd filed Critical Ube Industries Ltd
Application granted granted Critical
Publication of ES2149213T3 publication Critical patent/ES2149213T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN DERIVADO DE LA PIRIMIDINA REPRESENTADO POR LA FORMULA GENERAL (II) O (III) Y UNA SAL DEL MISMO, EN DONDE LOS DOS TIENEN UN EFECTO INHIBIDOR DE LA ESTERASA DE ACETILCOLINA Y UN EFECTO INHIBIDOR DE LA OXIDASA DE MONOAMINA TIPO A, POR LO QUE SON UTILES COMO ANTIDEPRESIVOS Y PARA CURAR LA DEMENCIA SENIL. EN DICHAS FORMULAS, R1 Y R2 REPRESENTAN CADA UNO H, HALOGENO, AMINO, NITRO, ALQUILO (NO)SUSTITUIDO, ALCOXI O ALCOXICARBONILO, CON LA CONDICION DE QUE R1 Y R2 SE PUEDAN COMBINAR ENTRE SI PARA REPRESENTAR UN ALQUILENO (NO)SUSTITUIDO; R3 REPRESENTA ARALQUILO O HETEROARIL-ALQUILO; R4 REPRESENTA H O ACILO; R5 REPRESENTA H, OH O ALCOXI; R6 REPRESENTA H, HALOGENO, ALQUILO O ALCOXI; X REPRESENTA -CH=, -CH=CH-(CH2)P-, -CH2O -CH2CH2-(CH2)P-; Y REPRESENTA =CH-(CH2)P-, -CH2-(CH2)P-, UN ENLACE SENCILLO O UN ENLACE DOBLE; P REPRESENTA 0 O 1; Y EL SIMBOLO DE LA RAYA CONTINUA CON PUNTOS ABAJO REPRESENTA UN ENLACE SENCILLO O UNO DOBLE.
ES93921102T 1992-10-05 1993-10-01 Compuesto de pirimidina. Expired - Lifetime ES2149213T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26635392 1992-10-05

Publications (1)

Publication Number Publication Date
ES2149213T3 true ES2149213T3 (es) 2000-11-01

Family

ID=17429767

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921102T Expired - Lifetime ES2149213T3 (es) 1992-10-05 1993-10-01 Compuesto de pirimidina.

Country Status (13)

