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ES2069881T3 - Derivado de 15-desoxiprostaglandina. - Google Patents

Derivado de 15-desoxiprostaglandina.

Info

Publication number
ES2069881T3
ES2069881T3 ES91905484T ES91905484T ES2069881T3 ES 2069881 T3 ES2069881 T3 ES 2069881T3 ES 91905484 T ES91905484 T ES 91905484T ES 91905484 T ES91905484 T ES 91905484T ES 2069881 T3 ES2069881 T3 ES 2069881T3
Authority
ES
Spain
Prior art keywords
derivative
formula
deoxyprostaglandine
alkyl
alkadienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91905484T
Other languages
English (en)
Inventor
Morio - Katagihara-Takod Kishi
Kimio - Furukawa-Cho Takahashi
Kenji C - - Shinsenrini Kawada
Yasumasa - Yayoigaoka -Cho Goh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2069881T3 publication Critical patent/ES2069881T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Control Of Electric Motors In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Dental Preparations (AREA)

Abstract

UN DERIVADO DE 15-DEOXIPROSTAGLANDINA DE LA FORMULA GENERAL (I) Y UN DEPRESOR DE PRESION INTRAOCULAR CONTENIENDO DICHO DERIVADO O SU SAL FARMACEUTICAMENTE ACEPTABLE COMO EL INGREDIENTE ACTIVO. EN LA FORMULA (I), (A) ES UN ANILLO DE CINCO MIEMBROS SELECCIONADO DE ENTRE (B), (C), (D), (E), (F); R ELEVADO 1 REPRESENTA HIDROGENO O ALQUILO INFERIOR; Y R (AL CUADRADO) REPRESENTA ALQUILO C SUB 6 A C SUB 12, ALQUENILO C SUB 6 A C SUB 12 O ALCADIENILO C SUB 6 A C SUB 12, SIEMPRE QUE SE EXCLUYA UN COMPUESTO DE LA FORMULA (II) (DONDE R ELEVADO 1 REPRESENTA H O CH SUB 3).
ES91905484T 1990-03-08 1991-03-07 Derivado de 15-desoxiprostaglandina. Expired - Lifetime ES2069881T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5747690 1990-03-08

Publications (1)

Publication Number Publication Date
ES2069881T3 true ES2069881T3 (es) 1995-05-16

Family

ID=13056760

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91905484T Expired - Lifetime ES2069881T3 (es) 1990-03-08 1991-03-07 Derivado de 15-desoxiprostaglandina.

Country Status (11)

Country Link
US (1) US5599837A (es)
EP (1) EP0471856B1 (es)
JP (1) JP3164368B2 (es)
KR (1) KR100224951B1 (es)
AT (1) ATE120188T1 (es)
AU (1) AU640767B2 (es)
CA (1) CA2054738C (es)
DE (1) DE69108326T2 (es)
DK (1) DK0471856T3 (es)
ES (1) ES2069881T3 (es)
WO (1) WO1991013869A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06107547A (ja) * 1992-10-01 1994-04-19 Aarutetsuku Ueno:Kk 眼科用組成物
SE9401087D0 (sv) * 1994-03-31 1994-03-31 Pharmacia Ab New prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US20020052413A1 (en) * 2000-07-19 2002-05-02 Christine Percicot Treatment of ocular complications
CN114262288B (zh) * 2020-09-16 2023-07-07 凯特立斯（深圳）科技有限公司 一类前列腺素类化合物合成关键中间体及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3290226A (en) 1964-02-19 1966-12-06 Upjohn Co Microbiological conversion of unsaturated fatty acids
BE659984A (es) 1964-02-19
US3872139A (en) 1972-05-12 1975-03-18 Syntex Inc 15 Deoxy PGE{HD 2
US3847962A (en) 1972-05-12 1974-11-12 Syntex Inc Prostaglandins and process and intermediates therefor
CA1045131A (en) 1972-07-24 1978-12-26 Middleton B. Floyd (Jr.) Derivatives of 9-hydroxy-13-trans-prostenoic acid
GB1440361A (en) * 1972-07-24 1976-06-23 American Cyanamid Co 11-deoxyprostaglandins of the e and f series and the preparation thereof
JPS5032151A (es) * 1973-07-27 1975-03-28
JPS5037753A (es) * 1973-08-13 1975-04-08
US4599353A (en) * 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
JPS58216155A (ja) * 1982-06-10 1983-12-15 Ono Pharmaceut Co Ltd 新規なプロスタグランジンｄ類似化合物
ES8607921A1 (es) * 1984-07-31 1986-06-16 Syntex Inc Procedimiento para preparar derivados de acidos 11-sustitui-dos-16-fenoxi y 16-fenoxi sustituido-prostatrienoicos
ES2053458T3 (es) * 1986-03-13 1994-08-01 Univ Columbia Utilizacion de prostaglandinas a, b y c y derivados de las mismas, para el tratamiento de la hipertension ocular y glaucoma.
DE3850676T2 (de) * 1987-09-18 1994-11-03 Ueno Seiyaku Oyo Kenkyujo Kk Hypotensive okulare Mittel.
JPH022108A (ja) * 1988-06-15 1990-01-08 Nec Corp シンクロトロン放射光露光装置
ATE117290T1 (de) * 1990-02-26 1995-02-15 R Tech Ueno Ltd 15-dehydroxy-16-oxoprostaglandine.
US5157052A (en) * 1990-12-27 1992-10-20 Monsanto Company Method for inhibiting ige production

Also Published As

Publication number Publication date
EP0471856A1 (en) 1992-02-26
US5599837A (en) 1997-02-04
KR100224951B1 (ko) 1999-10-15
EP0471856A4 (en) 1992-08-05
JP3164368B2 (ja) 2001-05-08
WO1991013869A1 (fr) 1991-09-19
DE69108326D1 (en) 1995-04-27
DE69108326T2 (de) 1995-07-27
DK0471856T3 (da) 1995-06-06
EP0471856B1 (en) 1995-03-22
AU640767B2 (en) 1993-09-02
AU7451491A (en) 1991-10-10
KR920701149A (ko) 1992-08-11
ATE120188T1 (de) 1995-04-15
CA2054738C (en) 2001-08-28
CA2054738A1 (en) 1991-09-09

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