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EP3493814A4 - Composés amino 1,2-et 1,3-diol substitués par des lipides en tant que modulateurs de la dimérisation de tlr2 - Google Patents

Composés amino 1,2-et 1,3-diol substitués par des lipides en tant que modulateurs de la dimérisation de tlr2 Download PDF

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Publication number
EP3493814A4
EP3493814A4 EP17837574.7A EP17837574A EP3493814A4 EP 3493814 A4 EP3493814 A4 EP 3493814A4 EP 17837574 A EP17837574 A EP 17837574A EP 3493814 A4 EP3493814 A4 EP 3493814A4
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EP
European Patent Office
Prior art keywords
modulators
lipid
substituted amino
diol compounds
tlr2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17837574.7A
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German (de)
English (en)
Other versions
EP3493814A1 (fr
Inventor
Wolfgang Wrasidlo
Srinivasa Reddy Natala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuropore Therapies Inc
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Neuropore Therapies Inc
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Publication of EP3493814A1 publication Critical patent/EP3493814A1/fr
Publication of EP3493814A4 publication Critical patent/EP3493814A4/fr
Withdrawn legal-status Critical Current

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    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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EP17837574.7A 2016-08-03 2017-08-01 Composés amino 1,2-et 1,3-diol substitués par des lipides en tant que modulateurs de la dimérisation de tlr2 Withdrawn EP3493814A4 (fr)

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US201662370637P 2016-08-03 2016-08-03
PCT/US2017/044984 WO2018026866A1 (fr) 2016-08-03 2017-08-01 Composés amino 1,2-et 1,3-diol substitués par des lipides en tant que modulateurs de la dimérisation de tlr2

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HK1260897A1 (zh) 2015-08-21 2019-12-27 Portola Pharmaceuticals, Inc. 使用四氢异喹啉小分子来结合并调节pcsk9的蛋白活性的组合物和方法
WO2017034994A1 (fr) * 2015-08-21 2017-03-02 Portola Pharmaceuticals, Inc. Composition et procédés d'utilisation de nouveaux petits composés organiques de phénylalanine pour moduler directement l'activité de la protéine pcsk9
HK1257102A1 (zh) 2015-08-21 2019-10-11 Portola Pharmaceuticals, Inc. 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用
US20190119236A1 (en) 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
CN114025847B (zh) 2019-03-26 2024-05-24 神经孔疗法股份有限公司 作为tlr信号传导的调节剂的化合物和组合物
WO2020262996A1 (fr) * 2019-06-25 2020-12-30 (주)앰틱스바이오 Composé dérivé introduisant un groupe biphényle dans un nouvel acide aminoalcanoïque et composition pharmaceutique antifongique le comprenant
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

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EP0451763A2 (fr) * 1990-04-09 1991-10-16 Fuji Photo Film Co., Ltd. Dérivés amphiphatiques de peptides, leurs intermédiaires, liposomes et films comprenant ces dérivés
WO2002072068A2 (fr) * 2001-03-12 2002-09-19 Cancer Research Technology Limited Lipides, compositions de lipides, liposomes et lipoplexes
WO2013135360A1 (fr) * 2012-03-16 2013-09-19 Merck Patent Gmbh Lipides d'acides aminés

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EP1664316B1 (fr) * 2003-09-15 2012-08-29 Protiva Biotherapeutics Inc. Composes lipidiques modifies avec du polyethyleneglycol et utilisations de ces composes
WO2005039504A2 (fr) * 2003-10-24 2005-05-06 Eisai Co., Ltd. Composes et methodes permettant de traiter les maladies et etats pathologiques lies au recepteur 2 de type toll
AU2012335978A1 (en) * 2011-11-08 2014-05-22 Arena Pharmaceuticals, Inc. Modulators of the G protein-coupled Mas receptor and the treatment of disorders related thereto
US9676818B2 (en) * 2013-01-17 2017-06-13 University Of Kansas Toll-like receptor 2-agonistic lipopeptides, and method of making the same

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0451763A2 (fr) * 1990-04-09 1991-10-16 Fuji Photo Film Co., Ltd. Dérivés amphiphatiques de peptides, leurs intermédiaires, liposomes et films comprenant ces dérivés
WO2002072068A2 (fr) * 2001-03-12 2002-09-19 Cancer Research Technology Limited Lipides, compositions de lipides, liposomes et lipoplexes
WO2013135360A1 (fr) * 2012-03-16 2013-09-19 Merck Patent Gmbh Lipides d'acides aminés

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