[go: up one dir, main page]

EP3495009B2 - Injecteur à jet de seringue préremplie - Google Patents

Injecteur à jet de seringue préremplie Download PDF

Info

Publication number
EP3495009B2
EP3495009B2 EP19150366.3A EP19150366A EP3495009B2 EP 3495009 B2 EP3495009 B2 EP 3495009B2 EP 19150366 A EP19150366 A EP 19150366A EP 3495009 B2 EP3495009 B2 EP 3495009B2
Authority
EP
European Patent Office
Prior art keywords
medicament
syringe
needle
injection
guard
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP19150366.3A
Other languages
German (de)
English (en)
Other versions
EP3495009B1 (fr
EP3495009A1 (fr
Inventor
Jr. Paul R. Lesch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antares Pharma Inc
Original Assignee
Antares Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36218390&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3495009(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Antares Pharma Inc filed Critical Antares Pharma Inc
Publication of EP3495009A1 publication Critical patent/EP3495009A1/fr
Publication of EP3495009B1 publication Critical patent/EP3495009B1/fr
Application granted granted Critical
Publication of EP3495009B2 publication Critical patent/EP3495009B2/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
    • A61M5/484—Regulating injection pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion

Definitions

  • the present invention relates to an injector, and more particularly to a needle-assisted injector that uses a low injection pressure.
  • needle-free injectors are described in U.S. Patent Nos. 5,599,302 ; 5,062,830 ; and 4,790,824 .
  • These traditional injectors administer medication as a fine, high velocity jet delivered under sufficient pressure to enable the jet to pass through the skin.
  • the pressure used to deliver the medication is typically greater than approximately 275.8 bar (4000 p.s.i.) inside the compartment that contains the medicament in the injector.
  • Benefits derived from such pressures, in addition to allowing injection without needles include the speed of the injection, the dispersion of the injected medicament in the tissue and injection delivery without impact from the resistance by the tissue where the medicament is delivered.
  • Self-injectors or autoinjectors like the ones disclosed in U.S. Patent Nos. 4,553,962 and 4,378,015 and PCT Publications WO 95/29720 and WO 97/14455 are constructed to inject medicament at a rate and in a manner similar to hand-operated hypodermic syringes.
  • the self-injectors or autoinjectors have needles that are extended at the time of activation to penetrate the user's skin to deliver medicament through movement of the drug container and related needle.
  • the mechanism that provides the force to deliver the medicament in self-injectors and autoinjectors is also used to extend the needle and the drug container to cause the insertion of the needle through the user's skin.
  • the pressures applied in the medicament-containing compartments of this type of device are very low, reaching a maximum of around 4.1 bar (60 p.s.i.) and take around 6 seconds to inject 1 mL.
  • These devices do not deliver of the medicament using jet injection, so the medicament is delivered in a bolus at the tip the needle, which typically penetrates the patient by typically at least about 12 mm.
  • these low pressures and injection rates are used with shorter needles, especially those that penetrate the patient around 5 mm or less, there is a high incidence of leakback of the injected medicament around the needle or through the hole in the tissue created.
  • Prefilled syringes such as those presently sold by Becton and Dickinson as the BD Hypak TM are intended for slow speed, manual or autoinjector injections. While prefilled syringes are readily available, the manufacturing techniques employed result in dimensional tolerances that traditionally have been considered too loose for jet injectors since the syringe would need to withstand a very sharp application of an elevated pressures sufficient to jet inject the medicament. Additionally, prefilled syringes include portions shaped to hold the needle and flanges for grasping for injection by hand that result in features that can be susceptible to breakage.
  • An injector is needed that can reliable inject medicament to a desired site without a substantial risk of the medicament leaking back out from the patient's skin, at a fast speed substantially without regard to tissue resistance, and preferably being able to use a standard prefilled syringe.
  • WO 00/24441 A discloses an auto injector with a container carrier designed to accommodate a container with different lengths and widths.
  • WO 03/070296 A discloses an injector with a substance container defining a substance chamber configured for containing a substance to be injected, and an injection conduit configured for injecting the substance into a patient.
  • US 2004/220524 A1 discloses a needle assisted jet injector and method for jet injecting medicament are disclosed.
  • US 6 056 716 A discloses a jet injector system for injecting fluid into a body.
  • the invention is related to an injector which employs a prefilled syringe that is prefilled with a medicament prior to the assembly of the device.
  • the syringe has a container portion that defines a fluid chamber containing a medicament.
  • An injection-assisting needle is disposed at the distal end of the chamber and has an injecting tip configured for piercing an insertion location.
  • the needle defines a fluid pathway in fluid communication with the chamber for injecting the fluid from the chamber into an injection site.
  • the syringe also has a plunger that is movable within the fluid chamber.
  • a housing houses the prefilled syringe and is configured for allowing insertion of the needle at the injection location to an insertion point that is at a penetration depth below the surface at the insertion location.
  • a syringe support supportively mounts the prefilled syringe to the housing, and an energy source is configured to bias the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber of between about 5.5 and 68.9 bar (80 and 1000 p.s.i.) This pressure injects the medicament from the fluid chamber through the needle to an injection site that is remote from the injecting tip.
  • the penetration depth and injecting pressure are sufficient to permit better medicament distribution than in autoinjectors and to substantially prevent backflow of the injected medicament.
  • the injection rate is substantially unaffected by tissue resistance.
  • the energy source which preferably comprises a spring, is preferably configured to produce the injecting pressure that remains below about 34.5 bar (500 p.s.i.) and above about 6.2 bar (90 p.s.i.) during the injection of the medicament. More preferably, the injecting pressure remains at least at about 6.9 bar (100 p.s.i.) and up to about 24.1 bar (350 p.s.i.) during the injection of the medicament.
  • the preferred housing is configured for allowing insertion of a portion of the needle to the penetration depth of between about 0.5 mm and 5 mm below the surface at the insertion location.
  • the penetration depth is between about 1 mm and 4 mm, and more preferably is less than about 3 mm.
  • the injecting pressure and penetration depth in some embodiments preferably are sufficient such that the injection site is subcutaneous, although other types of injection can be achieved in other embodiments.
  • the exposed portion of the needle can be around 10 mm to 15 mm, for example, with a preferred embodiment being around 13 mm.
  • the syringe has a distal portion of the prefilled syringe, in which the injection-assisting needle is located, and a proximal portion opposite the distal portion.
  • the syringe support can be configured to axial support the proximal portion of the pre-filled syringe during the jet injection of the medicament, such that the distal portion of the prefilled syringe is substantially unsupported in an axial direction.
  • the prefilled syringe is preferably made of blown glass, which can be formed on the injection-assisting needle, but is usually formed and adhered to the needle. Additionally, the preferred volume of the fluid chamber is about between 0.02 mL and 4 mL of the medicament.
  • the housing in accordance with the present invention comprises a retractable guard that is movable between a protecting position and an injecting position. In the protecting position, the needle is disposed within the guard, but in the injecting position, the tip of the needle is exposed for insertion to the insertion point.
  • a trigger mechanism can be operably associated with the energy source for activating the energy source to jet inject the medicament. The trigger mechanism is preferably configured for activating the energy source after the retractable guard is retracted from the protecting position, and most preferably once it is retracted to the injecting position.
  • a syringe cushion is provided in association with the syringe support and the prefilled syringe to compensate for shape irregularities of the pre-filled syringe and/or to cushion and provide shock absorption to the syringe during the device firing.
  • a ram that is biased by the spring against the plunger to produce the injecting pressure is provided with a bell portion on which the spring of the energy source is seated. The bell portion defines a hollow interior configured for receiving the prefilled syringe when the device is fired, such that the spring surrounds the prefilled syringe.
  • the present invention thus provides an injector that offers better medicament distribution. Also, the inventive injector can benefit from simplified manufacturing by using a prefilled syringe.
  • a preferred embodiment of an injector 10 has a housing 12 configured for allowing a user to handle the injector 10.
  • the housing 12 includes an outer housing 14 that substantially houses most of the components shown in Fig. 2 .
  • a syringe support member 16 is housed within and mounted with the housing 12.
  • the syringe support member 16 is configured to hold and position a prefilled syringe 18, which is shown in Fig. 3 .
  • the syringe support member 16 is substantially fixed to the housing 12, such as by snaps, an adhesive, a weld, or another known attachment.
  • the prefilled syringe 18 has a container portion 20 that defines in its interior a fluid chamber 22, which is prefilled with medicament to be injected.
  • an injection-assisting needle 24 At the distal end of the prefilled syringe 18 is an injection-assisting needle 24.
  • Needle 24 has an injecting tip 26 configured as known in the art to penetrate the tissue of a patient, preferably the skin.
  • a needle bore extends through the needle 24, as known of the art. The bore is in fluid communication with the medicament in the fluid chamber 22 and is open at the needle tip 26 to inject the medicament.
  • a plunger 28 that seals the medicament in the fluid chamber 22.
  • a syringe wall 30 preferably comprises a tubular portion, preferably closed at a distal end and open at a proximal end, to define the fluid chamber 22. Plunger 28 is slideably received in the tubular portion.
  • the prefilled syringe 20 is configured such that when the plunger 28 is displaced in a distal direction, the volume of the fluid chamber 22 is decreased, forcing the medicament out therefrom and through the bore of needle 24.
  • a syringe flange 34 extends radially, preferably from the proximal end of the syringe wall 30.
  • the syringe 18 has a syringe body 36 that includes the flange 34 wall 30 and hub portion 32 is of unitary construction.
  • a preferred material for the syringe body 36 is glass, but other materials can be used in other embodiments.
  • a suitable prefilled syringe is the BD Hypak TM , which is available in various sizes and volumes and is sold prefilled with medicament. The glass of the syringe body is adhered to the needle. Typical medicaments and medicament categories include epinephrine, atropine, sumatriptan, antibiotics, antidepressants, and anticoagulants. Using a prefilled syringe facilitates handling of the medicament when the injector is assembled, and there is an extensive body of knowledge of how the medicaments keep and behave in a prefilled syringe.
  • a syringe cushion 38 which is shown in detail in Fig. 4 , is preferably made of an elastomeric material or other resilient material.
  • a flange 40 of the syringe cushion 38 extends radially and is disposed and serves as an interface between the distal side of the syringe support member 16 and the syringe flange 34. Elevated portions, such as nubs 42 extend proximately from the cushion flange 40 and are configured and dimensioned to abut the syringe flange 34.
  • Prefilled syringes that are manufactured by a blown glass process can have significant dimensional tolerances and unevenness, particularly in the glass body 36.
  • the cushion 38 serves to accommodate the shape irregularities and to properly position and locate the prefilled syringe 18 within the syringe support 16.
  • the axial thickness of glass blown syringe flanges on a 1 mL prefilled syringe is within about ⁇ 0.5 mm.
  • the thickness of the syringe flange 34 is 2 mm +0.5 mm or -0.4 mm, and in a 1 mL long configuration BD Hypak TM syringe, the flange axial thickness is about 1.65 mm ⁇ 0.25 mm.
  • Other dimensional variations that occur in typical glass prefilled syringes are in the internal and external diameters of the tubular wall 30. These variations can be accommodated by the resilient sleeve portion 44 of the syringe cushion 38, which extends axially around the interior of the syringe support 16.
  • the syringe cushion 38 is preferably received in the interior of the syringe support member and receives the syringe body 36, preferably fitting snugly therein.
  • the sleeve portion 44 preferably has radially inwardly extending protrusions 46 with a surface area and configuration selected to allow the insertion of the prefilled syringe 18 therein during assembly, but providing sufficient friction to maintain the syringe 18 in place and to provide cushioning and shock absorption during the firing of the injector.
  • Outward protrusions 48 are also provided on the sleeve portion 44, which can be received in corresponding recesses of the syringe support 16 to prevent axial rotation therebetween.
  • Recessed areas 50 can be provided on the interior and exterior of the syringe cushion 38 opposite corresponding protrusions 48 on the opposite radial side of the sleeve portion 44 if an increased wall thickness of the sleeve portion 44 is not desired.
  • one or both of the flange 40 and sleeve 44 of the syringe cushion 38 are substantially smooth, substantially without any protrusions.
  • the material and configuration of the syringe cushion 38 is also sufficient to entirely support the prefilled syringe 20 to withstand a firing force applied axially in a distal direction on the plunger 28.
  • the entire support for the prefilled 20 can be provided on the syringe flange 34, while the distal end of the syringe 18 may itself be substantially unsupported in an axial direction. This can help withstand the shock on the glass body 36 of the prefilled syringe 20 produced by the elevated pressures within the fluid chamber 22.
  • the syringe support 16 preferably has a narrowed bore portion 51 that is preferably configured to abut the outside of the syringe wall 30. This is especially beneficial when the needle is inserted into the patient's skin.
  • the narrowed bore portion can be made of a resilient material, such as an elastomer, or it can be made unitarily with the rest of the syringe support 16, preferably of a plastic material.
  • a trigger mechanism 52 is preferably also housed within housing 12.
  • the trigger mechanism 52 includes an inner housing 54 that can be attached to the outer housing 14, such as by snaps, an adhesive, a weld, or other known attachment.
  • Trigger protrusions 56 extend inwardly from the proximal end of the inner housing 54 and are resiliently biased outwardly.
  • Trigger protrusions 56 are received in a recess 58 of ram 60 in blocking association therewith to prevent distal movement of the ram 60 prior to the firing of the device.
  • the ram 60 is urged towards the distal end of the injector 10 by an energy source, which preferably is a compression spring 52, although other suitable energy sources can alternative be used such as elastomer or compressed-gas springs.
  • a preferred type of compression spring is a coil spring.
  • a trigger member of the trigger mechanism 52 such as a latch housing 64, is provided exterior to the inner housing to retain the trigger protrusions 56 in the blocking association in the recess 58 to prevent premature firing of the injector 10.
  • the latch housing 64 is slideable inside the outer housing 14 with respect to the inner housing 54, preferably in an axial direction, and the latch housing 64 preferably surrounds the inner housing 54.
  • the housing 12 has a needle guard 66 that is moveable with respect to the outer housing 14.
  • the needle guard 66 is shown in Figs.1 and 2 in a protecting position, in which the needle 24 is disposed within the guard 66.
  • the needle guard 66 is retractable, preferably into the outer housing 14, in a proximal direction to an injecting position, in which the needle tip 26 and an end portion of the needle 24 is exposed as shown in Fig. 5 for insertion into a patient.
  • the proximal movement of the guard is prevented substantially at the injecting position.
  • the needle guard 66 is associated with the latch housing 64 such that when the guard 66 is displaced distally it slides the latch housing 64 also in a distal direction to release the trigger protrusions 56 from the recess 58.
  • the latch housing 64 has a latching portion 68 that abuts the inner housing 54 in an association to bias and maintain the trigger protrusions 58 positioned in the blocking association with the ram 60 prior to the firing of the device 10.
  • Latch housing 64 preferably defines trigger openings 70 adjacent to latching portions 68, which is configured to receive a portion of the inner housing 54, such as the surface disposed radially outwardly from the trigger protrusions 56.
  • the guard 66 is preferably resiliently biased distally towards the protecting position by compression coil spring 72. Also, the needle guard 66 has an axial opening 74 to allow the needle 24 pass there through, and which may be sized according to the type of injector desired.
  • the construction of the present embodiment allows a user to push the distal end of the injector 10 against the patient's skin, pushing the needle 24 into the skin at an insertion location, substantially at the same speed as the injector is pushed. Once the needle 24 is fully inserted to an insertion point at a penetration depth, the trigger mechanism 56 fires the jet injection to an injection site.
  • the prefilled syringe 18 and its needle 24 are not shuttled forward automatically into the patient's skin, such as by the firing energy source during the injection firing.
  • the user preferably gently pushes the entire device forward to insert the needle, preferably retracting a guard against the skin in the process.
  • the prefilled syringe 18 remains stationary within the outer housing 14, and is fixed thereto.
  • the present invention provides for a gentler treatment of the syringe during injection that enables the use of a sufficiently powerful spring 62 or other energy source to produce an injection without the risk of damaging the relatively fragile and complex shapes of the prefilled syringe, also allowing, for example, the injection of high viscosity solutions, where the risk of breaking a syringe, such as at the flange, is elevated in prior art injectors that shuttle the syringe forward in the housing and into the patient. Residual stresses are also often present in the glass bodies of prefilled syringes, and this configuration reduces the additional stresses imposed thereon during use, further protecting the syringe. Also, misalignments in the prefilled syringe are also rendered operationally less significant due to the gentle insertion of the needle that is possible with this configuration.
  • the injecting position of the guard 66 is such that a predetermined length of the end of needle 24 is exposed from the guard 66.
  • the skin of the patient maybe allowed to extend into the opening 74 when the device 10 is pressed there against, and a needle that does not protrude beyond the distal end of the guard 66 can be used while still penetrating the skin to a certain depth.
  • the distance 76 by which the needle tip 26 extends past the distal end of the guard 66 will be fairly close to the depth of the insertion of the needle.
  • the guard 66 is configured to allow insertion of the needle to a penetration depth in the skin that is up to about 5 mm below the skin surface. More preferably, the penetration depth is less than about 4 mm, and in one embodiment is less than about 3 mm. Preferably, the insertion depth is at least about 0.5 mm and more preferably at least about 1 mm. In another embodiment, the distance 76 by which the needle extends past the guard 66 or the distal surface of the guard 66 that contacts the skin is up to about 5 mm, more preferably up to about 4 mm, and in one embodiment up to about 3 mm.
  • extension distance 76 is at least about 0.5 mm, more preferably at least about 1 mm, and most preferably at least about 2 mm.
  • tip 26 extends by a distance 76 of around 2.5 mm beyond the portion of the guard 66 that contacts the skin in the injecting position.
  • the injector is configured to allow the needle to extend beyond the distal surface of the guard, by a maximum distance of about 15 mm. In one embodiment, this distance is about between 10 mm and 14 mm. In an embodiment for jet injection of epinephrine for instance, a preferred penetration depth or distance beyond the guard is between about 12 mm and 13.5 mm, and most preferably around 12.7 mm. Jet injection with this length needle improves the distribution of the medicament in the patient tissue compared to non-jet injection.
  • the needle guard is preferably configured for retracting from a protecting position, preferably covering the entire needle, to an injecting position, in which the desired length of the end of the needle is exposed.
  • the spring 62 and the prefilled syringe 18 are configured to jet inject the medicament.
  • the spring 62 applies a force on the plunger 28 that is sufficient to elevate the pressure within the fluid chamber 22 to a level high enough to eject the medicament from the needle 24 as a jet.
  • Jet injection is to be understood as an injection with sufficient velocity and force to drive the medicament to locations remote from the needle tip 26.
  • manual and autoinjector-type injections in which the injection pressures are very low, the medicament exits the needle tip inside the patient and is typically deposited locally around the needle in a bolus.
  • the medicament is jet injected distally or in other directions, such as generally radially by the elevated pressure jet, which beneficially improves the distribution of the medicament after the injection and keeps a large bolus from forming that can detrimentally force the medicament to leak back out of the patient around the needle or through the hole left behind by the needle after it is removed.
  • numeral 78 represents the point in time when device 10 is fired
  • numeral 80 represents the point of completion of the medicament injection, preferably when the plunger 28 hits the forward wall of the container portion 20.
  • Numeral 82 represents the initial and peak pressure during the injection
  • numeral 84 represents the final and low pressure during the injection. Since the spring 62 of the preferred embodiment has a linear spring constant and an injection-assisting needle is used to puncture the skin before commencing the injection, the pressure drops substantially linearly from the start of the injection 78 until the injection is completed.
  • the final pressure 84 at the end 80 of the injection is sufficiently elevated so that even at the end of the firing stroke of ram 60, the medicament is still jet injected, and a very small amount or none of the medicament is deposited in a bolus around the needle tip 26.
  • the peak pressure during the injection is less than about 68.9 bar (1,000 p.s.i.), more preferably less than 34.5 bar (500 p.s.i.), and most preferably less than about 24.1 bar (350 p.s.i.)
  • the pressure 84 applied to the medicament in the fluid chamber 22 is preferably at least about 5.5 bar (80 p.s.i.), more preferably at least about 6.2 bar (90 p.s.i.), and most preferably at least about 6.9 bar (100 p.s.i.)
  • the initial pressure 82 is around 22.8 bar (330 p.s.i.), and the final pressure is about 12.4 bar (180 p.s.i.), while in another embodiment the initial pressure 82 is about 20.7 bar (300 p.s.i.), dropping to around 7.6 bar (110 p.s.i.) at the end 80 of the injection.
  • the needles used in these embodiments are between 26 and 28 gage, and are most preferably around 27 gage, but alternatively other needle gages can be used where the other components are cooperatively configured to produce the desired injection.
  • the components of the injector 10 are configured to jet inject the medicament to a subterraneous injection site.
  • the amount of medicament contained and injected from fluid chamber 22 is preferably between about 0.02 mL and 4 mL, and preferably less than about 3 mL, and in the preferred embodiment is around 1 mL. Larger volumes may also be selected depending on the particular medicament and dosage required.
  • the prefilled syringe is assembled into the remaining parts of the jet injector 10 already containing the desired amount of medicament. In a preferred embodiment, the prefilled syringe contains about 1 mL of medicament.
  • Preferred injection rates are below about 0.75 mL/sec., more preferably below about 0.6 mL/sec., and preferably at least about 0.2 mL/sec., more preferably at least about 0.3 mL/sec, and most preferably at least about 0.4 mL/sec.
  • the injection of the entire amount of medicament is completed in less than about 4 seconds, more preferably in less than about 3 seconds, and most preferably in less than about 2.5 seconds.
  • the medicament injection takes at least about 1 second, and more preferably at least 1.5 seconds, and most preferably at least about 1.75 seconds.
  • a preferred embodiment injects the medicament at about 0.5 mL/sec., completing the injection of 1 mL in about 2 seconds.
  • U.S. Patent No. 6,391,003 discloses several experimental results of pressures that can be applied to medicament in a glass cartridge, using 26 and 27 gage needles.
  • the following table illustrates injections with different peak pressures that can be used with glass prefilled syringes: Pressure and Time (sec.) to Inject 1 cc Pressure 26 Gauge Needle 27 Gauge Needle 10.3 bar (150 p.s.i.) 2.1 4.2 13.8 bar (200 p.s.i.) 1.9 3.9 16.5 bar (240 p.s.i.) 1.7 3.3 25.9 bar (375 p.s.i.) 1.4 3.1
  • short needles can be used to inject medicament to different parts of the skin, preferably subcutaneously, substantially without any leakback.
  • the needle-assisted jet injector of the present invention permits jet injection of the medicament using a very short needle reliably regardless of the thickness of the patient's skin or the patient's age, weight or other typical factors that complicate non-jet injecting with short needles.
  • Figs.7 and 8 show another embodiment of the present invention that uses a prefilled syringe that has a long, but smaller-diameter configuration than the embodiment of Fig. 2 . While in the embodiment of Fig. 2 , the firing spring 62 extends into the bore of the prefilled syringe 18 during the firing stroke, the narrower prefilled syringe 88 of injector 86 does not provide as much space to accommodate a spring. Consequently, the ram 90 of injector 86 includes a bell portion 92 defining a hollow interior 94 that is configured to receive the proximal end of the prefilled syringe 88 and the syringe support 96 when the injector 86 is fired.
  • a bell-receiving space 98 is defined around the exterior of the prefilled syringe 88 and syringe support 96 to receive the bell portion 92 during the firing.
  • the bell 92 includes a spring seat 100 extending radially outwardly and configured and disposed to seat a compression spring 102.
  • spring 102 acts against seat 100 to drive the ram 90 against plunger 104 to jet inject the medicament from the fluid chamber 106.
  • the spring 102 radially surrounds the prefilled syringe 88.
  • the outer housing portion is wider than outer housing 14 of injector 10 to accommodate the bell portion 92 and larger diameter spring 102.
  • One available long configuration syringe with a 1 mL capacity has a cylindrical syringe body portion with a diameter of 8.15 mm, which would typically be used in the injector of Figs. 7 and 8
  • one available shorter configuration syringe of the same capacity has a cylindrical syringe body portion with a diameter of 10.85 mm, which would be used in the injector of Figs. 1 and 2
  • the embodiment with a bell portion can be used with wider/shorter syringes
  • I is preferred with prefilled syringes having an outer diameter cylindrical wall of less than about 10 mm, and more preferably of less than about 9 mm.
  • Injector 86 also includes a cap 110 fitted around the needle guard 66, and associated with the outer housing to prevent retraction of the needle guard 66 and the triggering of the device 86. Additionally, the cap 110 seals off the needle tip 26 and can be removed prior to using the device 86.
  • the cap 110 is preferably configured to fit over the needle guard 66 in a snap-fit association therewith, such as by including a narrower diameter portion 112 associated with an enlarged diameter portion 114 of the needle guard 66.
  • injector 86 employs a syringe cushion cap 116 that extends around the outside of the syringe flange 34 from the syringe cushion 118 to help trap and retain the prefilled syringe 88.
  • a cushion cap 122 is connected to the cushion 118 and is preferably of unitary construction therewith. The cushion cap 122 abuts the distal end of the syringe body 120 to radially position and hold the proximal end of the body 120 while the needle 24 is being inserted into the patient.
  • the syringe holder 96 is associated with the outer housing in a substantially fixed position, such as by mounting portion 124, which traps protrusions 126 of the syringe holder.
  • injector 128 has a needle guard 130 configured to retract further into the injector housing than the injector of Figs. 1 and 2 or Fig. 5 before the trigger mechanism 52 fires the jet injection.
  • the injector in this figure is shown in a position in which the trigger mechanism 52 is being released and about to fire the injection.
  • the distance 76 by which the needle extends past the guard 130 or the distal surface of the guard 130 that contacts the skin preferably between about 12.5 and 13 mm.
  • the guard is preferably configured to reextend to a protecting position after the device is fired and removed from the patient, such as under the bias of spring 72, and is locked in that position by locking members 132, as known in the art to prevent reuse on the injector.
  • the guard length, the location of the guard injecting position with respect to the needle tip (including the guard throw between the protecting and injecting positions), and the length of the needle from the syringe body can be selected to allow for shallower needle insertions before the device is fired, providing lesser distances 76, respectively.
  • the guard is kept from sliding further back than substantially at the firing position, to better control in insertion depth into the patient.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (12)

