ES2056648T3 - Liposomas con carga positiva en exceso. - Google Patents
Liposomas con carga positiva en exceso.Info
- Publication number
- ES2056648T3 ES2056648T3 ES91908541T ES91908541T ES2056648T3 ES 2056648 T3 ES2056648 T3 ES 2056648T3 ES 91908541 T ES91908541 T ES 91908541T ES 91908541 T ES91908541 T ES 91908541T ES 2056648 T3 ES2056648 T3 ES 2056648T3
- Authority
- ES
- Spain
- Prior art keywords
- liposomes
- formula
- pnn
- gly
- excess
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
SE DESCRIBEN NUEVAS ESTRUCTURAS DE LIPOSOMAS, QUE SE CARACTERIZAN PORCONTENER AL MENOS 1 % EN MOL DE UN COMPUESTO QUE PRESENTA UN EXCESO DE CARGA POSITIVA, DE LA FORMULA GENERAL (I), EN LA QUE R1 EQUIVALE A ALCOHILO O ALQUILO, CON 14 A 18 ATOMOS DE C, OLEOILO U OLEILO, R2 POSEE EL MISMO SIGNIFICADO QUE R1 (R1, SIN EMBARGO, NO DEBE SER NECESARIAMENTE IGUAL A R2), Y ADEMAS PNN (FORMULA (A)) O GLI (FORMULA (B)), DONDE A PUEDE EQUIVALER A NH3+, - NH2CH3+, - NH(CH3)+2, N(CH3)+3, R3 SIGNIFICA - O - R1, O - PNN, - O - GLI, NH3+, NH2CH3+, NH(CH3)2+ O N(CH3)3+, R POSEE UNO DE LOS SIGNIFICADOS DADOS A R1, R2 O R3, Y N EQUIVALE A UN NUMERO ENTERO ENTRE 0 Y 3, PREFERENTEMENTE 0, CON LA PREVISION DE QUE LA MOLECULA CONTENGA UNO DE LOS GRUPOS ARRIBA MENCIONADOS CON CARGA POSITIVA. DEBIDO A SU COMPORTAMIENTO ESPECIFICO ORGANICO, LOS LIPOSOMAS DE LA INVENCION SON MUY ADECUADOS COMO EXCIPIENTES EN PREPARADOS MEDICINALES, PARA EL TRATAMIENTO DE ENFERMEDADES DEL ORGANO DEL HIGADO, QUE CONTIENEN INCLUIDAS EN LOS LIPOSOMAS DE LA INVENCION UNA O VARIAS SUSTANCIAS ACTIVAS PARA EL HIGADO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4013632A DE4013632A1 (de) | 1990-04-27 | 1990-04-27 | Liposomen mit positiver ueberschussladung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2056648T3 true ES2056648T3 (es) | 1994-10-01 |
Family
ID=6405307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91908541T Expired - Lifetime ES2056648T3 (es) | 1990-04-27 | 1991-04-25 | Liposomas con carga positiva en exceso. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0526531B1 (es) |
| JP (1) | JPH05506661A (es) |
| AT (1) | ATE107503T1 (es) |
| AU (1) | AU643282B2 (es) |
| CA (1) | CA2081119A1 (es) |
| DE (2) | DE4013632A1 (es) |
| DK (1) | DK0526531T3 (es) |
| ES (1) | ES2056648T3 (es) |
| IE (1) | IE62548B1 (es) |
| PT (1) | PT97500B (es) |
| WO (1) | WO1991016880A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH087409B2 (ja) * | 1988-10-03 | 1996-01-29 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料の処理方法 |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| DE4208527A1 (de) * | 1992-03-17 | 1993-09-23 | Max Planck Gesellschaft | Liposomen mit negativer ueberschussladung |
| US5552155A (en) * | 1992-12-04 | 1996-09-03 | The Liposome Company, Inc. | Fusogenic lipsomes and methods for making and using same |
| EP0702516A4 (en) | 1993-06-01 | 1998-04-22 | Life Technologies Inc | GENETIC IMMUNIZATION WITH CATIONIC LIPIDS |
| EP0638639B1 (en) * | 1993-08-10 | 2000-04-12 | Akzo Nobel N.V. | Biodegradable fabric softening composition |
| NZ268146A (en) * | 1994-04-12 | 1997-10-24 | Liposome Co Inc | Liposome compositions and medicinal uses |
| US5429755A (en) * | 1994-06-16 | 1995-07-04 | Lever Brothers Company | Fabric conditioning molecules derived from glycerol and betaine |
| ES2123307T3 (es) * | 1995-02-24 | 1999-01-01 | Kao Corp | Sal de amonio cuaternario, metodo para la fabricacion de la misma y su utilizacion como composicion suavizante. |
| EP0863749A2 (en) | 1995-11-30 | 1998-09-16 | Vical Incorporated | Complex cationic lipids |
| DE19835611A1 (de) * | 1998-08-06 | 2000-02-10 | Max Planck Gesellschaft | Neuartige Phospholipide mit synthetischen, ungesättigten Alkyl- und Acylketten |
