EP3200615A4 - Édulcorants non caloriques et procédés de synthèse - Google Patents

Édulcorants non caloriques et procédés de synthèse Download PDF

Info

Publication number: EP3200615A4
Authority: EP; European Patent Office
Prior art keywords: synthesizing; methods; caloric sweeteners; caloric; sweeteners
Prior art date: 2014-10-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP15846977.5A

Other languages

German (de)

English (en)

Other versions

EP3200615A1 (fr

EP3200615B1 (fr

Inventor

Guohong MAO

Xiaodan Yu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Conagen Inc

Original Assignee

Conagen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-03

Filing date

2015-10-02

Publication date

2018-04-04

2015-10-02 Application filed by Conagen Inc filed Critical Conagen Inc

2017-08-09 Publication of EP3200615A1 publication Critical patent/EP3200615A1/fr

2018-04-04 Publication of EP3200615A4 publication Critical patent/EP3200615A4/fr

2019-05-29 Application granted granted Critical

2019-05-29 Publication of EP3200615B1 publication Critical patent/EP3200615B1/fr

Status Active legal-status Critical Current

2035-10-02 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1062—Sucrose synthase (2.4.1.13)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01013—Sucrose synthase (2.4.1.13)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Nutrition Science (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Seasonings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Non-Alcoholic Beverages (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Tea And Coffee (AREA)
Medicinal Preparation (AREA)
Fodder In General (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Cosmetics (AREA)

EP15846977.5A 2014-10-03 2015-10-02 Édulcorants non caloriques et procédés de synthèse Active EP3200615B1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462059498P	2014-10-03	2014-10-03
US201462098929P	2014-12-31	2014-12-31
PCT/US2015/053767 WO2016054534A1 (fr)	2014-10-03	2015-10-02	Édulcorants non caloriques et procédés de synthèse

Publications (3)

Publication Number	Publication Date
EP3200615A1 EP3200615A1 (fr)	2017-08-09
EP3200615A4 true EP3200615A4 (fr)	2018-04-04
EP3200615B1 EP3200615B1 (fr)	2019-05-29

Family

ID=55631622

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
EP15847668.9A Active EP3201351B1 (fr)	2014-10-03	2015-10-02	Édulcorants non caloriques et procédés pour les obtenir par synthèse
EP15846977.5A Active EP3200615B1 (fr)	2014-10-03	2015-10-02	Édulcorants non caloriques et procédés de synthèse
EP15847221.7A Active EP3201212B1 (fr)	2014-10-03	2015-10-02	Édulcorants non caloriques et procédés de synthèse
EP15845748.1A Active EP3201211B1 (fr)	2014-10-03	2015-10-02	Édulcorants non caloriques et procédés de synthèse

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
EP15847668.9A Active EP3201351B1 (fr)	2014-10-03	2015-10-02	Édulcorants non caloriques et procédés pour les obtenir par synthèse

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
EP15847221.7A Active EP3201212B1 (fr)	2014-10-03	2015-10-02	Édulcorants non caloriques et procédés de synthèse
EP15845748.1A Active EP3201211B1 (fr)	2014-10-03	2015-10-02	Édulcorants non caloriques et procédés de synthèse

Country Status (14)

