[go: up one dir, main page]

ES2003075A4 - Sintesis de peptidos en fase solida. - Google Patents

Sintesis de peptidos en fase solida.

Info

Publication number
ES2003075A4
ES2003075A4 ES87870196T ES87870196T ES2003075A4 ES 2003075 A4 ES2003075 A4 ES 2003075A4 ES 87870196 T ES87870196 T ES 87870196T ES 87870196 T ES87870196 T ES 87870196T ES 2003075 A4 ES2003075 A4 ES 2003075A4
Authority
ES
Spain
Prior art keywords
solid phase
resin
synthesis
peptides
union
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES87870196T
Other languages
English (en)
Inventor
Robert Martin Heintz
Daniel Paul Getman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/946,558 external-priority patent/US4764595A/en
Priority claimed from US06/947,651 external-priority patent/US4801665A/en
Priority claimed from US07/031,823 external-priority patent/US4764594A/en
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of ES2003075A4 publication Critical patent/ES2003075A4/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/04—Reduction, e.g. hydrogenation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UNA RESINA Y UN METODO PARA UTILIZAR LA RESINA PARA SINTESIS DE PEPTIDOS EN FASE SOLIDA. LA RESINA TIENE UNA UNION SULFOXIDO, QUE ES ESTABLE EN CONDICIONES DE ACIDO FUERTE. LA UNION SULFOXIDO PUEDE REDUCIRSE A UNION SULFURO, QUE PERMITE LA RUPTURA DEL PEPTIDO DE LA RESINA EN CONDICIONES ACIDAS SUAVES.
ES87870196T 1986-12-24 1987-12-22 Sintesis de peptidos en fase solida. Pending ES2003075A4 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/946,558 US4764595A (en) 1986-12-24 1986-12-24 Resin support for solid phase peptide synthesis
US06/947,651 US4801665A (en) 1986-12-30 1986-12-30 Resin method for making sulfoxide for solid phase peptide synthesis
US07/031,823 US4764594A (en) 1987-03-30 1987-03-30 Resin support for solid phase peptide synthesis

Publications (1)

Publication Number Publication Date
ES2003075A4 true ES2003075A4 (es) 1988-10-16

Family

ID=27363965

Family Applications (3)

Application Number Title Priority Date Filing Date
ES87870195T Pending ES2003862A4 (es) 1986-12-24 1987-12-22 Resina soporte para la sintesis de peptidos en fase solida.
ES87870196T Pending ES2003075A4 (es) 1986-12-24 1987-12-22 Sintesis de peptidos en fase solida.
ES87870197T Pending ES2003864A4 (es) 1986-12-24 1987-12-22 Resina soporte para la sintesis de peptidos en fase solida.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES87870195T Pending ES2003862A4 (es) 1986-12-24 1987-12-22 Resina soporte para la sintesis de peptidos en fase solida.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES87870197T Pending ES2003864A4 (es) 1986-12-24 1987-12-22 Resina soporte para la sintesis de peptidos en fase solida.

Country Status (2)

Country Link
EP (3) EP0274998A3 (es)
ES (3) ES2003862A4 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5286789A (en) * 1989-05-26 1994-02-15 Applied Immune Sciences, Inc. Solid phase multiple peptide synthesis
JPH0372496A (ja) * 1989-05-26 1991-03-27 Applied Immune Sci Inc 固相多重ペプチド合成
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use
FR2688788B1 (fr) * 1992-03-17 1994-05-13 Bio Merieux Composes hydrosolubles derives d'un homopolymere ou copolymere de l'anhydride maleique, et applications desdits composes au support de molecules biologiques.
DE69429542T2 (de) * 1993-06-21 2002-08-08 Selectide Corp., Tucson Selektiv spaltbare verbindungen, die auf iminodiessigsäure-ester-bindungen basieren
US5798035A (en) * 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
FR2767137A1 (fr) * 1997-08-07 1999-02-12 Bio Merieux Compose chimique complexe, synthese et applications diverses dudit compose
GB9717173D0 (en) * 1997-08-13 1997-10-22 Akzo Nobel Nv Solid phase supports
CA2222833A1 (en) 1997-11-28 1999-05-28 Brent R. Stranix Functional polymers bearing non-metal oxyacid derivatives on dimethylene spacers
WO2000026262A2 (en) * 1998-11-05 2000-05-11 Mitokor Functionalized polymeric substrates for binding molecular moieties
CN1300168C (zh) * 2001-01-04 2007-02-14 科学与工业研究委员会 一种新的用于肽和小分子有机合成的基于连接剂的固体载体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD88780A (es) *
BE578775A (es) * 1958-05-19
US4507230A (en) * 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4575541A (en) * 1984-05-24 1986-03-11 Research Corporation Polymer with sulfone-benzene appendage

