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ES2064371T3 - Procedimiento enzimatico para la produccion de cianhidrinas opticamente activas. - Google Patents

Procedimiento enzimatico para la produccion de cianhidrinas opticamente activas.

Info

Publication number
ES2064371T3
ES2064371T3 ES89101127T ES89101127T ES2064371T3 ES 2064371 T3 ES2064371 T3 ES 2064371T3 ES 89101127 T ES89101127 T ES 89101127T ES 89101127 T ES89101127 T ES 89101127T ES 2064371 T3 ES2064371 T3 ES 2064371T3
Authority
ES
Spain
Prior art keywords
cyanhydrines
production
optically active
enzymatic procedure
encymatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89101127T
Other languages
English (en)
Inventor
Uwe Niedermeyer
Udo Kragl
Maria-Regina Kula
Christian Wandrey
Kyriakos Makryaleas
Karlheinz Drauz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Evonik Operations GmbH
Original Assignee
Forschungszentrum Juelich GmbH
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich GmbH, Degussa GmbH filed Critical Forschungszentrum Juelich GmbH
Application granted granted Critical
Publication of ES2064371T3 publication Critical patent/ES2064371T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C12P13/004—Cyanohydrins

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA TRANSFORMACION ENCIMATICA DE ALDEHIDOS ALIFATICOS, AROMATICOS OHETEROAROMATICOS O CETONAS CON ACIDO AZUL PARA LOS CONOCIDOS (R) CIANHIDRINOS O (S) - CIANHIDRINA RESULTA DESPRECIABLE EN MEDIO ACUOSO EN PRESENCIA DE (R) - OXINITRILASA (4.1.2.10) EN SU CASO OXIMITILASA (4.1.2.11) BAJO CONDICIONES ACIDOS Y POR TALES TEMPERATURAS, QUE LA REACCION DE CONCURRENCIA QUIMICA Y LA RACEMIZACION FRENTE A LA SINTESIS ENCIMATICA.
ES89101127T 1988-01-29 1989-01-23 Procedimiento enzimatico para la produccion de cianhidrinas opticamente activas. Expired - Lifetime ES2064371T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3802624 1988-01-29
DE3823864A DE3823864A1 (de) 1988-01-29 1988-07-14 Enymatisches verfahren zur herstellung von optisch aktiven cyanhydrinen

Publications (1)

Publication Number Publication Date
ES2064371T3 true ES2064371T3 (es) 1995-02-01

Family

ID=25864385

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89101127T Expired - Lifetime ES2064371T3 (es) 1988-01-29 1989-01-23 Procedimiento enzimatico para la produccion de cianhidrinas opticamente activas.

Country Status (10)

Country Link
US (1) US5008192A (es)
EP (1) EP0326063B1 (es)
JP (1) JPH0753116B2 (es)
AT (1) ATE111159T1 (es)
AU (1) AU617747B2 (es)
BR (1) BR8900226A (es)
CA (1) CA1335269C (es)
DE (2) DE3823864A1 (es)
DK (1) DK38789A (es)
ES (1) ES2064371T3 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5329023A (en) * 1987-12-24 1994-07-12 Duphar International Research B.V. Method of preparing optically active alcohols which consist substantially or entirely of one enantiomer
DE3917374A1 (de) * 1988-07-14 1990-12-06 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von s-cyanhydrinen
EP0446826B1 (de) * 1990-03-16 1995-11-15 Forschungszentrum Jülich Gmbh Verfahren zur enzymatischen Herstellung optisch aktiver Cyanhydrine
DE4102327C1 (en) * 1991-01-26 1992-06-04 Degussa Ag, 6000 Frankfurt, De (R)-keto:cyanohydrin prepn. - by reacting ketone with prussic acid in organic solvent in presence of (R)-oxy:nitrilase; used in prepn. of alpha-hydroxy-alpha-(m)ethyl carboxylic acid
JP2676568B2 (ja) * 1991-06-26 1997-11-17 日東化学工業株式会社 Ｒ（−）−マンデル酸およびその誘導体の製造法
DE4126580A1 (de) * 1991-08-12 1993-02-18 Degussa D-2,4-dihydroxy-3,3-dimethylbutansaeurenitril, seine herstellung und verwendung
AT396252B (de) * 1991-10-31 1993-07-26 Chemie Linz Gmbh Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine
DE4139083A1 (de) * 1991-11-28 1993-06-03 Chemie Linz Deutschland Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine
US5177242A (en) * 1991-12-17 1993-01-05 Fmc Corporation Process for preparing optically active cyanohydrins with enzymes
US5241087A (en) * 1992-03-09 1993-08-31 Bend Research, Inc. Enantiomeric enrichment of cyanohydrins
AT400035B (de) * 1993-06-01 1995-09-25 Chemie Linz Gmbh Enzymatisches verfahren zur herstellung aliphatischer s-cyanhydrine
DE4322064A1 (de) * 1993-07-02 1995-01-12 Chemie Linz Deutschland Enzymatisches Verfahren zur Herstellung aliphatischer S-Cyanhydrine
DE19529116A1 (de) * 1995-08-08 1997-03-06 Chemie Linz Deutschland Gmbh I (S)-Hydroxynitrillyase aus Hevea brasiliensis
EP0799894B1 (de) * 1996-02-09 2004-05-19 Degussa AG Verfahren zur Herstellung von (S)-Cyanhydrinen
US7256027B1 (en) 1999-06-15 2007-08-14 Rutgers, The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
AT408231B (de) * 1999-12-15 2001-09-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von optisch aktiven cyanhydrinen unter verwendung von r-oxynitrilase
US7078225B2 (en) * 2000-06-02 2006-07-18 Nippon Shokubai Co., Ltd. Method for enzymatically producing an optically active cyanohydrin
EP1566441B1 (de) 2001-01-16 2009-02-18 DSM Fine Chemicals Austria Nfg GmbH & Co KG Gene, enthaltend eine für Hydroxynitrillyase codierende DNA-Sequenz, rekombinante Proteine mit Hydroxynitrillyase-Aktivität und deren Verwendung
AT411065B (de) * 2001-12-27 2003-09-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von heterocyclischen (r)- und (s)-cyanhydrinen
AT411064B (de) * 2001-12-27 2003-09-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von enantiomerenangereicherten cyanhydrinen unter verwendung von acetalen oder ketalen als substrate
WO2008071695A1 (en) 2006-12-14 2008-06-19 Dsm Ip Assets Bv R-hnl random variants and their use for preparing optically pure, sterically hindered cyanohydrins
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
EP2574667A1 (en) 2011-10-02 2013-04-03 Technische Universität Graz Enzyme variants

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1300111B (de) * 1965-04-07 1969-07-31 Pfeil Verfahren zur Herstellung von optisch aktiven Cyanhydrinen
DE3917374A1 (de) * 1988-07-14 1990-12-06 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von s-cyanhydrinen

Also Published As

Publication number Publication date
JPH025885A (ja) 1990-01-10
DK38789D0 (da) 1989-01-27
DK38789A (da) 1989-07-30
JPH0753116B2 (ja) 1995-06-07
EP0326063A3 (en) 1990-06-13
US5008192A (en) 1991-04-16
DE3823864A1 (de) 1989-08-10
ATE111159T1 (de) 1994-09-15
CA1335269C (en) 1995-04-18
BR8900226A (pt) 1989-09-12
EP0326063B1 (de) 1994-09-07
AU2891489A (en) 1989-08-03
EP0326063A2 (de) 1989-08-02
AU617747B2 (en) 1991-12-05
DE58908292D1 (de) 1994-10-13

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