Country Link
US (1) US5610303A (es)
EP (1) EP0664291B1 (es)
JP (1) JP2932693B2 (es)
KR (1) KR100262254B1 (es)
CN (1) CN1040322C (es)
AT (1) ATE194837T1 (es)
AU (1) AU672034B2 (es)
CA (1) CA2146333A1 (es)
DE (1) DE69329067T2 (es)
DK (1) DK0664291T3 (es)
ES (1) ES2149213T3 (es)
PT (1) PT664291E (es)
WO (1) WO1994007890A1 (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163747C (en) * 1993-05-26 2007-01-30 Robin Douglas Clark Novel 1-phenylalkanone 5-ht4 receptor ligands
US6251938B1 (en) 1996-12-18 2001-06-26 Teva Pharmaceutical Industries, Ltd., Phenylethylamine derivatives
DE69738275T2 (de) 1996-12-18 2008-08-28 Teva Pharmaceutical Industries Ltd. Aminoindanderivate
EP1107957B1 (en) * 1998-08-29 2006-10-18 AstraZeneca AB Pyrimidine compounds
AU5438499A (en) 1998-08-29 2000-03-21 Astrazeneca Ab Pyrimidine compounds
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB9907658D0 (en) 1999-04-06 1999-05-26 Zeneca Ltd Chemical compounds
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB0004888D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0007371D0 (en) 2000-03-28 2000-05-17 Astrazeneca Uk Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
GB0021726D0 (en) * 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
US6359046B1 (en) 2000-09-08 2002-03-19 Crompton Corporation Hydrocarbon core polysulfide silane coupling agents for filled elastomer compositions
US6635700B2 (en) 2000-12-15 2003-10-21 Crompton Corporation Mineral-filled elastomer compositions
GB0103926D0 (en) * 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
GB0113041D0 (en) 2001-05-30 2001-07-18 Astrazeneca Ab Chemical compounds
GB0205693D0 (en) * 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
AU2003208479A1 (en) * 2002-03-09 2003-09-22 Astrazeneca Ab 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
GB0205690D0 (en) * 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205688D0 (en) * 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0311276D0 (en) * 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
GB0311274D0 (en) * 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
TW200528101A (en) * 2004-02-03 2005-09-01 Astrazeneca Ab Chemical compounds
MX2007007272A (es) * 2004-12-17 2007-07-11 Astrazeneca Ab 4-(4-imidazol-4-il)pirimidin-2-ilamino)benzamidas como inhibidores de cdk.
BRPI0614502A2 (pt) * 2005-07-30 2011-03-29 Astrazeneca Ab Composto, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto
US7745428B2 (en) * 2005-09-30 2010-06-29 Astrazeneca Ab Imidazo[1,2-A]pyridine having anti-cell-proliferation activity
EP1956904B1 (en) 2005-12-09 2017-04-12 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Low-dose ladostigil for the treatment of mild cognitive impairment
TW200744576A (en) 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
TW200811169A (en) * 2006-05-26 2008-03-01 Astrazeneca Ab Chemical compounds
ATE532789T1 (de) 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
NZ573979A (en) * 2006-07-06 2012-02-24 Array Biopharma Inc Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8329701B2 (en) 2006-07-06 2012-12-11 Array Biopharma Inc. Dihydrofuro pyrimidines as AKT protein kinase inhibitors
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
US7968633B2 (en) 2006-12-28 2011-06-28 Continental Ag Tire compositions and components containing free-flowing filler compositions
US7968635B2 (en) 2006-12-28 2011-06-28 Continental Ag Tire compositions and components containing free-flowing filler compositions
US7737202B2 (en) 2006-12-28 2010-06-15 Momentive Performance Materials Inc. Free-flowing filler composition and rubber composition containing same
US7781606B2 (en) 2006-12-28 2010-08-24 Momentive Performance Materials Inc. Blocked mercaptosilane coupling agents, process for making and uses in rubber
US7687558B2 (en) 2006-12-28 2010-03-30 Momentive Performance Materials Inc. Silated cyclic core polysulfides, their preparation and use in filled elastomer compositions
US8592506B2 (en) 2006-12-28 2013-11-26 Continental Ag Tire compositions and components containing blocked mercaptosilane coupling agent
US7968634B2 (en) 2006-12-28 2011-06-28 Continental Ag Tire compositions and components containing silated core polysulfides
US7696269B2 (en) 2006-12-28 2010-04-13 Momentive Performance Materials Inc. Silated core polysulfides, their preparation and use in filled elastomer compositions
US7968636B2 (en) 2006-12-28 2011-06-28 Continental Ag Tire compositions and components containing silated cyclic core polysulfides
US7960460B2 (en) 2006-12-28 2011-06-14 Momentive Performance Materials, Inc. Free-flowing filler composition and rubber composition containing same
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
ES2551352T3 (es) 2007-07-05 2015-11-18 Array Biopharma, Inc. Pirimido ciclopentanos útiles para el tratamiento de enfermedades inflamatorias o hiperproliferativas
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
MX2009014013A (es) * 2007-07-05 2010-01-28 Array Biopharma Inc Pirimidil ciclopentanos como inhibidores de la proteina cinasa akt.
EP2240455B1 (en) * 2008-01-09 2012-12-26 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
ES2422733T3 (es) * 2008-01-09 2013-09-13 Array Biopharma Inc Pirimidilciclopentanos hidroxilados como inhibidores de proteínas cinasas AKT
WO2009152647A1 (zh) * 2008-06-20 2009-12-23 江苏恩华药业股份有限公司 芳烷基哌啶衍生物及其在制备镇痛、镇静药物中的应用
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
SG10201504303SA (en) 2011-04-01 2015-07-30 Genentech Inc Combinations Of AKT Inhibitor Compounds And Chemotherapeutic Agents, And Methods Of Use
TR201815685T4 (tr) 2011-04-01 2018-11-21 Genentech Inc Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları.
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57203072A (en) * 1981-06-05 1982-12-13 Sankyo Co Ltd 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient
DE3464406D1 (de) * 1984-04-10 1987-07-30 Reinhard Lipinski Linear transporter
DE3514074A1 (de) * 1985-04-18 1986-10-23 Herion-Werke Kg, 7012 Fellbach Kolbenstangenloser zylinder
JP2507933B2 (ja) * 1987-04-02 1996-06-19 三菱マテリアル株式会社 ボ−ルネジ
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JPH0819924B2 (ja) * 1987-06-30 1996-03-04 豊和工業株式会社 圧流体シリンダのクッション装置
JPH071041B2 (ja) * 1988-03-26 1995-01-11 豊和工業株式会社 ガイド付ロッドレスシリンダ
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
JPH02225807A (ja) * 1989-02-27 1990-09-07 G Liebermann Walter スライダー