| EP1261620A2 (en) * | 2000-02-07 | 2002-12-04 | Roche Diagnostics Corporation | Cationic amphiphiles for use in nucleic acid transfection |
| ITMI20032185A1 (it) * | 2003-11-12 | 2005-05-13 | Chemi Spa | Processo per la sintesi di lipidi cationici. |
| DE102004057303A1 (de) * | 2004-11-26 | 2006-06-01 | Merck Patent Gmbh | Stabile Kristallmodifikationen von DOTAP Chlorid |
| CA2927045A1 (en) * | 2006-10-03 | 2008-04-10 | Muthiah Manoharan | Lipid containing formulations |
| NZ605079A (en) * | 2010-06-03 | 2015-08-28 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| ES2562274T3 (es) * | 2010-10-06 | 2016-03-03 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Procedimiento para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de mama |
| SG194957A1 (en) | 2011-05-20 | 2013-12-30 | Merck Patent Gmbh | Stable crystal modifications of dotap chloride |
| JP2013043885A (ja) * | 2011-08-26 | 2013-03-04 | Kansai Bunri Sogo Gakuen | デヒドロアミノ酸含有グリセロール誘導体 |
| CA2856742A1 (en) | 2011-12-07 | 2013-06-13 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| CN117230193A (zh) | 2016-05-25 | 2023-12-15 | 生物运动有限公司 | 基于c-maf状态的乳腺癌治疗性治疗 |
| EP3713581A1 (en) | 2017-11-22 | 2020-09-30 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf |
| KR102054401B1 (ko) * | 2018-03-26 | 2019-12-10 | 주식회사 엔지켐생명과학 | 1,2-디아실글리세롤 화합물, 그 제조방법 및 이를 유효성분으로 함유하는 면역조절제 |
| EP4368609A1 (en) * | 2022-11-08 | 2024-05-15 | Mello Biotech Taiwan Co., Ltd. | Cationic lipids and uses thereof |
| KR20240174509A (ko) | 2023-06-07 | 2024-12-17 | 포항공과대학교 산학협력단 | 핵산 치료제에 사용되는 기능성 지질 라이브러리를 합성하기 위한 단일 연속 유동 합성 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2752553C2 (de) * | 1977-11-24 | 1985-07-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Neue phospholipidartige Verbindungen, ihre Verwendung zur Herstellung von Pflanzenhybriden und Verfahren zu ihrer Herstellung |
| AU5632880A (en) * | 1979-04-30 | 1980-11-06 | Brown, G. | Convertible sleeping and seating apparatus |
| DE3374837D1 (en) * | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| ZA8681B (en) * | 1985-01-07 | 1987-08-26 | Syntex Inc | 1,2-dialkoxy-omega-trialkylammonium cationic surfactants |
| US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| JPS632921A (ja) * | 1986-06-20 | 1988-01-07 | Yamanouchi Pharmaceut Co Ltd | リポソ−ム製剤 |
-
1990
- 1990-04-27 DE DE4013632A patent/DE4013632A1/de not_active Withdrawn
-
1991
- 1991-04-25 JP JP91508158A patent/JPH05506661A/ja active Pending
- 1991-04-25 CA CA002081119A patent/CA2081119A1/en not_active Abandoned
- 1991-04-25 ES ES91908541T patent/ES2056648T3/es not_active Expired - Lifetime
- 1991-04-25 DE DE59102030T patent/DE59102030D1/de not_active Expired - Fee Related
- 1991-04-25 AU AU77702/91A patent/AU643282B2/en not_active Ceased
- 1991-04-25 AT AT91908541T patent/ATE107503T1/de not_active IP Right Cessation
- 1991-04-25 EP EP91908541A patent/EP0526531B1/de not_active Expired - Lifetime
- 1991-04-25 WO PCT/EP1991/000796 patent/WO1991016880A1/de not_active Ceased
- 1991-04-25 DK DK91908541.5T patent/DK0526531T3/da active
- 1991-04-26 PT PT97500A patent/PT97500B/pt not_active IP Right Cessation
- 1991-04-26 IE IE142791A patent/IE62548B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE107503T1 (de) | 1994-07-15 |
| AU7770291A (en) | 1991-11-27 |
| WO1991016880A1 (de) | 1991-11-14 |
| DE59102030D1 (de) | 1994-07-28 |
| IE62548B1 (en) | 1995-02-08 |
| EP0526531B1 (de) | 1994-06-22 |
| PT97500B (pt) | 1998-08-31 |
| IE911427A1 (en) | 1991-11-06 |
| DK0526531T3 (da) | 1994-08-22 |
| EP0526531A1 (de) | 1993-02-10 |
| DE4013632A1 (de) | 1991-10-31 |
| PT97500A (pt) | 1992-01-31 |
| AU643282B2 (en) | 1993-11-11 |
| CA2081119A1 (en) | 1991-10-28 |
| JPH05506661A (ja) | 1993-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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