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EP3704033B1 - Packaging machine for producing an individual blister package - Google Patents

Packaging machine for producing an individual blister package Download PDF

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Publication number
EP3704033B1
EP3704033B1 EP18766244.0A EP18766244A EP3704033B1 EP 3704033 B1 EP3704033 B1 EP 3704033B1 EP 18766244 A EP18766244 A EP 18766244A EP 3704033 B1 EP3704033 B1 EP 3704033B1
Authority
EP
European Patent Office
Prior art keywords
packaging machine
station
containers
cleaning
transport container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18766244.0A
Other languages
German (de)
French (fr)
Other versions
EP3704033A2 (en
EP3704033C0 (en
Inventor
Detlef Steinweg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paracelsus Care GmbH
Original Assignee
Paracelsus Care GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paracelsus Care GmbH filed Critical Paracelsus Care GmbH
Publication of EP3704033A2 publication Critical patent/EP3704033A2/en
Application granted granted Critical
Publication of EP3704033B1 publication Critical patent/EP3704033B1/en
Publication of EP3704033C0 publication Critical patent/EP3704033C0/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B39/00—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
    • B65B39/007—Guides or funnels for introducing articles into containers or wrappers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
    • B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
    • B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/162—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by feeding web material to securing means
    • B65B7/164—Securing by heat-sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
    • B65B9/02—Enclosing successive articles, or quantities of material between opposed webs
    • B65B9/04—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material
    • B65B9/045—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material for single articles, e.g. tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52—Details
    • B65D75/527—Tear-lines for separating a package into individual packages
    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07F—COIN-FREED OR LIKE APPARATUS
    • G07F17/00—Coin-freed apparatus for hiring articles; Coin-freed facilities or services
    • G07F17/0092—Coin-freed apparatus for hiring articles; Coin-freed facilities or services for assembling and dispensing of pharmaceutical articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B2210/00—Specific aspects of the packaging machine
    • B65B2210/06—Sterilising or cleaning machinery or conduits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Definitions