Country	Link
US (22)	US9783566B2 (fr)
EP (4)	EP3201351B1 (fr)
JP (4)	JP6854238B2 (fr)
KR (4)	KR102557670B1 (fr)
CN (7)	CN106715451B (fr)
AU (4)	AU2015327858B2 (fr)
BR (3)	BR112017006139B1 (fr)
CA (4)	CA2958437C (fr)
DK (3)	DK3200615T3 (fr)
ES (3)	ES2741741T3 (fr)
HU (2)	HUE045992T2 (fr)
MX (4)	MX378831B (fr)
MY (4)	MY183062A (fr)
WO (4)	WO2016054540A1 (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG11201505597SA (en)	2013-02-06	2015-08-28	Evolva Sa	Methods for improved production of rebaudioside d and rebaudioside m
US9522929B2 (en)	2014-05-05	2016-12-20	Conagen Inc.	Non-caloric sweetener
US10264811B2 (en)	2014-05-19	2019-04-23	Epc Natural Products Co., Ltd.	Stevia sweetener with improved solubility
BR112017006139B1 (pt)	2014-10-03	2022-04-05	Conagen Inc	Método para a sintetização de rebaudiosídeo m ou rebaudiosídeo d e rebaudiosídeo m
AU2015364481B2 (en)	2014-12-17	2020-05-14	Cargill, Incorporated	Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
CN108337892B (zh)	2015-01-30	2022-06-24	埃沃尔瓦公司	在重组宿主中生产甜菊醇糖苷
EP3718417B1 (fr)	2015-04-03	2025-09-03	DSM IP Assets B.V.	Glycosides de stéviol
EP3283614B1 (fr)	2015-04-14	2020-07-08	Conagen Inc.	Production d'édulcorants non caloriques ayant recours à des catalyseurs de cellules entières modifiées
WO2017031424A1 (fr) *	2015-08-20	2017-02-23	Pepsico, Inc.	Préparation du rébaudioside m dans une cuve réactionnelle unique
WO2017178632A1 (fr)	2016-04-13	2017-10-19	Evolva Sa	Production de glycosides de stéviol dans des hôtes recombinants
AU2017284104B2 (en)	2016-06-15	2020-06-25	Codexis, Inc.	Engineered beta-glucosidases and glucosylation methods
BR112018076303B1 (pt) *	2016-06-17	2022-10-11	Cargill, Incorporated	Composição adoçante, bebida e método de modificação de uma característica sensorial de uma composição
JP7404068B2 (ja)	2016-08-12	2023-12-25	アミリス，インコーポレイテッド	レバウジオシドの高効率の産生のためのｕｄｐ依存性グリコシルトランスフェラーゼ
BR112019007504B1 (pt)	2016-10-14	2023-05-09	Conagen Inc	Método de preparação de uma composição de glicosídeo de esteviol
WO2018072211A1 (fr)	2016-10-21	2018-04-26	苏州汉酶生物技术有限公司	Procédé de préparation de rébaudioside j à l'aide d'un procédé enzymatique
CA3041152A1 (fr)	2016-10-21	2018-04-26	Pepsico, Inc.	Procede de preparation de rebaudioside n a l'aide d'un procede enzymatique
WO2018093196A1 (fr) *	2016-11-17	2018-05-24	서울대학교산학협력단	Procédé de synthèse de glycoside stéviosidique utilisant des souches modifiées appartenant au genre leuconostoc et nouveau glycoside stéviosidique ainsi préparé
PL3689868T3 (pl) *	2016-12-01	2024-03-11	Arvinas Operations, Inc.	Pochodne tetrahydronaftalenu i tetrahydroizochinoliny jako degradery receptorów estrogenowych
TW202237833A (zh)	2017-02-03	2022-10-01	美商克迪科思股份有限公司	經工程處理之醣基轉移酶及甜菊糖之葡萄糖苷化方法
CN111031805B (zh) *	2017-04-25	2023-11-17	可口可乐公司	二氢查耳酮对甜菊醇糖苷和罗汉果苷甜味剂的甜度和味道改善
CN107164435B (zh) *	2017-05-27	2020-03-31	中国药科大学	一种莱鲍迪苷ka的制备方法
MY209836A (en) *	2017-06-08	2025-08-07	Suntory Holdings Ltd	Food or beverage with increased sweetness
AU2018294258A1 (en)	2017-06-30	2020-02-06	Conagen Inc.	Hydrolysis of steviol glycosides by beta-glucosidase
CN111868252B (zh) *	2018-03-12	2025-06-03	科纳根公司	甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产