  1. Injecteur par jet (10, 86), comprenant :
    une seringue pré-remplie (18, 88) comprenant :
    une portion récipient (20) définissant une chambre de fluide (22, 106) contenant un médicament ;
    une aiguille (24) d'assistance à l'injection disposée au niveau de l'extrémité distale de la chambre de fluide (22, 106) ayant une pointe d'injection (26) configurée pour percer une localisation d'insertion et définissant un trajet de fluide en communication fluidique avec la chambre de fluide (22, 106) ; et
    un piston (28, 104) mobile à l'intérieur de la chambre de fluide (22, 106) ;
    un logement (12, 108) qui loge la seringue pré-remplie (18, 88) et qui comprend un logement externe (14) et une protection (66) qui est mobile par rapport au logement externe (14),
    dans lequel la protection (66) comprend une surface distale et est configurée pour permettre à l'aiguille (24) de s'étendre au-delà de la surface distale à une distance maximale d'environ 15 mm ;
    un support de seringue (16) montant en soutien la seringue pré-remplie (18, 88) au logement externe (14), de sorte que la seringue pré-remplie (18, 88) demeure stationnaire à l'intérieur du logement externe (14) et est fixée à celui-ci ;
    un coussin de seringue (38, 118) associé au support de seringue (16) et à la seringue pré-remplie (18, 88) pour compenser les irrégularités de forme de la seringue pré-remplie (18, 88) ; et
    une source d'énergie configurée pour solliciter le piston (28, 104) avec une force sélectionnée pour produire une pression d'injection dans le médicament dans la chambre de fluide (22, 106) qui demeure sensiblement d'environ 5,5 bars (80 lb/po2) à environ 68,9 bars (1 000 lb/po2) durant l'injection du médicament pour injecter le médicament par jet depuis la chambre de fluide (22, 106) à travers l'aiguille (24) au niveau d'un site d'injection,
    dans lequel une profondeur de pénétration et la pression d'injection sont suffisantes pour empêcher sensiblement le reflux du médicament injecté, dans lequel la protection (66) est mobile entre :
    une position de protection dans laquelle l'aiguille (24) est disposée à l'intérieur de la protection (66),
    une position d'injection dans laquelle la pointe (26) de l'aiguille (24) est exposée pour l'insertion au niveau du point d'insertion.
  2. Injecteur par jet (10, 86) selon la revendication 1, dans lequel la source d'énergie et la seringue pré-remplie (18, 88) sont configurées de sorte que la pression d'injection demeure d'environ 34,5 bars (500 lb/po2) à environ 6,2 bars (90 lb/po2), durant l'injection du médicament.
  3. Injecteur par jet (10, 86) selon la revendication 1, dans lequel la source d'énergie est configurée pour produire la pression d'injection qui demeure à un minimum d'environ 6,9 bars (100 lb/po2) durant l'injection du médicament.
  4. Injecteur par jet (10, 86) selon la revendication 3, dans lequel la source d'énergie et la seringue pré-remplie (18, 88) sont configurées de sorte que la pression d'injection demeure à un maximum d'environ 24,1 bars (350 lb/po2) durant l'injection du médicament.
  5. Injecteur par jet (10, 86) selon la revendication 1, dans lequel la protection (66) comprend une surface distale et est configurée pour permettre à l'aiguille (24) de s'étendre au-delà de la surface distale à une distance d'environ 10 mm à environ 14 mm.
  6. Injecteur par jet (10, 86) selon la revendication 1, dans lequel la source d'énergie comprend un ressort (52, 102).
  7. Injecteur par jet (10, 86) selon la revendication 1, dans lequel :
    la seringue pré-remplie (18, 88) présente une portion distale dans laquelle l'aiguille (24) d'assistance à l'injection est localisée, et une portion proximale opposée à la portion distale ; et
    le support de seringue (16) supporte axialement la portion proximale de la seringue pré-remplie (18, 88) durant l'injection du médicament, de sorte que la portion distale de la seringue pré-remplie (18, 88) est sensiblement non supportée dans un sens axial.
  8. Injecteur par jet (10, 86) selon la revendication 1, dans lequel la chambre contient d'environ 0,02 ml à environ 4 ml du médicament.
  9. Injecteur par jet (10, 86) selon la revendication 1, comprenant en outre un mécanisme de déclenchement (52, 102) fonctionnellement associé à la source d'énergie pour l'activation de la source d'énergie afin d'injecter le médicament, dans lequel le mécanisme de déclenchement (52, 102) est configuré pour activer la source d'énergie après que la protection (66) est déplacée depuis la position de protection.
  10. Injecteur par jet (10, 86) selon la revendication 9, dans lequel la protection (66) est fonctionnellement associée au mécanisme de déclenchement (52, 102) pour amener le mécanisme de déclenchement (52, 102) à activer la source d'énergie lorsque la protection (66) est déplacée vers la position d'injection.
  11. Injecteur par jet (10, 86) selon la revendication 1, dans lequel la profondeur de pénétration est d'environ 1 mm à environ 5 mm en-dessous d'une surface au niveau de la localisation d'insertion.
  12. Injecteur par jet (10, 86) selon la revendication 1, dans lequel la profondeur de pénétration est d'environ 3 mm en-dessous d'une surface au niveau de la localisation d'insertion.
EP19150366.3A 2005-01-24 2006-01-24 Injecteur à jet de seringue préremplie Active EP3495009B2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64559005P 2005-01-24 2005-01-24
US70911605P 2005-08-18 2005-08-18
EP06719329.2A EP1850892B2 (fr) 2005-01-24 2006-01-24 Injecteur a seringue preremplie assiste d'une aiguille
PCT/US2006/002429 WO2006079064A1 (fr) 2005-01-24 2006-01-24 Injecteur a seringue preremplie assiste d'une aiguille

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP06719329.2A Division EP1850892B2 (fr) 2005-01-24 2006-01-24 Injecteur a seringue preremplie assiste d'une aiguille
EP06719329.2A Division-Into EP1850892B2 (fr) 2005-01-24 2006-01-24 Injecteur a seringue preremplie assiste d'une aiguille

Publications (3)

Publication Number Publication Date
EP3495009A1 EP3495009A1 (fr) 2019-06-12
EP3495009B1 EP3495009B1 (fr) 2021-12-08
EP3495009B2 true EP3495009B2 (fr) 2025-01-15

Family

ID=36218390

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06719329.2A Active EP1850892B2 (fr) 2005-01-24 2006-01-24 Injecteur a seringue preremplie assiste d'une aiguille
EP19150366.3A Active EP3495009B2 (fr) 2005-01-24 2006-01-24 Injecteur à jet de seringue préremplie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP06719329.2A Active EP1850892B2 (fr) 2005-01-24 2006-01-24 Injecteur a seringue preremplie assiste d'une aiguille

Country Status (14)