  • the present invention relates to a packaging machine for producing individual blister packs for drug administration.
  • the EP 1 627 813 A1 , the WO 2005/108208 A1 as well as the US 7 225 597 B1 describe a packaging machine for producing individual blister packs for dispensing medicaments, wherein the packaging machine comprises a filling station with a plurality of containers, each container being provided for storing and dispensing a predetermined medicament, wherein the packaging machine has a conveyor device, wherein the conveyor device is provided for conveying a carrier of a blister pack.
  • US 2016/304 229 A1 shows a device for producing tube blister packs, which includes dispensing stations and a collection device for delivering medication doses to a blister packaging device.
  • the blister packaging device fills the resulting medication doses in groups into pockets of a tube blister pack.
  • the US 2009/255 952 A1 describes a cleaning station, in particular a separator plate, which is capable of efficiently cleaning a drug remaining in a V-gauge.
  • the US 2007/084 150 A1 relates to an automated packaging machine for pharmaceutical products that simultaneously processes a large number of Fills product packaging templates in parallel with the desired pharmaceutical dosage requirements.
  • US 4 655 026 A discloses a pill dispensing machine that can selectively dispense a variety of different medications into preformed recesses in a plastic strip.
  • Blister packs are already known. A distinction is made between bag-like tubular blisters and flat, essentially rigid card blisters. It is also known to fill and seal such a card blister pack with medications for several days and, if necessary, several times per patient, according to a doctor's prescription, so that the patient only needs to take all the medications contained in one compartment at the right time.
  • prefabricated carriers are used with a predetermined matrix of wells (e.g. in the form of a 7 x 2 matrix, i.e. 14 wells for 2 administration times over 7 days).
  • patient-specific packaging is often carried out at least partially manually.
  • cross-contamination occurs due to drug-carrying parts of the packaging machine coming into contact with different drugs.
  • the known packaging machines require a lot of space and are expensive, so that such packaging machines have so far only been used in so-called blister centers. It is therefore an object of the present invention to provide a packaging machine for producing such blister packs that can be operated flexibly and with little space requirement while avoiding cross-contamination and can preferably also be used on-site.
  • the packaging machine according to the invention achieves the significant advantage that the drugs are filled as immediately as possible, i.e. directly, into the recesses, thereby eliminating cross-contamination. In any case, a transfer device, for example a chute or a funnel, over which several different drugs are moved, is avoided.
  • a packaging machine according to the invention is also referred to as a blister machine.
  • the packaging machine comprises a control unit that controls the individual parts of the packaging machine.
  • the control unit is connected to at least one detection device in order to check correct functioning.
  • the data from the detection device is input into a feedback loop of the control unit.
  • the medicaments must be assigned to the individual wells.
  • this is achieved by arranging the carrier and/or the containers so that they can move transversely to the conveying direction.
  • the container and well are aligned relative to each other to enable precise filling.
  • the packaging machine preferably comprises a detection device that monitors the relative movement of the container and the carrier.
  • the container is configured to dispense a predetermined number of medicaments.
  • the packaging machine comprises at least one measuring device for measuring the fill level of at least one of the containers. This advantageously makes it possible to automatically dispense precisely measured amounts of medicaments and to detect early on when a container needs to be refilled or replaced.
  • the conveying device is provided for conveying at least one movable transport container, wherein the packaging machine is configured such that, in the filling station, the medicaments can be filled directly from the containers into the transport container, wherein the packaging machine comprises a transfer station, wherein the packaging machine is configured such that, in the transfer station, the medicaments can be transferred from the movable transport container into a recess of a blister pack carrier assigned to the transport container.
  • the packaging machine is configured such that, in the transfer station, the medicaments can be transferred from the movable transport container into a recess of a blister pack carrier assigned to the transport container.
  • the packaging machine comprises a plurality of movable transport containers, whereby the cycle speed of the packaging machine can advantageously be increased. is increased.
  • the packaging machine comprises at least as many transport containers as the carrier has adjacently arranged recesses, i.e., in particular, the number of transport containers corresponds to the number of columns of the carrier, particularly preferably twice the number of columns. This advantageously makes it possible to fill a row of recesses simultaneously and, if necessary, to have the transport containers assigned to the next row filled by the containers while the recesses are being filled.
  • the conveyor device is a conveyor belt, in particular an endless conveyor belt.
  • the conveyor device comprises at least one guide rail and a drive, in particular a magnetic drive.
  • the transport containers are movable essentially autonomously and independently of one another on the conveyor device.
  • the packaging machine comprises a sealing station, wherein the sealing station is arranged immediately after the filling station or the transfer station, wherein the sealing station is configured to seal a lidding film onto the carrier.
  • the sealing station is arranged such that the filled recesses are immediately sealed by the lidding film.
  • the packaging machine comprises a separating device for separating a predetermined length of the blister pack and/or the carrier, wherein the separating device is arranged before or after the filling station, the transfer station and/or the sealing station. It is advantageously possible to further increase flexibility with regard to different blister pack sizes.
  • the packaging machine comprises a cleaning station, wherein the cleaning station is arranged immediately after the transfer station, wherein the cleaning station is configured for the automatic cleaning of the at least one transport container and the containers.
  • the packaging machine is configured such that each transport container is cleaned, in particular sterilized and/or disinfected, immediately after the medicaments have been transferred into the recess. This further reduces the risk of cross-contamination in a particularly advantageous manner. The thorough cleaning makes it possible to use the transport containers multiple times without the risk of contamination.
  • the packaging machine comprises a printing station, wherein the printing station is configured to print information onto the lidding film and/or the carrier.
  • the printing station is particularly preferably arranged before or after the filling station or the sealing station.
  • the containers are designed to be exchangeable and/or refillable, particularly automatically. This advantageously makes it possible to increase the space requirements and flexibility of the packaging machine. For example, rarely used medications can be inserted into the packaging machine only when needed. Furthermore, simple and hygienic refilling of the containers is possible, particularly without requiring a downtime of the packaging machine, since the container can be exchanged for another container.
  • FIG. 1 A packaging machine is shown that does not correspond to the invention. In this case, only a section of the packaging machine 5 is shown schematically.
  • a conveyor device 7 for example an endless conveyor belt, transports an (endless) carrier 3 with matrix-like recesses 2 along a conveying direction, here linear.
  • the packaging machine 5 comprises a control unit, not shown here, which monitors and controls the operation of the packaging machine 5.
  • a filling station 10 contains a plurality of containers 6, each of which contains a predetermined medication. If a container 6 is positioned exactly above a recess 2 into which the medication contained in the container 6 is to be filled according to the patient's individual specifications, which the control unit can detect, for example, via a corresponding detection device, a predetermined amount of the medication is filled into the recess 2.
  • aids such as funnels or other filling aids can be used. It is important that these filling aids are not designed for containers 6. with different medicines to avoid cross-contamination.
  • each of the recesses 2 with the correct medication.
  • the containers 6 are displaceable at least transversely to the conveying direction.
  • the carrier 3 is at least partially displaceable transversely to the conveying direction.
  • filling aids are provided such that the medication can be poured from a container 6 into one or more recesses 2 in a targeted manner.
  • the lidding film 4 is sealed onto the carrier 3 in a sealing station 11, ideally immediately after the last filling. This hygienically seals the wells 2.
  • the lidding film 4 is unwound from a roll, for example, and sealed using ultrasound or heat. For the sake of simplicity, no sealing tool is shown here.
  • a separating device 8 is arranged after the sealing station 11, which separates the various blister packs from one another and/or separates the lidding film 4.
  • a printing station where the lidding film 4 and/or the carrier 3 can be printed with relevant information.
  • This printing station can be arranged before or after the filling station 10 or the sealing station 12.
  • FIG 2 a packaging machine 5 according to the present invention is shown.
  • the recesses 2 are not directly filled with the medicaments from the containers 6 are filled, but these are first filled into movable transport containers 9.
  • the transport containers 9 can be moved by the conveyor device 7 or they can be moved independently of one another, wherein the conveyor device 7 can provide a drive, for example a magnetic drive, or merely form a guide for the transport containers 9.
  • the transport containers 9 are filled through the containers 6, whereby this is easier due to an opening adapted to the containers 6 or at least a larger opening compared to the opening of the recesses 2 than with direct filling of the recesses 2.
  • the transport containers 9 can take on a variety of possible shapes, for example a trolley-like shape.
  • a transfer station (not shown here) is provided, in which the medicaments collected in the transport containers 9 are transferred into the respective recesses 2. It will be clear to the person skilled in the art that, for correct dosing, a transport container 9 is preferably assigned to each recess 2.
  • a sealing station 11 is provided immediately following the transfer station in order to close the recesses 2.
  • a cleaning station - also not shown - is provided in which the transport containers 9 are cleaned, preferably disinfected and particularly preferably sterilized in order to avoid possible cross-contamination during subsequent use.
  • the cleaning station is located immediately after the transfer station to avoid possible cross-contamination.
  • the number of transport containers 9 corresponds at least to the number of recesses 2 in one row, particularly preferably in two rows, in order to increase the cycle speed.
  • the number of transport containers 9 corresponds at least to the number of recesses 2 in one row, particularly preferably in two rows, in order to increase the cycle speed.
  • the number of transport containers 9 corresponds at least to the number of recesses 2 in a blister pack.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)
  • Packages (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)

Description

Die vorliegende Erfindung betrifft eine Verpackungsmaschine zur Herstellung von individuellen Blisterverpackungen zur Arzneimittelgabe.The present invention relates to a packaging machine for producing individual blister packs for drug administration.

