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EP3342485B1 - Supports d'éléments de réactifs - Google Patents

Supports d'éléments de réactifs Download PDF

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Publication number
EP3342485B1
EP3342485B1 EP17150044.0A EP17150044A EP3342485B1 EP 3342485 B1 EP3342485 B1 EP 3342485B1 EP 17150044 A EP17150044 A EP 17150044A EP 3342485 B1 EP3342485 B1 EP 3342485B1
Authority
EP
European Patent Office
Prior art keywords
support
assembly according
plate
holder
support elements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17150044.0A
Other languages
German (de)
English (en)
Other versions
EP3342485A1 (fr
Inventor
Lutz Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thinxxs Microtechnology GmbH
Original Assignee
Thinxxs Microtechnology GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thinxxs Microtechnology GmbH filed Critical Thinxxs Microtechnology GmbH
Priority to EP17150044.0A priority Critical patent/EP3342485B1/fr
Priority to US16/475,455 priority patent/US11071984B2/en
Priority to CN201780082071.2A priority patent/CN110198784B/zh
Priority to PCT/EP2017/081543 priority patent/WO2018121961A1/fr
Publication of EP3342485A1 publication Critical patent/EP3342485A1/fr
Application granted granted Critical
Publication of EP3342485B1 publication Critical patent/EP3342485B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components