Country Link
US (10) US8021335B2 (fr)
EP (2) EP1850892B2 (fr)
JP (1) JP5216328B2 (fr)
KR (1) KR20070117543A (fr)
CN (1) CN101132820B (fr)
BR (1) BRPI0614025A2 (fr)
CA (1) CA2595730C (fr)
DK (1) DK1850892T4 (fr)
ES (2) ES2716135T5 (fr)
FI (1) FI1850892T4 (fr)
HU (1) HUE042286T2 (fr)
IL (1) IL184765A (fr)
PT (1) PT1850892T (fr)
WO (1) WO2006079064A1 (fr)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003209095A1 (en) 2002-02-11 2003-09-04 Antares Pharma, Inc. Intradermal injector
CH696421A5 (de) 2003-12-18 2007-06-15 Tecpharma Licensing Ag Autoinjektor mit Arretierung des Wirkstoffbehälters.
CN101087625B (zh) 2004-11-22 2012-02-22 因特利杰克特有限公司 用于药物供给的装置和系统
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
DK1850892T4 (da) 2005-01-24 2023-06-06 Antares Pharma Inc Forfyldt nål-assisteret sprøjtejetinjektor
NZ560516A (en) 2005-02-01 2010-12-24 Intelliject Inc A delivery system where a medicant is automatically delivered on activation as well as a recorded instruction
FR2899482A1 (fr) * 2006-04-11 2007-10-12 Becton Dickinson France Soc Pa Dispositif d'injection automatique
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
US8162899B2 (en) * 2006-05-18 2012-04-24 Hyprotek, Inc. Intravascular line and port cleaning methods, methods of administering an agent intravascularly, methods of obtaining/testing blood, and devices for performing such methods
US9592375B2 (en) 2006-05-18 2017-03-14 Hyprotek, Inc. Intravascular line and port cleaning methods, methods of administering an agent intravascularly, methods of obtaining/testing blood, and devices for performing such methods
DE102007030327A1 (de) 2007-06-29 2009-01-02 Tecpharma Licensing Ag Injektionsvorrichtung mit einer Feder für eine Nadelschutzhülse
US8814834B2 (en) 2008-03-10 2014-08-26 Antares Pharma, Inc. Injector safety device
WO2009150071A1 (fr) * 2008-06-11 2009-12-17 Shl Group Ab Dispositif d’administration de médicament
CN102131539B (zh) * 2008-07-17 2013-04-24 医疗卫士有限公司 一种可缩回注射器
EP3581224A1 (fr) 2008-08-05 2019-12-18 Antares Pharma, Inc. Injecteur à dosage multiple
DE102008037310B4 (de) * 2008-08-11 2023-11-16 Ypsomed Ag Automatische Injektionsvorrichtung für die Verabreichung einer festen Dosis
US12097357B2 (en) 2008-09-15 2024-09-24 West Pharma. Services IL, Ltd. Stabilized pen injector
EP2408493B1 (fr) 2009-03-20 2024-07-24 Antares Pharma, Inc. Système d'injection d'agents dangereux
AR076718A1 (es) * 2009-06-02 2011-06-29 Sanofi Aventis Deutschland Modulo medicinal con seleccion del usuario
CN102470217B (zh) * 2009-07-31 2014-09-17 Shl集团有限责任公司 药物容器保持器装置
US8414533B2 (en) * 2009-10-08 2013-04-09 Shl Group Ab Medicament delivery device
AU2016219619B2 (en) * 2009-10-16 2017-11-30 Janssen Biotech, Inc. Palm activated drug delivery device
US9233213B2 (en) 2009-10-16 2016-01-12 Janssen Biotech, Inc. Palm activated drug delivery device
NZ705415A (en) 2009-10-16 2016-01-29 Janssen Biotech Inc Palm activated drug delivery device
DK2536452T3 (da) 2010-02-18 2019-01-02 Sanofi Aventis Deutschland Autoinjektor
FR2961403B1 (fr) * 2010-06-17 2013-06-14 Rexam Healthcare La Verpillier Ensemble d'une seringue et d'un dispositif de securite
WO2012000836A1 (fr) 2010-07-02 2012-01-05 Sanofi-Aventis Deutschland Gmbh Dispositif de sécurité pour seringue pré-remplie et dispositif d'injection
US9173999B2 (en) * 2011-01-26 2015-11-03 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
KR101875155B1 (ko) 2011-05-02 2018-07-09 밀레니엄 파머슈티컬스 인코퍼레이티드 항-α4β7 항체에 대한 제형
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
CN104093437B (zh) * 2012-02-06 2017-08-04 尤尼特拉克特注射器控股有限公司 具有低回缩作动力的自动注射器
KR20150003179A (ko) 2012-03-06 2015-01-08 안타레스 팔마, 인코퍼레이티드 분리력 특징을 가진 사전충전형 주사기
USD721802S1 (en) * 2012-03-23 2015-01-27 Terumo Kabushiki Kaisha Intradermal injection device
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US9265889B2 (en) 2012-04-25 2016-02-23 Adar Medtech, Inc. Prefilled medical injection device
WO2013169804A1 (fr) 2012-05-07 2013-11-14 Antares Pharma, Inc. Dispositif d'injection par jet assisté par une aiguille, présentant une force de déclenchement réduite
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US8784372B1 (en) 2012-06-12 2014-07-22 Johnathan D. Hoggatt First aid pen having separate compartments
EP2687251A1 (fr) * 2012-07-17 2014-01-22 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicaments
CN104684603B (zh) 2012-08-20 2017-11-24 卡贝欧洲有限公司 自动注射装置
US20150217058A1 (en) 2012-09-24 2015-08-06 Enable Injections, Llc Medical vial and injector assemblies and methods of use
DE102012024371A1 (de) * 2012-12-13 2014-06-18 Schott Ag Vorrichtung zur Aufbewahrung Lagerung von flüssigen Medien, insbesondere Arzneimitteln und Verfahren zum Ausbringen von flüssigen Medien
ES2727524T3 (es) * 2013-01-16 2019-10-16 Bayer Pharma AG Bloqueo para dispositivo de inyección de fármaco
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
EP3572108A1 (fr) 2013-03-11 2019-11-27 Antares Pharma, Inc. Injecteur de dose avec système à pignon
WO2014165136A1 (fr) 2013-03-12 2014-10-09 Antares Pharma, Inc. Seringues pré-remplies à volume constant et leurs trousses
EP2777684A1 (fr) 2013-03-14 2014-09-17 Sanofi-Aventis Deutschland GmbH Adaptateur et support de récipient de médicament
CA3096330A1 (fr) * 2013-03-15 2014-09-25 Janssen Biotech, Inc. Dispositif d'administration de medicament active par la paume
USD739011S1 (en) * 2013-03-15 2015-09-15 Eli Lilly And Company Automatic injection device
USD731051S1 (en) 2013-03-15 2015-06-02 Janssen Biotech, Inc. Drug delivery device
DE102013004860B3 (de) * 2013-03-21 2014-09-04 Fresenius Medical Care Deutschland Gmbh Vorrichtung zur Aufnahme einer Spritze in eine Fluidabgabevorrichtung sowie Verfahren hierzu und Verwendung einer solchen Aufnahme
WO2014204894A2 (fr) 2013-06-18 2014-12-24 Enable Injections, Llc Procédé et appareil de transfert de flacon et d'injection
EP2823841A1 (fr) 2013-07-09 2015-01-14 Sanofi-Aventis Deutschland GmbH Auto-injecteur
EP4382165A3 (fr) 2013-10-07 2024-08-21 Antares Pharma, Inc. Modulation de l'hématocrite par injection de testostérone par jet assistée par aiguille
CN105764546B (zh) * 2013-11-22 2020-07-17 赛诺菲-安万特德国有限公司 弹簧辅助式药物输送装置
EP4062918A1 (fr) 2014-02-19 2022-09-28 Antares Pharma, Inc. Administration par injection par jet assistée par une aiguille de compositions de testostérone
USD739932S1 (en) * 2014-03-03 2015-09-29 Sanofi Medicament injection device
EP2923714A1 (fr) 2014-03-28 2015-09-30 Sanofi-Aventis Deutschland GmbH Auto-injecteur declenché par contact avec la peau
US10872313B2 (en) 2015-06-02 2020-12-22 ROCA Medical Ltd. Method for repurposing NDC codes in a pharmaceutical database for venom derived allergens involved in venom immunotherapy
WO2015160600A1 (fr) * 2014-04-15 2015-10-22 Min Wei Dispositif d'administration de médicament
SG10201811702TA (en) 2014-05-07 2019-01-30 Amgen Inc Autoinjector with shock reducing elements
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
EP4585241A3 (fr) * 2014-08-10 2025-10-08 Antares Pharma, Inc. Amortisseur de chocs pour seringue destiné à être utilisé dans un dispositif d'injection
CA3009221A1 (fr) 2014-12-23 2016-06-30 Automed Pty Ltd Appareil d'administration, systeme et procedes associes
CA3129559C (fr) * 2015-01-16 2025-06-10 Becton Dickinson France Système de stockage et de distribution de contenants préremplis
US9415176B1 (en) 2015-01-22 2016-08-16 West Pharmaceutical Services, Inc. Autoinjector having an end-of-dose visual indicator
USD827817S1 (en) * 2015-03-02 2018-09-04 Neomed, Inc. Enteral syringe
USD831204S1 (en) * 2015-03-02 2018-10-16 Neomed, Inc. Enteral syringe
USD831203S1 (en) * 2015-03-02 2018-10-16 Neomed, Inc. Enteral syringe
WO2016154427A2 (fr) 2015-03-24 2016-09-29 Kaleo, Inc. Dispositifs et procédés pour administrer un médicament lyophilisé
US10624817B2 (en) 2015-03-24 2020-04-21 Neomed, Inc. Oral administration coupler for back-of-mouth delivery
US10548974B2 (en) 2015-06-02 2020-02-04 ROCA Medical Ltd. Therapeutic treatment kit for allergies based on DNA profiles
US20160362205A1 (en) * 2015-06-02 2016-12-15 ROCA Medical Ltd. Use of autoinjector for distributing antigens to the public
WO2017004345A1 (fr) 2015-06-30 2017-01-05 Kaleo, Inc. Auto-injecteurs destinés à l'administration d'un médicament à l'intérieur d'une seringue pré-remplie
US10682287B2 (en) 2015-07-14 2020-06-16 Neomed, Inc. Dosing control coupling for enteral fluid transfer and enteral couplings and syringes
EP3322463B1 (fr) 2015-07-14 2025-12-03 Avent, Inc. Couplage de commande de dosage pour transfert de fluide entéral
EP3162395A1 (fr) 2015-10-28 2017-05-03 NNE Pharmaplan A/S Auto-injecteur à usage unique
US10406282B2 (en) 2015-12-10 2019-09-10 Repro-Med Systems, Inc. System and method for a syringe micro pump with volute spring
USD796025S1 (en) * 2016-02-17 2017-08-29 Carebay Europe Ltd Training injector
EP3474928A4 (fr) 2016-06-22 2020-02-26 Antares Pharma, Inc. Dispositif de retrait de protège-aiguille
WO2018071561A1 (fr) 2016-10-12 2018-04-19 Repro-Med Systems, Inc. Système et procédé pour une micro-pompe à seringue présentant un ressort ondulé
AU2017379094B2 (en) 2016-12-23 2023-08-24 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
CN107126600B (zh) * 2017-05-23 2023-01-03 北京大学深圳医院 隔离保护器及具有该隔离保护器的注射装置
EP3634546A1 (fr) 2017-06-08 2020-04-15 Amgen Inc. Dispositif d'administration de médicament entraîné par couple
EP3610907A1 (fr) * 2017-08-09 2020-02-19 Gansu Changee Bio-pharmaceutical Co., Ltd. Seringue rapide et automatique
CN107308524B (zh) * 2017-08-09 2019-02-15 甘肃成纪生物药业有限公司 一种快速自动注射装置
US11083712B1 (en) 2018-03-20 2021-08-10 Relevale, Inc. Low concentration delivery of an ergoline derivative for treatment of a headache
RU182111U1 (ru) * 2018-04-06 2018-08-03 Федеральное государственное унитарное предприятие "Московский эндокринный завод" Автоматический инъектор
RU182223U1 (ru) * 2018-04-06 2018-08-07 Федеральное государственное унитарное предприятие "Московский эндокринный завод" Автоматический инъектор с защитой иглы
CA3099359A1 (fr) 2018-05-24 2019-11-28 Novartis Ag Dispositif d'administration de medicament automatique
JP7194756B2 (ja) 2018-06-08 2022-12-22 アンタレス・ファーマ・インコーポレーテッド 自動挿入注射器
USD946141S1 (en) * 2018-09-20 2022-03-15 Janssen Pharmaceuticals, Inc. Autoinjector
WO2020140040A1 (fr) 2018-12-29 2020-07-02 Kaleo, Inc. Dispositifs et procédés de distribution de substances dans une seringue pré-remplie
AU2020228948B2 (en) 2019-02-26 2022-09-08 Becton Dickinson France Auto-injector with audio indicator
LT4119172T (lt) * 2019-03-15 2024-12-27 Eli Lilly And Company Automatinė injekcijų sistema
USD915584S1 (en) * 2019-07-15 2021-04-06 Boehringer Ingelheim International Gmbh Injection pen casing
WO2021019443A1 (fr) 2019-07-31 2021-02-04 Janssen Pharmaceuticals, Inc. Dispositif d'injection à facteur de forme de boîtier ergonomique
IL290026B1 (en) 2019-08-09 2025-10-01 Kaleo Inc Devices and methods for transferring materials into a prefilled syringe
US11266792B2 (en) 2019-10-28 2022-03-08 FGC Holdings Limited Single use safety needle guard
US11957542B2 (en) 2020-04-30 2024-04-16 Automed Patent Holdco, Llc Sensing complete injection for animal injection device
WO2022061303A1 (fr) 2020-09-21 2022-03-24 Antares Pharma, Inc. Formulation pharmaceutique aqueuse de phosphate de sodium d'hydrocortisone et de monothioglycérol
RU204256U1 (ru) * 2020-11-17 2021-05-17 федеральное государственное бюджетное учреждение "Государственный научно-исследовательский испытательный институт военной медицины" Министерства обороны Российской Федерации (ФГБУ "ГНИИИ ВМ" МО РФ) Автоматический инъектор
US12268847B1 (en) 2021-02-10 2025-04-08 Kaleo, Inc. Devices and methods for delivery of substances within a medicament container
US20230211085A1 (en) * 2021-12-31 2023-07-06 Alvotech Hf Autoinjector Housing
USD1042803S1 (en) 2021-12-31 2024-09-17 Alvotech Hf Autoinjector housing
JP2025509955A (ja) 2022-03-21 2025-04-11 アンタレス・ファーマ・インコーポレーテッド リン酸ヒドロコルチゾンナトリウム及びモノチオグリセロール水性医薬製剤
USD1042805S1 (en) 2022-05-06 2024-09-17 Alvotech Hf Autoinjector housing
KR102530997B1 (ko) * 2022-12-13 2023-05-11 서정성 줄기세포 주입장치
CN117861021B (zh) * 2024-02-27 2024-10-15 江苏乐聚医药科技有限公司 一次性药芯单次装药多次注射的无针注射器及其配置方法
USD1105416S1 (en) * 2024-03-06 2025-12-09 Halozyme, Inc. Injection device
WO2025227129A2 (fr) 2024-04-25 2025-10-30 Starrock Pharma Llc Vecteurs de délivrance comprenant des polypeptides dérivés de proglucagon et des polypeptides anaboliques et leurs utilisations

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518416A1 (fr) † 1991-06-13 1992-12-16 Duphar International Research B.V Dispositif d'injection
US5681291A (en) † 1992-11-19 1997-10-28 Tebro S.A. Disposable auto-injector for prefilled syringes
WO1997041907A2 (fr) † 1996-05-02 1997-11-13 Ermanno Greco Dispositif d'injection automatique
US6102896A (en) † 1999-09-08 2000-08-15 Cambridge Biostability Limited Disposable injector device
US20010049496A1 (en) † 1998-05-15 2001-12-06 Fritz Kirchhofer Automatic injection device
WO2003039634A1 (fr) † 2001-11-09 2003-05-15 Alza Corporation Auto-injecteur pneumatique
WO2003068290A2 (fr) † 2002-02-11 2003-08-21 Antares Pharma, Inc. Injecteur intradermique
WO2004047892A1 (fr) † 2002-11-25 2004-06-10 Tecpharma Licensing Ag Dispositif d'injection pourvu d'une protection d'aiguille
WO2004067068A1 (fr) † 2003-01-24 2004-08-12 Alza Corporation Cartouche de seringue compressible