Die EP 1 627 813 A1 , die WO 2005/108208 A1 sowie die US 7 225 597 B1 beschreiben eine Verpackungsmaschine zur Herstellung von individuellen Blisterverpackungen zur Arzneimittelausgabe, wobei die Verpackungsmaschine eine Füllstation mit einer Vielzahl von Behältern umfasst, wobei jeder Behälter zur Lagerung und Abgabe eines vorbestimmten Arzneimittels vorgesehen ist, wobei die Verpackungsmaschine eine Fördereinrichtung aufweist, wobei die Fördereinrichtung zur Förderung eines Trägers einer Blisterverpackung, vorgesehen ist.The EP 1 627 813 A1 , the WO 2005/108208 A1 as well as the US 7 225 597 B1 describe a packaging machine for producing individual blister packs for dispensing medicaments, wherein the packaging machine comprises a filling station with a plurality of containers, each container being provided for storing and dispensing a predetermined medicament, wherein the packaging machine has a conveyor device, wherein the conveyor device is provided for conveying a carrier of a blister pack.

In der DE 10 2006 007 136 A1 ist eine Vorrichtung zur Individual-Verpackung von Tabletten nach enem Multi-Dose-System beschrieben. Die US 2016/304 229 A1 zeigt eine Vorrichtung zur Herstellung von Tubenblisterverpackungen, die Abgabestationen und eine Sammelvorrichtung zur Bereitstellung von Medikamentendosen an eine Blisterverpackungsvorrichtung umfasst. Die Blisterverpackungsvorrichtung füllt die erhaltenen Medikamentendosen gruppenweise in Taschen einer Tubenblisterverpackung.In the DE 10 2006 007 136 A1 A device for the individual packaging of tablets according to a multi-dose system is described. US 2016/304 229 A1 shows a device for producing tube blister packs, which includes dispensing stations and a collection device for delivering medication doses to a blister packaging device. The blister packaging device fills the resulting medication doses in groups into pockets of a tube blister pack.

Die US 2009/255 952 A1 beschreibt eine Reinigungsstation, insbesondere eine Trennplatte, die in der Lage ist, ein in einem V-Maß verbliebenes Medikament effizient zu reinigen.The US 2009/255 952 A1 describes a cleaning station, in particular a separator plate, which is capable of efficiently cleaning a drug remaining in a V-gauge.

Die US 2007/084 150 A1 betrifft eine eine automatisierte Verpackungsmaschine für pharmazeutische Produkte, die gleichzeitig eine Vielzahl von Produktverpackungsvorlagen parallel zu den gewünschten pharmazeutischen Dosierungsanforderungen füllt.The US 2007/084 150 A1 relates to an automated packaging machine for pharmaceutical products that simultaneously processes a large number of Fills product packaging templates in parallel with the desired pharmaceutical dosage requirements.

Weiterhin wird in der US 4 655 026 A eine Pillenausgabemaschine offenbart, die selektiv eine Vielzahl unterschiedlicher Medikamente in vorgeformte Aussparungen in einem Kunststoffstreifen abgeben kann.Furthermore, the US 4 655 026 A discloses a pill dispensing machine that can selectively dispense a variety of different medications into preformed recesses in a plastic strip.

Blisterverpackungen sind bereits bekannt. Dabei wird im Wesentlichen zwischen beutelartigen Schlauchblistern und flächigen, im Wesentlichen formstabilen, Kartenblistern unterschieden. Es ist weiterhin bekannt, einen solchen Kartenblister gemäß den Verschreibungen eines Arztes patientenindividuell für mehrere Tage und ggf. mehrere Einnahmezeitpunkte mit Arzneimitteln zu befüllen und zu verschließen, so dass der Patient lediglich pünktlich zu jedem Einnahmezeitpunkt alle in einer Vertiefung befindlichen Arzneimittel zu sich nehmen muss.Blister packs are already known. A distinction is made between bag-like tubular blisters and flat, essentially rigid card blisters. It is also known to fill and seal such a card blister pack with medications for several days and, if necessary, several times per patient, according to a doctor's prescription, so that the patient only needs to take all the medications contained in one compartment at the right time.

Dabei ist jedoch nachteilig, dass keine Flexibilität möglich ist, da vorgefertigte Träger verwendet werden mit einer vorbestimmten Matrix an Vertiefungen (z.B. in Form einer 7 x 2-Matrix, also 14 Vertiefungen für 2 Einnahmezeitpunkte an 7 Tagen). Ferner erfolgt eine solche patientenindividuelle Verpackung oftmals wenigstens zum Teil manuell. Bei bekannten Verpackungsmaschinen kommt es auf Grund der Berührung von arzneimittelführenden Teilen der Verpackungsmaschine mit verschiedenen Arzneimitteln zu Kreuzkontaminationen. Außerdem weisen die bekannten Verpackungsmaschinen einen hohen Raumbedarf auf und sind kostspielig, so dass derartige Verpackungsmaschinen bisher nur in so genannten Blisterzentren zum Einsatz kommen. Es ist daher eine Aufgabe der vorliegenden Erfindung, eine Verpackungsmaschine zur Herstellung solcher Blisterverpackungen bereitzustellen, die unter Vermeidung von Kreuzkontaminationen flexibel und mit geringem Raumbedarf betreibbar ist und vorzugsweise auch vor Ort einsetzbar ist.However, it is disadvantageous that no flexibility is possible because prefabricated carriers are used with a predetermined matrix of wells (e.g. in the form of a 7 x 2 matrix, i.e. 14 wells for 2 administration times over 7 days). Furthermore, such patient-specific packaging is often carried out at least partially manually. In known packaging machines, cross-contamination occurs due to drug-carrying parts of the packaging machine coming into contact with different drugs. In addition, the known packaging machines require a lot of space and are expensive, so that such packaging machines have so far only been used in so-called blister centers. It is therefore an object of the present invention to provide a packaging machine for producing such blister packs that can be operated flexibly and with little space requirement while avoiding cross-contamination and can preferably also be used on-site.

