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ES2059327T3 - DERIVATIVES OF TETRAHIDRONAFTALENO AND INDANO, OBTAINING THE SAME AND USE IN PHARMACEUTICAL PREPARATIONS. - Google Patents

DERIVATIVES OF TETRAHIDRONAFTALENO AND INDANO, OBTAINING THE SAME AND USE IN PHARMACEUTICAL PREPARATIONS.

Info

Publication number
ES2059327T3
ES2059327T3 ES87109891T ES87109891T ES2059327T3 ES 2059327 T3 ES2059327 T3 ES 2059327T3 ES 87109891 T ES87109891 T ES 87109891T ES 87109891 T ES87109891 T ES 87109891T ES 2059327 T3 ES2059327 T3 ES 2059327T3
Authority
ES
Spain
Prior art keywords
lower alkyl
hydrogen
chor7
chr8
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87109891T
Other languages
Spanish (es)
Inventor
Michael Dr Klaus
Ekkehard Dr Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2059327T3 publication Critical patent/ES2059327T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/36—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE LA FORMULA GENERAL (I) DONDE X E Y SON -CH2- O >C(CH3)2; Z ES UN RESTO -CHR8-, >CO, >CR8OR7, -CHR8-CHR8, -CHOR7-CH2-, -CO-CHOR7- O -CHOR7-CHOR7; R1 ES UN RESTO MONO-CICLICO-HETEROCICLICO DE 5 O 6 MIEMBROS, QUE PUEDE SER SUSTITUIDO, POR HALOGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, ACILOXI, NITRO, HIDROXI, AMINO, ALQUILAMINO INFERIOR O DI-ALQUILAMINO INFERIOR SUSTITUIDO EN C Y/O UN GRUPO NH EN ANILLO POR ALQUILO INFERIOR; R2 Y R3 SON HIDROGENO, ALQUILO INFERIOR, TRIFLUOROMETILO O HALOGENO Y UNO DE LOS RESTOS R2 Y R3 ES TRIFLUOROMETILO O ALQUILO INFERIOR, R4 Y R5 ES HIDROGENO, ALQUILO, ALCOXI O HALOGENO; R6 ES HIDROGENO, ALQUILO INFERIOR O UN RESTO -OR7; R7 ES HIDROGENO, ALQUILO INFERIOR O ACILO; R8 ES HIDROGENO O ALQUILO INFERIOR, Y MAS RESTOS R7 Y R8 PUEDEN SER DIFERENTES ENTRE SI. SON APROPIADOS PARA EL TRATAMIENTO DE NEOPLASIAS Y DERMATOSIS.COMPOUNDS OF THE GENERAL FORMULA ARE DESCRIBED (I) WHERE X E AND ARE -CH2- O> C (CH3) 2; Z IS A REST -CHR8-,> CO,> CR8OR7, -CHR8-CHR8, -CHOR7-CH2-, -CO-CHOR7- OR -CHOR7-CHOR7; R1 IS A MONO-CYCLIC-HETERO-CYCLE REST OF 5 OR 6 MEMBERS, WHICH CAN BE REPLACED, BY HALOGEN, LOWER ALKYL, ALCOXI LOWER, ACILOXI, NITRO, HYDROXY, AMINO, LOWER ALKYLAMINE OR DI-ALKYLUTHANUT. NH GROUP IN RING FOR LOWER RENT; R2 AND R3 ARE HYDROGEN, LOWER ALKYL, TRIFLUOROMETHYL OR HALOGEN AND ONE OF THE REMAINS R2 AND R3 IS TRIFLUOROMETHYL OR LOWER ALKYL, R4 AND R5 IS HYDROGEN, ALKYL, ALCOXY OR HALOGEN; R6 IS HYDROGEN, LOWER ALKYL OR A REST -OR7; R7 IS HYDROGEN, LOWER ALKYL OR ACIL; R8 IS HYDROGEN OR LOWER ALKYL, AND MORE R7 AND R8 MAY BE DIFFERENT FROM ONE TO THE OTHER. THEY ARE APPROPRIATE FOR THE TREATMENT OF NEOPLASMS AND DERMATOSIS.

ES87109891T 1986-07-15 1987-07-08 DERIVATIVES OF TETRAHIDRONAFTALENO AND INDANO, OBTAINING THE SAME AND USE IN PHARMACEUTICAL PREPARATIONS. Expired - Lifetime ES2059327T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH282686 1986-07-15

Publications (1)

Publication Number Publication Date
ES2059327T3 true ES2059327T3 (en) 1994-11-16

Family

ID=4242469

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87109891T Expired - Lifetime ES2059327T3 (en) 1986-07-15 1987-07-08 DERIVATIVES OF TETRAHIDRONAFTALENO AND INDANO, OBTAINING THE SAME AND USE IN PHARMACEUTICAL PREPARATIONS.

Country Status (23)

Country Link
US (1) US4876349A (en)
EP (1) EP0253302B1 (en)
JP (1) JP2516989B2 (en)
KR (1) KR880001591A (en)
AR (1) AR243880A1 (en)
AT (1) ATE111452T1 (en)
AU (1) AU600958B2 (en)
CA (1) CA1316534C (en)
DE (1) DE3750529D1 (en)
DK (1) DK167010B1 (en)
ES (1) ES2059327T3 (en)
FI (1) FI872736A7 (en)
HU (1) HU198183B (en)
IE (1) IE64427B1 (en)
IL (1) IL83140A (en)
MC (1) MC1837A1 (en)
MX (1) MX7372A (en)
NO (1) NO170483C (en)
NZ (1) NZ220997A (en)
PH (1) PH23432A (en)
PT (1) PT85329B (en)
ZA (1) ZA874980B (en)
ZW (1) ZW10287A1 (en)

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Also Published As

Publication number Publication date
MC1837A1 (en) 1988-06-03
AU600958B2 (en) 1990-08-30
DE3750529D1 (en) 1994-10-20
HU198183B (en) 1989-08-28
IL83140A0 (en) 1987-12-31
FI872736A7 (en) 1988-01-16
EP0253302B1 (en) 1994-09-14
EP0253302A3 (en) 1989-11-29
AU7569587A (en) 1988-01-21
ZA874980B (en) 1988-01-15
KR880001591A (en) 1988-04-25
NZ220997A (en) 1990-04-26
DK167010B1 (en) 1993-08-16
PH23432A (en) 1989-08-07
IL83140A (en) 1992-06-21
MX7372A (en) 1993-09-01
ATE111452T1 (en) 1994-09-15
DK366787D0 (en) 1987-07-14
HUT44505A (en) 1988-03-28
NO170483B (en) 1992-07-13
DK366787A (en) 1988-01-16
JP2516989B2 (en) 1996-07-24
PT85329A (en) 1987-08-01
JPS6323864A (en) 1988-02-01
NO872939L (en) 1988-01-18
IE64427B1 (en) 1995-08-09
AR243880A1 (en) 1993-09-30
US4876349A (en) 1989-10-24
NO872939D0 (en) 1987-07-14
EP0253302A2 (en) 1988-01-20
CA1316534C (en) 1993-04-20
ZW10287A1 (en) 1988-01-13
NO170483C (en) 1992-10-21
PT85329B (en) 1990-04-30
FI872736A0 (en) 1987-06-18
IE871896L (en) 1988-01-15

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