[go: up one dir, main page]

ES2058089T3 - Un procedimiento para la preparacion de un nuevo derivado de prolinal. - Google Patents

Un procedimiento para la preparacion de un nuevo derivado de prolinal.

Info

Publication number
ES2058089T3
ES2058089T3 ES87116613T ES87116613T ES2058089T3 ES 2058089 T3 ES2058089 T3 ES 2058089T3 ES 87116613 T ES87116613 T ES 87116613T ES 87116613 T ES87116613 T ES 87116613T ES 2058089 T3 ES2058089 T3 ES 2058089T3
Authority
ES
Spain
Prior art keywords
new
group
procedure
preparation
replacing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87116613T
Other languages
English (en)
Inventor
Masaaki Toda
Shuichi Ohuchida
Hiroyuki Ohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2058089T3 publication Critical patent/ES2058089T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO DERIVADO DE PROLINAL DE FORMULA GENERAL (I): EN LA QUE A REPRESENTA UN GRUPO ALQUILENO O ALQUENILENO DE 1 A 8 C O UN ANILLO HIDROCARBONADO SATURADO DE 3 A 7 C; R REPRESENTA UN ATOMO DE H O UN GRUPO FENILO, BENCILO, ALQUILO DE 1 A 8 C, O CICLOALQUILO DE 3 A 7 C; B REPREENTA UN GRUPO ALQUILENO DE 1 A 8 C SIN SUSTITUIR O SUSTITUIDO POR UN GRUPO FENILO O BENCILO O UN ENLACE SENCILLO; D REPRESENTA UN ANILLO CARBOCICLICO O HETEROCICLICO SIN SUSTITUIR O SUSTITUIDO CON UNO A TRES ATOMOS DE HALOGENOS, GRUPOS ALQUILO O ALCOXI DE 1 A 4 ATOMOS DE C, NITRO O TRIFLUORMETILO. EL COMPUESTO TIENE ACTIVIDAD INHIBIDORA DE LA PROLILENDOPEPTIDASA POR LO QUE PUEDE SER UTIL COMO AGENTE PARA EL TRATAMIENTO O PREVENCION DE LA AMNESIA.
ES87116613T 1986-11-20 1987-11-10 Un procedimiento para la preparacion de un nuevo derivado de prolinal. Expired - Lifetime ES2058089T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27537586 1986-11-20
JP22845287 1987-09-14

Publications (1)

Publication Number Publication Date
ES2058089T3 true ES2058089T3 (es) 1994-11-01

Family

ID=26528260

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87116613T Expired - Lifetime ES2058089T3 (es) 1986-11-20 1987-11-10 Un procedimiento para la preparacion de un nuevo derivado de prolinal.

Country Status (6)

Country Link
US (3) US4956380A (es)
EP (1) EP0268190B1 (es)
JP (1) JPH064583B2 (es)
KR (1) KR950013849B1 (es)
DE (1) DE3786229T2 (es)
ES (1) ES2058089T3 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3786229T2 (de) * 1986-11-20 1993-10-07 Ono Pharmaceutical Co Prolinalderivate.
US5262431A (en) * 1986-12-29 1993-11-16 Ono Pharmaceutical Co., Ltd. Prolinal derivatives and pharmaceutical compositions thereof
EP0275482B1 (en) * 1986-12-29 1993-01-20 Ono Pharmaceutical Co., Ltd. Proline derivatives
EP0277588B1 (en) * 1987-02-04 1993-03-24 Ono Pharmaceutical Co., Ltd. Prolinal derivatives
US5053414A (en) * 1988-04-08 1991-10-01 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
US5118811A (en) * 1989-04-13 1992-06-02 Japan Tobacco Inc. Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities
WO1991018891A1 (en) * 1990-06-04 1991-12-12 Pfizer Inc. Aromatic pyrrolidine and thiazolidine amides
US5506256A (en) * 1990-07-27 1996-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Proline derivatives possessing prolyl endopeptidase-inhibitory activity
EP0468469A2 (en) * 1990-07-27 1992-01-29 Japan Tobacco Inc. Proline derivatives
FR2703050B1 (fr) * 1993-03-24 1995-04-28 Adir Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP1120408A1 (en) 1998-10-02 2001-08-01 Ono Pharmaceutical Co., Ltd. Remedies for motor dysfunction and gapdh expression inhibitors
US6121311A (en) * 1999-04-28 2000-09-19 Japan Tobacco Inc. Method for treating cocainism
WO2003077847A2 (en) 2002-03-12 2003-09-25 Merck & Co., Inc. Substituted amides
WO2004098591A2 (en) 2003-05-05 2004-11-18 Probiodrug Ag Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
EP1824846A2 (en) 2003-11-03 2007-08-29 Probiodrug AG Novel compounds for the treatment of neurological disorders
AU2004290499C1 (en) 2003-11-03 2011-02-24 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1713780B1 (en) 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080822A1 (en) * 1981-11-27 1983-06-08 Beecham Group Plc Anti-hypertensive prolinol-based peptides
JPS60188317A (ja) * 1984-03-09 1985-09-25 Yakult Honsha Co Ltd 抗健忘症剤
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0680077B2 (ja) * 1985-02-08 1994-10-12 サントリー株式会社 プロリンエンドペプチダ−ゼインヒビタ−活性を有する新規ペプチド化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
JPH0623191B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 ペプチダ−ゼ阻害活性化合物およびその製法ならびに用途
CA1309805C (en) * 1985-04-16 1992-11-03 Naoki Higuchi Dipeptide derivative and synthesis and use thereof
CA1298033C (en) * 1985-04-16 1992-03-24 Takaharu Tanaka Dipeptide derivative of fatty acid
DE3786229T2 (de) * 1986-11-20 1993-10-07 Ono Pharmaceutical Co Prolinalderivate.
JP2589163B2 (ja) * 1988-09-28 1997-03-12 日東化成株式会社 非対称トリオルガノ錫ハライドの製法