Gelöst wird diese Aufgabe mit einer Verpackungsmaschine zur Herstellung von individuellen Blisterverpackungen zur Arzneimittelgabe, gemäß des Anspruchs 1. Im Vergleich zu bekannten Verpackungsmaschinen wird also bei der erfindungsgemäßen Verpackungsmaschine der wesentlichen Vorteile erzielt, dass die Arzneimittel möglichst unmittelbar, also direkt, in die Vertiefungen eingefüllt werden, wodurch eine Kreuzkontamination ausgeschlossen wird. In jedem Fall wird eine Überführungsvorrichtung, beispielsweise eine Rutsche oder ein Trichter, über die mehrere verschiedene Arzneimittel bewegt werden, vermieden. Eine erfindungsgemäße Verpackungsmaschine wird auch als Blisterautomat bezeichnet. Vorzugsweise umfasst die Verpackungsmaschine eine Steuereinheit, die die einzelnen Teile der Verpackungsmaschine steuert. Besonders bevorzugt ist die Steuereinheit mit wenigstens einer Detektionsvorrichtung verbunden, um die korrekte Funktionsweise zu überprüfen. Ganz besonders bevorzugt werden die Daten der Detektionsvorrichtung in eine Rückkopplungsschleife der Steuereinheit eingegeben.This object is achieved with a packaging machine for producing individual blister packs for drug administration, according to claim 1. Compared to known packaging machines, the packaging machine according to the invention achieves the significant advantage that the drugs are filled as immediately as possible, i.e. directly, into the recesses, thereby eliminating cross-contamination. In any case, a transfer device, for example a chute or a funnel, over which several different drugs are moved, is avoided. A packaging machine according to the invention is also referred to as a blister machine. Preferably, the packaging machine comprises a control unit that controls the individual parts of the packaging machine. Particularly preferably, the control unit is connected to at least one detection device in order to check correct functioning. Very particularly preferably, the data from the detection device is input into a feedback loop of the control unit.

Die diesen Gegenstand der vorliegenden Erfindung betreffenden Ausführungen gelten auch für die übrigen Gegenstände und umgekehrt.The statements relating to this subject matter of the present invention also apply to the other subjects and vice versa.

Der Fachmann erkennt, dass bei einer matrixartigen Anordnung der Vertiefungen eine Zuordnung der Arzneimittel zu den einzelnen Vertiefungen erfolgen muss. Gemäß einer bevorzugten Ausführungsform wird dies dadurch erreicht, dass der Träger und/oder die Behälter quer zur Förderrichtung beweglich angeordnet sind. Somit werden Behälter und Vertiefung relativ zueinander ausgerichtet, um eine exakte Befüllung zu ermöglichen. Dazu umfasst die Verpackungsmaschine bevorzugt eine Detektionsvorrichtung, die die Relativbewegung von Behälter und Träger überwacht.Those skilled in the art will recognize that with a matrix-like arrangement of the wells, the medicaments must be assigned to the individual wells. According to a preferred embodiment, this is achieved by arranging the carrier and/or the containers so that they can move transversely to the conveying direction. Thus, the container and well are aligned relative to each other to enable precise filling. For this purpose, the packaging machine preferably comprises a detection device that monitors the relative movement of the container and the carrier.

Gemäß der vorliegenden Erfindung ist vorgesehen, dass der Behälter dazu eingerichtet ist, eine vorbestimmte Anzahl an Arzneimitteln abzugeben. Besonders bevorzugt umfasst die Verpackungsmaschine wenigstens eine Messeinrichtung zur Messung des Füllstandes wenigstens eines der Behälter. Hierdurch ist es vorteilhafterweise möglich, automatisch genau dosierte Mengen an Arzneimitteln abzugeben und frühzeitig zu erkennen, wenn ein Behälter nachgefüllt oder ausgetauscht werden muss.According to the present invention, the container is configured to dispense a predetermined number of medicaments. Particularly preferably, the packaging machine comprises at least one measuring device for measuring the fill level of at least one of the containers. This advantageously makes it possible to automatically dispense precisely measured amounts of medicaments and to detect early on when a container needs to be refilled or replaced.