CN112135527B (zh) *	2018-05-08	2023-08-15	伊比西(北京)植物药物技术有限公司	具有改善风味的甜菊醇糖甙组合物
CN109021038B (zh) *	2018-06-11	2021-07-27	江西师范大学	一种甜菊糖苷的制备方法
WO2020028039A1 (fr) *	2018-07-30	2020-02-06	Codexis, Inc.	Glycosyltransférases modifiées et procédés de glucosylation de glycosides de stéviol
CN110913864B (zh) *	2018-08-17	2022-12-13	邦泰生物工程(深圳)有限公司	一种稳定型烟酰胺核糖组合物及其制备方法
CN111073923A (zh) *	2018-10-22	2020-04-28	山东三元生物科技股份有限公司	一种莱鲍迪苷m的酶法制备方法
CN113302298B (zh)	2018-11-09	2025-02-25	银杏生物制品公司	罗汉果甙的生物合成
WO2020116638A1 (fr) *	2018-12-07	2020-06-11	サントリーホールディングス株式会社	Boisson au café de qualité gustative améliorée grâce à du sucre et un édulcorant
JP7486432B2 (ja) *	2018-12-07	2024-05-17	サントリーホールディングス株式会社	糖および甘味料の呈する味質が改善したコーヒー飲料
US20210145026A1 (en) *	2018-12-07	2021-05-20	Suntory Holdings Limited	Composition
AU2019391599B2 (en) *	2018-12-07	2025-09-18	Suntory Holdings Limited	Composition
MX2021006986A (es) *	2018-12-12	2021-08-16	Conagen Inc	Produccion biosintetica de variantes de glucosidos de esteviol.
CN109750072B (zh) *	2019-01-31	2022-04-19	南京工业大学	一种酶法制备莱鲍迪苷e的方法
EP3799057A1 (fr)	2019-09-25	2021-03-31	Koninklijke Philips N.V.	Outil de prédiction de la réponse immunitaire d'un patient à une thérapie
WO2021076924A1 (fr) *	2019-10-16	2021-04-22	Sweegen, Inc.	Formulations de glycoside de stéviol pour aliments et boissons
CN110846363B (zh) *	2019-11-11	2023-02-17	天津大学	一锅法生产莱鲍迪苷d的方法
CN110734944B (zh) *	2019-11-11	2023-02-21	中化健康产业发展有限公司	一步法合成莱鲍迪苷m的方法
CN110872586B (zh) *	2019-11-11	2024-01-30	天津大学	固定化葡萄糖基转移酶及制备方法及催化生产莱鲍迪苷d的方法
CN110846305B (zh) *	2019-11-11	2023-11-28	中化健康产业发展有限公司	一种固定化糖基转移酶催化莱鲍迪苷a生成莱鲍迪苷m的方法
PH12022552315A1 (en) *	2020-03-13	2024-01-08	Amyris Inc	Rebaudioside m sweetener compositions
CN115666265B (zh) *	2020-04-20	2025-10-28	可口可乐公司	具有增强风味的包含赛门苷i的饮料
US20250320470A1 (en) *	2020-12-23	2025-10-16	Samyang Corporation	Glycosyltransferase and steviol glucoside preparation method using same
JP7210626B2 (ja) *	2021-02-18	2023-01-23	ペプシコ・インク	酵素的方法を使用してレバウディオサイドｊを調製するための方法
WO2023121426A1 (fr) *	2021-12-24	2023-06-29	주식회사 삼양사	Production de rébaudioside
EP4496482A1 (fr)	2022-03-23	2025-01-29	Sweegen, Inc.	Édulcorant comprenant du rébaudioside m et de la brazzéine
CN114921434B (zh) *	2022-05-27	2024-02-20	中化健康产业发展有限公司	催化Reb A生产Reb M的重组糖基转移酶
DE202022103252U1 (de)	2022-06-09	2022-07-01	Wal Ankita	Eine natürliche Süßstoffzusammensetzung als Süßungsmittel für Diabetes
CN116076694B (zh) *	2022-10-12	2024-06-28	四川盈嘉合生科技有限公司	一种甜菊糖苷甜味剂及其制备方法
CN117209563B (zh) *	2023-09-15	2025-09-19	郑州大学	呈味肽及其应用
KR102876472B1 (ko) *	2023-12-26	2025-10-27	주식회사 삼양사	수크로우스 합성효소 변이체, udp-글루코실트랜스퍼라제 변이체 및 이들의 스테비올 배당체 생산 용도
KR102777875B1 (ko) *	2024-10-22	2025-03-13	대한민국	신규 페디오코커스 속 균주 및 그의 용도
CN119842657B (zh) *	2025-03-18	2025-05-27	青岛奔月生物技术有限公司	蔗糖合酶突变体及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014122328A1 (fr) *	2013-02-11	2014-08-14	Evolva Sa	Production efficace de glycosides de stéviol dans des hôtes recombinés
WO2014122227A2 (fr) *	2013-02-06	2014-08-14	Evolva Sa	Procédés pour la production améliorée de rébaudioside d et de rébaudioside m
WO2015065650A2 (fr) *	2013-11-01	2015-05-07	Conagen Inc.	Production par recombinaison de glycosides de stéviol

