EP3172342A4 - Criblage et surveillance de la progression du diabète de type 2 par l'identification moléculaire de la flore intestinale à l'aide de fta comme dispositif de recueil de matières fécales - Google Patents

Criblage et surveillance de la progression du diabète de type 2 par l'identification moléculaire de la flore intestinale à l'aide de fta comme dispositif de recueil de matières fécales Download PDF

Info

Publication number: EP3172342A4
Authority: EP; European Patent Office
Prior art keywords: fta; progression; diabetes; screening; monitoring
Prior art date: 2014-07-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP15824750.2A

Other languages

German (de)

English (en)

Other versions

EP3172342A1 (fr

EP3172342B1 (fr

Inventor

Jeffrey Kenneth Horton

Peter James Tatnell

Matthew Sam Morrison

Alan Stuart Pierce

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Global Life Sciences Solutions Operations UK Ltd

Original Assignee

GE Healthcare UK Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-07-25

Filing date

2015-07-23

Publication date

2017-12-13

2015-07-23 Application filed by GE Healthcare UK Ltd filed Critical GE Healthcare UK Ltd

2017-05-31 Publication of EP3172342A1 publication Critical patent/EP3172342A1/fr

2017-12-13 Publication of EP3172342A4 publication Critical patent/EP3172342A4/fr

2024-11-13 Application granted granted Critical

2024-11-13 Publication of EP3172342B1 publication Critical patent/EP3172342B1/fr

Status Active legal-status Critical Current

2035-07-23 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/06—Quantitative determination
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Immunology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

EP15824750.2A 2014-07-25 2015-07-23 Criblage et surveillance de la progression du diabète de type 2 par l'identification moléculaire de la flore intestinale à l'aide de fta comme dispositif de recueil de matières fécales Active EP3172342B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201462029155P	2014-07-25	2014-07-25
PCT/US2015/041779 WO2016014822A1 (fr)	2014-07-25	2015-07-23	Criblage et surveillance de la progression du diabète de type 2 par l'identification moléculaire de la flore intestinale à l'aide de fta comme dispositif de recueil de matières fécales

Publications (3)

Publication Number	Publication Date
EP3172342A1 EP3172342A1 (fr)	2017-05-31
EP3172342A4 true EP3172342A4 (fr)	2017-12-13
EP3172342B1 EP3172342B1 (fr)	2024-11-13

Family

ID=55163773

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP15824750.2A Active EP3172342B1 (fr)	2014-07-25	2015-07-23	Criblage et surveillance de la progression du diabète de type 2 par l'identification moléculaire de la flore intestinale à l'aide de fta comme dispositif de recueil de matières fécales

Country Status (3)

Country	Link
US (1)	US10982290B2 (fr)
EP (1)	EP3172342B1 (fr)
WO (1)	WO2016014822A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3622289B1 (fr) *	2017-05-11	2023-08-23	Immundiagnostik AG	Procédé et kit pour déterminer quantitativement des biomarqueurs dans des échantillons fécals
CN108893523A (zh) *	2018-05-31	2018-11-27	厦门安捷致善医学数据科技有限公司	一种粪便样品常温保存液
CN110512011A (zh) *	2019-08-27	2019-11-29	深圳百诺精准医疗科技有限公司	一种肠道菌群检测分析方法、装置、系统及存储介质
CN111876510A (zh) *	2020-09-14	2020-11-03	壹宏(深圳)基因有限公司	一种用于粪便微生物检测的试剂及其在粪便拟杆菌属检测中的应用
CN115261271B (zh) *	2022-08-01	2023-12-12	厦门承葛生物科技有限公司	一种肠道菌群的高通量分离培养与筛选方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2338989A1 (fr) *	2008-08-26	2011-06-29	Olympus Corporation	Procédé de préparation d un échantillon fécal, solution de préparation d un échantillon fécal et kit de recueillement de fèces
WO2012080754A2 (fr) *	2010-12-16	2012-06-21	Genetic Analysis As	Ensemble de sondes oligonucléotidiques et procédés de profilage de microbiote