Gemäß der vorliegenden Erfindung ist vorgesehen, dass die Fördereinrichtung zur Förderung wenigstens eines beweglichen Transportbehälters vorgesehen ist, wobei die Verpackungsmaschine derart konfiguriert ist, dass in der Füllstation die Arzneimittel unmittelbar von den Behältern in den Transportbehälter einfüllbar sind, wobei die Verpackungsmaschine eine Übergabestation umfasst, wobei die Verpackungsmaschine derart konfiguriert ist, dass in der Übergabestation die Arzneimittel von dem beweglichen Transportbehälter in eine dem Transportbehälter zugeordneten Vertiefung eines Trägers einer Blisterverpackung, überführbar sind. Hierdurch ist es erfindungsgemäß vorteilhaft möglich, dass über individuell bewegliche Transportbehälter die Arzneimittel gesammelt und anschließend in die Vertiefungen überführt werden. Da die Transportbehälter beweglich sind, sind die Behälter vorzugsweise ortsfest angeordnet. Dies vereinfacht den Aufbau der erfindungsgemäßen Verpackungsmaschine und vermeidet Fehler, da die Einfüllöffnungen der Transportbehälter größer sein können als die vergleichsweise kleinen Öffnungen der Vertiefungen. Vorzugsweise umfasst die Verpackungsmaschine eine Vielzahl von beweglichen Transportbehältern, wodurch vorteilhafterweise die Taktgeschwindigkeit der Verpackungsmaschine erhöht wird. Besonders bevorzugt umfasst die Verpackungsmaschine mindestens so viele Transportbehälter wie der Träger nebeneinander angeordnete Vertiefungen aufweist, d.h. insbesondere, dass die Anzahl der Transportbehälter der Anzahl der Spalten des Trägers entspricht, besonders bevorzugt der doppelten Anzahl an Spalten. Somit ist es vorteilhaft möglich, eine Reihe von Vertiefungen gleichzeitig zu befüllen und ggf. während der Befüllung der Vertiefungen die Transportbehälter, die der nächsten Reihe zugeordnet sind, bereits von den Behältern befüllen zu lassen.According to the present invention, the conveying device is provided for conveying at least one movable transport container, wherein the packaging machine is configured such that, in the filling station, the medicaments can be filled directly from the containers into the transport container, wherein the packaging machine comprises a transfer station, wherein the packaging machine is configured such that, in the transfer station, the medicaments can be transferred from the movable transport container into a recess of a blister pack carrier assigned to the transport container. This advantageously makes it possible according to the invention for the medicaments to be collected via individually movable transport containers and then transferred into the recesses. Since the transport containers are movable, the containers are preferably arranged in a stationary manner. This simplifies the structure of the packaging machine according to the invention and avoids errors, since the filling openings of the transport containers can be larger than the comparatively small openings of the recesses. Preferably, the packaging machine comprises a plurality of movable transport containers, whereby the cycle speed of the packaging machine can advantageously be increased. is increased. Particularly preferably, the packaging machine comprises at least as many transport containers as the carrier has adjacently arranged recesses, i.e., in particular, the number of transport containers corresponds to the number of columns of the carrier, particularly preferably twice the number of columns. This advantageously makes it possible to fill a row of recesses simultaneously and, if necessary, to have the transport containers assigned to the next row filled by the containers while the recesses are being filled.

Gemäß einer bevorzugten Ausführungsform der vorliegenden Erfindung ist vorgesehen, dass die Fördereinrichtung ein Förderband, insbesondere ein Endlosförderband ist. Besonders bevorzugt umfasst die Fördereinrichtung wenigstens eine Führungsschiene und einen Antrieb, insbesondere einen Magnetantrieb. Ganz besonders bevorzugt sind die Transportbehälter im Wesentlichen autonom und unabhängig voneinander auf der Fördereinrichtung beweglich.According to a preferred embodiment of the present invention, the conveyor device is a conveyor belt, in particular an endless conveyor belt. Particularly preferably, the conveyor device comprises at least one guide rail and a drive, in particular a magnetic drive. Most preferably, the transport containers are movable essentially autonomously and independently of one another on the conveyor device.

Gemäß der vorliegenden Erfindung ist vorgesehen, dass die Verpackungsmaschine eine Siegelstation umfasst, wobei die Siegelstation unmittelbar nach der Füllstation oder der Übergabestation angeordnet ist, wobei die Siegelstation zur Aufsiegelung einer Deckelfolie auf den Träger eingerichtet ist. Hierdurch ist es in besonders vorteilhafter Weise möglich, dass das Risiko einer Kreuzkontamination weiter verringert wird und die Hygiene der Maschine verbessert wird. Besonders bevorzugt ist die Siegelstation derart angeordnet, dass die befüllten Vertiefungen sofort durch die Deckelfolie verschlossen werden.According to the present invention, the packaging machine comprises a sealing station, wherein the sealing station is arranged immediately after the filling station or the transfer station, wherein the sealing station is configured to seal a lidding film onto the carrier. This makes it particularly advantageous to further reduce the risk of cross-contamination and improve the hygiene of the machine. Particularly preferably, the sealing station is arranged such that the filled recesses are immediately sealed by the lidding film.

Gemäß einer bevorzugten Ausführungsform der vorliegenden Erfindung ist vorgesehen, dass die Verpackungsmaschine eine Trennvorrichtung zum Abtrennen einer vorbestimmten Länge der Blisterverpackung und/oder des Trägers umfasst, wobei die Trennvorrichtung vor oder nach der Füllstation, der Übergabestation und/oder der Siegelstation angeordnet ist. Hierdurch ist es in vorteilhafter Weise möglich, die Flexibilität hinsichtlich verschiedener Blisterverpackungsgrößen weiter zu erhöhen.According to a preferred embodiment of the present invention, the packaging machine comprises a separating device for separating a predetermined length of the blister pack and/or the carrier, wherein the separating device is arranged before or after the filling station, the transfer station and/or the sealing station. It is advantageously possible to further increase flexibility with regard to different blister pack sizes.

