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ES2008360A6 - Un procedimiento para la preparacion de cetonas triciclicas. - Google Patents

Un procedimiento para la preparacion de cetonas triciclicas.

Info

Publication number
ES2008360A6
ES2008360A6 ES8703405A ES8703405A ES2008360A6 ES 2008360 A6 ES2008360 A6 ES 2008360A6 ES 8703405 A ES8703405 A ES 8703405A ES 8703405 A ES8703405 A ES 8703405A ES 2008360 A6 ES2008360 A6 ES 2008360A6
Authority
ES
Spain
Prior art keywords
carbazolone
tetrahydro
intermediates
compounds
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8703405A
Other languages
English (en)
Inventor
Ian Harold Coates
John Bradshaw
James Angus Bell
David Cedric Humber
George Blanch Ewan
William Leonard Mitchell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868628473A external-priority patent/GB8628473D0/en
Priority claimed from GB878726537A external-priority patent/GB8726537D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES2008360A6 publication Critical patent/ES2008360A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE CETONAS TRICICLICAS DE FORMULA (I), DONDE IM ES UN GRUPO IMIDAZOLILO; R1 ES H O ALQUILO C1-6, ALQUENILO C3-6, ALQUINILO C3-10, CICLOALQUILO C3-7, (CICLOALQUILO C3-7) ALQUILO C1-4, FENILO, FENIL-ALQUILO C1-3, -CO2R5, -COR5 O SO2R5; UNO DE R2, R3 Y R4 ES H O ALQUILO C1-6, CICLOALQUILO C3-7, ALQUENILO C3-6, FENIL O FENIL-ALQUILO C1-3 Y LOS OTROS SON H O ALQUILO C1-6; Q ES H, HALOGENO, HIDROXI, ALCOXI C1-4, FENILALCOXI C1-3, ALQUILO C1-6, -NR7R8 O -CONR7R8; N ES 1, 2 O 3; Y A-B ES CH-CH2 O C=CH. LOS COMPUESTOS (I) PUEDEN OBTENERSE POR: A) DESHIDRATACION DE (II); B) REACCION DE (III) CON LCH2-IM, DONDE L ES UN GRUPO SALIENTE; C) OXIDACION DE (VI); O D) CICLACION DE (VII) SEGUIDO DE ELIMINACION DE GRUPOS PROTECTORES. LOS COMPUESTOS (I) SON POTENTES ANTAGONISTAS DEL EFECTO 5-HT EN RECEPTORES 5-TH3 Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS PSICOTICOS, ANSIEDAD, NAUSEAS Y VOMITOS.
ES8703405A 1986-11-28 1987-11-27 Un procedimiento para la preparacion de cetonas triciclicas. Expired ES2008360A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868628473A GB8628473D0 (en) 1986-11-28 1986-11-28 Chemical compounds
GB878726537A GB8726537D0 (en) 1987-11-12 1987-11-12 Tricyclic ketones

Publications (1)

Publication Number Publication Date
ES2008360A6 true ES2008360A6 (es) 1989-07-16

Family

ID=26291603

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8703405A Expired ES2008360A6 (es) 1986-11-28 1987-11-27 Un procedimiento para la preparacion de cetonas triciclicas.

Country Status (24)

