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ES2003862A4 - Resina soporte para la sintesis de peptidos en fase solida. - Google Patents

Resina soporte para la sintesis de peptidos en fase solida.

Info

Publication number
ES2003862A4
ES2003862A4 ES87870195T ES87870195T ES2003862A4 ES 2003862 A4 ES2003862 A4 ES 2003862A4 ES 87870195 T ES87870195 T ES 87870195T ES 87870195 T ES87870195 T ES 87870195T ES 2003862 A4 ES2003862 A4 ES 2003862A4
Authority
ES
Spain
Prior art keywords
peptides
solid phase
synthesis
resin
resin support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES87870195T
Other languages
English (en)
Inventor
Robert Martin Heintz
Daniel Paul Getman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/946,558 external-priority patent/US4764595A/en
Priority claimed from US06/947,651 external-priority patent/US4801665A/en
Priority claimed from US07/031,823 external-priority patent/US4764594A/en
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of ES2003862A4 publication Critical patent/ES2003862A4/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/04—Reduction, e.g. hydrogenation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION PROPORCIONA UNA RESINA PARA LA SINTESIS DE PEPTIDOS EN FASE SOLIDA, Y UN METODO PARA SINTETIZAR LA RESINA QUE TIENE UN ESLABON SULFOXIDO ESTABLE EN CONDICIONES DESPROTEGIDAS FRENTE A ACIDOS FUERTES. EL ESLABON SULFOXIDO PUEDE SER REDUCIDO A UN ESLABON SULFURO QUE PERMITE LA SEPARACION DEL PEPTIDO DE LA RESINA EN CONDICIONES ACIDAS SUAVES.
ES87870195T 1986-12-24 1987-12-22 Resina soporte para la sintesis de peptidos en fase solida. Pending ES2003862A4 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/946,558 US4764595A (en) 1986-12-24 1986-12-24 Resin support for solid phase peptide synthesis
US06/947,651 US4801665A (en) 1986-12-30 1986-12-30 Resin method for making sulfoxide for solid phase peptide synthesis
US07/031,823 US4764594A (en) 1987-03-30 1987-03-30 Resin support for solid phase peptide synthesis

Publications (1)

Publication Number Publication Date
ES2003862A4 true ES2003862A4 (es) 1988-12-01

Family

ID=27363965

Family Applications (3)

Application Number Title Priority Date Filing Date
ES87870195T Pending ES2003862A4 (es) 1986-12-24 1987-12-22 Resina soporte para la sintesis de peptidos en fase solida.
ES87870197T Pending ES2003864A4 (es) 1986-12-24 1987-12-22 Resina soporte para la sintesis de peptidos en fase solida.
ES87870196T Pending ES2003075A4 (es) 1986-12-24 1987-12-22 Sintesis de peptidos en fase solida.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES87870197T Pending ES2003864A4 (es) 1986-12-24 1987-12-22 Resina soporte para la sintesis de peptidos en fase solida.
ES87870196T Pending ES2003075A4 (es) 1986-12-24 1987-12-22 Sintesis de peptidos en fase solida.

Country Status (2)

Country Link
EP (3) EP0274998A3 (es)
ES (3) ES2003862A4 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372496A (ja) * 1989-05-26 1991-03-27 Applied Immune Sci Inc 固相多重ペプチド合成
US5286789A (en) * 1989-05-26 1994-02-15 Applied Immune Sciences, Inc. Solid phase multiple peptide synthesis
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use
FR2688788B1 (fr) * 1992-03-17 1994-05-13 Bio Merieux Composes hydrosolubles derives d'un homopolymere ou copolymere de l'anhydride maleique, et applications desdits composes au support de molecules biologiques.
EP1156059B1 (en) * 1993-06-21 2007-08-08 Aventis Pharmaceuticals, Inc. Selectively cleavable linkers based on a methionine group and an ester group
US5798035A (en) 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
FR2767137A1 (fr) * 1997-08-07 1999-02-12 Bio Merieux Compose chimique complexe, synthese et applications diverses dudit compose
GB9717173D0 (en) * 1997-08-13 1997-10-22 Akzo Nobel Nv Solid phase supports
CA2222833A1 (en) 1997-11-28 1999-05-28 Brent R. Stranix Functional polymers bearing non-metal oxyacid derivatives on dimethylene spacers
WO2000026262A2 (en) * 1998-11-05 2000-05-11 Mitokor Functionalized polymeric substrates for binding molecular moieties
DE60124376T2 (de) 2001-01-04 2007-09-06 Council Of Scientific And Industrial Research Funktionalisierter festträger zur organischen synthese von peptiden und kleinen molekülen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD88780A (es) *
NL239215A (es) * 1958-05-19
US4507230A (en) * 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4575541A (en) * 1984-05-24 1986-03-11 Research Corporation Polymer with sulfone-benzene appendage

Also Published As

Publication number Publication date
EP0273895A3 (en) 1988-12-21
EP0274999A2 (en) 1988-07-20
EP0274999A3 (en) 1988-12-14
EP0273895A2 (en) 1988-07-06
EP0274998A2 (en) 1988-07-20
EP0274998A3 (en) 1988-12-14
ES2003864A4 (es) 1988-12-01
ES2003075A4 (es) 1988-10-16

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