Also Published As

Publication number Publication date
US5100904A (en) 1992-03-31
KR880006190A (ko) 1988-07-22
DE3786229T2 (de) 1993-10-07
US5340832A (en) 1994-08-23
EP0268190A1 (en) 1988-05-25
US4956380A (en) 1990-09-11
KR950013849B1 (ko) 1995-11-17
JPH01156957A (ja) 1989-06-20
JPH064583B2 (ja) 1994-01-19
EP0268190B1 (en) 1993-06-16
DE3786229D1 (de) 1993-07-22

Similar Documents

Publication Publication Date Title
ES2058089T3 (es) Un procedimiento para la preparacion de un nuevo derivado de prolinal.
AR003962A1 (es) Dihidrodibenzo/b,f/azepinas útiles en el tratamiento de algunos desórdenes del sistema nervioso central y períferico, método para preparar dichos compuestos y sus composiciones farmacéuticas,y, sus usos
ES2059335T3 (es) Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento.
AR006720A1 (es) Un compuesto derivado de azahexano heterociclico, su uso para la preparacion de una composicion farmaceutica, procedimiento para prepararlo y una composicion farmaceutica que lo comprende
ES2052772T3 (es) Procedimiento y agente contra enfermedades de plantas.
ES2139943T3 (es) Nuevos inhibidores de la sintasa de prostaglandina.
DK502781A (da) Fremgangsmaade til fremstilling af 3-aryloxy-3-phenylpropylaminer
ES2053508T3 (es) Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos.
PA8610801A1 (es) Compuestos de aril o heteroaril amida
PE107999A1 (es) Derivados 3-amidinoanilina, inhibidores del factor x de coagulacion de la sangre activado e intermediarios de los mismos
ES2063153T3 (es) Amino-4 quinoleinas y naftiridinas, su procedimiento de preparacion y su aplicacion como medicamentos.
AR247415A1 (es) Composiciones organopolisiloxanicas curables con catalizadores de estano (iv)
ES2062486T3 (es) 3-fenilbenzofuran-2-onas.
ES2061580T3 (es) Compuestos de 3,7-diazabiciclo(3,3,1)nonano, asi como procedimiento para su preparacion y medicamentos que contienen estos compuestos.
ES2052539T3 (es) Procedimiento para preparar isoxazolidinas 2,3-disustituidas.
ES2038630T3 (es) Un procedimiento para preparar un compuesto de acido fenoxiacetico.
ES2048222T3 (es) Procedimiento para preparar derivados de beta-lactama.
MX9300742A (es) Derivados de quinolina substituidos con bifenilo y composicion farmaceutica que los contiene.
AR241422A1 (es) Procedimiento para la preparacion de derivados de difenil(metil-etil-0 etenil) piperidinas.
ES2037708T3 (es) Un procedimiento para preparar un derivado de bencimidazol.
AR246518A1 (es) Composicion, compuesto y complejo y sal metalicos de derivado de tiona heterociclica.
ES2032752T3 (es) Procedimiento de preparacion de derivados de la 1-bencenosulfonil-2-oxo-5-alcoxi-pirrolidina.
AR005532A1 (es) Compuestos de dihalopropeno, las composiciones insecticidas/acaricidas que los contienen y los intermediarios de sintesis de dichos compuestos
ES2090024T3 (es) Compuestos de cefemo y procedimientos para su preparacion.
ES8706148A1 (es) Un procedimiento para preparar nuevos derivados de carbapenem.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 268190

Country of ref document: ES