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ES2061646T3 - Complejos de platino antitumorales, su preparacion y su uso en terapeutica. - Google Patents

Complejos de platino antitumorales, su preparacion y su uso en terapeutica.

Info

Publication number
ES2061646T3
ES2061646T3 ES88304140T ES88304140T ES2061646T3 ES 2061646 T3 ES2061646 T3 ES 2061646T3 ES 88304140 T ES88304140 T ES 88304140T ES 88304140 T ES88304140 T ES 88304140T ES 2061646 T3 ES2061646 T3 ES 2061646T3
Authority
ES
Spain
Prior art keywords
therapeutics
preparation
platinum complexes
formula
antitumoral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88304140T
Other languages
English (en)
Inventor
Yokio Sugimura
Yukiko Kameyama
Toshihiko Hashimoto
Kimio Iino
Tomoyuki Shibata
Shigeki Muramatsu
Tomowo Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2061646T3 publication Critical patent/ES2061646T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LOS COMPUESTOS DE FORMULA (I) EN LA QUE A Y B SON SEPARADAMENTE MONOAMINAS O JUNTOS FORMAN UNA DIAMINA, Y Z ES UN GRUPO DE FORMULA (II) O (III), EN LAS QUE R1, R2 Y R7 SON VARIOS GRUPOS ORGANICOS, N ES 0, 1 O 2, Y X ES UN ENLACE CARBONO-CARBONO DIRECTO O UN ALQUILENO DE CADENA CORTA) MUESTRAN UNA VALIOSA ACTIVIDAD ANTITUMORAL Y PUEDEN SER PREPARADOS POR REACCION DE UN COMPLEJO AMINO-PLATINO CON UN COMPUESTO QUE PROPORCIONE EL GRUPO REPRESENTADO POR Z.
ES88304140T 1987-05-08 1988-05-06 Complejos de platino antitumorales, su preparacion y su uso en terapeutica. Expired - Lifetime ES2061646T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11218187 1987-05-08
JP11450087 1987-05-13

Publications (1)

Publication Number Publication Date
ES2061646T3 true ES2061646T3 (es) 1994-12-16

Family

ID=26451415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88304140T Expired - Lifetime ES2061646T3 (es) 1987-05-08 1988-05-06 Complejos de platino antitumorales, su preparacion y su uso en terapeutica.

Country Status (13)

Country Link
US (2) US5527905A (es)
EP (1) EP0290280B1 (es)
KR (1) KR950008372B1 (es)
CN (1) CN1017803B (es)
AU (1) AU617314B2 (es)
CA (1) CA1308723C (es)
DE (1) DE3887194T2 (es)
DK (1) DK252688A (es)
ES (1) ES2061646T3 (es)
FI (1) FI87572C (es)
HU (1) HU199492B (es)
NO (1) NO178069C (es)
RU (1) RU2039064C1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0164460B1 (ko) * 1995-10-02 1999-03-20 김은영 고분자 백금 착화합물, 그의 제조방법 및 그를 유효성분으로 하는 항암제
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2388844A1 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
KR100363394B1 (ko) * 2000-08-21 2002-12-05 한국과학기술연구원 온도감응성을 갖는 포스파젠삼량체-백금착물 복합체, 그의제조방법 및 그를 함유하는 항암제 조성물
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
WO2005056641A1 (ja) * 2003-12-10 2005-06-23 Toudai Tlo, Ltd. ジアミノシクロヘキサン白金(ii)とポリ(カルボン酸)セグメント含有ブロック共重合体との配位錯体、その抗腫瘍剤
ES2704303T3 (es) 2010-08-24 2019-03-15 Dana Farber Cancer Inst Inc Procedimientos para la predicción de una respuesta contra el cáncer
CA2839210A1 (en) 2011-06-17 2012-12-20 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
EP3660161B1 (en) 2011-12-21 2024-07-31 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
EP3415915B1 (en) 2012-02-23 2024-10-23 Children's Medical Center Corporation Methods for predicting response to parp inhibitors
CA2867434C (en) 2012-06-07 2021-10-12 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
US10308986B2 (en) 2013-03-14 2019-06-04 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
EP4023765A1 (en) 2013-12-09 2022-07-06 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
ES2800673T3 (es) 2014-08-15 2021-01-04 Myriad Genetics Inc Métodos y materiales para evaluar una deficiencia de recombinación homóloga
CN111721842B (zh) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 洛铂中有关物质的检测方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
GB2019397B (en) * 1978-04-20 1982-10-27 Johnson Matthey Co Ltd Pt 2 and 4 complexes with amino-acids
IL67789A (en) * 1983-01-31 1986-09-30 Yissum Res Dev Co Amino-substituted malonato platinum(ii)complexes and method for their preparation
FI83086C (fi) * 1985-09-06 1991-05-27 Sankyo Co Foerfarande foer framstaellning av komplex med tumormotverkande effekt.
DE3630497A1 (de) * 1986-09-08 1988-03-10 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
US5527905A (en) 1996-06-18
EP0290280A3 (en) 1990-07-25
NO178069C (no) 1996-01-17
NO882012D0 (no) 1988-05-09
DE3887194D1 (de) 1994-03-03
NO882012L (no) 1989-02-27
EP0290280A2 (en) 1988-11-09
AU1581388A (en) 1988-11-10
CN1017803B (zh) 1992-08-12
RU2039064C1 (ru) 1995-07-09
FI882130A0 (fi) 1988-05-06
NO178069B (no) 1995-10-09
AU617314B2 (en) 1991-11-28
FI87572C (fi) 1993-01-25
KR880013961A (ko) 1988-12-22
US5633243A (en) 1997-05-27
HUT47301A (en) 1989-02-28
DK252688D0 (da) 1988-05-06
KR950008372B1 (ko) 1995-07-28
FI87572B (fi) 1992-10-15
DK252688A (da) 1988-11-09
EP0290280B1 (en) 1994-01-19
DE3887194T2 (de) 1994-07-28
CA1308723C (en) 1992-10-13
HU199492B (en) 1990-02-28
FI882130A7 (fi) 1988-11-09
CN1034544A (zh) 1989-08-09

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