Family Cites Families (799)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1465793A (en) 1923-08-21 Detachable spout fob containkbs
US547370A (en) 1895-10-01 Detachable spout and can-opener
US1687323A (en) 1921-07-01 1928-10-09 Cook Lab Inc Medicament cartridge and hypodermic syringe embodying the same
US1512294A (en) 1922-05-02 1924-10-21 Ernest H Marcy Hypodermic syringe
US3812584A (en) 1972-09-20 1974-05-28 Wolf Machine Co Safety guard for a cloth cutting machine
US2354649A (en) 1942-03-04 1944-08-01 Kimble Glass Co Dental syringe
GB677523A (en) 1948-04-13 1952-08-20 Becton Dickinson Co Discharge structure for hypodermic injection device
US2699166A (en) 1949-07-29 1955-01-11 Becton Dickinson Co Hypodermic injection unit
US2717601A (en) 1949-08-10 1955-09-13 Frederick M Turnbull Syringe ampule
US2737946A (en) 1949-09-01 1956-03-13 Jr George N Hein Hypodermic injection apparatus
US2648334A (en) 1949-10-28 1953-08-11 Turnbull Hypodermic injection assembly
US2645223A (en) 1951-02-17 1953-07-14 Becton Dickinson Co Injection device
US2607344A (en) 1951-08-01 1952-08-19 Frederick M Turnbull Syringe assembly
US2728341A (en) 1951-11-05 1955-12-27 Zbislaw M Roehr Hypodermic syringe
US2687730A (en) 1951-12-04 1954-08-31 Jr George N Hein Ampoule
US2688967A (en) 1953-06-02 1954-09-14 Huber Jennie Metal aspirating syringe
US2893390A (en) 1954-04-28 1959-07-07 Edgar H Wilburn Hypodermic syringes
GB933975A (en) 1954-10-27 1963-08-14 Astra Apotekarnes Kem Fab Operating mechanism for automatic hypodermic syringes
US2813528A (en) 1956-02-13 1957-11-19 Omega Prec Medical Instr Co In Hypodermic syringe
US2866458A (en) 1956-05-09 1958-12-30 Becton Dickinson Co Hypodermic assembly
US2888924A (en) 1958-02-25 1959-06-02 Russell P Dunmire Hypodermic syringes
US3021335A (en) 1958-04-26 1962-02-13 Hoffmann La Roche Method for the production of isoxazolidones
US3048035A (en) 1958-12-31 1962-08-07 Texaco Inc Method and apparatus for metering wet gas
US3130724A (en) 1962-05-07 1964-04-28 Roehr Products Company Inc Syringe structure
US3375825A (en) 1965-09-02 1968-04-02 Becton Dickinson Co Prefilled syringe
US3382865A (en) 1965-10-18 1968-05-14 Ashton L. Worrall Jr. Device for taking multiple blood samples or the like
US3526225A (en) 1967-03-31 1970-09-01 Tokyo Sokuhan Kk Jet-type hypodermic injection device
GB1181037A (en) 1968-05-31 1970-02-11 Glover Lab Proprietary Ltd J Disposable Hypodermic Syringe
US3563098A (en) 1968-06-28 1971-02-16 Rex Chainbelt Inc Automatic quick release mechanism
DE1957833A1 (de) 1968-11-21 1970-07-02 Maurice Steiner Injektionsspritze,insbesondere von dem Patienten selbst gehandhabte Injektionsspritze
US3557784A (en) 1968-12-24 1971-01-26 Walter A Shields Syringe
GB1216813A (en) 1969-02-21 1970-12-23 Shozo Narusawa Transcutaneous injection device
US3605744A (en) 1969-04-22 1971-09-20 Edward M Dwyer Injection apparatus and method of injecting
US3831814A (en) 1969-07-25 1974-08-27 Cutter Lab Trocar-cannula
BE755224A (fr) 1969-08-25 1971-02-24 Philips Nv Seringue d'injection
US3688765A (en) 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
JPS501001B1 (fr) 1969-10-14 1975-01-14
JPS5016490B1 (fr) 1970-02-19 1975-06-13
US3848593A (en) 1970-10-09 1974-11-19 Affiliated Hospital Prod Side loading disposable carpule syringe
JPS5033792B1 (fr) 1970-12-16 1975-11-04
JPS5026411B1 (fr) 1970-12-24 1975-09-01
US3712301A (en) 1971-01-11 1973-01-23 Survival Technology Gun type hypodermic injector with rapid cartridge displacement within holder
US3797491A (en) 1971-02-11 1974-03-19 Ampoules Inc Method of performing an intramuscular injection
US3770026A (en) 1971-09-17 1973-11-06 J Isenberg Apparatus and method for accurately loading syringes
BE795162A (fr) 1972-02-10 1973-08-08 Philips Nv Injektie-inrichting
US3811441A (en) 1972-02-10 1974-05-21 Survival Technology Cartridge syringe
JPS5112330B2 (fr) 1972-07-24 1976-04-19
US3790048A (en) 1972-07-28 1974-02-05 Ortho Pharma Corp Incremental dose dispenser
FR2198811B1 (fr) 1972-09-13 1978-09-29 Crasnianski France Sa
GB1445977A (en) 1972-09-21 1976-08-11 Rolls Royce Probes
JPS4992147A (fr) 1972-10-23 1974-09-03
JPS5124990B2 (fr) 1972-11-10 1976-07-28
JPS5039135B2 (fr) 1972-11-11 1975-12-15
DE2257768A1 (de) 1972-11-24 1974-05-30 Fritz Pietrowiak Anlage zur herstellung von fertigbeton-teilen
JPS4977252A (fr) 1972-11-28 1974-07-25
JPS4977209A (fr) 1972-11-29 1974-07-25
JPS4979686A (fr) 1972-12-07 1974-08-01
JPS4990151A (fr) 1972-12-27 1974-08-28
US3868064A (en) 1973-02-23 1975-02-25 Dravo Corp Apparatus for reducing automobile bodies and other waste to usable scrap
JPS5016490A (fr) 1973-06-09 1975-02-21
JPS5759692B2 (fr) 1973-07-07 1982-12-16 Toshiro Inohara
FR2237643B1 (fr) 1973-07-17 1978-03-17 Steiner Maurice
JPS5314437B2 (fr) 1973-07-25 1978-05-17
US3882863A (en) 1973-08-01 1975-05-13 Survival Technology Hypodermic injection device having cannula covered with resilient sheath
US3946732A (en) 1973-08-08 1976-03-30 Ampoules, Inc. Two-chamber mixing syringe
JPS5039135A (fr) 1973-08-09 1975-04-11
JPS5234128B2 (fr) 1973-08-24 1977-09-01
JPS5113847A (ja) 1974-07-26 1976-02-03 Asahi Chemical Ind Yoekijugosuchirennbutajenkyojugotaino ratetsukusuno seizohoho
US3895633A (en) 1973-09-27 1975-07-22 Survival Technology Large capacity syringe
JPS5066177A (fr) 1973-10-12 1975-06-04
JPS533899B2 (fr) 1973-10-31 1978-02-10
JPS557799B2 (fr) 1973-11-30 1980-02-28
JPS5112330A (ja) 1974-07-22 1976-01-30 Nippon Steel Corp Nabekeidosochi
SE7502318L (sv) 1975-03-03 1976-09-06 Af Ekenstam Thuresson Bo Emballage for flytande till halvfasta material, passande for smerre kvantiteter
AT341649B (de) 1975-08-07 1978-02-27 Immuno Ag Injektionsspritze
US4031893A (en) 1976-05-14 1977-06-28 Survival Technology, Inc. Hypodermic injection device having means for varying the medicament capacity thereof
US4127118B1 (en) 1977-03-16 1995-12-19 Alvaro Latorre Method of effecting and enhancing an erection
US4171698A (en) 1977-08-15 1979-10-23 Abbott Laboratories Prefilled two-compartment syringe
US4222392A (en) 1979-05-23 1980-09-16 Alier-Screen, Inc. Allergy testing device with vented base
US4227528A (en) 1978-12-26 1980-10-14 Wardlaw Stephen C Automatic disposable hypodermic syringe
DE2929425A1 (de) 1979-07-20 1981-02-12 Lothar Kling Vorrichtung fuer injektionsspritzen zur intramuskulaeren und subentanen injektion
US4258713A (en) 1979-07-23 1981-03-31 Wardlaw Stephen C Automatic disposable hypodermic syringe
US4338980A (en) 1980-01-14 1982-07-13 Schwebel Paul R Device for filling medicament injectors
US4316643A (en) 1980-03-25 1982-02-23 The General Tire & Rubber Co. Vehicle suspension bushing
US4328802A (en) 1980-05-14 1982-05-11 Survival Technology, Inc. Wet dry syringe package
US4411661A (en) 1980-10-22 1983-10-25 Travenol European Research And Development Centre Spike connector
US4316463A (en) 1981-01-26 1982-02-23 Vac-O-Cast, Inc. Corrosive protected hypodermic module
US4333458A (en) 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating syringe with positively engaged locking collet
US4333456A (en) 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating hypodermic syringe and self-aspirating assembly therefor
FR2506161A1 (fr) 1981-05-20 1982-11-26 Alsetex Armement Seringue auto-injectante
ATE32432T1 (de) 1981-08-10 1988-02-15 Duphar Int Res Automatische injektionsspritze.
US4378015A (en) 1981-12-21 1983-03-29 Wardlaw Stephen C Automatic injecting syringe
US4558690A (en) 1982-01-26 1985-12-17 University Of Scranton Method of administration of chemotherapy to tumors
DE3274802D1 (en) 1982-08-25 1987-02-05 Wagner Wolfgang Device for injection by the effect of vacuum on the skin
ATE23802T1 (de) 1982-10-27 1986-12-15 Duphar Int Res Automatische injektionsvorrichtung.
FR2539302B1 (fr) 1983-01-17 1986-03-14 Brunet Jean Louis Seringue a usage medical
US4484910A (en) 1983-12-21 1984-11-27 Survival Technology, Inc. Dual mode automatic injector
US4592745A (en) 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
US5078680A (en) 1984-08-08 1992-01-07 Survival Technology, Inc. Automatic injector for emergency treatment
US4678461A (en) 1984-11-01 1987-07-07 Survival Technology, Inc. Automatic injector with improved glass container protector
ATE39325T1 (de) 1984-11-02 1989-01-15 Duphar Int Res Automatische injektionsvorrichtung.
FR2635009B2 (fr) 1984-11-20 1990-11-09 Poutrait Morin Dispositif de retenue d'une ampoule de seringue hypodermique dans son boitier
US4634027A (en) 1985-01-04 1987-01-06 Mvm Valve Co., Inc. Liquid dispensing apparatus and an anti-drip valve cartridge therefor
EP0219899B1 (fr) 1985-10-11 1990-08-08 Duphar International Research B.V Seringue automatique
AU6541986A (en) 1985-11-08 1987-06-02 Disetronic A.G. Injection instrument
US4662878A (en) 1985-11-13 1987-05-05 Patents Unlimited Ltd. Medicine vial adaptor for needleless injector
IE59361B1 (en) 1986-01-24 1994-02-09 Akzo Nv Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension
US4664653A (en) 1986-02-24 1987-05-12 Sagstetter William E Manually operated reusable injection apparatus
US4664655A (en) 1986-03-20 1987-05-12 Norman Orentreich High viscosity fluid delivery system
US4719825A (en) 1986-03-24 1988-01-19 Lahaye Peter G Metering needle assembly
DE3613489A1 (de) 1986-04-22 1987-11-05 Helmut Vetter Vorrichtung zur handhabung von fertigspritzen
DE3773048D1 (de) 1986-05-15 1991-10-24 Duphar Int Res Automatische injektionsspritze.
DE3644984A1 (de) 1986-07-01 1988-07-07 Eberhardt Schlueter Patrone oder ampulle fuer eine injektionsvorrichtung sowie selbsttaetige injektionsvorrichtung
JP2619365B2 (ja) 1986-07-25 1997-06-11 株式会社日立製作所 ブロッホラインメモリの書き込み方法
DE3638984C3 (de) 1986-11-14 1993-11-18 Haselmeier Wilhelm Fa Injektionsgerät
DE3715337C2 (de) 1986-11-14 1994-04-14 Haselmeier Wilhelm Fa Injektionsgerät
US4722728A (en) 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
DE3715258C2 (de) 1987-05-08 1996-10-31 Haselmeier Wilhelm Fa Injektionsgerät
DE3715340C2 (de) 1987-05-08 1995-10-19 Haselmeier Wilhelm Fa Injektionsgerät
US4758235A (en) * 1987-05-26 1988-07-19 Tu Ho C Cardiopulmonary resuscitation medication assembly
US5569190A (en) 1987-06-08 1996-10-29 D'antonio; Nicholas F. Hypodermic fluid dispenser
US5080648A (en) 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
GB8713810D0 (en) 1987-06-12 1987-07-15 Hypoguard Uk Ltd Measured dose dispensing device
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
JPH02504391A (ja) 1987-07-31 1990-12-13 シタス　コーポレイション 腫瘍壊死因子による感染の治療
US4976701A (en) 1987-09-25 1990-12-11 Nordisk Gentofte A/S Injection apparatus
KR970011449B1 (ko) 1988-01-29 1997-07-11 더 리전트 오브 디 유니버시티 오브 캘리포니아 이온전기 영동형 비침입 검체 채취 또는 이송 장치 및 방법
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
EP0328699B1 (fr) 1988-02-16 1991-09-18 Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg Seringue à usage médical
US4830217A (en) 1988-02-19 1989-05-16 Becton, Dickinson And Company Body fluid sample collection tube assembly
US4913699A (en) 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
GB8809115D0 (en) * 1988-04-18 1988-05-18 Turner R C Syringes
BR8801952A (pt) 1988-04-22 1989-11-14 Sergio Landau Capsula descartavel,nao re-utilizavel,contendo dose individual de vacina a ser injetada hipodermicamente,sem agulha,com aparelho injetor a pressao
GB8819977D0 (en) 1988-08-23 1988-09-21 Medimech Ltd Automatic injectors
US4929238A (en) 1988-11-23 1990-05-29 Coeur Laboratories, Inc. Multi-pressure injector device
IT1227658B (it) 1988-12-01 1991-04-23 Vittorio Boschetti B Siringa monouso con rientro e blocco dell'ago a fine iniezione a scopo di evitare il reimpiego
GB8900763D0 (en) 1989-01-13 1989-03-08 Kabi Vitrum Peptide Hormones A Multi-dose syringe
US4986816A (en) 1989-01-18 1991-01-22 On-Gard Systems, Inc. Needle unsheathing, resheathing and handling apparatus
US4915701A (en) 1989-02-21 1990-04-10 Halkyard Douglas R Protective device and syringe
DE3916101A1 (de) 1989-05-17 1990-11-22 Vetter & Co Apotheker Spritze fuer medizinische zwecke
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5569236A (en) 1989-06-16 1996-10-29 Science Incorporated Fluid delivery apparatus
US5085641A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use auto-injector with improved cap structure
US5085642A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5102393A (en) 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
DE3924830A1 (de) 1989-07-27 1991-02-07 Vetter & Co Apotheker Spritzenzylinder fuer medizinische zwecke
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
GB8926825D0 (en) 1989-11-28 1990-01-17 Glaxo Group Ltd Device
DE59001705D1 (de) 1990-02-07 1993-07-15 Vetter & Co Apotheker Doppelkammerspritze und verwendungsverfahren.
US4982769A (en) 1990-02-21 1991-01-08 Survival Technology, Inc. Package
US5050400A (en) 1990-02-26 1991-09-24 Bohn, Inc. Simplified hot gas defrost refrigeration system
AU649029B2 (en) 1990-02-28 1994-05-12 Sri International Method for spectral estimation to improve noise robustness for speech recognition
GB9007113D0 (en) 1990-03-29 1990-05-30 Sams Bernard Dispensing device
US5062830A (en) 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
DE4021836C1 (fr) 1990-07-09 1991-05-02 Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg, 7980 Ravensburg, De
US5505694A (en) 1990-08-22 1996-04-09 Tcnl Technologies, Inc. Apparatus and method for raising a skin wheal
DK228290D0 (da) 1990-09-21 1990-09-21 Novo Nordisk As An injektion unit
US5350367A (en) 1990-11-06 1994-09-27 Sterling Winthrop Inc. Snap together hypodermic syringe holder
DE69127614T2 (de) 1990-11-17 1998-04-09 Santen Pharma Co Ltd Spritzenzylinder mit zwei kammern
US5137528A (en) 1990-11-26 1992-08-11 Crose Virginia W Ampoule for administering a liquid local anaesthetic
GB9100819D0 (en) 1991-01-15 1991-02-27 Medimech Int Ltd Subcutaneous injector
FR2672868B1 (fr) * 1991-02-15 1993-06-04 Pasteur Merieux Serums Vacc Procede de conditionnement de vaccins lyophilises en seringue et bouchon pour sa mise en óoeuvre.
US5451210A (en) 1991-04-29 1995-09-19 Lifequest Medical, Inc. System and method for rapid vascular drug delivery
US5271744A (en) 1991-04-29 1993-12-21 George C. Kramer System and method for rapid vascular drug delivery
US5868711A (en) 1991-04-29 1999-02-09 Board Of Regents, The University Of Texas System Implantable intraosseous device for rapid vascular access
US5176643A (en) 1991-04-29 1993-01-05 George C. Kramer System and method for rapid vascular drug delivery
US5405362A (en) 1991-04-29 1995-04-11 The Board Of Regents For The University Of Texas System Interactive external defibrillation and drug injection system
GB9111049D0 (en) 1991-05-22 1991-07-17 Parkin Adrian Hypodermic needle
GB9111600D0 (en) * 1991-05-30 1991-07-24 Owen Mumford Ltd Improvements relating to injection devices
US5163907A (en) 1991-06-24 1992-11-17 Szuszkiewicz Christine M Single use retractable needle syringe
US5102388A (en) 1991-07-15 1992-04-07 Richmond John E Sequential delivery syringe
DE59202070D1 (de) 1991-07-24 1995-06-08 Medico Dev Investment Co Injektor.
IT1252832B (it) 1991-08-06 1995-06-28 Sicim Spa Testina monouso per iniettori per iniezioni sottocutanee senza ago
DE4127650C1 (fr) 1991-08-21 1993-02-25 Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg, 7980 Ravensburg, De
US5195983A (en) 1991-08-27 1993-03-23 Penta Associates Syringe guard and disposal system
US5544234A (en) * 1991-09-04 1996-08-06 Canon Kabushiki Kaisha Facsimile apparatus with automatic answering telephone function, and communication method in said apparatus
US5221348A (en) 1991-11-26 1993-06-22 Masano Thomas C High pressure glue injector
US5263934A (en) 1991-11-28 1993-11-23 Haak Abraham Van Den Stroke limiting syringe with retractable needle
US5332399A (en) 1991-12-20 1994-07-26 Abbott Laboratories Safety packaging improvements
GB9200219D0 (en) 1992-01-07 1992-02-26 Medimech Int Ltd Automatic injectors
US5279586A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
EP0562671B1 (fr) 1992-03-27 1996-05-29 Duphar International Research B.V Seringue automatique
US5873857A (en) 1992-04-17 1999-02-23 Science Incorporated Fluid dispenser with fill adapter
SE9201246D0 (sv) 1992-04-21 1992-04-21 Kabi Pharmacia Ab Injection cartridge arrangement
AU665067B2 (en) 1992-04-30 1995-12-14 Takeda Pharmaceutical Company Limited Prefilled syringe
US5281198A (en) 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
US5180370A (en) 1992-05-18 1993-01-19 Gillespie Elgene R Safety hypodermic syringe with retractable needle
US5279576A (en) 1992-05-26 1994-01-18 George Loo Medication vial adapter
US5304128A (en) 1992-09-22 1994-04-19 Habley Medical Technology Corporation Gas powered self contained syringe
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
GB9223183D0 (en) 1992-11-05 1992-12-16 Medimech Int Ltd Improvements related to auto injectors
JP3172005B2 (ja) 1992-11-27 2001-06-04 株式会社大協精工 注射器兼容器
GB9226423D0 (en) 1992-12-18 1993-02-10 Sams Bernard Incrementing mechanisms
IL108532A (en) 1993-02-02 1997-07-13 Vidamed Inc Transurethral needle ablation device
AU682670B2 (en) 1993-02-05 1997-10-16 Becton Dickinson & Company Syringe needle isolation device
US5330431A (en) 1993-03-12 1994-07-19 Glenn Herskowitz Infusion pump
EP0693946B1 (fr) * 1993-03-24 2001-05-16 Owen Mumford Limited Amelioration concernant des dispositifs d'injection
US5358489A (en) 1993-05-27 1994-10-25 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
WO1995031235A1 (fr) 1994-05-16 1995-11-23 Washington Biotech Corporation Systeme d'injection de medicament, modulaire, automatique ou manuel, utilise en urgence
US5540664A (en) 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5415648A (en) 1993-07-08 1995-05-16 Malay; Manuel R. Multiple purpose syringe
KR100223616B1 (ko) 1993-07-31 1999-10-15 웨스톤 테렌스 에드워드 바늘 없는 주사기
US5425715A (en) 1993-08-05 1995-06-20 Survival Technology, Inc. Reloadable injector
US5308341A (en) 1993-09-28 1994-05-03 Becton, Dickinson And Company Method of testing the dose accuracy of a medication delivery device
CA2135707C (fr) 1993-11-11 1999-07-13 Ian Ross Phillips Injecteur avec emboitement retractable
US5354286A (en) 1993-12-07 1994-10-11 Survival Technology, Inc. Injection device having polyparaxylylene coated container
US5505697A (en) * 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5514107A (en) 1994-02-10 1996-05-07 Habley Medical Technology Corporation Safety syringe adapter for cartridge-needle unit
US5514097A (en) 1994-02-14 1996-05-07 Genentech, Inc. Self administered injection pen apparatus and method
WO1995024176A1 (fr) 1994-03-07 1995-09-14 Bioject, Inc. Dispositif de remplissage d'ampoule
FR2718357B1 (fr) 1994-04-06 1997-10-03 Defarges Alain Moreau Perfectionnements apportés à un dispositif d'injection par jet sans aiguille.
GB9408500D0 (en) 1994-04-28 1994-06-22 Pa Consulting Services Improvements in or relating to injection devices
FR2719224B1 (fr) 1994-04-29 1996-08-02 Nycomed Lab Sa Cathéter de dilatation à échange rapide.
ES2204878T3 (es) 1994-05-30 2004-05-01 B D Medico S.A.R.L. Aparato de inyeccion.
GB9412301D0 (en) 1994-06-17 1994-08-10 Safe T Ltd Hollow-needle drugs etc applicators
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5637094A (en) 1994-11-04 1997-06-10 Pos-T-Vac, Inc. Multiple dosage syringe
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
DE4445969C1 (de) 1994-12-22 1996-03-14 Schott Glaswerke Spritzenzylinder für eine Zweikammer-Fertigspritze, Zweikammer-Fertigspritze und Verfahren zum Herstellen und Füllen derselben
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
AU696439B2 (en) 1995-03-07 1998-09-10 Eli Lilly And Company Recyclable medication dispensing device
GB9506087D0 (en) * 1995-03-24 1995-05-10 Owen Mumford Ltd Improvements relating to medical injection devices
US5562625A (en) 1995-05-02 1996-10-08 Stefancin, Jr.; Ronald J. Reusasble syringe with a disposable needle sheath
IT1275428B (it) 1995-05-16 1997-08-07 Bracco Spa Processo per la produzione di siringhe preriempite prive di bolle di gas residuo
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
AU1860697A (en) 1995-09-08 1997-07-28 Visionary Medical Products Corporation Pen-type injector drive mechanism
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5542760A (en) 1995-09-26 1996-08-06 Becton Dickinson And Company Syringe filler for mixing insulins
DE19537163C1 (de) 1995-10-06 1997-01-30 Vetter & Co Apotheker Spritze für medizinische Zwecke
US6080130A (en) 1998-11-14 2000-06-27 Castellano; Thomas P. Gas power source for a needle-less injector
US5776103A (en) 1995-10-11 1998-07-07 Science Incorporated Fluid delivery device with bolus injection site
US5658259A (en) 1995-10-19 1997-08-19 Meridian Medical Technologies, Inc. Dental cartridge assembly auto-injector with protective needle cover
US5567160A (en) 1995-10-26 1996-10-22 Survival Technology, Inc. Autoinjector training device
US5858001A (en) 1995-12-11 1999-01-12 Elan Medical Technologies Limited Cartridge-based drug delivery device
US5836911A (en) 1996-02-01 1998-11-17 Medi-Ject Corporation Injection device having positioning means
US5865795A (en) 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5801057A (en) 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
US5860456A (en) 1996-03-22 1999-01-19 Eli Lilly And Company Syringe alignment device
US5769138A (en) 1996-04-01 1998-06-23 Medi-Ject Corporation Nozzle and adapter for loading medicament into an injector
GB9612724D0 (en) * 1996-06-18 1996-08-21 Owen Mumford Ltd Improvements relating to injection devices
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US5875976A (en) 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
WO1998031369A1 (fr) 1997-01-16 1998-07-23 Sekisui Chemical Co., Ltd. Preparations a usage externe a absorption percutanee
GB9701413D0 (en) 1997-01-24 1997-03-12 Smithkline Beecham Biolog Novel device
BR9807112A (pt) 1997-01-24 2001-09-18 Autoimmune Inc Composição, formulação farmacêutica, combinação e uso relacionados ao tratamento de doenças autoimunes utilizando antìgeno ou agente tolerante em combinação com metotrexato
US5851197A (en) 1997-02-05 1998-12-22 Minimed Inc. Injector for a subcutaneous infusion set
US6607509B2 (en) 1997-12-31 2003-08-19 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
BR9700930A (pt) 1997-02-07 1998-12-08 Rhone Poulenc Rorer Gmbh Unidade para venda que se destina a aplicação parenteral um dispositivo para a execução da aplicação parenteral bem como uma unidade de recarga destinada á unidade para venda acima mencionada
EP0996477B1 (fr) * 1997-07-14 2004-01-14 Novo Nordisk A/S Element d'injection
GB9714948D0 (en) * 1997-07-16 1997-09-17 Owen Mumford Ltd Improvements relating to injection devices
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US5957896A (en) 1997-08-11 1999-09-28 Becton, Dickinson And Company Medication delivery pen
ATE252399T1 (de) 1997-08-21 2003-11-15 Ares Trading Sa Injektionsvorrichtung
IE970782A1 (en) 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
US6045534A (en) 1997-10-27 2000-04-04 Sarcos, Inc. Disposable fluid injection module
FR2770404B1 (fr) 1997-11-05 2000-01-28 Sedat Injecteur automatique a retraction d'aiguille en fin d'injection
DE19751219A1 (de) 1997-11-19 1999-05-27 Vetter & Co Apotheker Spritze, insbesondere vorgefüllte Spritze, oder Karpule
DK1032446T3 (da) 1997-11-19 2004-06-14 B D Medico S A R L Nåleindretning
US6706000B2 (en) 1997-11-21 2004-03-16 Amira Medical Methods and apparatus for expressing body fluid from an incision
DE69827036T2 (de) 1997-12-16 2006-03-09 Meridian Medical Technologies, Inc. Automatische injektionsvorrichtung zur verabreichung eines medikamentes
DE29801168U1 (de) * 1998-01-24 1999-08-12 Medico Dev Investment Co Injektionsgerät
UA56256C2 (uk) 1998-01-30 2003-05-15 Ново Нордіск А/С Шприц для ін'єкцій
GB9803084D0 (en) * 1998-02-14 1998-04-08 Owen Mumford Ltd Improvements relating to medical injection devices
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US5935949A (en) 1998-03-20 1999-08-10 Trustees Of Dartmouth College Use of androgen therapy in fibromyalgia and chronic fatigue syndrome
GB9808408D0 (en) * 1998-04-18 1998-06-17 Owen Mumford Ltd Improvements relating to injection devices
EP1082124A1 (fr) 1998-06-05 2001-03-14 Supergen, Inc. Compositions comprenant methotrexate et pentostatine pour traiter la polyarthrite rhumatoide
AU5317699A (en) 1998-07-27 2000-02-21 Medi-Ject Corporation Loading mechanism for medical injector assembly
KR100622160B1 (ko) 1998-07-27 2006-09-07 안타레스 팔마, 인코퍼레이티드 주사장치.
US6428528B2 (en) * 1998-08-11 2002-08-06 Antares Pharma, Inc. Needle assisted jet injector
SE9803662D0 (sv) 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab Autoinjector
US6264629B1 (en) 1998-11-18 2001-07-24 Bioject, Inc. Single-use needle-less hypodermic jet injection apparatus and method
US6383168B1 (en) 1998-12-08 2002-05-07 Bioject Medical Technologies Inc. Needleless syringe with prefilled cartridge
US6132395A (en) 1998-12-08 2000-10-17 Bioject, Inc. Needleless syringe with prefilled cartridge
US6083201A (en) 1999-01-07 2000-07-04 Mckinley Medical, Llp Multi-dose infusion pump
DE29900482U1 (de) 1999-01-14 2000-08-31 Medico Development Investment Co., Ascona Injektionsgerät
US6695830B2 (en) 1999-01-15 2004-02-24 Scimed Life Systems, Inc. Method for delivering medication into an arterial wall for prevention of restenosis
GB9903475D0 (en) * 1999-02-17 1999-04-07 Owen Mumford Ltd Improvements relating to injection devices
EP1033143B1 (fr) 1999-02-26 2007-01-10 F. Hoffmann-La Roche Ag Appareil pour l'administration de médicaments
SE9901366D0 (sv) 1999-04-16 1999-04-16 Pharmacia & Upjohn Ab Injector device and method for its operation
KR100335050B1 (ko) 1999-07-06 2002-05-02 구자홍 다기능 전자레인지
DE19935681A1 (de) 1999-07-29 2001-02-15 Vetter & Co Apotheker Vorrichtung zum Befüllen eines Spritzenzylinders und/oder zum Setzen eines Stopfens im Spritzenzylinder
US6936032B1 (en) 1999-08-05 2005-08-30 Becton, Dickinson And Company Medication delivery pen
US6319224B1 (en) 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6673035B1 (en) 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US6391003B1 (en) † 1999-10-25 2002-05-21 Antares Pharma, Inc. Locking mechanism for a jet injector
ATE281857T1 (de) 2000-01-27 2004-11-15 Afra Design Pty Ltd Einwegspritze
WO2001060311A1 (fr) 2000-02-16 2001-08-23 B D Medico S.A.R.L. Procede servant a la reconstitution d'un liquide pour injection et appareil pour injection servant a l'execution d'un tel procede
GB0003790D0 (en) 2000-02-18 2000-04-05 Astrazeneca Uk Ltd Medical device
US6689092B2 (en) 2000-03-03 2004-02-10 Boehringer International Gmbh Needle-less injector of miniature type
AU2001247721A1 (en) 2000-03-23 2001-10-03 Antares Pharma, Inc. Single use disposable jet injector
GB0007071D0 (en) 2000-03-24 2000-05-17 Sams Bernard One-way clutch mechanisms and injector devices
US6607508B2 (en) 2000-04-27 2003-08-19 Invivotech, Inc. Vial injector device
US6740062B2 (en) * 2000-05-22 2004-05-25 Pharmacia Ab Medical device
