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ES2068191T3 - Conjugados anticuerpo-enzima en combinacion con profarmacos para el suministro de agentes citotoxicos a celulas tumorales. - Google Patents

Conjugados anticuerpo-enzima en combinacion con profarmacos para el suministro de agentes citotoxicos a celulas tumorales.

Info

Publication number
ES2068191T3
ES2068191T3 ES88112646T ES88112646T ES2068191T3 ES 2068191 T3 ES2068191 T3 ES 2068191T3 ES 88112646 T ES88112646 T ES 88112646T ES 88112646 T ES88112646 T ES 88112646T ES 2068191 T3 ES2068191 T3 ES 2068191T3
Authority
ES
Spain
Prior art keywords
enzyme
administration
antibody
tumor cells
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88112646T
Other languages
English (en)
Inventor
Peter D Senter
Mark G Saulnier
Joseph P Brown
David E Kerr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/211,301 external-priority patent/US4975278A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2068191T3 publication Critical patent/ES2068191T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTE INVENCION REVELA UN NUEVO METODO PARA LA INTRODUCCION DE DROGAS CITOTOXICAS EN CELULAS TUMORALES A TRAVES DE LA ADMINISTRACION DE UN COMPLEJO ANTICUERPO - ENZIMA ESPECIFICO PARA EL TUMOR QUE SE UNE A LAS CELULAS TUMURALES, SEGUIDA DE LA ADMINISTRACION DE UN PRECURSOR DE LA DROGA QUE SUFRE UNA TRANSFORMACION EN EL MISMO EMPLAZAMIENTO DEL TUMOR, EN PRESENCIA DE LA ENZIMA LIGADA AL ANTICUERPO, DANDO COMO RESULTADO UNA DROGA CITOTOXICA ACTIVA. DE ACUERDO CON LAS ESPECIFICACIONES DE LA INVENCION, COMPLEJOS ANTICUERPO - ENZIMA CONTENIENDO LA ENZIMA FOSFATOSA ALCALINA (AP), HAN SIDO UTILIZADAS CON EL NUEVO PRECURSOR DE LA DROGA, UN ETAPOSIDO - 4 - FOSFATO O 7 - (2 - AMINOETILFOSFATO)MITOMICINA, O UNA COMBINACION DE AMBOS, CONSIGUIENDO UNA ELEVADA EFECTIVIDAD EN LA DESTRUCCION DE CELULAS CANCEROSAS. DE ACUERDO OTRA DE LAS ESPICIFICACIONES DE LA INVENCION, UN COMPLEJO ANTICUERPO - ENZIMA CONTENIENDO LA ENZIMA PENICILINA V AMIDOSA (PVA) A SIDO UTILIZADO CON UN NUEVO PRECURSOR DE DROGA, LA N - (P - HIDROXIFENOSCIACETIL) ADRIAMICINA CON ALTA EFECTIVIDAD EN LA DESTRUCCION DE CELULAS TUMORALES.
ES88112646T 1987-08-04 1988-08-03 Conjugados anticuerpo-enzima en combinacion con profarmacos para el suministro de agentes citotoxicos a celulas tumorales. Expired - Lifetime ES2068191T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8138287A 1987-08-04 1987-08-04
US16106888A 1988-02-26 1988-02-26
US07/211,301 US4975278A (en) 1988-02-26 1988-06-29 Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells

Publications (1)

Publication Number Publication Date
ES2068191T3 true ES2068191T3 (es) 1995-04-16

Family

ID=27373967

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88112646T Expired - Lifetime ES2068191T3 (es) 1987-08-04 1988-08-03 Conjugados anticuerpo-enzima en combinacion con profarmacos para el suministro de agentes citotoxicos a celulas tumorales.

Country Status (19)

Country Link
EP (2) EP0540859B1 (es)
JP (2) JP2738414B2 (es)
KR (1) KR930006757B1 (es)
AT (2) ATE162196T1 (es)
AU (1) AU614532B2 (es)
CA (1) CA1336887C (es)
DE (2) DE3856112T2 (es)
DK (1) DK175406B1 (es)
EG (1) EG18751A (es)
ES (1) ES2068191T3 (es)
FI (1) FI98197C (es)
GR (1) GR3015065T3 (es)
HU (1) HU207230B (es)
IE (2) IE68309B1 (es)
IL (1) IL87319A (es)
NO (1) NO178138C (es)
NZ (1) NZ225599A (es)
PT (2) PT88187B (es)
YU (1) YU150888A (es)