Also Published As

Publication number Publication date
ES2003864A4 (es) 1988-12-01
EP0274998A3 (en) 1988-12-14
EP0273895A3 (en) 1988-12-21
EP0274998A2 (en) 1988-07-20
EP0274999A3 (en) 1988-12-14
EP0273895A2 (en) 1988-07-06
ES2003862A4 (es) 1988-12-01
EP0274999A2 (en) 1988-07-20

Similar Documents

Publication Publication Date Title
ES2003075A4 (es) Sintesis de peptidos en fase solida.
DK83092D0 (da) Fremgangsmaade til udvinding af thrombin
BR8903577A (pt) Composicao de peroxido de hidrogenio estabilizada,e,processo para estabilizar uma solucao de peroxido de hidrogenio
ES2075155T3 (es) Separacion enzimatica de una secuencia de una proteina con amino terminal.
MX9204268A (es) Una composicion para la liberacion prolongada y controlada de substancias medicamentosas y un proceso para preparar la misma.
ES2083989T3 (es) Proteina modificada con glucosaminoglucano, procedimiento para la produccion de dicha proteina, utilizacion y composicion farmaceutica que la contiene
DK164538C (da) Middel til kosmetisk hudpleje og fremgangsmaade til dets fremstilling
ES2097426T3 (es) Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos.
AR004668A1 (es) Un acido nucleico aislado purificado, un vector de expresion recombinante que lo comprende, una celula que comprende dicho vector, un metodo para laproduccion de un polipeptido de h.pylori, una composicion de vacuna, el uso de dicha composicion para preparar medicamentos, un polipeptido purificado de h.
ES8606399A1 (es) Un procedimiento para preparar un peptido que tiene influencia sobre la funcion de la glandula pituitaria
AR246765A1 (es) Novedosos genes y secuencias de adn del factor i del crecimiento del tipo de la preproinsulina humana.
ATE81135T1 (de) Aktive thymopentin-analoga.
ES8800274A1 (es) Un procedimiento para la preparacion de un polipeptido-c-terminal p21ras
UY24651A1 (es) Método para la síntesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea.
BR8503619A (pt) Processo para a preparacao de uma resina de fenol-fomaldeido modificada por lignina;e,resina de fenol-formaldeido modificada,contendo ligno-sulfonato
PT81941B (pt) Processo para a preparacao de novos peptidos e de composicoes farmaceuticas que os contem
AR026063A1 (es) Metodo para la preparacion de 5-carboxiftalida.
ES2092868T3 (es) Utilizacion de derivados de la 4-tiorresorcina en unas composiciones cosmeticas o dermofarmaceuticas de accion despigmentante.
ES2038969T3 (es) Procedimiento para la renaturalizacion de proteinas.
ES2091598T3 (es) Proceso para la reduccion del contenido de formaldehido en formulaciones de microcapsulas.
IT8421068A0 (it) Derivati di acido poliidrossibenzoico ad azione farmaceutica.
DE58906338D1 (de) Kombination von Angiotensin-Converting-Enzyme-Hemmern mit Kaliumkanal-Modulatoren sowie deren Verwendung in Arzneimitteln.
ES2018667B3 (es) Derivados del acido 4-qionolon-3-carboxilico, procedimiento para su obtencion y preparados farmaceuticos que los contienen.
ES2044067T3 (es) Separacion de sulfuro de hidrogeno de una mezcla gaseosa.
BR8403822A (pt) Composto de matriz de resina de filamento interfoliado,composto de matriz de resina de fibra interfoliado e processo para produzir uma matriz de resina de fibra e de filamento interfoliada