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020086289A1 (en) *	1999-06-15	2002-07-04	Don Straus	Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms
CN104774924B (zh) *	2006-09-18	2021-04-13	通用电气医疗集团生物科学公司	用玻璃覆盖的生物学试剂的制备
EP2137323A4 (fr) *	2007-02-28	2011-01-12	Ge Healthcare Bio Sciences	Réactifs chimiques/biologiques stables à température ambiante sur membranes ou filtres
US20110256592A1 (en) *	2008-12-12	2011-10-20	Eurogentec S.A	Use of cyclodextrins to improve the specificity, sensitivity and yield of nucleic acid amplification reactions
EP2249140B1 (fr) *	2009-05-07	2018-06-27	F. Hoffmann-La Roche AG	Procédé d'extraction d'échantillons biologiques sur un support solide
CN101792808A (zh) *	2010-03-30	2010-08-04	广州市香港科大霍英东研究院	以Alu间聚合酶链式反应为基础的检测基因区特征的方法
BE1019267A3 (nl)	2010-03-31	2012-05-08	Gols Johan De	Gaassamenstel voor het verstevigen van weefsel dat zich rondom een chirurgisch gecreeerde stoma uitstrekt.
KR102083695B1 (ko) *	2012-04-10	2020-03-02	옥스포드 나노포어 테크놀로지즈 리미티드	돌연변이체 리세닌 기공

2015
- 2015-07-23 WO PCT/US2015/041779 patent/WO2016014822A1/fr not_active Ceased
- 2015-07-23 US US15/326,382 patent/US10982290B2/en active Active
- 2015-07-23 EP EP15824750.2A patent/EP3172342B1/fr active Active

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2338989A1 (fr) *	2008-08-26	2011-06-29	Olympus Corporation	Procédé de préparation d un échantillon fécal, solution de préparation d un échantillon fécal et kit de recueillement de fèces
WO2012080754A2 (fr) *	2010-12-16	2012-06-21	Genetic Analysis As	Ensemble de sondes oligonucléotidiques et procédés de profilage de microbiote

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LAYTON ALICE ET AL: "Development of Bacteroides 16S rRNA gene TaqMan-based real-time PCR assays for estimation of total, human, and bovine fecal pollution in water", APPLIED AND ENVIRONMENTAL MICROBIOLOGY,, vol. 72, no. 6, 1 June 2006 (2006-06-01), pages 4214 - 4224, XP002428213, ISSN: 0099-2240, DOI: 10.1128/AEM.01036-05 *
NADJA LARSEN ET AL: "Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults", PLOS ONE, vol. 5, no. 2, 1 January 2010 (2010-01-01), pages e9085 - e9085, XP055004750, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0009085 *
O. PALIY ET AL: "High-Throughput Quantitative Analysis of the Human Intestinal Microbiota with a Phylogenetic Microarray", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 75, no. 11, 1 June 2009 (2009-06-01), pages 3572 - 3579, XP055020698, ISSN: 0099-2240, DOI: 10.1128/AEM.02764-08 *
See also references of WO2016014822A1 *

Also Published As

Publication number	Publication date
EP3172342A1 (fr)	2017-05-31
US20170211130A1 (en)	2017-07-27
EP3172342B1 (fr)	2024-11-13
WO2016014822A1 (fr)	2016-01-28
US10982290B2 (en)	2021-04-20