US6613025B1 (en) 2000-05-25 2003-09-02 Scimed Life Systems, Inc. Method and apparatus for diagnostic and therapeutic agent delivery
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6406456B1 (en) 2000-06-08 2002-06-18 Avant Drug Delivery Systems, Inc. Jet injector
US6517517B1 (en) 2000-06-08 2003-02-11 Mayo Foundation For Medical Education And Research Automated injection device for administration of liquid medicament
EP1292345B1 (fr) 2000-06-15 2009-02-25 Hambley Limited Seringue hypodermique dotee d'une caracteristique d'aspiration passive
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
US6530904B1 (en) 2000-08-15 2003-03-11 Evan T. Edwards Medical injector
KR100782606B1 (ko) 2000-10-09 2007-12-06 일라이 릴리 앤드 캄파니 부갑상선 호르몬 투약을 위한 펜 장치
US7621887B2 (en) 2000-10-10 2009-11-24 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
US6641561B1 (en) 2000-10-10 2003-11-04 Meridian Medical Technologies, Inc. Drug delivery device
US6656150B2 (en) 2000-10-10 2003-12-02 Meridian Medical Technologies, Inc. Wet/dry automatic injector assembly
FR2815543B1 (fr) 2000-10-19 2003-10-24 Sedat Seringue d'auto-injection d'un melange extemporane
SE518981C2 (sv) 2000-12-14 2002-12-17 Shl Medical Ab Autoinjektor
US6387078B1 (en) 2000-12-21 2002-05-14 Gillespie, Iii Richard D. Automatic mixing and injecting apparatus
IL156245A0 (en) 2000-12-22 2004-01-04 Dca Design Int Ltd Drive mechanism for an injection device
DE10106367B4 (de) 2001-02-12 2009-11-19 Tecpharma Licensing Ag Ablesehilfe für eine Vorrichtung zur Verabreichung einer einstellbaren Dosis eines injizierbaren Produkts
US6471669B2 (en) 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US6645170B2 (en) 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
JP2002264621A (ja) 2001-03-12 2002-09-18 Pacific Ind Co Ltd タイヤ状態監視装置の送信機
GB0107608D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to an injection device
GB0107604D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to injection device
BR0116973A (pt) 2001-04-13 2004-10-13 Becton Dickinson Co Método de injetar substâncias de forma intradérmica
GB0110053D0 (en) 2001-04-24 2001-06-13 Axis Shield Asa Assay
US6903100B2 (en) 2001-05-03 2005-06-07 Midamerica Neuroscience Research Foundation Use of regularly scheduled high dose intravenous methotrexate therapy, with interim administration of immunomodulatory agents, to treat multiple sclerosis and other diseases of the central nervous system
EP2275158B1 (fr) 2001-05-16 2013-01-23 Eli Lilly and Company Appareil injecteur de médication
US6585685B2 (en) 2001-06-08 2003-07-01 Bioject Inc. Jet injector apparatus and method
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
DE10129585A1 (de) 2001-06-20 2003-01-09 Disetronic Licensing Ag Vorrichtung für eine dosierte Verabreichung eines injizierbaren Produkts
JP4288156B2 (ja) 2001-07-16 2009-07-01 イーライ リリー アンド カンパニー 充填用に回転かつ注射用にプル・プッシュ形式の投薬装置
US7544188B2 (en) 2001-07-19 2009-06-09 Intelliject, Inc. Medical injector
GB0118419D0 (en) 2001-07-28 2001-09-19 Owen Mumford Ltd Improvements relating to injection devices
US20030040697A1 (en) 2001-08-17 2003-02-27 Antares Pharma, Inc. Administration of insulin by jet injection
CA2457949A1 (fr) 2001-08-27 2003-03-06 Novo-Nordisk A/S Cartouche et systeme medical de distribution accueillant une telle cartouche
GB2391480B (en) 2002-08-05 2007-02-28 Caretek Medical Ltd Drug delivery system
EP1307012A3 (fr) 2001-10-26 2009-12-30 Tenovis GmbH & Co. KG Dispositif de télécommunication et son procédé de contrôle de commutation en circuits et en paquets
US6872193B2 (en) 2001-10-26 2005-03-29 Retractable Technologies, Inc. IV catheter introducer with retractable needle
CN1607968A (zh) 2001-11-02 2005-04-20 梅里迪安医学技术公司 药物容器、用于施用药物的药物配送套件及其包装方法
US7569035B1 (en) 2001-11-02 2009-08-04 Meridian Medical Technologies, Inc. Automatic injector with anti-coring needle
US7011649B2 (en) 2001-11-09 2006-03-14 Alza Corporation Collapsible syringe cartridge
US20040030294A1 (en) * 2001-11-28 2004-02-12 Mahurkar Sakharam D. Retractable needle single use safety syringe
US7488313B2 (en) 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
US20030105430A1 (en) 2001-11-30 2003-06-05 Elan Pharma International Limited Wil House Automatic injector
GB0129171D0 (en) 2001-12-06 2002-01-23 Dca Design Int Ltd Improvements in and relating to a medicament cartridge
GB0130139D0 (en) 2001-12-18 2002-02-06 Dca Design Int Ltd Improvements in and relating to a medicament injection apparatus
US7247149B2 (en) 2001-12-20 2007-07-24 Advanced Cardiovascular Systems, Inc. Contact and penetration depth sensor for a needle assembly
GB0200637D0 (en) 2002-01-12 2002-02-27 Dca Design Int Ltd Improvements in and relating to medicament injection apparatus
GB0203276D0 (en) 2002-02-12 2002-03-27 Novartis Ag Organic compounds
EP1476211B1 (fr) 2002-02-15 2015-06-24 Antares Pharma, Inc. Injecteur avec canal de derivation
GB0205066D0 (en) 2002-03-05 2002-04-17 Owen Mumford Ltd Improvements relating to injection devices
GB0205485D0 (en) 2002-03-08 2002-04-24 Dca Design Int Ltd Improvements in and relating to a medicament delivery service
WO2003080160A1 (fr) 2002-03-18 2003-10-02 Eli Lilly And Company Appareil de distribution de medicament dote d'un train d'engrenages apportant un avantage technique
US20030187401A1 (en) * 2002-03-27 2003-10-02 Safety Syringes, Inc. Syringe with integral safety system
US7218962B2 (en) 2002-03-29 2007-05-15 Boston Scientific Scimed, Inc. Magnetically enhanced injection catheter
DE10215567A1 (de) 2002-04-09 2003-10-23 Siemens Ag Verfahren zur Übertragung von Daten, insbesondere mit multimedialen Inhalten, in einem Mobilfunknetz
US6584910B1 (en) 2002-04-19 2003-07-01 David J. Plass Animal syringe system
US20040267355A1 (en) 2002-04-30 2004-12-30 Neal Scott Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
CA2484265C (fr) 2002-05-06 2012-08-07 Becton, Dickinson And Company Methode et dispositif de controle pharmacocinetique de medicaments
GB0210631D0 (en) 2002-05-09 2002-06-19 Glaxo Group Ltd Novel device
EP1511528A4 (fr) 2002-05-16 2008-07-02 Scott Lab Inc Mecanismes de penetration dans un contenant a medicaments, et procede associe
GB0211294D0 (en) 2002-05-17 2002-06-26 Owen Mumford Ltd Improvements relating to injection devices
US6979316B1 (en) 2002-05-23 2005-12-27 Seedlings Life Science Ventures Llc Apparatus and method for rapid auto-injection of medication
MY139059A (en) * 2002-06-24 2009-08-28 Alza Corp Reusable, spring driven autoinjector
EP2286857A1 (fr) 2002-07-02 2011-02-23 Panasonic Corporation Instrument d'administration automatique pour usage médicale
US20040039337A1 (en) 2002-08-21 2004-02-26 Letzing Michael Alexander Portable safety auto-injector
AU2003278798A1 (en) 2002-09-12 2004-04-30 Children's Hospital Medical Center Method and device for painless injection of medication
JP4448448B2 (ja) 2002-09-24 2010-04-07 エス・ホー・エル・グループ・アクチボラゲット 注射装置
AU2003275353A1 (en) 2002-10-01 2004-04-23 Becton, Dickinson And Company Medication delivery pen
WO2004041331A1 (fr) 2002-11-01 2004-05-21 Antares Pharma, Inc. Administration d'insuline par injection à l'aide d'un pistolet à injection
AU2003287640A1 (en) 2002-11-12 2004-06-03 Collegium Pharmaceutical, Inc. Inertial drug delivery system
AU2002952691A0 (en) 2002-11-15 2002-11-28 Sunshine Heart Company Pty Ltd Heart assist device utilising aortic deformation
JP2006507061A (ja) 2002-11-25 2006-03-02 テクファーマ・ライセンシング・アクチェンゲゼルシャフト リセット可能な解放安全装置を有する自動注射装置
WO2004057959A2 (fr) 2002-12-20 2004-07-15 Generipharm, Inc. Injection intracutanee
US6969372B1 (en) 2003-01-07 2005-11-29 Halseth Thor R Automatic retraction Huber needle safety enclosure
US7252651B2 (en) 2003-01-07 2007-08-07 Becton, Dickinson And Company Disposable injection device
US6767336B1 (en) 2003-01-09 2004-07-27 Sheldon Kaplan Automatic injector
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
EP2210634A1 (fr) 2009-01-22 2010-07-28 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicaments, mécanisme de définition de dose
US7390314B2 (en) 2003-03-05 2008-06-24 Medtronic Minimed, Inc. Lead screw driven reservoir with integral plunger nut and method of using the same
GB0306642D0 (en) 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
US6932794B2 (en) 2003-04-03 2005-08-23 Becton, Dickinson And Company Medication delivery pen
GB0308267D0 (en) 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
US7517342B2 (en) 2003-04-29 2009-04-14 Boston Scientific Scimed, Inc. Polymer coated device for electrically medicated drug delivery
US6805686B1 (en) 2003-05-06 2004-10-19 Abbott Laboratories Autoinjector with extendable needle protector shroud
GB0312852D0 (en) 2003-06-05 2003-07-09 Owen Mumford Ltd Improvements relating to syringe firing mechanisms
US20070100288A1 (en) 2003-06-05 2007-05-03 University Of Florida Research Foundation, Inc. Auto-injection devices and methods for intramuscular administration of medications
US8308232B2 (en) 2003-06-10 2012-11-13 Antonio Zamperla S.P.A. Seat for amusement apparatus
GB0315600D0 (en) 2003-07-04 2003-08-13 Owen Mumford Ltd Improvements relating to automatic injection devices
DE10330986B4 (de) 2003-07-09 2010-01-07 Tecpharma Licensing Ag Berührungslose Abtastung mit magnetoresistivem Sensor
US7500963B2 (en) 2003-07-22 2009-03-10 Safety Syringes, Inc. Systems and methods for automatic medical injection with safeguard
US20050027255A1 (en) 2003-07-31 2005-02-03 Sid Technologies, Llc Automatic injector
DE20311996U1 (de) 2003-08-01 2003-10-16 Hoelzle Dieter Tech Projekte Injektionsvorrichtung
KR101121317B1 (ko) 2003-08-12 2012-03-09 일라이 릴리 앤드 캄파니 기계적 확대율을 갖는 삼중 나사식 쓰레드를 갖는 약제투여 장치
AT7347U1 (de) 2003-08-29 2005-02-25 Pharma Consult Ges M B H & Co Vorrichtung zum automatischen injizieren von injektionsflüssigkeiten
DE10342058B4 (de) 2003-09-11 2007-10-25 Tecpharma Licensing Ag Verabreichungsvorrichtung für ein injizierbares Produkt mit einer Auslösesicherung
DE10342059B4 (de) 2003-09-11 2007-03-01 Tecpharma Licensing Ag Verabreichungsvorrichtung mit Einstech- und Ausschütteinrichtung
IL157981A (en) 2003-09-17 2014-01-30 Elcam Medical Agricultural Cooperative Ass Ltd Auto injector
US7615030B2 (en) 2003-10-06 2009-11-10 Active O, Llc Apparatus and method for administering a therapeutic agent into tissue
US8777889B2 (en) 2004-06-15 2014-07-15 Ceramatec, Inc. Apparatus and method for administering a therapeutic agent into tissue
US8066659B2 (en) 2004-06-15 2011-11-29 Ceramatec, Inc. Apparatus and method for treating and dispensing a material into tissue
KR100763046B1 (ko) 2003-10-16 2007-10-04 일라이 릴리 앤드 캄파니 고정 용량 약물 분배 장치
US8360114B2 (en) 2003-10-23 2013-01-29 Niles Clark Apparatus and method for filing a syringe
DE20317377U1 (de) 2003-11-03 2005-03-17 B D Medico S A R L Injektionsgerät
US7635348B2 (en) * 2003-11-04 2009-12-22 Meridian Medical Technologies, Inc. Container for medicament automatic injector and automatic injector adapted therefor
US20050101919A1 (en) 2003-11-07 2005-05-12 Lennart Brunnberg Device for an injector
EP1541185A1 (fr) 2003-12-08 2005-06-15 Novo Nordisk A/S Seringue automatique avec mécanisme d'amorçage
CH696421A5 (de) 2003-12-18 2007-06-15 Tecpharma Licensing Ag Autoinjektor mit Arretierung des Wirkstoffbehälters.
AU2004298302B2 (en) 2003-12-18 2009-04-02 Tecpharma Licensing Ag Releasable injection device
US8275454B2 (en) 2003-12-26 2012-09-25 Hisamitsu Pharmaceutical Co., Inc. Iontophoresis device activated in use
US7967772B2 (en) 2004-01-12 2011-06-28 Iscience Interventional Corporation Injector for viscous materials
GB2410188B (en) * 2004-01-23 2006-01-25 Medical House Plc Injection device
US7670314B2 (en) 2004-02-17 2010-03-02 Children's Hospital Medical Center Injection device for administering a vaccine
WO2005091922A2 (fr) * 2004-03-03 2005-10-06 Becton, Dickinson And Company Procedes et dispositifs pour l'amelioration de l'administration cutanee d'une substance
EP1732629B1 (fr) 2004-03-30 2019-04-24 Eli Lilly And Company Appareil d'administration de medicament comprenant une caracteristique de verrouillage au moyen d'un ressort pour l'administration d'une dose finale
ATE526052T1 (de) 2004-03-30 2011-10-15 Lilly Co Eli Medikationsabgabegerät mit getriebeset mit einer öffnung zur aufnahme eines antriebselements
DE202004006611U1 (de) 2004-04-23 2005-08-25 Tecpharma Licensing Ag Injektionsgerät zur Verabreichung eines injizierbaren Produkts mit gesicherter Dosiereinrichtung
GB2414404B (en) 2004-05-28 2009-06-03 Cilag Ag Int Injection device
US20050273054A1 (en) 2004-06-03 2005-12-08 Florida Atlantic University Epinephrine auto-injector
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
US7572613B2 (en) 2004-06-25 2009-08-11 Klein Jeffrey A Drug delivery system for accelerated subcutaneous absorption
US7615041B2 (en) 2004-07-29 2009-11-10 Boston Scientific Scimed, Inc. Vial adaptor
US8048035B2 (en) 2004-08-06 2011-11-01 Meridian Medical Technologies, Inc. Automatic injector with needle cover
US7449012B2 (en) 2004-08-06 2008-11-11 Meridian Medical Technologies, Inc. Automatic injector
US20080262445A1 (en) 2004-09-08 2008-10-23 Dermatrends, Inc. Transdermal Delivery of Hydrophobic Bioactive Agents
JP5016490B2 (ja) 2004-09-24 2012-09-05 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬剤デリバリ装置のためのキャップ
AU2005291585B2 (en) 2004-10-04 2011-04-07 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
EP1642607A1 (fr) 2004-10-04 2006-04-05 Sanofi-Aventis Deutschland GmbH Mécanisme d'affichage de dose destiné à un dispositif d'administration de médicament
US8313763B2 (en) 2004-10-04 2012-11-20 Tolmar Therapeutics, Inc. Sustained delivery formulations of rapamycin compounds
WO2006044390A2 (fr) 2004-10-14 2006-04-27 Safety Medical International, Inc. Seringue medicale de securite a aiguille retractable
US8083711B2 (en) 2004-10-21 2011-12-27 Novo Nordisk A/S Injection device with internal dose indicator
AU2005298946B2 (en) 2004-10-21 2011-06-09 Novo Nordisk A/S Injection device with torsion spring and rotatable display
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
CN101087625B (zh) 2004-11-22 2012-02-22 因特利杰克特有限公司 用于药物供给的装置和系统
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
AU2005310060B2 (en) 2004-11-24 2010-01-14 Shl Medical Ag Injection device
US7905352B2 (en) 2004-12-06 2011-03-15 Washington Biotech Corporation Kits containing medicine injection devices and containers
US7621891B2 (en) 2004-12-06 2009-11-24 Washington Biotech Corporation Method and apparatus for delivering epinephrine
US20060129122A1 (en) 2004-12-06 2006-06-15 Wyrick Ronald E Method and apparatus for delivering epinephrine
US7297136B2 (en) 2004-12-06 2007-11-20 Wyrick Ronald E Medicine injection devices and methods
US8123724B2 (en) 2004-12-09 2012-02-28 West Pharmaceutical Services Of Delaware, Inc. Auto-injection syringe having vent device
US7403261B2 (en) 2004-12-15 2008-07-22 Asml Netherlands B.V. Lithographic apparatus and device manufacturing method
DE102004063648A1 (de) 2004-12-31 2006-07-20 Tecpharma Licensing Ag Injektions- oder Infusionsgerät mit Lebensdauer-Ermittlungseinrichtung
PL1843809T3 (pl) 2005-01-21 2017-09-29 Novo Nordisk A/S Automatyczne urządzenie wstrzykujące z górnym mechanizmem wyzwalania
DK1850892T4 (da) * 2005-01-24 2023-06-06 Antares Pharma Inc Forfyldt nål-assisteret sprøjtejetinjektor
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
NZ560516A (en) 2005-02-01 2010-12-24 Intelliject Inc A delivery system where a medicant is automatically delivered on activation as well as a recorded instruction
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
CN101115520B (zh) 2005-02-11 2010-04-21 诺和诺德公司 注射装置
DE102005017477A1 (de) 2005-02-18 2006-08-31 Tecpharma Licensing Ag Feder in einem oder für ein Injektionsgerät
DE102005008280B3 (de) 2005-02-23 2006-07-13 Tecpharma Licensing Ag Verabreichungsvorrichtung mit Anzeigetrommel
US8017633B2 (en) 2005-03-08 2011-09-13 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
JP4353113B2 (ja) 2005-03-14 2009-10-28 ヤマハ株式会社 オーディオミキサのパラメータ設定装置
US7390319B2 (en) 2005-04-13 2008-06-24 Steven Friedman Automatic needle injector having safety triggering mechanism
US20090043264A1 (en) 2005-04-24 2009-02-12 Novo Nordisk A/S Injection Device
CH699723B1 (de) 2005-04-25 2010-04-30 Tecpharma Licensing Ag Vorrichtung zur Verabreichung eines fluiden Produkts.
ATE495775T1 (de) 2005-05-10 2011-02-15 Novo Nordisk As Injektionsvorrichtung mit optischem sensor
DE102005023824A1 (de) 2005-05-24 2006-12-07 Tecpharma Licensing Ag Dosiervorrichtung für eine Injektionsvorrichtung
DE102005023854B4 (de) 2005-05-24 2020-12-17 Tecpharma Licensing Ag Dosiervorrichtung für eine Injektionsvorrichtung
EP1907031A2 (fr) 2005-05-31 2008-04-09 Novo Nordisk A/S Dispositif d'injection comprenant une indication visuelle de fin de contenu
WO2006130098A1 (fr) 2005-06-01 2006-12-07 Shl Medical Ab Administrateur de doses posologiques
DK2364742T4 (da) 2005-06-01 2025-08-18 Shl Medical Ag Anordning til afgivelse af lægemiddel
EP1904145A2 (fr) 2005-07-06 2008-04-02 Washington Biotech Corp. Procede et appareil de delivrance d'epinephrine
ATE519513T1 (de) 2005-07-08 2011-08-15 Novo Nordisk As Injektionsvorrichtung
US7955304B2 (en) 2005-07-15 2011-06-07 Shl Group Ab Injector
US8998881B2 (en) 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
GB0517699D0 (en) 2005-09-01 2005-10-05 Owen Mumford Ltd Needle shroud assembly
US20070185432A1 (en) 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20110098656A1 (en) 2005-09-27 2011-04-28 Burnell Rosie L Auto-injection device with needle protecting cap having outer and inner sleeves
AU2006304009A1 (en) 2005-10-11 2007-04-26 Eli Lilly And Company Apparatus for injecting a pharmaceutical
US7611502B2 (en) 2005-10-20 2009-11-03 Covidien Ag Connector for enteral fluid delivery set
DE102005052502A1 (de) 2005-11-03 2007-05-16 Tecpharma Licensing Ag Autoinjektor-Aktivierung Auslöseelement
GB0524604D0 (en) 2005-12-02 2006-01-11 Owen Mumford Ltd Injection method and apparatus
GB0524962D0 (en) 2005-12-07 2006-01-18 Pharmakodex Ltd Topical pharmaceutical compositions
GB2433032A (en) 2005-12-08 2007-06-13 Owen Mumford Ltd Syringe with dose adjustment means
US7988675B2 (en) 2005-12-08 2011-08-02 West Pharmaceutical Services Of Delaware, Inc. Automatic injection and retraction devices for use with pre-filled syringe cartridges
EP1962947A4 (fr) 2005-12-20 2017-06-28 Antares Pharma, Inc. Dispositif d'injection sans aiguille
TW200744697A (en) 2006-02-28 2007-12-16 Verus Pharmaceuticals Inc Shock absorber for an automatic injector
JP5062768B2 (ja) 2006-03-10 2012-10-31 ノボ・ノルデイスク・エー／エス 注射装置および該装置のカートリッジを交換する方法
US8361036B2 (en) 2006-03-10 2013-01-29 Novo Nordisk A/S Injection device having a gearing arrangement
EP1999666A1 (fr) 2006-03-20 2008-12-10 Novo Nordisk A/S Module électronique pour système mécanique de délivrance de médicaments
US20090069756A1 (en) 2006-03-20 2009-03-12 Novo Nordisk A/S Determination of Cartridge Content by Capacitive Means
FR2899482A1 (fr) 2006-04-11 2007-10-12 Becton Dickinson France Soc Pa Dispositif d'injection automatique
DE102006017209A1 (de) 2006-04-12 2007-10-18 Tecpharma Licensing Ag Injektionsvorrichtung mit Spannfeder und Spannelement
JP4982722B2 (ja) 2006-04-19 2012-07-25 ノボ・ノルデイスク・エー／エス 流体注入システム、同システムの組み立て方法、及び同システムに使用される薬剤容器
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
GB2465919B (en) 2006-05-10 2010-12-08 Owen Mumford Ltd Injection device with cap that can be re-fitted post injection
GB2437924B (en) 2006-05-11 2010-12-22 Owen Mumford Ltd Injection device
US8226618B2 (en) 2006-05-16 2012-07-24 Novo Nordisk A/S Gearing mechanism for an injection device
AU2007253481B2 (en) 2006-05-18 2013-01-17 Novo Nordisk A/S An injection device with mode locking means
CA2653401A1 (fr) 2006-05-29 2007-12-06 Novo Nordisk A/S Mecanisme pour dispositif d'injection
EP2029198B1 (fr) 2006-05-30 2010-06-23 Eli Lilly And Company Module pour dispositif d'injection de médication englobant un contenant primaire, un contenant secondaire et une cassette d'aiguilles
US20070293582A1 (en) 2006-06-05 2007-12-20 Malcolm Hill Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms
WO2007147741A1 (fr) 2006-06-21 2007-12-27 Novo Nordisk A/S Mécanisme de mélange et d'expulsion de médicament à une main
KR101440795B1 (ko) 2006-06-30 2014-09-22 애브비 바이오테크놀로지 리미티드 자동 주사 장치
US8574199B2 (en) 2006-07-03 2013-11-05 Novo Nordisk A/S Coupling for injection devices
ITMO20060222A1 (it) 2006-07-10 2008-01-11 Alfio Bertolini Pacchetto di medicazione antiemorragico
DE102006033837A1 (de) 2006-07-21 2008-01-31 Medac Gesellschaft für klinische Spezialpräparate m.b.H Konzentrierte Methotrexat-Lösungen
DE102006038101A1 (de) 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injektionsvorrichtung mit Klauensicherung
DE102007001432A1 (de) 2006-08-14 2008-02-21 Tecpharma Licensing Ag Dosiermechaniksperrung
CN101511410B (zh) 2006-08-28 2013-02-06 诺沃-诺迪斯克有限公司 适合于轴向锁紧和旋转松开的医用配送系统
DE102006041809B4 (de) 2006-09-06 2012-11-15 Tecpharma Licensing Ag Nadelschutzvorrichtung mit Blockiereinrichtung
DE102006042236A1 (de) 2006-09-06 2008-03-27 Tecpharma Licensing Ag Nadelschutzvorrichtung mit blockierter Schutzposition
DE102006042233B3 (de) 2006-09-06 2008-03-06 Tecpharma Licensing Ag Nadelschutzvorrichtung mit distalem und proximalem Nadelschutz
FR2905273B1 (fr) 2006-09-06 2009-04-03 Becton Dickinson France Soc Pa Dispositif d'injection automatique avec moyen de temporisation.
JP2010503430A (ja) 2006-09-15 2010-02-04 テクファーマ・ライセンシング・アクチェンゲゼルシャフト 低損失駆動部を備える注射装置
AU2007301890B2 (en) 2006-09-29 2012-08-16 Novo Nordisk A/S An injection device with electronic detecting means
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
US7811254B2 (en) 2006-10-18 2010-10-12 Meridian Medical Technologies, Inc. Autoinjector with needle depth adapter
WO2008047372A2 (fr) 2006-10-19 2008-04-24 Elcam Medical Agricultural Cooperative Association Ltd. Dispositif d'injection automatique
EP1923084A1 (fr) 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Mechanisme de dosage et transmission pour dispositif d'administration de médicament
EP1923083A1 (fr) 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Mécanismes d'entraînement destinés à être utilisés dans des dispositifs d'administration de médicaments
DK2099384T3 (en) 2006-11-28 2018-10-08 Hoffmann La Roche IMPLEMENTATION DEVICE AND PROCEDURE FOR INTRODUCING A SUBCUTANT IMPORTANT ELEMENT IN A BODY
WO2008071804A1 (fr) 2006-12-15 2008-06-19 Novo Nordisk A/S Système distributeur médical comprenant un conteneur et un ensemble doseur avec élément de fixation à déplacement radial
CN101600468B (zh) 2006-12-21 2012-12-12 诺沃-诺迪斯克有限公司 注射器装置
ATE473772T1 (de) 2007-01-17 2010-07-15 Shl Group Ab Vorrichtung zur abgabe von medikamenten
DE102007004211A1 (de) 2007-01-27 2008-07-31 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit mindestens einem Zughaken
AU2008213084B2 (en) 2007-02-05 2013-03-28 Novo Nordisk A/S Injection button
WO2008106806A1 (fr) 2007-03-02 2008-09-12 Tecpharma Licensing Ag Système d'administration modulaire
JP2010519993A (ja) 2007-03-07 2010-06-10 ノボ・ノルデイスク・エー／エス 複数のリザーバを備える薬剤送達デバイス
JP5361744B2 (ja) 2007-03-07 2013-12-04 ノボ・ノルデイスク・エー／エス 後方針
ES2657483T3 (es) 2007-03-09 2018-03-05 Eli Lilly And Company Mecanismo de retardo para un dispositivo de inyección automática
KR100820523B1 (ko) 2007-03-14 2008-04-08 홍관호 채혈기
WO2008116031A2 (fr) 2007-03-21 2008-09-25 Safety Medical International, Inc. Seringue médicale de sécurité avec aiguille rétractable et comprenant un plongeur qui est reçu dans un cylindre
CN101678167B (zh) 2007-03-22 2013-09-18 特克法马许可公司 注射装置中的弹簧机构
CA2681023C (fr) 2007-03-23 2015-11-03 Novo Nordisk A/S Dispositif d'injection comprenant un ecrou de blocage
CN101678170B (zh) 2007-03-23 2012-05-30 Shl集团有限责任公司 自动注射器
GB0705782D0 (en) 2007-03-26 2007-05-02 Novartis Ag Vial assemblies
DE102007016811A1 (de) 2007-04-05 2008-10-09 Tecpharma Licensing Ag Vorrichtung zur Verabreichung eines fluiden Wirkstoffes aus einer Mehrkammerampulle
PL2144649T3 (pl) 2007-04-05 2012-01-31 Tecpharma Licensing Ag Aplikator wyposażony w człon napędowy z funkcją sterującą
DE102007018868A1 (de) 2007-04-19 2008-10-23 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit mindestens einem Zughaken und einem Schiebekeilgetriebe zum entsichernden Lösen eines Sperrelements
US8057427B2 (en) 2007-05-09 2011-11-15 Meridian Medical Technologies, Inc. Drug delivery system with a small amount of a therapeutic agent
EP2162230B1 (fr) 2007-05-14 2010-11-03 SHL Group AB Dispositif de distribution
DE102007026083A1 (de) 2007-05-25 2008-11-27 Haselmeier S.A.R.L. Injektionsgerät
ES2612032T3 (es) 2007-06-04 2017-05-11 Shear/Kershman Laboratories, Inc. Formas farmacéuticas orales basadas en lípidos inviolables para agonistas opiáceos
EP2192939B1 (fr) 2007-06-19 2011-03-16 SHL Group AB Dispositif de distribution de médicaments
WO2008157610A1 (fr) 2007-06-19 2008-12-24 Stat Medical Devices, Inc. Dispositif de lancette avec ajustement de profondeur et système d'extraction de lancette et procédé
DE102007030327A1 (de) 2007-06-29 2009-01-02 Tecpharma Licensing Ag Injektionsvorrichtung mit einer Feder für eine Nadelschutzhülse
WO2009007305A1 (fr) 2007-07-06 2009-01-15 Novo Nordisk A/S Dispositif d'injection automatique
JP4992147B2 (ja) 2007-07-06 2012-08-08 エス・ホー・エル・グループ・アクチボラゲット 二重ばねを有するワンショット注射器
GB2452030A (en) 2007-08-10 2009-02-25 Owen Mumford Ltd Injection devices
ES2651624T3 (es) 2007-09-25 2018-01-29 Becton Dickinson France Autoinjector recibido en un receptáculo externo
CN101854965B (zh) 2007-09-25 2013-02-13 贝克顿迪金森法国公司 具有可通过防护罩的运动定位在激活位置的触发装置和激活位置的指示的自动注射装置
WO2009040602A1 (fr) 2007-09-25 2009-04-02 Becton Dickinson France Dispositif d'injection automatique équipé de moyen de désactivation rendu mobile par une protection de sécurité
ES2710175T3 (es) 2007-09-25 2019-04-23 Becton Dickinson France Autoinyector con un medio de desactivación que se puede mover mediante un protector de seguridad
EP2211943B1 (fr) 2007-10-10 2016-12-21 SHL Group AB Dispositif de distribution médical
DE202008014334U1 (de) 2007-10-17 2009-02-26 Haselmeier S.A.R.L. Injektionsgerät
EP2201259B1 (fr) 2007-10-22 2013-12-11 Gkn Sinter Metals, Llc Cliquet à contrainte réduite et dent d'arrêt pour embrayage unidirectionnel
EP2224980B1 (fr) 2007-11-12 2018-07-25 Medicom Innovation Partner a/s Injecteur automatique avec points d'ancrage variables du propulseur mécanique
DE102007053743A1 (de) 2007-11-12 2009-06-10 Tecpharma Licensing Ag Drehbare Führungshülse mit überspannungsgesicherter Feder
WO2009063030A1 (fr) 2007-11-14 2009-05-22 Shl Group Ab Dispositif d'injection automatique comportant une fonction de retrait de seringue à déclenchement actif
CN101909673B (zh) 2007-12-31 2012-12-26 诺沃-诺迪斯克有限公司 电子监控的注射设备
GB0800103D0 (en) 2008-01-04 2008-02-13 Owen Mumford Ltd Sheath removver device
BRPI0923666A2 (pt) 2008-01-23 2012-12-25 Novo Nordisk As dispositivo de injeÇço para administrar doses distribuÍdas de fÁrmaco lÍquido
WO2009100550A1 (fr) 2008-02-11 2009-08-20 Tecpharma Licensing Ag Système d'administration de produit à élément d'actionnement pouvant être bloqué