Definitions

  • the invention relates to an arrangement of a multiplicity of carrier elements for a reagent which is to be introduced via the respective carrier element into a microfluidic device, in particular a flow cell, and a holder which holds the multiplicity of carrier elements, the respective carrier element being kept at least free by the holder one of the reagent-receiving areas of the support element is fixed in all spatial directions by positive locking, and the support elements are formed in a plug-like manner with only one reagent receiving area on one end face and an expansion comprising a handling area on the other end face, and the holder is a support plate with through-openings into which the Carrier elements can be used with the reagent receiving area ahead.
  • the result is a flow cell that has an outwardly opening passage for introducing a dry reagent through a carrier element.
  • the carrier element receiving the dry reagent By finally inserting the carrier element receiving the dry reagent into the passage, the dry reagent reaches the intended location within the flow cell and the carrier element closes the passage in a fluid-tight manner.
  • the above EP 2 821 138 A1 also describes a holder which holds a large number of carrier elements provided with the dry reagent for processing in the process of flow cell production.
  • the carrier plate with through openings receives plug-like carrier elements in a grid arrangement, the carrier elements having a receiving area for a reagent at one end and a handling area formed by a flange-like widening at the other end.
  • the EP 1 792 654 A1 describes carrier elements in the form of an expanding cuvette.
  • the cuvettes which are open on both sides, can be inserted into through-openings in a carrier plate, with one flange of the cuvettes abutting against the carrier plate.
  • IT MI20 112 073 A An arrangement with the features mentioned above is the IT MI20 112 073 A refer to. This results in chambers for receiving cell cultures that are inserted into through openings in a two-part mounting plate.
  • the chambers are defined in the through openings by connecting pieces protruding laterally between the plate parts and each containing a channel.
  • the invention has for its object to facilitate the manufacture of reagents containing microfluidic flow cells.
  • Such an arrangement according to the invention can advantageously be used both for processing the carrier elements, in particular for applying the dry reagent and possibly surface functionalization, and for holding the processed carrier elements ready for further processing in the manufacturing process of the flow cells.
  • the carrier elements remain fixed to the holder in every processing position.
  • An efficient process chain can be formed with the arrangement according to the invention.
  • the carrier element is fixed by the holder while keeping a further area free, in particular a handling area separated from the receiving area for the dry reagent.
  • a handling area separated from the receiving area for the dry reagent.
  • the handling area that is kept free during the processing of the carrier elements can e.g. be labeled or marked.
  • the carrier element is designed in a plug-like manner with the receiving area at one end and a handling area at the other end, the widening being formed at the other end.
  • the holder receives the carrier elements, preferably arranged in one plane and in particular in a grid arrangement.
  • the carrier element is fixed so that it can move with play.
  • there is a play of the carrier element in the holder such that the carrier element can be removed from the holder without any force after the positive connection has been released. This considerably facilitates its further processing in the context of an automated manufacturing process, if necessary.
  • the holder comprises a carrier plate with through-openings into which the carrier elements with the receiving area can be inserted, the carrier elements being fixed in each of the through-openings by the holding plate arranged behind the flanges in the insertion direction and connected to the carrier plate.
  • the holding plate preferably also has through openings which are aligned with the carrier elements inserted into the through openings in the carrier plate. At least part of the handling area remains freely accessible for processing.
  • the carrier plate is preferably connected to a frame and in particular arranged sunk into the frame.
  • the holding plate can also expediently be lowered into the frame and can preferably be connected to the frame by latching.
  • the frame preferably has dimensions such that the reagent receiving areas of the carrier elements are arranged sunk into the frame.
  • this arrangement allows holders provided with occupied support elements to be stacked in a space-saving manner without affecting the dry reagents.
  • a separate locking mechanism for fixing the carrier element in all spatial directions can be assigned to each through opening of the carrier plate, this locking mechanism being e.g. has elastic locking levers which snap in behind the widening, in particular in a paired diametrical arrangement, with a sliding bevel for unlocking.
  • the sliding bevels can be aligned with each other in such a way that all locking levers can be unlocked simultaneously with the aid of a stamping tool.
  • the carrier plate is formed in several parts from carrier plate parts. Accordingly, the frame has a number of compartments which receive the plates, for example by latching.
  • the carrier plate and the frame are formed in one piece from a deep-drawn film.
  • holder areas made of frame and carrier plates made of deep-drawn film are connected to one another to form a band, and the holding plate is designed as a continuous film band.
  • the arrangement shown comprises carrier elements 1 for a reagent which is to be introduced into a microfluidic flow cell (not shown) and a holder 2 which receives the carrier elements 1 in a flat grid arrangement.
  • carrier elements 1 and the parts of the holder 2 in particular by injection molding, come for example plastics such as PP, PMMA, PC, PS, PE and PEEK into consideration, but also glass, metal, ceramics, composite materials or combinations of different materials such as a plastic body with a local or complete glass or metal coating.
  • the carrier elements 1 are plug-shaped with a slightly conical section 3 and an expansion 4 in the form of a flange at one end.
  • a depression in the ring at the other end in the example forms a receiving area 5 for the reagent.
  • the multi-part holder 2 comprises a carrier plate 6 and a holding plate 7 which fixes the carrier elements 1 to the carrier plate 6.
  • the carrier plate 6 is connected in one piece to a frame 8, the frame 8 protruding from the carrier plate 6 on both sides of the carrier plate 6 perpendicular to the plane of the plate. That is, the carrier plate 6 is sunk into the frame 8.
  • the frame 8 has reinforcing beads and ribs distributed over its circumference.
  • Through openings 9 formed in a grid in the support plate 6 serve to receive the support elements 1, which can be inserted into the through openings 9 until the expansion 4 stops against the support plate 6.
  • the receiving area 5 protrudes from the carrier plate 6 and the carrier element 1 has less play in the through opening 9 parallel to the plane of the plate.
  • the play is preferably less than 0.1 mm, in particular 0.05 mm.
  • the receiving area 5 of the carrier elements 1 is set back with respect to a surface 21 of the frame 8 which is parallel to the plate plane.
  • the holding plate 7 forms a lock in the insertion direction behind the widening 4 of the carrier elements 1, so that the carrier elements 1 are fixed in the holder 2 in all spatial directions, apart from the slight play parallel to the plane of the plate.
  • the holding plate 7 can be snapped onto the frame 8 via elastic locking elements 11 and 12. On its side facing away from the carrier plate 6, the holding plate 7 has a stabilizing honeycomb structure 13 that avoids material accumulation. The holding plate 7 is sunk into the frame 8 in the locked state.
  • the frame 8 has a circumferentially widened end edge 14, which forms a stack seat 15, on which one in a stack according Fig. 8 adjacent arrangement with the frame surface 21 rests. How Fig. 8 shows, stack packs can be formed, in which the reagents are protected from contact by the offset of the receiving areas 5 to the surface 21.
  • the stack packages can be sealed in foil and, if necessary, vacuumed or placed under protective gas.
  • Fig. 9 shows a compared to the embodiment of Fig. 1 downsized embodiment.
  • Fig. 10 shows an embodiment with a carrier plate formed from four carrier plate parts 16, wherein the carrier plate parts 16 can be clipped into a frame 8 having cross struts 17. Likewise, four clip-on holding plate parts 18 are formed, which are congruent with the supporting plate parts 16 in the example.
  • the carrier plate parts 16 and holding plate parts 18 are, for example, metallic, possibly etched stamped parts.
  • Fig. 10 shows an empty frame compartment, a frame compartment with a carrier plate part 16, a frame compartment with an equipped carrier plate part 16 and a frame compartment with a (not visible) carrier plate part 16 and a holding plate part 18.
  • Fig. 11 shows a support plate 6 integrally connected to a frame 8 with through openings 9, with each individual through opening 9 being assigned a separate holding mechanism for a support element 1, by means of which a support plate common to all support elements 1 is unnecessary.
  • each holding mechanism has four, elastically bendable latching levers 19, which are connected in one piece to the carrier plate 6, in pairs in a diametrical arrangement, which are behind the widening 4 of the carrier element in question 1 snap in and reach behind the carrier elements 1.
  • bracket parts are not made as in the previous embodiments by injection molding or printing or from metal but only from film material.
  • the arrangement shown comprises a band in which successive holding regions 25 with frames 8 and carrier plates 6 are formed by deep drawing in the longitudinal direction of the band and through openings 9 for punching carrier elements 1 are punched into the carrier plates 6.
  • the deep-drawn tape has perforated edges 22, whereby transport means can engage in the perforation holes.
  • a holding plate holding the carrier elements 1 in the carrier plate 6 is designed continuously as a film tape 24 and is glued to the tape containing the carrier plates 6.
  • a continuous cover 23 as a band covers the recessed exposed areas of the carrier elements 1.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Claims (13)