Gemäß der vorliegenden Erfindung ist vorgesehen, dass die Verpackungsmaschine eine Reinigungsstation umfasst, wobei die Reinigungsstation unmittelbar nach der Übergabestation angeordnet ist, wobei die Reinigungsstation zur automatischen Reinigung des wenigstens einen Transportbehälters und der Behälter eingerichtet ist. Besonders bevorzugt ist die Verpackungsmaschine derart konfiguriert, dass jeder Transportbehälter unmittelbar nach der Überführung der Arzneimittel in die Vertiefung gereinigt, insbesondere sterilisiert und/oder desinfiziert, wird. Hierdurch wir in besonders vorteilhafter Weise die Gefahr einer Kreuzkontamination weiter verringert. Durch die gründliche Reinigung ist es möglich, die Transportbehälter mehrfach zu verwenden, ohne dass die Gefahr einer Kontamination besteht.According to the present invention, the packaging machine comprises a cleaning station, wherein the cleaning station is arranged immediately after the transfer station, wherein the cleaning station is configured for the automatic cleaning of the at least one transport container and the containers. Particularly preferably, the packaging machine is configured such that each transport container is cleaned, in particular sterilized and/or disinfected, immediately after the medicaments have been transferred into the recess. This further reduces the risk of cross-contamination in a particularly advantageous manner. The thorough cleaning makes it possible to use the transport containers multiple times without the risk of contamination.

Gemäß einer bevorzugten Ausführungsform der vorliegenden Erfindung ist vorgesehen, dass die Verpackungsmaschine eine Druckstation umfasst, wobei die Druckstation dazu eingerichtet ist, die Deckelfolie und/oder den Träger mit Informationen zu bedrucken. Besonders bevorzugt ist die Druckstation vor oder nach der Füllstation oder der Siegelstation angeordnet.According to a preferred embodiment of the present invention, the packaging machine comprises a printing station, wherein the printing station is configured to print information onto the lidding film and/or the carrier. The printing station is particularly preferably arranged before or after the filling station or the sealing station.

Gemäß einer bevorzugten Ausführungsform der vorliegenden Erfindung ist vorgesehen, dass die Behälter, insbesondere automatisch, austauschbar und/oder befüllbar vorgesehen sind. Hierdurch ist es vorteilhafterweise möglich, den Raumbedarf und die Flexibilität der Verpackungsmaschine zu erhöhen. So können beispielsweise selten benötigte Arzneimittel nur im Bedarfsfall in die Verpackungsmaschine eingesetzt werden. Ferner wird eine einfache und hygienische Nachfüllung der Behälter ermöglicht, insbesondere ohne dass ein Stillstand der Verpackungsmaschine notwendig ist, da der Behälter gegen einen weiteren Behälter ausgetauscht werden kann.According to a preferred embodiment of the present invention, the containers are designed to be exchangeable and/or refillable, particularly automatically. This advantageously makes it possible to increase the space requirements and flexibility of the packaging machine. For example, rarely used medications can be inserted into the packaging machine only when needed. Furthermore, simple and hygienic refilling of the containers is possible, particularly without requiring a downtime of the packaging machine, since the container can be exchanged for another container.

Im folgendem wird die Erfindung anhand der Figuren 1 und 2 erläutert. Diese Erläuterungen sind lediglich beispielhaft und schränken den allgemeinen erfindungsgemäßen Gedanken nicht ein. Die Erläuterungen gelten für die die erfindungsgemäße Verpackungsmaschine. Dabei werden gleiche Teile mit den gleichen Bezugszeichen bezeichnet.

Figur 1
zeigt eine Verpackungsmaschine.
Figur 2
zeigt eine Verpackungsmaschine gemäß einer weiteren beispielhaften Ausführungsform der vorliegenden Erfindung.
In the following, the invention is described with reference to Figures 1 and 2 These explanations are merely exemplary and do not limit the general concept of the invention. The explanations apply to the packaging machine according to the invention. Identical parts are designated by the same reference numerals.
Figure 1
shows a packaging machine.
Figure 2
shows a packaging machine according to another exemplary embodiment of the present invention.

In Figur 1 ist eine Verpackungsmaschine dargestellt, die nicht der Erfindung entspricht. Dabei ist vorliegend lediglich ein Ausschnitt der Verpackungsmaschine 5 schematisch dargestellt. Von links kommend transportiert eine Fördereinrichtung 7, beispielsweise ein Endlosförderband, einen (Endlos-)Träger 3 mit matrixartig angeordneten Vertiefungen 2 entlang einer, hier linearen, Förderrichtung.In Figure 1 A packaging machine is shown that does not correspond to the invention. In this case, only a section of the packaging machine 5 is shown schematically. Coming from the left, a conveyor device 7, for example an endless conveyor belt, transports an (endless) carrier 3 with matrix-like recesses 2 along a conveying direction, here linear.

Die Verpackungsmaschine 5 umfasst eine hier nicht dargestellte Steuereinheit, die den Betrieb der Verpackungsmaschine 5 überwacht und steuert.The packaging machine 5 comprises a control unit, not shown here, which monitors and controls the operation of the packaging machine 5.

In einer Füllstation 10 ist eine Vielzahl von Behältern 6 angeordnet, von denen jeder ein vorbestimmtes Arzneimittel enthält. Ist ein Behälter 6 exakt oberhalb einer Vertiefung 2 angeordnet, in die das Arzneimittel, welches in dem Behälter 6 enthalten ist, eingefüllt werden soll gemäß der patientenindividuellen Vorgabe, was die Steuereinheit beispielsweise über eine entsprechende Detektionsvorrichtung erfassen kann, wird eine vorbestimmte Menge des Arzneimittels in die Vertiefung 2 eingefüllt. Dazu können Hilfsmittel wie Trichter oder sonstige Einfüllhilfen zur Anwendung kommen. Wichtig ist dabei lediglich, dass diese Einfüllhilfen nicht für Behälter 6 mit unterschiedlichen Arzneimitteln verwendet werden, um eine Kreuzkontamination zu vermeiden.A filling station 10 contains a plurality of containers 6, each of which contains a predetermined medication. If a container 6 is positioned exactly above a recess 2 into which the medication contained in the container 6 is to be filled according to the patient's individual specifications, which the control unit can detect, for example, via a corresponding detection device, a predetermined amount of the medication is filled into the recess 2. For this purpose, aids such as funnels or other filling aids can be used. It is important that these filling aids are not designed for containers 6. with different medicines to avoid cross-contamination.