WO2009101005A1 (fr) 2008-02-12 2009-08-20 Shl Group Ab Auto-injecteur
DE102008011881A1 (de) 2008-02-29 2009-09-10 Tecpharma Licensing Ag Leerschießgeschwindigkeitsbegrenzungsbremse
US8814834B2 (en) 2008-03-10 2014-08-26 Antares Pharma, Inc. Injector safety device
US8177758B2 (en) 2008-04-08 2012-05-15 Rochester Area Consulting Engineers (RACE) Pneumatic injector
US8647309B2 (en) 2008-05-02 2014-02-11 Sanofi-Aventis Deutschland Gmbh Medication delivery device
US8187233B2 (en) 2008-05-02 2012-05-29 Sanofi-Aventis Deutschland Gmbh Medication delivery device
GB2460398A (en) 2008-05-20 2009-12-02 Owen Mumford Ltd Auto-injector having a magnetic injection indicator and a needle sheath retainer
EP2288400B1 (fr) 2008-05-20 2012-09-19 Tecpharma Licensing AG Dispositif d'administration d'un produit injectable comportant une indication de quantité résiduelle
WO2009147026A1 (fr) 2008-06-02 2009-12-10 Shl Group Ab Dispositif d'administration de médicament
AT506690B1 (de) 2008-06-16 2009-11-15 Pharma Consult Ges M B H & Co Injektionsvorrichtung
GB2461088B (en) 2008-06-19 2012-09-26 Cilag Gmbh Int Injection device
WO2009155277A1 (fr) 2008-06-20 2009-12-23 West Pharmaceutical Services, Inc. Mécanisme d'injection automatique avec renfort frontal
EP2310073B1 (fr) 2008-07-09 2012-10-24 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicament et procédé de montage d'un dispositif d'administration de médicament
SI2307079T1 (sl) 2008-07-15 2015-10-30 Shl Group Ab, Ipr Department Naprava za dajanje zdravila
CN102131539B (zh) 2008-07-17 2013-04-24 医疗卫士有限公司 一种可缩回注射器
EP3581224A1 (fr) 2008-08-05 2019-12-18 Antares Pharma, Inc. Injecteur à dosage multiple
DE202008011175U1 (de) 2008-08-18 2010-01-07 Haselmeier Gmbh Injektionsgerät
GB2462811B (en) 2008-08-18 2012-08-15 Medical House Ltd Improved autoinjector
GB2463034B (en) 2008-08-28 2012-11-07 Owen Mumford Ltd Autoinjection devices
BRPI0918845A2 (pt) 2008-08-29 2015-12-08 Novo Nordisk As dispositivo médico de injeção com indicador de retardo de tempo
DK2355866T3 (en) 2008-10-01 2014-02-24 Shl Group Ab The drug delivery mechanism EVOLUTFJEDER
ES2393173T5 (es) 2008-10-13 2020-06-26 Sanofi Aventis Deutschland Dispositivo para administración de fármacos y método de fabricación de un dispositivo para administración de fármacos
US8568434B2 (en) 2008-10-14 2013-10-29 Bionime Corporation Lancing device
BRPI0919925B8 (pt) 2008-10-24 2021-06-22 Novo Nordisk As mecanismo de seletor descendente para dispositivo de injeção
WO2010056986A2 (fr) 2008-11-14 2010-05-20 The Board Of Regents Of The University Of Texas System Mécanisme à nanocanal et méthodes associées
EP2355877B1 (fr) 2008-12-12 2016-11-16 SHL Group AB Dispositif de fixation d'élément d'apport
US9186458B2 (en) 2008-12-12 2015-11-17 Shl Group Ab Medicament delivery device
EP2196233A1 (fr) 2008-12-12 2010-06-16 Sanofi-Aventis Deutschland GmbH Mécanisme de commande réenclenchable pour dispositif d'administration de médicaments et dispositif d'administration de médicaments
DK2376149T3 (en) 2008-12-12 2014-11-24 Shl Group Ab Drug delivery device
CN102307610B (zh) 2008-12-12 2014-02-12 Shl集团有限责任公司 药物供给装置
WO2010066591A1 (fr) 2008-12-12 2010-06-17 Shl Group Ab Dispositif d'administration de médicaments
JP5194176B2 (ja) 2008-12-12 2013-05-08 エス・ホー・エル・グループ・アクチボラゲット 薬剤送達装置
GB0823693D0 (en) 2008-12-31 2009-02-04 Owen Mumford Ltd Autoinjector
EP2208503A1 (fr) 2009-01-20 2010-07-21 Sanofi-Aventis Deutschland GmbH Ensemble de commande et dispositif d'administration de médicaments
WO2010084084A1 (fr) 2009-01-23 2010-07-29 Sanofi-Aventis Deutschland Gmbh Système d'identification de médicament pour dispositifs d'injection multi-dose
EP2393062A4 (fr) 2009-01-29 2013-01-23 Nec Corp Procédé de traitement d'image couleur, dispositif de traitement d'image couleur et support d'enregistrement
WO2010086273A1 (fr) 2009-01-30 2010-08-05 Sanofi-Aventis Deutschland Gmbh Cartouche et dispositif d'administration de médicament
DK2393533T3 (en) 2009-02-05 2015-06-29 Sanofi Aventis Deutschland DELIVERY DEVICE FOR medications
GB0901801D0 (en) 2009-02-05 2009-03-11 Medical House Plc The Improved autoinjector
NZ594318A (en) 2009-02-05 2012-12-21 Sanofi Aventis Deutschland Medicament delivery devices with a telescopic piston rod assembly
WO2010093834A2 (fr) 2009-02-12 2010-08-19 Incube Labs, Llc Dispositif pénétrant la peau et procédé d'administration sous-cutanée de médicaments solides
WO2010097116A1 (fr) 2009-02-26 2010-09-02 Tecpharma Licensing Ag Support de réservoir à produit pour un dispositif d'injection et pour la réception d'un réservoir à produit
US8372042B2 (en) 2009-02-26 2013-02-12 Shl Group Ab Dose setting mechanism
US8366682B2 (en) 2009-03-04 2013-02-05 Washington Biotech Corporation Medicine injection apparatuses
US20120116306A1 (en) 2009-03-05 2012-05-10 Sanofi-Aventis Deutschland Gmbh Needle unit
CA2763555A1 (fr) 2009-03-05 2010-09-10 Sanofi-Aventis Deutschland Gmbh Ensemble aiguille
EP2403569B1 (fr) 2009-03-05 2014-04-23 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicaments avec aiguille retractable
EP2403561B1 (fr) 2009-03-06 2017-10-18 Sanofi-Aventis Deutschland GmbH Seringue, dispositif d'auto-injecteur et ensemble de dispositifs d'auto-injecteur et seringues
JP2012519575A (ja) 2009-03-09 2012-08-30 パーデュー・リサーチ・ファウンデーション 物質を迅速に混合し患者に送達するための小型装置
CN102348476B (zh) 2009-03-13 2014-06-25 伊莱利利公司 注射之后注射器自动缩回的用于注射药物的装置
EP2408493B1 (fr) 2009-03-20 2024-07-24 Antares Pharma, Inc. Système d'injection d'agents dangereux
KR101713538B1 (ko) 2009-03-30 2017-03-08 사노피-아벤티스 도이칠란트 게엠베하 개선된 피스톤 로드를 갖는 약제 운반 디바이스
DK2414008T3 (en) 2009-03-31 2016-04-18 Sanofi Aventis Deutschland Medical device with a mechanical with a spring and use of a wave spring or wave disc in a medical device
JP5787875B2 (ja) 2009-03-31 2015-09-30 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 機構を有する医療デバイス及び医療デバイス内における低摩擦合成材料の使用
DK2414003T3 (en) 2009-03-31 2015-08-24 Sanofi Aventis Deutschland Device for pharmaceutical feed
CN102448515B (zh) 2009-03-31 2014-07-23 赛诺菲-安万特德国有限公司 用于给药设备的安装装置和联接组件
CN102448521B (zh) 2009-03-31 2014-07-23 赛诺菲-安万特德国有限公司 药物递送装置
DK2414007T3 (en) 2009-03-31 2015-06-08 Sanofi Aventis Deutschland PHARMACEUTICAL Feed mechanism
CN102422336B (zh) 2009-03-31 2016-01-20 赛诺菲-安万特德国有限公司 使用粘结剂制造药物递送装置主体的方法和药物递送装置主体
CA2756141A1 (fr) 2009-03-31 2010-10-07 Sanofi-Aventis Deutschland Gmbh Corps de dispositif d'administration de medicament
US9457148B2 (en) 2009-04-01 2016-10-04 Shl Group Ab Medicament delivery device
DK2414005T3 (en) 2009-04-03 2017-09-11 Shl Group Ab Drug delivery device
US8424768B2 (en) 2009-04-09 2013-04-23 Metrologic Instruments, Inc. Trigger mechanism for hand held devices
GB0906640D0 (en) 2009-04-17 2009-06-03 Owen Mumford Ltd A needle cap assembly
GB2469672B (en) 2009-04-23 2013-09-25 Medical House Ltd Improved autoinjector
CN102802699B (zh) 2009-04-24 2014-10-22 Shl集团有限责任公司 药物递送装置
DK2424599T3 (da) 2009-04-27 2020-08-24 Shl Medical Ag Sikkerhedspenkanyleindretning
US8636704B2 (en) 2009-04-29 2014-01-28 Abbvie Biotechnology Ltd Automatic injection device
US9227009B2 (en) 2009-04-30 2016-01-05 Sanofi-Aventis Deutschland Gmbh Pen-type injector with ergonomic button arrangement
CA2768000A1 (fr) 2009-04-30 2010-11-04 Sanofi-Aventis Deutschland Gmbh Connexion ajustable axialement d'une tige de piston a un piston pour un mecanisme d'entrainement dans un dispositif d'administration de medicament
GB0907534D0 (en) 2009-05-01 2009-06-10 Owen Mumford Ltd Injection devices
WO2010127449A1 (fr) 2009-05-07 2010-11-11 Medical Injection Devices Inc. Dispositif de délivrance d'un médicament
DK2954914T3 (en) 2009-05-29 2019-03-11 Tecpharma Licensing Ag Injection device, especially auto-injector with plug protection and / or overload protection for a product container
US9125994B2 (en) 2009-06-01 2015-09-08 Sanofi—Aventis Deutschland GmbH Drug delivery device with dose dial sleeve rotational stop
US9457150B2 (en) 2009-06-01 2016-10-04 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a drug delivery device
US8974423B2 (en) 2009-06-01 2015-03-10 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
US9199040B2 (en) 2009-06-01 2015-12-01 Sanofi-Aventis Deutschland Gmbh Drug delivery device last dose lock-out mechanism
US9345840B2 (en) 2009-06-01 2016-05-24 Sanofi-Aventis Deutschland Gmbh Drug delivery dose setting mechanism with variable maximum dose
US20110015576A1 (en) 2009-06-01 2011-01-20 Sanofi-Aventis Deutschland Gmbh Medicament identification system for multi-dose injection devices
US10034982B2 (en) 2009-06-01 2018-07-31 Sanofi-Aventis Deutschland Gmbh Spindle for a drug delivery device
US9238106B2 (en) 2009-06-01 2016-01-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US8672896B2 (en) 2009-06-01 2014-03-18 Sanofi-Aventis Deutschland Gmbh Inner housing for a drug delivery device
US9623187B2 (en) 2009-06-01 2017-04-18 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
US8585656B2 (en) 2009-06-01 2013-11-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US8257319B2 (en) 2009-06-01 2012-09-04 Sanofi-Aventis Deutschland Gmbh Drug delivery device inner housing having helical spline
US9950116B2 (en) 2009-06-01 2018-04-24 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US8728043B2 (en) 2009-06-01 2014-05-20 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
US9463283B2 (en) 2009-06-01 2016-10-11 Sanofi-Aventis Deutschland Gmbh Dosing mechanism for a drug deliver device
US9108007B2 (en) 2009-06-01 2015-08-18 Sanofi-Aventis Deutschland Gmbh Spindle and bearing combination and drug delivery device
TW201103592A (en) 2009-06-02 2011-02-01 Sanofi Aventis Deutschland Medicated module for a drug delivery device
AR076623A1 (es) 2009-06-02 2011-06-22 Sanofi Aventis Deutschland Suministro de dos o mas medicamentos por medio de una unica seleccion de dosis e interfaz de dispensacion
AR076718A1 (es) 2009-06-02 2011-06-29 Sanofi Aventis Deutschland Modulo medicinal con seleccion del usuario
AR076716A1 (es) 2009-06-02 2011-06-29 Sanofi Aventis Deutschland Modulo medicado con medicamento de premezcla
TW201109058A (en) 2009-06-02 2011-03-16 Sanofi Aventis Deutschland Medicated module with needle guard
TW201109056A (en) 2009-06-02 2011-03-16 Sanofi Aventis Deutschland Delivery of two or more medicaments through a single dose selection and single dispense interface
WO2010140974A1 (fr) 2009-06-05 2010-12-09 Shl Group Ab Dispositif d'administration de médicament
US20100324480A1 (en) 2009-06-17 2010-12-23 Thomas Chun Automatic injection syringe assembly
EP2445551B1 (fr) 2009-06-23 2019-09-18 Tecpharma Licensing AG Dispositif d'injection muni d'un mécanisme de dosage pour limiter un réglage de dose
GB2471304B (en) 2009-06-24 2013-12-11 Oval Medical Technologies Ltd A pre-filled syringe or autoinjector
WO2010149214A1 (fr) 2009-06-24 2010-12-29 Tecpharma Licensing Ag Appareil d’administration à fonction d’amorçage
EP2266647A1 (fr) 2009-06-25 2010-12-29 Sanofi-Aventis Deutschland GmbH Mécanisme d'entraînement pour dispositif d'administration de médicament
GB2471473A (en) 2009-06-30 2011-01-05 Owen Mumford Ltd Syringe sheath remover
US8263581B2 (en) 2009-07-03 2012-09-11 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
TWI393578B (zh) 2009-07-07 2013-04-21 Shl Group Ab 注射裝置
JP5778143B2 (ja) 2009-07-08 2015-09-16 ノボ・ノルデイスク・エー／エス 自動プライミング注射装置
US9616175B2 (en) 2009-07-08 2017-04-11 Novo Nordisk A/S Frost protected injection device
GB2471726B (en) 2009-07-10 2013-09-11 Oval Medical Technologies Ltd A pre-filled syringe including an oxygen absorber
CA2765441A1 (fr) 2009-07-14 2011-01-20 Sanofi-Aventis Deutschland Gmbh Agencement d'injection
EP2453956A1 (fr) 2009-07-15 2012-05-23 Sanofi-Aventis Deutschland GmbH Ensemble d'entraînement pour injecteur de type stylo et injecteur de type stylo avec ensemble d'entraînement
BR112012000786A2 (pt) 2009-07-15 2016-02-23 Sanofi Aventis Deutschland conjunto de mancal de impulso, sistema de direção, e dispositivo de envio de medicamento
CN102470213A (zh) 2009-07-15 2012-05-23 赛诺菲-安万特德国有限公司 用于注射装置的驱动机构及具有该驱动机构的注射装置
GB0913385D0 (en) 2009-07-31 2009-09-16 Medical House The Plc Improved autoinjector
CN102470217B (zh) 2009-07-31 2014-09-17 Shl集团有限责任公司 药物容器保持器装置
GB2472578A (en) 2009-08-10 2011-02-16 Owen Mumford Ltd Sheath removal device and needle protector
JP5279953B2 (ja) 2009-08-21 2013-09-04 エス・ホー・エル・グループ・アクチボラゲット 安全ペン型注射針装置
CN102573963B (zh) 2009-08-24 2014-09-24 Shl集团有限责任公司 剂量重置机构及包括该剂量重置机构的药物递送装置
FR2949284B1 (fr) 2009-08-24 2011-09-09 Alcatel Lucent Representation des degradations physiques dans un reseau de communication optique
AU2010288506B2 (en) 2009-08-27 2014-10-30 Sanofi-Aventis Deutschland Gmbh Reminder device for drug delivery devices
US9089646B2 (en) 2009-08-27 2015-07-28 Sanofi-Aventis Deutshcland GmbH Housing component for a drug delivery device
EP2475411B1 (fr) 2009-09-07 2014-12-31 Sanofi-Aventis Deutschland GmbH Mécanisme d'entrainement pour dispositif d'approvisionnement de médicament
JP5701882B2 (ja) 2009-09-10 2015-04-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬剤容器
EP2477681B1 (fr) 2009-09-18 2014-06-25 Sanofi-Aventis Deutschland GmbH Unité de verrouillage et de contrôle à intégrer dans un appareil médical
CN102510762B (zh) 2009-09-23 2015-08-12 赛诺菲-安万特德国有限公司 用于药物输送装置的组件和药物输送装置
CA2772686C (fr) 2009-09-23 2018-01-02 Sanofi-Aventis Deutschland Gmbh Ensemble et indicateur pour un dispositif de distribution de medicaments
DE102009048497A1 (de) 2009-09-26 2011-03-31 Haselmeier Gmbh Injektionsgerät
TW201121600A (en) 2009-09-29 2011-07-01 Sanofi Aventis Deutschland Assembly for a drug delivery device
WO2011039201A2 (fr) 2009-09-30 2011-04-07 Sanofi-Aventis Deutschland Gmbh Mécanisme d'entraînement pour un dispositif de distribution de médicaments, et élément élastique pour un mécanisme d'entraînement
US9375534B2 (en) 2009-09-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
TW201121601A (en) 2009-09-30 2011-07-01 Sanofi Aventis Deutschland Drive assembly, piston rod, drug delivery device, and use of a spring
DK2482891T3 (en) 2009-09-30 2017-02-06 Sanofi Aventis Deutschland RETRIEVABLE DRIVING AND PHARMACEUTICAL SUPPLY
AR078459A1 (es) 2009-09-30 2011-11-09 Sanofi Aventis Deutschland Conjunto de accionamiento, vastago de piston, dispositivo para la entrega de drogas, y uso de un resorte
EP2482878B1 (fr) 2009-09-30 2016-12-14 Sanofi-Aventis Deutschland GmbH Dispositif de délivrance de médicaments, ensemble de dispositif de délivrance de médicaments et procédé de montage d'un dispositif de délivrance de médicaments
BR112012007310A2 (pt) 2009-09-30 2016-04-19 Sanofi Aventis Deutschland mecanismo de acionamento para um dispositivo de entrega de fármaco e uso de um membro de reajuste para um mecanismo de acionamento
DK2482890T3 (en) 2009-09-30 2015-03-02 Sanofi Aventis Deutschland KEY ELEMENT OF OPERATION a driving device
DK2482887T3 (da) 2009-09-30 2014-10-27 Sanofi Aventis Deutschland Drivmekanisme til en lægemiddelfremføringsanordnng
US20120283660A1 (en) 2009-09-30 2012-11-08 Sanofi-Aventis Deutschland Gmbh Method and assembly for a drug delivery device
EP2482873A1 (fr) 2009-09-30 2012-08-08 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicament
CA2774578A1 (fr) 2009-09-30 2011-04-07 Sanofi-Aventis Deutschland Gmbh Ensemble destine a l'utilisation dans un dispositif d'administration de medicament
WO2011039209A1 (fr) 2009-09-30 2011-04-07 Sanofi-Aventis Deutschland Gmbh Ensemble tige de manoeuvre pour dispositif de distribution de médicament
JP5805092B2 (ja) 2009-09-30 2015-11-04 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 注射デバイス
CN102639170B (zh) 2009-09-30 2014-10-15 Shl集团有限责任公司 药物输送装置
AR078457A1 (es) 2009-09-30 2011-11-09 Sanofi Aventis Deutschland Mecanismo accionador para un dispositivo de descarga de farmacos
US8414533B2 (en) 2009-10-08 2013-04-09 Shl Group Ab Medicament delivery device
WO2011042540A1 (fr) 2009-10-08 2011-04-14 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection de médicament avec élément de verrouillage
US8882748B2 (en) 2009-10-08 2014-11-11 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including chemical permeation enhancers
CA2776352A1 (fr) 2009-10-08 2011-04-14 Sanofi-Aventis Deutschland Gmbh Dispositif de delivrance de medicament au moyen d'elements en plastique biodegradables
WO2011044589A2 (fr) 2009-10-09 2011-04-14 Board Of Regents, The University Of Texas System Procédés et appareil d'administration de médicaments ophtalmologiques photokinésiques
KR101762327B1 (ko) 2009-10-15 2017-07-27 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 정전기 소산성 ｔｐｕ 및 이의 조성물
US9108003B2 (en) 2009-10-16 2015-08-18 Sanofi-Aventis Deutschland Gmbh Drug delivery device
US9592341B2 (en) 2009-10-16 2017-03-14 Sanofi-Aventis Deutschland Gmbh Arrangement for use in a drug delivery device
GB0918145D0 (en) 2009-10-16 2009-12-02 Owen Mumford Ltd Injector apparatus
EP2311513A1 (fr) 2009-10-16 2011-04-20 Sanofi-Aventis Deutschland GmbH Ensemble support de cartouche pour dispositif d'administration de médicaments
EP3366337B1 (fr) 2009-10-21 2019-12-04 Owen Mumford Limited Auto-injecteur
EA023812B1 (ru) 2009-10-23 2016-07-29 Массачусетс Инститьют Оф Текнолоджи Каталитический материал
CN102686255B (zh) 2009-10-23 2014-11-26 邦奥鲁夫森梅迪康股份有限公司 具有自动针保护功能的自动注射器
CN102665802B (zh) 2009-10-26 2014-06-25 Shl集团有限责任公司 药剂输送装置
JP5856966B2 (ja) 2009-10-30 2016-02-10 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス
JP5777629B2 (ja) 2009-11-03 2015-09-09 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス用のアセンブリ及び薬物送達デバイス
EP2496292B1 (fr) 2009-11-06 2014-08-20 SHL Group AB Dispositif d'administration de médicament
JP2013510668A (ja) 2009-11-11 2013-03-28 アルファテック スパイン， インコーポレイテッド ポータルを脊椎に固定する方法およびデバイス
EP2335755A1 (fr) 2009-12-17 2011-06-22 Sanofi-Aventis Deutschland GmbH Dispositif et procédé pour la fourniture de deux ou plusieurs agents de médicament
DK2506898T3 (da) 2009-12-02 2013-12-09 Sanofi Aventis Deutschland Medikamentleveringsanordning og pakning deraf
EP2329857A1 (fr) 2009-12-03 2011-06-08 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicament
GB0921295D0 (en) 2009-12-04 2010-01-20 Owen Mumford Ltd Injection appaeratus
JP5684982B2 (ja) 2009-12-04 2015-03-18 東レ・ダウコーニング株式会社 シリコーンオイルエマルジョン、その製造方法、およびシリコーンオイル組成物
EP2509663B1 (fr) 2009-12-07 2015-01-21 Sanofi-Aventis Deutschland GmbH Ensemble de commande pour dispositif d'administration de médicaments et dispositif d'administration de médicaments
US8856501B2 (en) 2009-12-14 2014-10-07 Sandisk Technologies Inc. Method and system for controlling operation of interconnected devices by circulating host capability without a centralized manager
ES2574057T3 (es) 2009-12-15 2016-06-14 Shl Group Ab Dispositivo de administración de medicamento
US9463279B2 (en) 2009-12-17 2016-10-11 Sanofi-Aventis Deutschland Gmbh Medical device and method of assembly
KR101828236B1 (ko) 2009-12-18 2018-02-13 사노피-아벤티스 도이칠란트 게엠베하 최대 투여량 제한요소를 갖는 투여량 설정기구
DE202010018328U1 (de) 2009-12-18 2015-08-18 Sanofi-Aventis Deutschland Gmbh Stopfen für eine Kartusche für Medikamentenabgabevorrichtungen
EP2515973B1 (fr) 2009-12-23 2018-02-21 Tecpharma Licensing AG Dispositif d'injection comportant une gaine de protection d'aiguille
EP3421028A3 (fr) 2010-01-22 2019-04-10 Sanofi-Aventis Deutschland GmbH Réservoir de médicaments démontable codé
EP3539595B1 (fr) 2010-01-22 2022-06-29 Sanofi-Aventis Deutschland GmbH Support de cartouche codé et attache activée par la taille de la cartouche
EP2351591A1 (fr) 2010-02-02 2011-08-03 Sanofi-Aventis Deutschland GmbH Assemblage pour dispositif d'administration de médicaments et dispositif d'administration de médicaments
JP5813013B2 (ja) 2010-02-05 2015-11-17 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング プッシュロッド起動薬用モジュール
WO2011095480A1 (fr) 2010-02-05 2011-08-11 Sanofi-Aventis Deutschland Gmbh Module médicamenteux équipé de deux gaines de protection
BR112012019658A2 (pt) 2010-02-05 2016-05-03 Sanofi Aventis Deutschland mecanismo de travamento para uso com um dispositivo de entrga de fármaco, módulo medicado e dispositivo de entrega de fármaco
US9358342B2 (en) 2010-02-05 2016-06-07 Sanofi-Aventis Deutschland Gmbh Flexible reservoir for a medicated module
AU2011212564B2 (en) 2010-02-05 2015-02-05 Sanofi-Aventis Deutschland Gmbh Medicated module with lockable needle guard
US9155838B2 (en) 2010-02-05 2015-10-13 Sanofi-Aventis Deutschland Gmbh Medicated module having a double needle guard
CN102821801B (zh) 2010-02-09 2014-10-01 Shl集团有限责任公司 药物递送装置
JP5950828B2 (ja) 2010-02-17 2016-07-13 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 注射デバイス
CA2790190A1 (fr) 2010-02-17 2011-08-25 Sanofi-Aventis Deutschland Gmbh Dispositif d'injection
US8808250B2 (en) 2010-02-18 2014-08-19 Sanofi-Aventis Deutschland Gmbh Auto-injector with a torsion spring
DK2536455T3 (da) 2010-02-18 2014-06-23 Sanofi Aventis Deutschland Fingerbeskyttelse til en injektionsanordning
JP5807022B2 (ja) 2010-02-18 2015-11-10 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 自動注射器
WO2011101376A1 (fr) 2010-02-18 2011-08-25 Sanofi-Aventis Deutschland Gmbh Mécanisme d'embrayage
EP2536451B1 (fr) 2010-02-18 2018-03-28 Sanofi-Aventis Deutschland GmbH Auto-injecteur avec un ressort à torsion
DK2536452T3 (da) 2010-02-18 2019-01-02 Sanofi Aventis Deutschland Autoinjektor
WO2011101382A1 (fr) 2010-02-22 2011-08-25 Sanofi-Aventis Deutschland Gmbh Auto-injecteur avec fourreau d'aiguille et capuchon de protection d'aiguille
WO2011101383A1 (fr) 2010-02-22 2011-08-25 Sanofi-Aventis Deutschland Gmbh Agencement de transmission de force pour auto-injecteur
WO2011101381A2 (fr) 2010-02-22 2011-08-25 Sanofi-Aventis Deutschland Gmbh Boîte de vitesse
UA110026C2 (uk) 2010-03-01 2015-11-10 Пристрій для автоматичного виконання ін'єкції з механізмом затримки, який включає в себе пересувальний елемент подвійного призначення
GB2478349A (en) 2010-03-05 2011-09-07 Owen Mumford Ltd Injection device having projections reducing the diameter of the syringe passage
EP2364739A1 (fr) 2010-03-09 2011-09-14 Sanofi-Aventis Deutschland GmbH Auto-injecteur réutilisable
EP2364740A1 (fr) 2010-03-09 2011-09-14 Sanofi-Aventis Deutschland GmbH Agencement pour transférer une translation de moyen de commande à un piston
AU2011224884B2 (en) 2010-03-09 2013-08-15 Shl Medical Ag Medicament delivery device
EP2364741A1 (fr) 2010-03-09 2011-09-14 Sanofi-Aventis Deutschland GmbH Mécanisme d'interverrouillage pour la définition d'une séquence d'opération d'un auto-injecteur
IT1398501B1 (it) 2010-03-10 2013-03-01 Menarini Int Operations Lu Sa Dispositivo autoiniettore di due dosi di farmaco
WO2011114430A1 (fr) 2010-03-15 2011-09-22 富士通株式会社 Station radio de base et procédé de réglage d'un paramètre radio
JP6087152B2 (ja) 2010-03-16 2017-03-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 注射デバイスのモータの制御方法及び制御装置
TWI633902B (zh) 2010-03-22 2018-09-01 賽諾菲阿凡提斯德意志有限公司 用於判定與醫療裝置有關的資訊之裝置、方法、系統及電腦程式
EP2550044A1 (fr) 2010-03-25 2013-01-30 Sanofi-Aventis Deutschland GmbH Module médicamenteux avec entrée en prise automatique du réservoir
CA2793790A1 (fr) 2010-03-25 2011-09-29 Sanofi-Aventis Deutschland Gmbh Module medicamenteux avec selection par l'utilisateur
TW201200190A (en) 2010-03-26 2012-01-01 Sanofi Aventis Deutschland Electro-mechanical drug delivery device
CN103120819B (zh) 2010-03-31 2015-05-06 Shl集团有限责任公司 药物输送设备
US8986259B2 (en) 2010-03-31 2015-03-24 Sanofi-Aventis Deutschland Gmbh Piston rod assembly for a drug delivery device
EP2552510B1 (fr) 2010-03-31 2017-02-15 Sanofi-Aventis Deutschland GmbH Ensemble de dispositifs d'administration de médicaments avec aides d'identification tactiles ou visuelles
AU2011238967B2 (en) 2010-04-07 2013-08-15 Shl Medical Ag Medicament delivery device
JP5828886B2 (ja) 2010-04-09 2015-12-09 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイスと一緒に使用するためのコード化されたキャップ
CA2796570A1 (fr) 2010-04-23 2011-10-27 Sanofi-Aventis Deutschland Gmbh Element de retenue de cartouche et interface d'alignement
CA2796790A1 (fr) 2010-04-23 2011-10-27 Sanofi-Aventis Deutschland Gmbh Ensemble de fermoir code
AU2011244237B2 (en) 2010-04-23 2015-01-22 Sanofi-Aventis Deutschland Gmbh Coded cartridge assembly
US8926570B2 (en) 2010-06-03 2015-01-06 Shl Group Ab Medicament delivery device
AR081651A1 (es) 2010-06-11 2012-10-10 Sanofi Aventis Deutschland Un conjunto de accionamiento para un dispositivo de suministro de medicamentos y un dispositivo de suministro de medicamentos
EP2584984B1 (fr) 2010-06-23 2019-02-20 Genesis Fracture Care, Inc. Fixation à plaque souple de fractures osseuses
WO2011163511A1 (fr) 2010-06-23 2011-12-29 Tcb Medical Devices, Llc Injecteur pour auto-injection de médicament et procédé d'utilisation associé
US8790379B2 (en) 2010-06-23 2014-07-29 Zimmer, Inc. Flexible plate fixation of bone fractures
EP2588167B1 (fr) 2010-07-02 2018-02-21 Sanofi-Aventis Deutschland GmbH Dispositif de sécurité pour une seringue pré-remplie et dispositif d'injection
EP2588165B1 (fr) 2010-07-02 2020-06-17 Sanofi-Aventis Deutschland GmbH Dispositif de sécurité pour une seringue préremplie, dispositif d'injection et kit d'injection
NZ604079A (en) 2010-07-02 2014-02-28 Sanofi Aventis Deutschland Safety device for a pre-filled syringe and injection device
WO2012000836A1 (fr) 2010-07-02 2012-01-05 Sanofi-Aventis Deutschland Gmbh Dispositif de sécurité pour seringue pré-remplie et dispositif d'injection
ES2538371T3 (es) 2010-07-02 2015-06-19 Sanofi-Aventis Deutschland Gmbh Dispositivo de seguridad para una jeringuilla llenada previamente y dispositivo de inyección
MX2013000058A (es) 2010-07-02 2013-02-15 Sanofi Aventis Deutschland Dispositivo de inyeccion.
SG186320A1 (en) 2010-07-02 2013-02-28 Sanofi Aventis Deutschland Safety device for a pre-filled syringe and injection device
SG186321A1 (en) 2010-07-02 2013-02-28 Sanofi Aventis Deutschland Needle shield for a safety device, safety device and injection device
CN103153367A (zh) 2010-08-13 2013-06-12 赛诺菲-安万特德国有限公司 用于药物输送装置贮液器的连接器
CA2808469A1 (fr) 2010-08-19 2012-02-23 Sanofi-Aventis Deutschland Gmbh Procede et systeme pour determiner des informations concernant un reservoir de medicament utilisant un capteur electronique
US20120101475A1 (en) 2010-10-21 2012-04-26 Meridian Medical Technologies, Inc. High Efficiency Auto-Injector
TWI425719B (zh) * 2010-11-16 2014-02-01 Compal Electronics Inc 連接埠
US20130281934A1 (en) 2010-12-30 2013-10-24 Meridian Medical Technologies, Inc. Slip-Resistant Autoinjectors
US9283020B2 (en) 2011-01-03 2016-03-15 Warsaw Orthopedic, Inc. Surgical tack delivery system, method and kit
WO2012122643A1 (fr) 2011-03-11 2012-09-20 University Of Saskatchewan Dispositif d'assistance à l'injection et procédé associé
US20120253314A1 (en) 2011-03-30 2012-10-04 Ziv Harish Palm-controlled injectors
KR20120119280A (ko) 2011-04-21 2012-10-31 한국전자통신연구원 커패시터
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
PT2837396E (pt) 2011-08-24 2016-06-20 Unitract Syringe Pty Ltd Auto-injetor para seringa pré-cheia retrátil
GB2576384B (en) 2018-10-30 2022-09-21 Grey Orange Pte Ltd Method for operating a pallet pick put system for transporting objects