  1. Ensemble d'une multitude d'éléments support (1) pour un réactif, qui est à introduire via l'élément support (1) respectif dans un dispositif microfluidique, en particulier une cellule d'écoulement, et d'une fixation (2) recevant la multitude d'éléments support (1), l'élément support (1) respectif étant fixé par la fixation (2) par complémentarité de forme dans toutes les directions spatiales tout en réservant au moins une zone (5) recevant le réactif de l'élément support (1),
    les éléments support (1) étant conçus comme des bouchons présentant une zone de réception de réactif (5) en l'une extrémité frontale et un élargissement (4) comprenant une zone de manipulation en l'autre extrémité frontale et la fixation (2) présentant une plaque support (6) pourvue d'ouvertures de passage (9) formées en une grille, dans lesquelles les éléments support (1) pourvus de la zone de réception de réactif (5) peuvent être introduits,
    et l'élargissement (4) des éléments support (1) étant formé par une bride et les éléments support (1) pouvant être introduits par l'intermédiaire d'une section (3) légèrement conique dans les ouvertures de passage (9) jusqu'à la butée de la bride (4) contre la plaque support (6), avec un léger jeu, parallèlement au plan de la plaque, la zone de réception de réactif des éléments support (1), dans la position de butée, étant en saillie par rapport à la plaque support (6), caractérisé
    en ce qu'une plaque de fixation (7) commune à tous les éléments support (1), reliée à la plaque support (6) ou un mécanisme de verrouillage séparé, associé à chacune des ouvertures de passage (9) sollicite la bride (4) sur son côté opposé à la plaque support (6).
  2. Ensemble selon la revendication 1, caractérisé
    en ce que l'élément support (1) est fixé par la fixation (2) tout en réservant une autre zone, en particulier une zone éloignée de la zone de réception de réactif (5), servant de préférence à la manipulation de l'élément support (1).
  3. Ensemble selon la revendication 1 ou 2, caractérisé
    en ce que la fixation (2) est conçue pour recevoir les éléments support (1) tout en disposant les éléments support (1) dans un plan, de préférence dans une disposition en grille.
  4. Ensemble selon l'une quelconque des revendications 1 à 3, caractérisé
    en ce que l'élément support (1) est fixé par la fixation (2) tout en présentant un jeu assurant une mobilité.
  5. Ensemble selon l'une quelconque des revendications 1 à 4, caractérisé
    en ce que la plaque de fixation (7) présente des ouvertures de passage (10) orientés vers les éléments support (1) introduits dans les ouvertures de passage (9).
  6. Ensemble selon l'une quelconque des revendications 1 à 5, caractérisé
    en ce que la plaque support (6) est reliée à un cadre (8) et de préférence disposée de manière enfoncée dans le cadre (8).
  7. Ensemble selon la revendication 6, caractérisé
    en ce que la plaque support (7) peut être enfoncée dans le cadre (8) et peut de préférence être reliée au cadre (8) par encliquetage.
  8. Ensemble selon la revendication 6 ou 7, caractérisé
    en ce que les zones de réception de réactif (4) des éléments support (1) sont disposées de manière enfoncée dans le cadre (8).
  9. Ensemble selon l'une quelconque des revendications 1 à 8, caractérisé
    en ce que le mécanisme de verrouillage présente des leviers d'encliquetage (15) élastiques, s'encliquetant derrière l'élargissement dans une disposition diamétrale par paire, présentant une rampe de glissement (20) pour le déverrouillage.
  10. Ensemble selon l'une quelconque des revendications 1 à 9, caractérisé
    en ce que la plaque support (6) est conçue en plusieurs éléments à partir d'éléments (16) de plaques support.
  11. Ensemble selon l'une quelconque des revendications 1 à 10, caractérisé
    en ce que l'ensemble peut être empilé.
  12. Ensemble selon l'une quelconque des revendications 1 à 11, caractérisé
    en ce que la plaque support (6) et le cadre (8) sont formés d'une seule pièce à partir d'une feuille emboutie.
  13. Ensemble selon la revendication 12, caractérisé
    en ce que des zones de fixation (25) constituées par des cadres (8) et des plaques support (6) en feuille emboutie sont reliées les unes aux autres en un ruban et la plaque de fixation est réalisée comme un ruban de feuille continue (24) et/ou plusieurs zones de fixation peuvent être enroulées.
EP17150044.0A 2017-01-02 2017-01-02 Supports d'éléments de réactifs Active EP3342485B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP17150044.0A EP3342485B1 (fr) 2017-01-02 2017-01-02 Supports d'éléments de réactifs
US16/475,455 US11071984B2 (en) 2017-01-02 2017-12-05 Holder for reagent tray elements
CN201780082071.2A CN110198784B (zh) 2017-01-02 2017-12-05 用于试剂载体元件的支架
PCT/EP2017/081543 WO2018121961A1 (fr) 2017-01-02 2017-12-05 Dispositif de retenue pour éléments de support de réactif

