ES2046195T3 - Un procedimiento para la preparacion de los derivados de prolinal. - Google Patents
Un procedimiento para la preparacion de los derivados de prolinal.Info
- Publication number
- ES2046195T3 ES2046195T3 ES198787118566T ES87118566T ES2046195T3 ES 2046195 T3 ES2046195 T3 ES 2046195T3 ES 198787118566 T ES198787118566 T ES 198787118566T ES 87118566 T ES87118566 T ES 87118566T ES 2046195 T3 ES2046195 T3 ES 2046195T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- chem
- general formula
- carbon atoms
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- AGRIQBHIKABLPJ-UHFFFAOYSA-N 1-Pyrrolidinecarboxaldehyde Chemical class O=CN1CCCC1 AGRIQBHIKABLPJ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 102000056251 Prolyl Oligopeptidases Human genes 0.000 abstract 1
- 101710178372 Prolyl endopeptidase Proteins 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN NUEVO DERIVADO DE PROLINAL DE FORMULA GENERAL (I), DONDE A REPRESENTA UN GRUPO DE FORMULA GENERAL (II) EN LA QUE UNO DE LOS SUSTITUYENTES R1 Y R2 REPRESENTA UN ATOMO DE HIDROGENO Y EL OTRO UN GRUPO ALQUILO DE 2 A 5 ATOMOS DE CARBONO, UN GRUPO ALCOXI DE 1 A 5 ATOMOS DE CARBONO, UN GRUPO FENILO, UN GRUPO BENCILO, UN GRUPO CICLOALQUILO DE 4 A 6 ATOMOS DE CARBONO O UN GRUPO (CICLOALQUIL DE 4 A 6 ATOMOS DE CARBONO)-METILO, O BIEN R1 Y R2 REPRESENTAN CADA UNO UN GRUPO ALQUILO DE 1 A 4 ATOMOS DE CARBONO IGUALES O DISTINTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31015186 | 1986-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2046195T3 true ES2046195T3 (es) | 1994-02-01 |
Family
ID=18001775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198787118566T Expired - Lifetime ES2046195T3 (es) | 1986-12-29 | 1987-12-15 | Un procedimiento para la preparacion de los derivados de prolinal. |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US4983624A (es) |
| EP (1) | EP0275482B1 (es) |
| KR (1) | KR950009359B1 (es) |
| AT (1) | ATE84787T1 (es) |
| DE (1) | DE3783754T2 (es) |
| ES (1) | ES2046195T3 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0277588B1 (en) * | 1987-02-04 | 1993-03-24 | Ono Pharmaceutical Co., Ltd. | Prolinal derivatives |
| US5212191A (en) * | 1988-04-08 | 1993-05-18 | Ono Pharmaceutical Co., Ltd. | Heterocyclic compounds |
| US5118811A (en) * | 1989-04-13 | 1992-06-02 | Japan Tobacco Inc. | Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities |
| US7371871B2 (en) | 2003-05-05 | 2008-05-13 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| CA2544573A1 (en) | 2003-11-03 | 2005-06-02 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| KR101099206B1 (ko) | 2004-02-05 | 2011-12-27 | 프로비오드룩 아게 | 신규한 글루타미닐 시클라제 저해제 |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| US8524654B2 (en) * | 2007-05-21 | 2013-09-03 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| CA2789440C (en) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
| JPH0623190B2 (ja) * | 1985-04-16 | 1994-03-30 | サントリー株式会社 | インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途 |
| CA1298033C (en) * | 1985-04-16 | 1992-03-24 | Takaharu Tanaka | Dipeptide derivative of fatty acid |
| ES2058089T3 (es) * | 1986-11-20 | 1994-11-01 | Ono Pharmaceutical Co | Un procedimiento para la preparacion de un nuevo derivado de prolinal. |
-
1987
- 1987-12-15 EP EP87118566A patent/EP0275482B1/en not_active Expired - Lifetime
- 1987-12-15 DE DE8787118566T patent/DE3783754T2/de not_active Expired - Fee Related
- 1987-12-15 ES ES198787118566T patent/ES2046195T3/es not_active Expired - Lifetime
- 1987-12-15 AT AT87118566T patent/ATE84787T1/de not_active IP Right Cessation
- 1987-12-28 KR KR1019870015052A patent/KR950009359B1/ko not_active Expired - Fee Related
- 1987-12-29 US US07/139,231 patent/US4983624A/en not_active Expired - Lifetime
-
1990
- 1990-06-12 US US07/536,830 patent/US5112847A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR880007457A (ko) | 1988-08-27 |
| DE3783754D1 (de) | 1993-03-04 |
| US4983624A (en) | 1991-01-08 |
| ATE84787T1 (de) | 1993-02-15 |
| EP0275482A2 (en) | 1988-07-27 |
| DE3783754T2 (de) | 1993-08-05 |
| EP0275482B1 (en) | 1993-01-20 |
| US5112847A (en) | 1992-05-12 |
| EP0275482A3 (en) | 1988-12-28 |
| KR950009359B1 (ko) | 1995-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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