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518416A1 (fr) † 1991-06-13 1992-12-16 Duphar International Research B.V Dispositif d'injection
US5681291A (en) † 1992-11-19 1997-10-28 Tebro S.A. Disposable auto-injector for prefilled syringes
WO1997041907A2 (fr) † 1996-05-02 1997-11-13 Ermanno Greco Dispositif d'injection automatique
US20010049496A1 (en) † 1998-05-15 2001-12-06 Fritz Kirchhofer Automatic injection device
US6102896A (en) † 1999-09-08 2000-08-15 Cambridge Biostability Limited Disposable injector device
WO2003039634A1 (fr) † 2001-11-09 2003-05-15 Alza Corporation Auto-injecteur pneumatique
WO2003068290A2 (fr) † 2002-02-11 2003-08-21 Antares Pharma, Inc. Injecteur intradermique
WO2004047892A1 (fr) † 2002-11-25 2004-06-10 Tecpharma Licensing Ag Dispositif d'injection pourvu d'une protection d'aiguille
WO2004067068A1 (fr) † 2003-01-24 2004-08-12 Alza Corporation Cartouche de seringue compressible

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VEILLEUX JEAN-CHRISTOPHE; SHEPHERD JOSEPH E.: "Pressure and stress transients in autoinjector devices", DRUG DELIVERY AND TRANSLATIONAL RESEARCH, SPRINGER, GERMANY, vol. 8, no. 5, 6 August 2018 (2018-08-06), Germany , pages 1238 - 1253, ISSN: 2190-393X, DOI: 10.1007/s13346-018-0568-7 †