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AU633867B2 (en) * 1989-02-02 1993-02-11 Eli Lilly And Company Delivery of cytotoxic agents
GB8907617D0 (en) * 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
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DE3935016A1 (de) * 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
DE4106389A1 (de) * 1991-02-28 1992-09-03 Behringwerke Ag Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5270196A (en) * 1989-10-20 1993-12-14 Bristol-Myers Squibb Company Arylsulfatase from streptomyces
FI94362C (fi) * 1989-10-20 1995-08-25 Squibb Bristol Myers Co Oleellisesti puhdistettu sulfataasi, menetelmä sen valmistamiseksi ja sitä tuottava Streptomyces-kanta
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
EP0505357B1 (en) * 1989-12-11 1999-03-10 Immunomedics, Inc. Method for antibody targeting of diagnostic or therapeutic agents
EP0505566A1 (en) * 1989-12-15 1992-09-30 Takeda Chemical Industries, Ltd. Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics
GB9001641D0 (en) * 1990-01-24 1990-03-21 Imp Cancer Res Tech Compounds
KR920007937B1 (ko) * 1990-01-30 1992-09-19 현대자동차 주식회사 밸브시트용 철(Fe)계 소결합금
DE4002888A1 (de) * 1990-02-01 1991-08-08 Behringwerke Ag Anthracyclin-glycosyl-prodrugs, verfahren zu ihrer herstellung und ihre verwendung in kombination mit funktionalisierten tumorspezifischen enzymkonjugaten
KR100208957B1 (ko) * 1990-04-25 1999-07-15 로렌스 티. 마이젠헬더 신규한 cc-1065 유사체
AU649275B2 (en) * 1990-11-06 1994-05-19 Bristol-Myers Squibb Company Prodrugs for beta-lactamase and uses thereof
GB9200417D0 (en) * 1992-01-09 1992-02-26 Bagshawe Kenneth D Cytotoxic drug therapy
DE4233152A1 (de) 1992-10-02 1994-04-07 Behringwerke Ag Antikörper-Enzym-Konjugate zur Prodrug-Aktivierung
EP0647450A1 (en) * 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
US5516679A (en) * 1994-12-23 1996-05-14 Bristol-Myers Squibb Company Penicillin V amidohydrolase gene from Fusarium oxysporum
DE19720312A1 (de) * 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
GB9712370D0 (en) 1997-06-14 1997-08-13 Aepact Ltd Therapeutic systems
JPH1160499A (ja) * 1997-08-22 1999-03-02 Hiroshi Maeda 抗腫瘍剤
US6159706A (en) * 1997-12-23 2000-12-12 Newbiotics, Inc. Application of enzyme prodrugs as anti-infective agents
AU763628B2 (en) * 1998-09-18 2003-07-31 Immunomedics Inc. Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug
GB2348203B (en) 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
HK1043312B (en) 1999-05-07 2006-07-28 Genentech, Inc. Treatment of autoimmune diseases with antagonists which bind to b cell surface markers
US7514067B2 (en) 2000-04-25 2009-04-07 President And Fellows Of Harvard College Methods for tumor diagnosis and therapy
WO2001093826A1 (fr) * 2000-06-06 2001-12-13 Sumitomo Pharmaceuticals Company, Limited Preparations polymere synthetiques biocompatibles
US7445802B2 (en) 2000-12-26 2008-11-04 Yeda Research And Development Co. Ltd Site-specific in situ generation of allicin using a targeted alliinase delivery system for the treatment of cancers, tumors, infectious diseases and other allicin-sensitive diseases
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Also Published As

Publication number Publication date
EP0302473A2 (en) 1989-02-08
HUT47437A (en) 1989-03-28
FI883597A7 (fi) 1989-02-05
KR930006757B1 (ko) 1993-07-23
EP0540859A1 (en) 1993-05-12
NZ225599A (en) 1991-09-25
IL87319A0 (en) 1990-02-09
FI98197C (fi) 1997-05-12
FI883597A0 (fi) 1988-08-01
PT88187B (pt) 1995-12-29
JP3127136B2 (ja) 2001-01-22
EP0540859B1 (en) 1998-01-14
IE882379L (en) 1989-02-04
PT88187A (pt) 1989-06-30
IE950981L (en) 1989-02-04
NO883414L (no) 1989-02-06
ATE162196T1 (de) 1998-01-15
DE3853028D1 (de) 1995-03-23
DE3856112T2 (de) 1998-08-27
JPH02223532A (ja) 1990-09-05
JP2738414B2 (ja) 1998-04-08
EP0302473A3 (en) 1990-01-17
DK434188A (da) 1989-02-05
HU207230B (en) 1993-03-29
EG18751A (en) 1993-12-30
DE3856112D1 (de) 1998-02-19
PT101702A (pt) 1996-01-31
IE68309B1 (en) 1996-06-12
IL87319A (en) 1995-08-31
FI98197B (fi) 1997-01-31
DK434188D0 (da) 1988-08-03
EP0302473B1 (en) 1995-02-15
CA1336887C (en) 1995-09-05
DK175406B1 (da) 2004-09-27
ATE118354T1 (de) 1995-03-15
AU2020188A (en) 1989-05-25
JPH10130295A (ja) 1998-05-19
AU614532B2 (en) 1991-09-05
NO178138B (no) 1995-10-23
PT101702B (pt) 1999-11-30
YU150888A (en) 1990-06-30
KR890003408A (ko) 1989-04-14
NO883414D0 (no) 1988-08-02
GR3015065T3 (en) 1995-05-31
NO178138C (no) 1996-01-31
DE3853028T2 (de) 1995-12-14

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