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ES2001389A6 - Procedimiento para preparar derivados de o-toluidina - Google Patents

Procedimiento para preparar derivados de o-toluidina

Info

Publication number
ES2001389A6
ES2001389A6 ES8601270A ES8601270A ES2001389A6 ES 2001389 A6 ES2001389 A6 ES 2001389A6 ES 8601270 A ES8601270 A ES 8601270A ES 8601270 A ES8601270 A ES 8601270A ES 2001389 A6 ES2001389 A6 ES 2001389A6
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
gastric secretion
secretion inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601270A
Other languages
English (en)
Inventor
Hans-Jochen Lang
Gerhard Rackur
Manfred Rosner
Andreas W Herling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853530342 external-priority patent/DE3530342A1/de
Priority claimed from DE19863610609 external-priority patent/DE3610609A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES2001389A6 publication Critical patent/ES2001389A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA DONDE A SIGNIFICA S, SO O SO2 Y R1 A R8, R13, R14 Y R15 REPRESENTAN HIDROGENO Y/O SUSTITUYENTES DEFINIDOS, HACIENDO REACCIONAR COMPUESTOS DE FORMULAS DONDE R1 A R8 Y R13 A R15 SON COMO ANTES, Q2 Y Q2 SIGNIFICAN UN GRUPO LABIL, -SH, -SC O -SO2C. EXISTEN OTRAS VIAS DE SINTESIS QUE SE DESCRIBEN EN LA MEMORIA. LOS COMPUESTOS OBTENIDOS SON UTILES COMO INHIBIDORES DE LA SECRECION DE ACIDOS GASTRICOS.
ES8601270A 1985-08-24 1986-08-22 Procedimiento para preparar derivados de o-toluidina Expired ES2001389A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853530342 DE3530342A1 (de) 1985-08-24 1985-08-24 Substituierte toluidine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE19863610609 DE3610609A1 (de) 1986-03-29 1986-03-29 Substituierte toluidine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer

Publications (1)

Publication Number Publication Date
ES2001389A6 true ES2001389A6 (es) 1988-05-16

Family

ID=25835350

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601270A Expired ES2001389A6 (es) 1985-08-24 1986-08-22 Procedimiento para preparar derivados de o-toluidina

Country Status (17)

Country Link
EP (1) EP0213474B1 (es)
JP (1) JPH0791276B2 (es)
KR (1) KR940005020B1 (es)
AR (1) AR243167A1 (es)
AT (1) ATE85328T1 (es)
DE (1) DE3687675D1 (es)
DK (1) DK401586A (es)
ES (1) ES2001389A6 (es)
FI (1) FI89910C (es)
GR (1) GR862180B (es)
HU (1) HU199126B (es)
IE (1) IE59587B1 (es)
IL (1) IL79813A0 (es)
NO (1) NO169169C (es)
NZ (1) NZ217322A (es)
PH (1) PH24073A (es)
PT (1) PT83240B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2047451A1 (es) * 1992-07-10 1994-02-16 Vita Invest Sa Procedimiento para la preparacion de una composicion farmaceutica oral estable.

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963566A (en) * 1986-03-28 1990-10-16 Otsuka Pharmaceutical Co., Ltd. Benzimidazolyl-sulfinyl-tetrahydroquinolines
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
US4957932A (en) * 1987-11-25 1990-09-18 Merck Frosst Canada, Inc. Benzoheterazoles
EP0318085A3 (en) * 1987-11-25 1990-03-14 Merck Frosst Canada Inc. Heterazole dialkanoic acids
JP2564162B2 (ja) * 1988-02-12 1996-12-18 日本ケミファ株式会社 ベンズイミダゾール誘導体の四級塩
KR20040028815A (ko) * 2004-01-07 2004-04-03 화인고무(주) 접착제를 사용하지 않는 사출 및 열융착을 가능하게하는인조피혁
CN115433167B (zh) * 2022-11-10 2023-03-24 中国药科大学 具有Snail抑制活性的苯并杂环类化合物、其制备方法、药物组合物和医药用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE332167C (de) 1918-08-09 1921-01-26 Chem Fab Vorm Goldenberg Glyzerinersatz
BE788805A (fr) 1971-09-22 1973-01-02 Lafon Victor Nouveaux derives antalgiques de la serie des arylamines soufrees
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
US4472409A (en) 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
DE3333314A1 (de) 1983-09-15 1985-03-28 Hoechst Ag, 6230 Frankfurt Substituierte pyrido(1,2-c)imidazo(1,2-a)benzimidazole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3585252D1 (de) 1984-07-06 1992-03-05 Fisons Plc Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen.
GB8417271D0 (en) * 1984-07-06 1984-08-08 Fisons Plc Biologically active nitrogen heterocycles
AU4640985A (en) 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
DE3509333A1 (de) 1985-03-15 1986-09-18 Hoechst Ag, 6230 Frankfurt Substituierte benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
EP0204215B1 (en) * 1985-05-24 1993-08-11 G.D. Searle & Co. 2-[(1H-benzimidazol-2-ylsulfinyl)methyl]-benzenamines
WO1987001114A2 (en) * 1985-08-21 1987-02-26 Byk Gulden Lomberg Chemische Fabrik Gmbh New amines, process for their manufacture, their use and medicines containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2047451A1 (es) * 1992-07-10 1994-02-16 Vita Invest Sa Procedimiento para la preparacion de una composicion farmaceutica oral estable.

Also Published As

Publication number Publication date
IL79813A0 (en) 1986-11-30
ATE85328T1 (de) 1993-02-15
AR243167A1 (es) 1993-07-30
IE59587B1 (en) 1994-03-09
KR940005020B1 (ko) 1994-06-09
EP0213474A2 (de) 1987-03-11
NO863389D0 (no) 1986-08-22
HU199126B (en) 1990-01-29
FI863382A0 (fi) 1986-08-21
AU6174586A (en) 1987-02-26
NO863389L (no) 1987-02-25
NO169169B (no) 1992-02-10
AU595231B2 (en) 1990-03-29
HUT44242A (en) 1988-02-29
EP0213474B1 (de) 1993-02-03
PT83240A (de) 1986-09-01
PH24073A (en) 1990-03-05
FI863382L (fi) 1987-02-25
GR862180B (en) 1986-12-23
NO169169C (no) 1992-05-20
DK401586D0 (da) 1986-08-22
JPH0791276B2 (ja) 1995-10-04
NZ217322A (en) 1990-02-26
EP0213474A3 (en) 1987-05-20
KR870002087A (ko) 1987-03-30
DK401586A (da) 1987-02-25
DE3687675D1 (de) 1993-03-18
FI89910B (fi) 1993-08-31
JPS6251671A (ja) 1987-03-06
PT83240B (pt) 1989-03-30
FI89910C (fi) 1993-12-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000202