Also Published As

Publication number Publication date
ES2716135T5 (es) 2023-06-15
WO2006079064A1 (fr) 2006-07-27
ES2908027T5 (en) 2025-03-12
US9533102B2 (en) 2017-01-03
DK1850892T4 (da) 2023-06-06
EP3495009B1 (fr) 2021-12-08
JP2008528126A (ja) 2008-07-31
US11446441B2 (en) 2022-09-20
US9629959B2 (en) 2017-04-25
US10478560B2 (en) 2019-11-19
ES2716135T3 (es) 2019-06-10
US20200038589A1 (en) 2020-02-06
BRPI0614025A2 (pt) 2012-12-25
EP1850892B2 (fr) 2023-04-19
DK1850892T3 (en) 2019-04-15
US20130150797A1 (en) 2013-06-13
ES2908027T3 (es) 2022-04-27
US9180259B2 (en) 2015-11-10
US20160317746A1 (en) 2016-11-03
JP5216328B2 (ja) 2013-06-19
IL184765A0 (en) 2007-12-03
KR20070117543A (ko) 2007-12-12
HUE042286T2 (hu) 2019-06-28
US20170216527A1 (en) 2017-08-03
US20250041521A1 (en) 2025-02-06
FI1850892T4 (fi) 2023-08-31
US20120004608A1 (en) 2012-01-05
US20140155828A1 (en) 2014-06-05
US8562564B2 (en) 2013-10-22
EP3495009A1 (fr) 2019-06-12
EP1850892A1 (fr) 2007-11-07
US8021335B2 (en) 2011-09-20
US20080154200A1 (en) 2008-06-26
CN101132820A (zh) 2008-02-27
US20220379032A1 (en) 2022-12-01
EP1850892B1 (fr) 2019-01-09
US20160051759A1 (en) 2016-02-25
CN101132820B (zh) 2010-05-19
CA2595730A1 (fr) 2006-07-27
PT1850892T (pt) 2019-02-08
IL184765A (en) 2012-01-31
CA2595730C (fr) 2014-10-07

Similar Documents

Publication Publication Date Title
US20250041521A1 (en) Prefilled syringe injector
US12409272B2 (en) Prefilled syringe with breakaway force feature
HK40108705A (en) Prefilled syringe with breakaway force feature

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 1850892

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20191211

RBV Designated contracting states (corrected)

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RIC1 Information provided on ipc code assigned before grant

Ipc: A61M 5/20 20060101ALI20201202BHEP

Ipc: A61M 5/178 20060101ALN20201202BHEP

Ipc: A61M 5/30 20060101AFI20201202BHEP

Ipc: A61M 5/32 20060101ALN20201202BHEP

Ipc: A61M 5/48 20060101ALN20201202BHEP

Ipc: A61M 5/28 20060101ALI20201202BHEP

Ipc: A61M 5/46 20060101ALN20201202BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20210112

RIC1 Information provided on ipc code assigned before grant

Ipc: A61M 5/28 20060101ALI20201214BHEP

Ipc: A61M 5/46 20060101ALN20201214BHEP

Ipc: A61M 5/20 20060101ALI20201214BHEP

Ipc: A61M 5/30 20060101AFI20201214BHEP

Ipc: A61M 5/178 20060101ALN20201214BHEP

Ipc: A61M 5/48 20060101ALN20201214BHEP

Ipc: A61M 5/32 20060101ALN20201214BHEP

GRAJ Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTC Intention to grant announced (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: A61M 5/30 20060101AFI20210602BHEP

Ipc: A61M 5/20 20060101ALI20210602BHEP

Ipc: A61M 5/28 20060101ALI20210602BHEP

Ipc: A61M 5/178 20060101ALN20210602BHEP

Ipc: A61M 5/32 20060101ALN20210602BHEP

Ipc: A61M 5/46 20060101ALN20210602BHEP

Ipc: A61M 5/48 20060101ALN20210602BHEP

INTG Intention to grant announced

Effective date: 20210621

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AC Divisional application: reference to earlier application

Ref document number: 1850892

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1453280

Country of ref document: AT

Kind code of ref document: T

Effective date: 20211215

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602006060252

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: PK

Free format text: BERICHTIGUNGEN

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602006060252

Country of ref document: DE

Owner name: ANTARES PHARMA, INC., EWING, US

Free format text: FORMER OWNER: ANTARES PHARMA, INC., MINNEAPOLIS, MN, US

RAP4 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: ANTARES PHARMA, INC.

RIN2 Information on inventor provided after grant (corrected)

Inventor name: LESCH, JR., PAUL R.

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20211208

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2908027

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20220427

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220308

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1453280

Country of ref document: AT

Kind code of ref document: T

Effective date: 20211208

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220309

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220408

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

REG Reference to a national code

Ref country code: DE

Ref legal event code: R026

Ref document number: 602006060252

Country of ref document: DE

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20220408

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20220131

26 Opposition filed

Opponent name: BANDPAY & GREUTER

Effective date: 20220904

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220124

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220131

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220124

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230516

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20060124

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208

REG Reference to a national code

Ref country code: CH

Ref legal event code: PK

Free format text: TITEL

PUAH Patent maintained in amended form

Free format text: ORIGINAL CODE: 0009272

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT MAINTAINED AS AMENDED

27A Patent maintained in amended form

Effective date: 20250115

AK Designated contracting states

Kind code of ref document: B2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R102

Ref document number: 602006060252

Country of ref document: DE

REG Reference to a national code

Ref country code: ES

Ref legal event code: DC2A

Ref document number: 2908027

Country of ref document: ES

Kind code of ref document: T5

Effective date: 20250312

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20250129

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20250203

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20250201

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20250127

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20250127

Year of fee payment: 20

Ref country code: IT

Payment date: 20250220

Year of fee payment: 20

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20211208