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US17804A (en) *		1857-07-14		Improvement in locks
US4612942A (en)	1984-03-08	1986-09-23	Stevia Company, Inc.	Flavor enhancing and modifying materials
JPH04149191A (ja) *	1990-10-09	1992-05-22	Nakano Vinegar Co Ltd	ステビオサイド糖転移化合物及びその製造方法
US20090183270A1 (en)	2002-10-02	2009-07-16	Adams Thomas R	Transgenic plants with enhanced agronomic traits
US9107436B2 (en)	2011-02-17	2015-08-18	Purecircle Sdn Bhd	Glucosylated steviol glycoside as a flavor modifier
MX2009004344A (es) *	2006-10-24	2009-05-05	Givaudan Sa	Productos de consumo.
US8277862B2 (en)	2007-03-14	2012-10-02	Concentrate Manufacturing Company Of Ireland	Beverage products having steviol glycosides and at least one acid
US20130071521A1 (en) *	2007-03-14	2013-03-21	Pepsico, Inc.	Rebaudioside d sweeteners and food products sweetened with rebaudioside d
KR102061165B1 (ko) *	2008-10-03	2019-12-31	모리타 가가쿠 고교 가부시키가이샤	신규 스테비올 배당체
US8501261B2 (en) *	2010-05-21	2013-08-06	Purecircle Sdn Bhd	High-purity Rebaudioside C and process for purification of the same
CN105671108A (zh) *	2010-06-02	2016-06-15	沃维公司	甜菊糖苷的重组生产
WO2012075030A1 (fr) *	2010-11-30	2012-06-07	Massachusetts Institute Of Technology	Production microbienne d'édulcorants naturels, glycosides de stéviol diterpénoïdes
WO2013022989A2 (fr)	2011-08-08	2013-02-14	Evolva Sa	Production par recombinaison de glycosides de stéviol
ES2787899T3 (es)	2011-12-19	2020-10-19	Purecircle Sdn Bhd	Métodos para purificar glucósidos de esteviol
CA2867112C (fr)	2012-03-16	2021-04-20	Suntory Holdings Limited	Glycosyltransferase de steviol et gene codant correspondant
CN103974628B (zh) *	2012-05-22	2019-04-05	谱赛科有限责任公司	高纯度的甜菊醇糖苷
US9752174B2 (en)	2013-05-28	2017-09-05	Purecircle Sdn Bhd	High-purity steviol glycosides
EP2902410B1 (fr) *	2012-09-29	2022-01-05	Sichuan Ingia Biosynthetic Co., Ltd.	Méthode de production de composés stévioside au moyen de microorganismes
US20160015064A1 (en) *	2013-03-14	2016-01-21	Chromocell Corporation	Compounds, compositions, and methods for modulating sweet taste
US9717267B2 (en)	2013-03-14	2017-08-01	The Coca-Cola Company	Beverages containing rare sugars
EP2970354B1 (fr)	2013-03-15	2018-05-30	The Coca-Cola Company	Glycosides de stéviol et leurs compositions
US20140342043A1 (en) *	2013-05-14	2014-11-20	Pepsico, Inc.	Rebaudioside Sweetener Compositions and Food Products Sweetened with Same
JP2016529878A (ja)	2013-06-19	2016-09-29	ファイトテックコーポレーション	レバウジオシドｅおよびレバウジオシドｅで甘味化された食品製品
CN108064135A (zh)	2013-07-15	2018-05-22	帝斯曼知识产权资产管理有限公司	二萜的生产
CN103397064B (zh) *	2013-08-14	2015-04-15	苏州汉酶生物技术有限公司	一种酶法制备瑞鲍迪甙m的方法
EP3508584A1 (fr)	2014-01-28	2019-07-10	PepsiCo, Inc.	Procédé de préparation de rébaudioside m à l'aide d'un procédé d'enzyme
US9522929B2 (en) *	2014-05-05	2016-12-20	Conagen Inc.	Non-caloric sweetener
MY164345A (en) *	2014-09-30	2017-12-15	Suntory Beverage & Food Ltd	Carbonated beverage, syrup used for preparing carbonated beverage, method for manufacturing carbonated beverage, and method for suppressing foaming in carbonated beverage
BR112017006139B1 (pt)	2014-10-03	2022-04-05	Conagen Inc	Método para a sintetização de rebaudiosídeo m ou rebaudiosídeo d e rebaudiosídeo m
EP3283614B1 (fr) *	2015-04-14	2020-07-08	Conagen Inc.	Production d'édulcorants non caloriques ayant recours à des catalyseurs de cellules entières modifiées
BR112018076303B1 (pt) *	2016-06-17	2022-10-11	Cargill, Incorporated	Composição adoçante, bebida e método de modificação de uma característica sensorial de uma composição
BR112019007504B1 (pt) *	2016-10-14	2023-05-09	Conagen Inc	Método de preparação de uma composição de glicosídeo de esteviol
MX2021006986A (es) *	2018-12-12	2021-08-16	Conagen Inc	Produccion biosintetica de variantes de glucosidos de esteviol.
WO2021076924A1 (fr) *	2019-10-16	2021-04-22	Sweegen, Inc.	Formulations de glycoside de stéviol pour aliments et boissons

