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ES2064328T3 - Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos. - Google Patents

Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos.

Info

Publication number
ES2064328T3
ES2064328T3 ES88109770T ES88109770T ES2064328T3 ES 2064328 T3 ES2064328 T3 ES 2064328T3 ES 88109770 T ES88109770 T ES 88109770T ES 88109770 T ES88109770 T ES 88109770T ES 2064328 T3 ES2064328 T3 ES 2064328T3
Authority
ES
Spain
Prior art keywords
compounds
indolilpropanoles
procedure
manufacture
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88109770T
Other languages
English (en)
Inventor
Wolfgang Dr Stenzel
Ben Dr Armah
Thomas Dr Beuttler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf Lilly GmbH
Original Assignee
Beiersdorf Lilly GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Lilly GmbH filed Critical Beiersdorf Lilly GmbH
Application granted granted Critical
Publication of ES2064328T3 publication Critical patent/ES2064328T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INDOLILPROPANOLES SUSTITUIDOS DE FORMULA (I) EN LA QUE R1 ES UN GRUPO CIANO, CARBOXAMIDA, ALCOXICARBONILO, HIDROXILO O ACETILO; Y ES EL GRUPO (A) DONDE N ES EL NUMERO 2 O 3 O EL GRUPO (B); R2, R3 TIENEN EL SIGNIFICADO DETALLADO EN LA INVENCION. ESTOS COMPUESTOS POSEEN ACCION NIOTROPICA POSITIVA, VASODILATADORA Y ANTIARRITMICA Y SON APROPIADOS PARA EL TRATAMIENTO DE INSUFICIENCIA CORONARIA, ALTERACIONES DEL RITMO CARDIACO E HIPERTONIA, ENFERMEDADES CORONARIAS Y ALTERACIONES DE CIRCULACION ARTERIAL PERIFERICA Y CENTRAL.
ES88109770T 1987-06-27 1988-06-20 Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos. Expired - Lifetime ES2064328T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873721260 DE3721260A1 (de) 1987-06-27 1987-06-27 Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen

Publications (1)

Publication Number Publication Date
ES2064328T3 true ES2064328T3 (es) 1995-02-01

Family

ID=6330413

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88109770T Expired - Lifetime ES2064328T3 (es) 1987-06-27 1988-06-20 Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos.

Country Status (11)

Country Link
US (1) US4935414A (es)
EP (1) EP0297380B1 (es)
JP (1) JP2577442B2 (es)
AT (1) ATE112565T1 (es)
AU (1) AU609359B2 (es)
CA (1) CA1312078C (es)
CY (1) CY1910A (es)
DE (2) DE3721260A1 (es)
ES (1) ES2064328T3 (es)
HK (1) HK87696A (es)
ZA (1) ZA884388B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ234087A (en) * 1989-06-19 1991-08-27 Teikoku Hormone Mfg Co Ltd 2-(3-aryloxy(2-hydroxy-propylamino))-2-methylpropyl- aminophenyl pyridazine derivatives
US5221674A (en) * 1989-06-19 1993-06-22 Teikoku Hormone Mfg. Co., Ltd. Pyridazinone derivatives
DE4002391A1 (de) * 1990-01-27 1991-08-01 Beiersdorf Ag Indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
CA2154318A1 (en) * 1994-08-25 1996-02-26 Richard David Poole Adaptable radio telephone handset
US5741789A (en) 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5614523A (en) * 1995-01-17 1997-03-25 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5789402A (en) * 1995-01-17 1998-08-04 Eli Lilly Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
WO1997012611A1 (en) * 1995-10-03 1997-04-10 Beiersdorf-Lilly Gmbh Treatment of atherosclerosis
US5843938A (en) * 1995-10-03 1998-12-01 Beiersdorf-Lilly Gmbh Treatment of atherosclerosis
EP0766962A3 (en) * 1995-10-03 2000-05-10 Beiersdorf-Lilly GmbH Treatment of atherosclerosis
JP2009220797A (ja) * 2008-03-19 2009-10-01 Tokuo Suzuki 特に広範囲な視野を持つバックミラー

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4137331A (en) * 1974-06-19 1979-01-30 Sandoz Ltd. 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones
DE2737630A1 (de) * 1977-08-20 1979-03-01 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2651574A1 (de) * 1976-11-12 1978-05-18 Boehringer Mannheim Gmbh Ein neues aminopropanol-derivat und verfahren zu dessen herstellung
DE2824677A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung
WO1980000152A1 (fr) * 1978-07-03 1980-02-07 Sandoz Ag Derives d'un 3-aminopropoxy-aryle, leur preparation et utilisation
DE3068678D1 (en) * 1979-08-10 1984-08-30 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
FR2543952B1 (fr) * 1982-09-03 1986-02-21 Bristol Myers Co Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique
DE3524955A1 (de) * 1984-07-19 1986-01-30 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
GB2163150B (en) * 1984-07-19 1988-05-25 Sandoz Ltd 3-aminopropoxyaryl derivatives
GB8502887D0 (en) * 1985-02-05 1985-03-06 Sandoz Ltd Pharmaceutical compositions

Also Published As

Publication number Publication date
AU1833488A (en) 1989-01-05
JPS6426558A (en) 1989-01-27
ZA884388B (en) 1989-03-29
DE3721260A1 (de) 1989-01-12
AU609359B2 (en) 1991-04-26
ATE112565T1 (de) 1994-10-15
CA1312078C (en) 1992-12-29
DE3851720D1 (de) 1994-11-10
EP0297380B1 (de) 1994-10-05
EP0297380A2 (de) 1989-01-04
JP2577442B2 (ja) 1997-01-29
CY1910A (en) 1997-03-07
HK87696A (en) 1996-05-24
EP0297380A3 (en) 1990-05-09
US4935414A (en) 1990-06-19

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