Um jede der Vertiefungen 2 mit den korrekten Arzneimitteln zu befüllen sind verschiedene Alternativen denkbar. Gemäß einer Ausführungsform sind die Behälter 6 zumindest quer zur Förderrichtung verschiebbar. Gemäßer einer zusätzlichen oder alternativen Ausführungsform ist der Träger 3 wenigstens teilweise quer zur Förderrichtung verschiebbar. Alternativ oder zusätzlich sind Einfüllhilfen derart vorgesehen, dass das Arzneimittel aus einem Behälter 6 gezielt in eine oder mehrere Vertiefungen 2 einfüllbar ist.Various alternatives are conceivable for filling each of the recesses 2 with the correct medication. According to one embodiment, the containers 6 are displaceable at least transversely to the conveying direction. According to an additional or alternative embodiment, the carrier 3 is at least partially displaceable transversely to the conveying direction. Alternatively or additionally, filling aids are provided such that the medication can be poured from a container 6 into one or more recesses 2 in a targeted manner.

Nachdem alle Vertiefungen 2 gemäß den patientenindividuellen Vorgaben mit Arzneimitteln befüllt sind, wird, möglichst unmittelbar nach der letzten Befüllung, die Deckelfolie 4 auf den Träger 3 in einer Siegelstation 11 aufgesiegelt. Dadurch werden die Vertiefungen 2 hygienisch verschlossen. Die Deckelfolie 4 wird beispielsweise von einer Rolle abgewickelt und durch Ultraschall oder Hitze aufgesiegelt. Der Einfachheit halber ist vorliegend kein Siegelwerkzeug dargestellt.After all wells 2 have been filled with medication according to the patient's individual specifications, the lidding film 4 is sealed onto the carrier 3 in a sealing station 11, ideally immediately after the last filling. This hygienically seals the wells 2. The lidding film 4 is unwound from a roll, for example, and sealed using ultrasound or heat. For the sake of simplicity, no sealing tool is shown here.

Vorliegend ist nach der Siegelstation 11 noch eine Trennvorrichtung 8 angeordnet, die die verschiedenen Blisterverpackungen voneinander trennt und/oder die Deckelfolie 4 abtrennt.In the present case, a separating device 8 is arranged after the sealing station 11, which separates the various blister packs from one another and/or separates the lidding film 4.

Nicht dargestellt ist ferner eine Bedruckungsstation, in der die Deckelfolie 4 und/oder der Träger 3 bedruckt werden können mit relevanten Informationen. Diese Bedruckungsstation kann dabei vor oder nach der Füllstation 10 bzw. der Siegelstation 12 angeordnet sein.Also not shown is a printing station where the lidding film 4 and/or the carrier 3 can be printed with relevant information. This printing station can be arranged before or after the filling station 10 or the sealing station 12.

In Figur 2 ist eine Verpackungsmaschine 5 gemäß der vorliegenden Erfindung dargestellt. Im Unterschied zu der im Zusammenhang mit Figur 1 beschriebenen Ausführungsform werden hier die Vertiefungen 2 nicht direkt mit den Arzneimitteln aus den Behältern 6 befüllt, sondern diese werden zunächst in bewegliche Transportbehälter 9 eingefüllt. Die Transportbehälter 9 können durch die Fördereinrichtung 7 bewegt werden oder sie können unabhängig voneinander selbsttätig bewegbar sein, wobei die Fördereinrichtung 7 einen Antrieb bereitstellen kann, beispielsweise einen magnetischen Antrieb, oder lediglich eine Führung für die Transportbehälter 9 bildet.In Figure 2 a packaging machine 5 according to the present invention is shown. In contrast to the packaging machine 5 described in connection with Figure 1 In the embodiment described here, the recesses 2 are not directly filled with the medicaments from the containers 6 are filled, but these are first filled into movable transport containers 9. The transport containers 9 can be moved by the conveyor device 7 or they can be moved independently of one another, wherein the conveyor device 7 can provide a drive, for example a magnetic drive, or merely form a guide for the transport containers 9.

Die Transportbehälter 9 werden durch die Behälter 6 befüllt, wobei dies auf Grund einer an die Behälter 6 angepassten Öffnung bzw. wenigstens einer größeren Öffnung im Vergleich zu der Öffnung der Vertiefungen 2 einfacher möglich ist als bei der Direktbefüllung der Vertiefungen 2.The transport containers 9 are filled through the containers 6, whereby this is easier due to an opening adapted to the containers 6 or at least a larger opening compared to the opening of the recesses 2 than with direct filling of the recesses 2.

Die Transportbehälter 9 können dabei eine Vielzahl von möglichen Formen annehmen, beispielsweise eine lorenähnliche Form.The transport containers 9 can take on a variety of possible shapes, for example a trolley-like shape.

Der Füllstation 10 nachgeordnet ist eine - hier nicht dargestellte - Übergabestation vorgesehen, in der die in den Transportbehältern 9 gesammelten Arzneimittel in die jeweiligen Vertiefungen 2 übergeben werden. Dem Fachmann ist dabei klar, dass zur korrekten Dosierung vorzugsweise jeder Vertiefung 2 ein Transportbehälter 9 zugeordnet ist.Downstream of the filling station 10, a transfer station (not shown here) is provided, in which the medicaments collected in the transport containers 9 are transferred into the respective recesses 2. It will be clear to the person skilled in the art that, for correct dosing, a transport container 9 is preferably assigned to each recess 2.