2015
- 2015-10-02 BR BR112017006139-2A patent/BR112017006139B1/pt active IP Right Grant
- 2015-10-02 AU AU2015327858A patent/AU2015327858B2/en active Active
- 2015-10-02 BR BR112017006155-4A patent/BR112017006155A2/pt not_active Application Discontinuation
- 2015-10-02 CN CN201580052182.XA patent/CN106715451B/zh active Active
- 2015-10-02 MX MX2017004246A patent/MX378831B/es unknown
- 2015-10-02 JP JP2017516928A patent/JP6854238B2/ja not_active Expired - Fee Related
- 2015-10-02 KR KR1020177008543A patent/KR102557670B1/ko active Active
- 2015-10-02 AU AU2015327940A patent/AU2015327940B2/en active Active
- 2015-10-02 CA CA2958437A patent/CA2958437C/fr active Active
- 2015-10-02 AU AU2015327862A patent/AU2015327862B2/en active Active
- 2015-10-02 WO PCT/US2015/053777 patent/WO2016054540A1/fr not_active Ceased
- 2015-10-02 CN CN201580051860.0A patent/CN106714578B/zh active Active
- 2015-10-02 DK DK15846977.5T patent/DK3200615T3/da active
- 2015-10-02 WO PCT/US2015/053789 patent/WO2016054548A1/fr not_active Ceased
- 2015-10-02 CN CN202211009324.2A patent/CN115918884B/zh active Active
- 2015-10-02 ES ES15846977T patent/ES2741741T3/es active Active
- 2015-10-02 MY MYPI2017701156A patent/MY183062A/en unknown
- 2015-10-02 JP JP2017517349A patent/JP6722177B2/ja active Active
- 2015-10-02 CN CN202210685584.5A patent/CN114908135B/zh active Active
- 2015-10-02 KR KR1020177008545A patent/KR102526446B1/ko active Active
- 2015-10-02 MY MYPI2017701154A patent/MY179680A/en unknown
- 2015-10-02 MY MYPI2017701146A patent/MY190567A/en unknown
- 2015-10-02 ES ES15847221.7T patent/ES2693371T3/es active Active
- 2015-10-02 HU HUE15846977A patent/HUE045992T2/hu unknown
- 2015-10-02 CN CN201580052483.2A patent/CN106795547B/zh active Active
- 2015-10-02 EP EP15847668.9A patent/EP3201351B1/fr active Active
- 2015-10-02 CN CN201580053379.5A patent/CN106795195B/zh active Active
- 2015-10-02 WO PCT/US2015/053767 patent/WO2016054534A1/fr not_active Ceased
- 2015-10-02 BR BR112017006163-5A patent/BR112017006163B1/pt active IP Right Grant
- 2015-10-02 EP EP15846977.5A patent/EP3200615B1/fr active Active
- 2015-10-02 MX MX2017004247A patent/MX368414B/es active IP Right Grant
- 2015-10-02 US US14/873,481 patent/US9783566B2/en active Active
- 2015-10-02 US US14/873,470 patent/US9850270B2/en active Active
- 2015-10-02 US US14/873,474 patent/US9567619B2/en active Active
- 2015-10-02 DK DK15847221.7T patent/DK3201212T3/en active
- 2015-10-02 JP JP2017517085A patent/JP6774945B2/ja active Active
- 2015-10-02 MY MYPI2017701153A patent/MY182725A/en unknown
- 2015-10-02 EP EP15847221.7A patent/EP3201212B1/fr active Active
- 2015-10-02 EP EP15845748.1A patent/EP3201211B1/fr active Active
- 2015-10-02 CA CA2958434A patent/CA2958434C/fr active Active
- 2015-10-02 DK DK15847668.9T patent/DK3201351T3/da active
- 2015-10-02 CN CN202110535948.7A patent/CN113603736A/zh active Pending
- 2015-10-02 US US14/873,476 patent/US10023604B2/en active Active
- 2015-10-02 MX MX2017004245A patent/MX367090B/es active IP Right Grant
- 2015-10-02 JP JP2017517121A patent/JP6883512B2/ja active Active
- 2015-10-02 HU HUE15847668A patent/HUE053331T2/hu unknown
- 2015-10-02 KR KR1020177008546A patent/KR102536036B1/ko active Active
- 2015-10-02 CA CA2958093A patent/CA2958093C/fr active Active
- 2015-10-02 ES ES15847668T patent/ES2869823T3/es active Active
- 2015-10-02 MX MX2017004248A patent/MX389979B/es unknown
- 2015-10-02 AU AU2015327854A patent/AU2015327854B2/en active Active
- 2015-10-02 KR KR1020177008544A patent/KR102521967B1/ko active Active
- 2015-10-02 CA CA2958105A patent/CA2958105C/fr active Active
- 2015-10-02 WO PCT/US2015/053782 patent/WO2016054544A1/fr not_active Ceased
2016
- 2016-01-19 US US15/000,774 patent/US9908913B2/en active Active
- 2016-06-03 US US15/172,953 patent/US9643990B2/en active Active
2017
- 2017-03-03 US US15/449,108 patent/US10010099B2/en active Active
- 2017-03-03 US US15/449,130 patent/US10010101B2/en active Active
- 2017-04-12 US US15/485,301 patent/US10059732B2/en active Active
- 2017-04-12 US US15/485,309 patent/US10160781B2/en active Active
- 2017-09-07 US US15/697,628 patent/US10570163B2/en active Active
- 2017-11-01 US US15/800,209 patent/US10450338B2/en active Active
- 2017-11-01 US US15/800,194 patent/US10442831B2/en active Active
- 2017-11-02 US US15/801,411 patent/US10774103B2/en active Active
- 2017-11-02 US US15/801,431 patent/US10800803B2/en active Active
2018
- 2018-05-21 US US15/984,821 patent/US20180258124A1/en not_active Abandoned
- 2018-05-21 US US15/984,846 patent/US10597419B2/en active Active
- 2018-05-21 US US15/984,872 patent/US10584143B2/en active Active
2020
- 2020-01-28 US US16/775,040 patent/US11186604B2/en active Active
- 2020-02-24 US US16/799,522 patent/US11453692B2/en active Active
2021
- 2021-11-29 US US17/536,919 patent/US11884694B2/en active Active
2022
- 2022-08-19 US US17/820,921 patent/US20230002435A1/en active Pending