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17150044.0A EP3342485B1 (fr) 2017-01-02 2017-01-02 Supports d'éléments de réactifs

Publications (2)

Publication Number Publication Date
EP3342485A1 EP3342485A1 (fr) 2018-07-04
EP3342485B1 true EP3342485B1 (fr) 2020-07-08

Family

ID=57962989

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17150044.0A Active EP3342485B1 (fr) 2017-01-02 2017-01-02 Supports d'éléments de réactifs

Country Status (4)

Country Link
US (1) US11071984B2 (fr)
EP (1) EP3342485B1 (fr)
CN (1) CN110198784B (fr)
WO (1) WO2018121961A1 (fr)

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US11596919B2 (en) * 2018-08-17 2023-03-07 Sierra Biosystems, Inc. Row-independent oligonucleotide synthesis
USD905267S1 (en) * 2019-03-27 2020-12-15 Avidien Technologies, Inc. Pipette tip adapter
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
TWI785636B (zh) * 2021-06-07 2022-12-01 新加坡商克雷多生醫有限公司 檢測卡匣
USD1050481S1 (en) * 2021-09-28 2024-11-05 Roche Molecular Systems, Inc. Microwell plate assembly
USD1036696S1 (en) * 2022-09-15 2024-07-23 Nicoya Lifesciences Inc. Analysis cartridge cover plate
USD1036697S1 (en) * 2022-09-15 2024-07-23 Nicoya Lifesciences Inc. Analysis cartridge cover plate
USD1036695S1 (en) * 2022-09-15 2024-07-23 Nicoya Lifesciences Inc. Analysis cartridge top plate
USD1067461S1 (en) * 2023-04-28 2025-03-18 Nanolive Sa Well of assay plate

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CN104531529A (zh) * 2003-10-31 2015-04-22 维特克公司 用于检测循环肿瘤和内皮细胞的血液测试样机和方法
EP2283923A2 (fr) * 2005-11-30 2011-02-16 F. Hoffmann-La Roche AG Réseau de cuvettes linéaire sans moyen de positionnement
CA2852950C (fr) * 2011-10-20 2021-04-20 Research Foundation Of The City University Of New York Reseau de cellules vivantes microfluidique en couches
ITMI20112073A1 (it) * 2011-11-15 2013-05-16 Univ Pisa Supporto per camere di coltura cellulare
US20140017806A1 (en) * 2012-07-11 2014-01-16 Samsung Electronics Co., Ltd. Microfluidic structure, microfluidic device having the same and method of controlling the microfluidic device
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DK2821138T4 (da) * 2013-07-05 2022-05-16 Thinxxs Microtechnology Gmbh Flydecelle med integreret tørstof
SG11201601668PA (en) * 2013-09-04 2016-04-28 Credo Biomedical Pte Ltd Assay test device, kit and method of using
EP3060683A4 (fr) * 2013-10-22 2017-08-09 Corporos Inc. Procédés et appareil permettant l'amplification et la détection d'acides nucléiques au point d'intervention
WO2015078884A1 (fr) * 2013-11-26 2015-06-04 Alleati Ag Procédé et ensemble microfluidique pour test de sensibilité aux antibiotiques
EP3108962B1 (fr) * 2015-06-22 2024-10-16 thinXXS Microtechnology GmbH Porte échantillons

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Also Published As

Publication number Publication date
US20200023367A1 (en) 2020-01-23
WO2018121961A1 (fr) 2018-07-05
EP3342485A1 (fr) 2018-07-04
US11071984B2 (en) 2021-07-27
CN110198784A (zh) 2019-09-03
CN110198784B (zh) 2021-07-20

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