Wie in der zuvor beschriebenen Ausführungsform ist unmittelbar auf die Übergabestation folgend eine Siegelstation 11 vorgesehen, um die Vertiefungen 2 zu verschließen.As in the previously described embodiment, a sealing station 11 is provided immediately following the transfer station in order to close the recesses 2.

Weiterhin ist erfindungsgemäss eine - ebenfalls nicht dargestellte - Reinigungsstation vorgesehen, in der die Transportbehälter 9 gereinigt, vorzugsweise desinfiziert und besonders bevorzugt sterilisiert werden, um bei einem darauf folgenden Einsatz eine mögliche Kreuzkontamination zu vermeiden.Furthermore, according to the invention, a cleaning station - also not shown - is provided in which the transport containers 9 are cleaned, preferably disinfected and particularly preferably sterilized in order to avoid possible cross-contamination during subsequent use.

Die Reinigungsstation ist unmittelbar nach der Übergabestation angeordnet, um eine mögliche Kreuzkontamination zu vermeiden.The cleaning station is located immediately after the transfer station to avoid possible cross-contamination.

Gemäß einer bevorzugten Ausführungsform ist vorgesehen, dass die Anzahl der Transportbehälter 9 wenigstens der Anzahl an Vertiefungen 2 in einer Zeile, besonders bevorzugt in zwei Zeilen, entspricht, um die Taktgeschwindigkeit zu erhöhen. So sind beispielsweise bei einer 7x3-matrixartigen Blisterverpackung wenigstens sieben, besser 14 und ganz besonders bevorzugt 21 Transportbehälter 9 vorgesehen. Insbesondere wird eine hohe Prozessgeschwindigkeit der Verpackungsmaschine 5 erreicht, wenn die Anzahl an Transportbehältern 9 wenigstens der Anzahl der Vertiefungen 2 einer Blisterverpackung entspricht.According to a preferred embodiment, the number of transport containers 9 corresponds at least to the number of recesses 2 in one row, particularly preferably in two rows, in order to increase the cycle speed. For example, in a 7x3 matrix-like blister pack, at least seven, better 14, and most preferably 21 transport containers 9 are provided. In particular, a high process speed of the packaging machine 5 is achieved when the number of transport containers 9 corresponds at least to the number of recesses 2 in a blister pack.

BezugszeichenlisteList of reference symbols

2 -2 -
VertiefungDeepening
3 -3 -
Trägercarrier
4 -4 -
DeckelfolieLid film
5 -5 -
Verpackungsmaschinepackaging machine
6 -6 -
Behältercontainer
7 -7 -
Fördereinrichtungconveyor system
8 -8 -
TrennvorrichtungSeparating device
9 -9 -
beweglicher Transportbehältermovable transport container
10 -10 -
Füllstationfilling station
11 -11 -
SiegelstationSealing station

Claims (5)

  1. Packaging machine (5) for producing individual blister packs for dispensing medicaments, wherein the packaging machine (5) comprises a filling station (10) with a plurality of containers (6), wherein each container (6) is provided for storing and dispensing a predetermined medicament, wherein the packaging machine (5) has a conveying device (7), characterised in that the conveying device (7) is provided for conveying at least one movable transport container (9), wherein the packaging machine (5) is configured in such a way that in the filling station (10) the medicaments can be filled directly from the containers (9) into the transport container (9), wherein the packaging machine (5) comprises a transfer station, wherein the packaging machine (5) is configured in such a way that in the transfer station the medicaments can be transferred from the movable transport container (9) into a recess (2) of a carrier (3) of a blister pack associated with the transport container (9), wherein the packaging machine (5) comprises a sealing station (11), wherein the sealing station (11) is arranged immediately after the transfer station, wherein the sealing station (11) is set up for sealing a lidding film (4) onto the carrier (3), wherein the packaging machine (5) comprises a cleaning station, wherein the cleaning station is arranged immediately after the transfer station, wherein the cleaning station is set up for automatic cleaning of the at least one transport container (9).
  2. Packaging machine (5) according to claim 1, characterised in that the packaging machine (5) comprises a separating device (8) for separating a predetermined length of the blister pack and/or the carrier (3), the separating device (8) being arranged before or after the filling station (10), the transfer station and/or the sealing station (11).
  3. Packaging machine (5) according to claim 2, characterised in that the packaging machine (5) comprises a cleaning station, the cleaning station being arranged, in particular directly, after the transfer station, the cleaning station being set up for cleaning, in particular automatically, the at least one transport container (9) and/or the containers (6).
  4. Packaging machine according to one of the preceding claims 1 to 3, characterised in that the carriers (3) are provided by different machines and preferably comprise a tablet, a powder, an ointment and/or a liquid.
  5. Packaging machine (5) according to one of claims 1 to 4, characterised in that the containers (6) are provided to be exchangeable and/or fillable, in particular automatically.
EP18766244.0A 2017-09-08 2018-09-07 Packaging machine for producing an individual blister package Active EP3704033B1 (en)

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DE102017215917.0A DE102017215917A1 (en) 2017-09-08 2017-09-08 Individual blister packaging, packaging machine and method of making an individual blister package
PCT/EP2018/074178 WO2019048625A2 (en) 2017-09-08 2018-09-07 INDIVIDUAL BLISTER PACKAGING, PACKAGING MACHINE AND METHOD FOR PRODUCING AN INDIVIDUAL BLISTER PACKAGING

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EP3704033A2 (en) 2020-09-09
WO2019048625A3 (en) 2019-04-25
WO2019048625A2 (en) 2019-03-14
DE102017215917A1 (en) 2019-03-14
US20210147133A1 (en) 2021-05-20
EP3704033C0 (en) 2025-06-25

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