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014122227A2 (fr) *	2013-02-06	2014-08-14	Evolva Sa	Procédés pour la production améliorée de rébaudioside d et de rébaudioside m
WO2014122328A1 (fr) *	2013-02-11	2014-08-14	Evolva Sa	Production efficace de glycosides de stéviol dans des hôtes recombinés
WO2015065650A2 (fr) *	2013-11-01	2015-05-07	Conagen Inc.	Production par recombinaison de glycosides de stéviol

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"RecName: Full=Glycosyltransferase {ECO:0000256\|RuleBase:RU362057}; EC=2.4.1.- {ECO:0000256\|RuleBase:RU362057}", UNIPROT,, 31 May 2011 (2011-05-31), XP002777939 *
See also references of WO2016054534A1 *

Also Published As

Publication number	Publication date
AU2015327862A1 (en)	2017-03-09
JP6883512B2 (ja)	2021-06-09
DK3201212T3 (en)	2018-11-26
US10774103B2 (en)	2020-09-15
US9908913B2 (en)	2018-03-06
KR102521967B1 (ko)	2023-04-13
US11884694B2 (en)	2024-01-30
EP3201212A4 (fr)	2017-11-22
US10010101B2 (en)	2018-07-03
JP2017531634A (ja)	2017-10-26
CA2958093A1 (fr)	2016-04-07
US20170181452A1 (en)	2017-06-29
CN106714578B (zh)	2020-07-28
BR112017006163B1 (pt)	2022-04-05
KR102557670B1 (ko)	2023-07-20
EP3201351A1 (fr)	2017-08-09
US10597419B2 (en)	2020-03-24
CN114908135B (zh)	2024-10-18
JP6774945B2 (ja)	2020-10-28
MY183062A (en)	2021-02-10
US20230002435A1 (en)	2023-01-05
CN106714578A (zh)	2017-05-24
ES2741741T3 (es)	2020-02-12
WO2016054540A1 (fr)	2016-04-07
JP2017529857A (ja)	2017-10-12
EP3201211A1 (fr)	2017-08-09
AU2015327854A1 (en)	2017-03-09
MX378831B (es)	2025-03-10
CA2958105C (fr)	2021-01-26
MX2017004247A (es)	2017-05-19
US10059732B2 (en)	2018-08-28
CN106715451B (zh)	2022-11-08
US20160153018A1 (en)	2016-06-02
KR20170061680A (ko)	2017-06-05
CA2958434C (fr)	2021-01-19
KR20170066371A (ko)	2017-06-14
EP3201351A4 (fr)	2018-03-28
US20200331952A1 (en)	2020-10-22
US10800803B2 (en)	2020-10-13
BR112017006139A2 (pt)	2018-07-03
US20200339621A1 (en)	2020-10-29
CN113603736A (zh)	2021-11-05
CA2958434A1 (fr)	2016-04-07
US20180258124A1 (en)	2018-09-13
JP6854238B2 (ja)	2021-04-14
ES2869823T3 (es)	2021-10-25
US10584143B2 (en)	2020-03-10
CN106795195A (zh)	2017-05-31
US20180258125A1 (en)	2018-09-13
US10450338B2 (en)	2019-10-22
CN114908135A (zh)	2022-08-16
DK3200615T3 (da)	2019-08-19
MX368414B (es)	2019-10-02
HUE045992T2 (hu)	2020-01-28
ES2693371T3 (es)	2018-12-11
US20180057522A1 (en)	2018-03-01
US20160326206A1 (en)	2016-11-10
US20220162248A1 (en)	2022-05-26
EP3201211A4 (fr)	2018-04-04
US10160781B2 (en)	2018-12-25
US10570163B2 (en)	2020-02-25
CN115918884B (zh)	2024-04-30
US20170218420A1 (en)	2017-08-03
BR112017006330A2 (pt)	2018-01-16
KR102536036B1 (ko)	2023-05-23
JP2017537606A (ja)	2017-12-21
US9567619B2 (en)	2017-02-14
KR102526446B1 (ko)	2023-04-27
AU2015327858A1 (en)	2017-03-09
EP3201211B1 (fr)	2021-09-29
BR112017006163A2 (pt)	2018-07-31
AU2015327940B2 (en)	2020-04-16
WO2016054534A1 (fr)	2016-04-07
US20160095338A1 (en)	2016-04-07
CN106715451A (zh)	2017-05-24
US10442831B2 (en)	2019-10-15
US20170196248A1 (en)	2017-07-13
US11186604B2 (en)	2021-11-30
US20160097072A1 (en)	2016-04-07
US20160097071A1 (en)	2016-04-07
KR20170062461A (ko)	2017-06-07
CN106795547A (zh)	2017-05-31
JP6722177B2 (ja)	2020-07-15
HUE053331T2 (hu)	2021-06-28
BR112017006139B1 (pt)	2022-04-05
US20160097070A1 (en)	2016-04-07
EP3201212A1 (fr)	2017-08-09
CA2958437C (fr)	2021-03-30
CA2958105A1 (fr)	2016-04-07
MX2017004246A (es)	2017-05-19
WO2016054544A1 (fr)	2016-04-07
CN106795195B (zh)	2021-11-12
MX2017004248A (es)	2017-05-19
US11453692B2 (en)	2022-09-27
EP3201212B1 (fr)	2018-09-19
US20170218421A1 (en)	2017-08-03
MY190567A (en)	2022-04-27
AU2015327940A1 (en)	2017-03-16
MY179680A (en)	2020-11-11
US9783566B2 (en)	2017-10-10
CN106795547B (zh)	2021-07-23
US10010099B2 (en)	2018-07-03
EP3200615A1 (fr)	2017-08-09
KR20170067738A (ko)	2017-06-16
MX389979B (es)	2025-03-20
US9850270B2 (en)	2017-12-26
EP3201351B1 (fr)	2021-01-06
BR112017006155A2 (pt)	2018-07-03
MX367090B (es)	2019-08-05
AU2015327858B2 (en)	2020-06-18
US20180057520A1 (en)	2018-03-01
DK3201351T3 (da)	2021-02-22
CN115918884A (zh)	2023-04-07
AU2015327862B2 (en)	2020-05-07
US10023604B2 (en)	2018-07-17
US20170362267A1 (en)	2017-12-21
CA2958437A1 (fr)	2016-04-07
MX2017004245A (es)	2017-05-19
US20180057519A1 (en)	2018-03-01
US9643990B2 (en)	2017-05-09
JP2017535251A (ja)	2017-11-30
US20180057521A1 (en)	2018-03-01
WO2016054548A1 (fr)	2016-04-07
AU2015327854B2 (en)	2019-09-12
EP3200615B1 (fr)	2019-05-29
MY182725A (en)	2021-02-03
US20180258126A1 (en)	2018-09-13
CA2958093C (fr)	2021-01-26