Country Link
US (1) US4822881A (es)
AT (1) AT396933B (es)
AU (1) AU605805B2 (es)
BE (1) BE1001004A4 (es)
CA (1) CA1326032C (es)
CH (1) CH676120A5 (es)
CZ (1) CZ404591A3 (es)
DE (1) DE3740352A1 (es)
DK (1) DK169675B1 (es)
ES (1) ES2008360A6 (es)
FI (1) FI92062C (es)
FR (1) FR2611366B1 (es)
GB (1) GB2202530B (es)
GR (1) GR871809B (es)
HK (1) HK51591A (es)
IE (1) IE61510B1 (es)
IL (1) IL84635A (es)
IT (1) IT1211936B (es)
NL (1) NL8702851A (es)
NO (1) NO172581C (es)
NZ (1) NZ222725A (es)
PH (1) PH30436A (es)
SE (1) SE467255B (es)
SG (1) SG46591G (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
US5360800A (en) * 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
US4939144A (en) * 1987-10-22 1990-07-03 Glaxo Group Limited Tricyclic ketone derivatives as 5-HT antagonists
US5116984A (en) * 1988-04-07 1992-05-26 Glaxo Group Limited Imidazole derivatives
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5049563A (en) * 1988-07-07 1991-09-17 Duphar International Research B.V. Annelated indoleketones with an imidazolylalkyl substituent
NZ230154A (en) * 1988-08-02 1991-10-25 Glaxo Group Ltd Imidazolyl-substituted 6- or 7-membered ring lactam derivatives and pharmaceutical composition
HU207078B (en) * 1988-08-02 1993-03-01 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
EP0356098A3 (en) * 1988-08-15 1990-07-25 Glaxo Group Limited Lactam derivatives
GB8820653D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
US4997831A (en) * 1988-09-01 1991-03-05 Glaxo Group Limited Lactam derivatives
GB8820651D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
GB8820650D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
GB8823980D0 (en) * 1988-10-13 1988-11-23 Glaxo Group Ltd Chemical compounds
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
GB8904552D0 (en) 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical process
HU204049B (en) * 1989-02-28 1991-11-28 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising same
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
ES2061024T3 (es) 1989-04-21 1994-12-01 Sandoz Ag Uso terapeutico de antagonistas de receptores de 5-ht3.
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
KR100368895B1 (ko) * 2000-03-30 2003-01-24 하나제약 주식회사 1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법
ES2281646T3 (es) * 2002-01-18 2007-10-01 Aryx Therapeutics Antagonistas del receptor 5-ht3 y procedimientos de utilizacion.
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
LT2432467T (lt) 2009-05-20 2018-04-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonino 5-ht3 receptoriaus antagonistai, skirti panaudoti pažeidimų sukeltų vestibiuliarinių sutrikimų gydymui

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
GB1365296A (en) * 1970-10-30 1974-08-29 Unilever Ltd Dentifrice compositions
US4176230A (en) * 1977-08-04 1979-11-27 Hoffmann-La Roche Inc. 5-(6-Alkylindol-3-ylmethylene)-1,3-dimethyl-2-(methylimino)-4-imidazolidinones
BG33279A3 (en) * 1978-11-01 1983-01-14 The Wellcome Foundation Limited Method for making of carbazole compounds
DK151884C (da) * 1979-03-07 1988-06-13 Pfizer Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf
PT79890B (en) * 1984-01-25 1987-02-03 Glaxo Group Ltd Process for preparing tetrahydro-methylimidazolylcarbazolones
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
EP0191562B1 (en) * 1985-01-23 1991-07-10 Glaxo Group Limited Tetrahydrocarbazolone derivatives
GB8518745D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process

Also Published As

Publication number Publication date
GB8727835D0 (en) 1987-12-31
PH30436A (en) 1997-05-09
FI875235A7 (fi) 1988-05-29
FI92062C (fi) 1994-09-26
US4822881A (en) 1989-04-18
SE8704746D0 (sv) 1987-11-27
CA1326032C (en) 1994-01-11
FR2611366B1 (fr) 1990-03-16
SE467255B (sv) 1992-06-22
GR871809B (en) 1988-03-07
IL84635A0 (en) 1988-04-29
NL8702851A (nl) 1988-06-16
DK624887A (da) 1988-05-29
DK624887D0 (da) 1987-11-27
AU605805B2 (en) 1991-01-24
IL84635A (en) 1993-01-31
CH676120A5 (es) 1990-12-14
SE8704746L (sv) 1988-05-29
NO172581B (no) 1993-05-03
IT1211936B (it) 1989-11-08
IE873232L (en) 1988-05-28
DE3740352A1 (de) 1988-06-09
BE1001004A4 (fr) 1989-06-06
HK51591A (en) 1991-07-12
AU8184587A (en) 1988-06-02
SG46591G (en) 1991-07-26
FR2611366A1 (fr) 1988-09-02
FI875235A0 (fi) 1987-11-27
NZ222725A (en) 1990-08-28
NO874959L (no) 1988-05-30
FI92062B (fi) 1994-06-15
IT8748642A0 (it) 1987-11-27
CZ404591A3 (en) 1993-08-11
GB2202530B (en) 1990-04-18
IE61510B1 (en) 1994-11-16
ATA312487A (de) 1993-05-15
DK169675B1 (da) 1995-01-09
AT396933B (de) 1993-12-27
NO172581C (no) 1993-08-11
GB2202530A (en) 1988-09-28
NO874959D0 (no) 1987-11-27

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2007-11-27