Also Published As

Publication number Publication date
KR100262254B1 (ko) 2000-07-15
DE69329067D1 (de) 2000-08-24
CN1088207A (zh) 1994-06-22
EP0664291B1 (en) 2000-07-19
PT664291E (pt) 2000-11-30
WO1994007890A1 (fr) 1994-04-14
US5610303A (en) 1997-03-11
DK0664291T3 (da) 2000-10-30
EP0664291A4 (en) 1995-05-23
DE69329067T2 (de) 2001-05-10
AU672034B2 (en) 1996-09-19
AU4834893A (en) 1994-04-26
KR950703553A (ko) 1995-09-20
CA2146333A1 (en) 1994-04-14
EP0664291A1 (en) 1995-07-26
CN1040322C (zh) 1998-10-21
JP2932693B2 (ja) 1999-08-09
ATE194837T1 (de) 2000-08-15

Similar Documents

Publication Publication Date Title
ES2149213T3 (es) Compuesto de pirimidina.
LU88621I2 (fr) Sandopril
FI855117A0 (fi) Segmenttipolyestereitä ja niiden kaltaisia yhdisteitä käytettäviksi lianirrotusaineina pesuainekoostumuksissa
PT756594E (pt) Preparacao de oxadiazinas artropodicidas
IE873467L (en) Aryloxy and arylacyloxymethyl aminomethylketones
CO5050332A1 (es) Composiciones fungicidas que comprenden 2-metoxibenzofenonas
DE60220188D1 (de) Hemmer des phosphattransports
IS6257A (is) Frumuviðloðunartálmar
ZA9710292B (en) Atherosclerosis treatment
ATE263771T1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
EP0937726A4 (en) INTERMEDIATE PRODUCTS FOR THE PREPARATION OF DUOCARMYCIN SA AND DERIVATIVES THEREOF, AND PROCESS FOR PRODUCING SUCH INTERMEDIATE PRODUCTS
DK0806416T3 (da) Huperzinderivater, deres fremstilling og anvendelse
EA200000679A1 (ru) Фунгицидная смесь на базе амидных соединений и производных морфолина, соответственно, пиперидина
DE3563847D1 (de) Novel arylacitic acid derivatives
EP0882721A4 (en) SIALIC ACIDS 2,7-DIDEOXY-7-FLUORO- 2, 3-DIDEHYDRO A QUADRUPLE SUBSTITUTION
DK1049686T3 (da) Nyttige mellemprodukter og fremgangsmåder ved semisyntese af paclitaxel og analoger deraf
ES2112337T3 (es) Derivado de benzodioxano.
FI914525A0 (fi) Foerening, anvaendning och framstaellning.
PL325082A1 (en) Novel compounds of benzene sulphonylamine, method of obtaining them and pharmaceutic compositions containing such compounds
FR2684993B1 (fr) Procede de preparation de derives d'amino-2 nitro-4 benzothiazole et intermediaires.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 664291

Country of ref document: ES