Publication	Publication Date	Title
EP3201211A4 (fr)	2018-04-04	Édulcorants non caloriques et procédés de synthèse
EP3148959A4 (fr)	2017-12-27	Procédés intégrés pour la synthèse de produits chimiques
EP3136368A4 (fr)	2017-11-29	Appareil de reconnaissance d'environnement externe
EP3191438A4 (fr)	2018-03-28	Exhausteur de sucrosité
EP3114107A4 (fr)	2017-11-01	Dérivés de propellane et synthèse
EP3113594A4 (fr)	2017-03-01	Appareil de placement de pièces
EP3101922A4 (fr)	2017-08-30	Appareil
EP3166447A4 (fr)	2018-03-21	Appareil de fixation
EP3137646A4 (fr)	2017-11-01	Appareil de pulvérisation
EP3209051A4 (fr)	2018-05-30	Appareil
EP3186793A4 (fr)	2018-04-11	Mecanisme de détection de sécurité de portail
EP3125947A4 (fr)	2017-12-13	Procédé de production de compositions d'édulcorant et compositions d'édulcorant
EP3118003A4 (fr)	2017-10-25	Appareil d'impression
EP3168433A4 (fr)	2017-08-09	Appareil de rotation
EP3141543B8 (fr)	2022-06-08	Intermédiaire de vortioxétine et son procédé de synthèse
EP3172535A4 (fr)	2018-03-14	Sonde
EP3108271A4 (fr)	2018-01-03	Auto-test de localisateur
EP3226179A4 (fr)	2018-08-08	Appareil électronique
EP3178834A4 (fr)	2018-04-04	Procédé de synthèse chimique de la phillyrine
EP3109940A4 (fr)	2017-02-22	Appareil d'antenne
EP3203719A4 (fr)	2018-03-07	Appareil électronique
EP3136769A4 (fr)	2018-05-09	Appareil
EP3104642A4 (fr)	2017-06-28	Appareil
EP3138268A4 (fr)	2017-12-13	Réglage d'orientation d'écran
EP3093884A4 (fr)	2017-04-26	Appareil électronique

Legal Events

Date	Code	Title	Description
2017-02-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2017-07-07	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2017-07-07	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2017-08-09	17P	Request for examination filed	Effective date: 20170217
2017-08-09	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-08-09	AX	Request for extension of the european patent	Extension state: BA ME
2017-08-16	RIN1	Information on inventor provided before grant (corrected)	Inventor name: MAO, GUOHONG Inventor name: YU, XIAODAN
2018-01-10	DAV	Request for validation of the european patent (deleted)
2018-01-10	DAX	Request for extension of the european patent (deleted)
2018-04-04	A4	Supplementary search report drawn up and despatched	Effective date: 20180302
2018-04-04	RIC1	Information provided on ipc code assigned before grant	Ipc: C07H 15/256 20060101AFI20180226BHEP
2018-05-22	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Ref document number: 602015031205 Country of ref document: DE Free format text: PREVIOUS MAIN CLASS: A23L0027300000 Ipc: C07H0015256000
2018-06-24	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2018-06-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: GRANT OF PATENT IS INTENDED
2018-06-27	RIC1	Information provided on ipc code assigned before grant	Ipc: C07H 15/256 20060101AFI20180522BHEP
2018-07-25	INTG	Intention to grant announced	Effective date: 20180625
2018-09-11	GRAS	Grant fee paid	Free format text: ORIGINAL CODE: EPIDOSNIGR3
2018-10-06	GRAJ	Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted	Free format text: ORIGINAL CODE: EPIDOSDIGR1
2018-10-06	GRAL	Information related to payment of fee for publishing/printing deleted	Free format text: ORIGINAL CODE: EPIDOSDIGR3
2018-10-06	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2018-10-31	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: CONAGEN INC.
2018-11-14	INTC	Intention to grant announced (deleted)
2018-12-11	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2018-12-11	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: GRANT OF PATENT IS INTENDED
2019-01-09	INTG	Intention to grant announced	Effective date: 20181212
2019-04-26	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
2019-04-26	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE PATENT HAS BEEN GRANTED
2019-05-29	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2019-05-29	REG	Reference to a national code	Ref country code: GB Ref legal event code: FG4D
2019-05-31	REG	Reference to a national code	Ref country code: CH Ref legal event code: EP
2019-06-15	REG	Reference to a national code	Ref country code: AT Ref legal event code: REF Ref document number: 1138190 Country of ref document: AT Kind code of ref document: T Effective date: 20190615
2019-06-19	REG	Reference to a national code	Ref country code: DE Ref legal event code: R096 Ref document number: 602015031205 Country of ref document: DE
2019-06-26	REG	Reference to a national code	Ref country code: IE Ref legal event code: FG4D
2019-08-19	REG	Reference to a national code	Ref country code: DK Ref legal event code: T3 Effective date: 20190816
2019-08-28	REG	Reference to a national code	Ref country code: NL Ref legal event code: FP
2019-09-10	REG	Reference to a national code	Ref country code: SE Ref legal event code: TRGR
2019-10-10	REG	Reference to a national code	Ref country code: LT Ref legal event code: MG4D
2019-10-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190829 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190930 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2019-11-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190830 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190829 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2020-01-28	REG	Reference to a national code	Ref country code: HU Ref legal event code: AG4A Ref document number: E045992 Country of ref document: HU
2020-01-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2020-02-12	REG	Reference to a national code	Ref country code: ES Ref legal event code: FG2A Ref document number: 2741741 Country of ref document: ES Kind code of ref document: T3 Effective date: 20200212
2020-02-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2020-03-03	REG	Reference to a national code	Ref country code: DE Ref legal event code: R097 Ref document number: 602015031205 Country of ref document: DE
2020-03-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2020-04-03	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
2020-04-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
2020-05-01	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2020-05-06	26N	No opposition filed	Effective date: 20200303
2020-05-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529 Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2020-07-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20191002
2021-05-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2021-06-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190929
2021-07-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2022-04-15	REG	Reference to a national code	Ref country code: AT Ref legal event code: UEP Ref document number: 1138190 Country of ref document: AT Kind code of ref document: T Effective date: 20190529
2022-06-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190529
2024-11-15	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: NL Payment date: 20241021 Year of fee payment: 10
2024-11-28	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: HU Payment date: 20241024 Year of fee payment: 10
2025-01-10	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: DE Payment date: 20241021 Year of fee payment: 10
2025-01-15	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: DK Payment date: 20241025 Year of fee payment: 10
2025-01-16	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: BE Payment date: 20241021 Year of fee payment: 10
2025-01-17	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: GB Payment date: 20241025 Year of fee payment: 10
2025-01-23	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: FR Payment date: 20241030 Year of fee payment: 10 Ref country code: AT Payment date: 20241022 Year of fee payment: 10
2025-01-24	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: IE Payment date: 20241028 Year of fee payment: 10
2025-01-28	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: ES Payment date: 20241127 Year of fee payment: 10
2025-01-29	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: SE Payment date: 20241021 Year of fee payment: 10
2025-01-31	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: CH Payment date: 20241101 Year of fee payment: 10