Publication	Publication Date	Title
GB2556455B (en)	2022-04-20	Process device condition and performance monitoring
EP3119271A4 (fr)	2018-01-03	Dispositif de surveillance d'état de santé
EP3110311A4 (fr)	2017-09-27	Dispositif et procédé de surveillance séparable
EP3188648A4 (fr)	2018-03-28	Système de surveillance de la santé d'un animal de compagnie
EP3236839A4 (fr)	2018-07-25	Dispositif de surveillance de santé et de réponse
EP3174576A4 (fr)	2018-03-28	Dispositif d'injection pour surveillance continue du glucose
EP3099224A4 (fr)	2017-09-27	Systèmes et méthodes de contrôle de la santé
EP3240569A4 (fr)	2018-05-30	Anticorps anti-cd47 et leurs utilisations
EP3151551A4 (fr)	2017-11-15	Dispositif et procédé de surveillance intelligent
EP3116395A4 (fr)	2017-12-06	Vêtements de surveillance physiologique
EP3264888A4 (fr)	2018-12-05	Dispositif de surveillance d'un animal
EP2980546B8 (fr)	2022-07-13	Dispositif de surveillance de bruit intelligent et procédé de surveillance de bruit l'utilisant
EP3167267A4 (fr)	2018-01-10	Dispositif de surveillance d'usure de chaîne
EP3220627A4 (fr)	2018-04-25	Dispositif de détection de lumière, dispositif de capture d'image et élément de capture d'image
EP3469983A4 (fr)	2019-06-12	Dispositif intelligent portable de surveillance de la santé
EP3106557A4 (fr)	2017-09-13	Appareil de fabrication de feuille et appareil de défibrage de matière première
EP3193733A4 (fr)	2018-06-13	Dispositif de collecte de spécimen séparable
EP3177920A4 (fr)	2018-06-20	Système de diagnostic sur site et procédé correspondant
SG11201709608UA (en)	2018-02-27	Biological monitoring device and biological monitoring program
EP3105747B8 (fr)	2020-11-18	Surveillance de présence
PL3143071T3 (pl)	2025-04-28	Sieciowalne masy na bazie polimerów zakończonych organyloksysilanem
EP3138477A4 (fr)	2018-01-10	Système de surveillance de la santé et procédé de collecte de données
EP3254412A4 (fr)	2018-10-10	Surveillance et analyse de retouches
EP3172342A4 (fr)	2017-12-13	Criblage et surveillance de la progression du diabète de type 2 par l'identification moléculaire de la flore intestinale à l'aide de fta comme dispositif de recueil de matières fécales
EP3188990A4 (fr)	2018-04-18	Surveillance d'orientation de courroie tubulaire

Legal Events

Date	Code	Title	Description
2017-01-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2017-04-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2017-04-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2017-05-31	17P	Request for examination filed	Effective date: 20170112
2017-05-31	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-05-31	AX	Request for extension of the european patent	Extension state: BA ME
2017-11-01	DAV	Request for validation of the european patent (deleted)
2017-11-01	DAX	Request for extension of the european patent (deleted)
2017-12-13	A4	Supplementary search report drawn up and despatched	Effective date: 20171114
2017-12-13	RIC1	Information provided on ipc code assigned before grant	Ipc: C12Q 1/68 20060101AFI20171108BHEP
2018-07-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2018-08-29	17Q	First examination report despatched	Effective date: 20180731
2020-08-19	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD
2023-07-05	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20230526
2024-07-01	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Ref document number: 602015090407 Country of ref document: DE Free format text: PREVIOUS MAIN CLASS: C12Q0001680000 Ipc: C12Q0001688300
2024-07-08	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2024-07-08	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: GRANT OF PATENT IS INTENDED
2024-08-07	INTG	Intention to grant announced	Effective date: 20240709
2024-08-07	RIC1	Information provided on ipc code assigned before grant	Ipc: C12Q 1/689 20180101ALI20240701BHEP Ipc: C12Q 1/6883 20180101AFI20240701BHEP
2024-10-08	GRAS	Grant fee paid	Free format text: ORIGINAL CODE: EPIDOSNIGR3
2024-10-11	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
2024-10-11	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE PATENT HAS BEEN GRANTED
2024-11-13	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2024-11-13	REG	Reference to a national code	Ref country code: GB Ref legal event code: FG4D
2024-11-15	REG	Reference to a national code	Ref country code: CH Ref legal event code: EP
2024-12-04	REG	Reference to a national code	Ref country code: IE Ref legal event code: FG4D
2024-12-05	REG	Reference to a national code	Ref country code: DE Ref legal event code: R096 Ref document number: 602015090407 Country of ref document: DE
2025-03-10	REG	Reference to a national code	Ref country code: LT Ref legal event code: MG9D
2025-03-19	REG	Reference to a national code	Ref country code: NL Ref legal event code: MP Effective date: 20241113
2025-04-11	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20250313 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20250313
2025-04-15	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113 Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-04-15	REG	Reference to a national code	Ref country code: AT Ref legal event code: MK05 Ref document number: 1741734 Country of ref document: AT Kind code of ref document: T Effective date: 20241113
2025-04-16	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-04-17	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-04-23	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20250213
2025-04-24	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20250214 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-04-25	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-04-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20250213
2025-07-03	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-07-10	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-07-18	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-07-24	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-07-25	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-07-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-07-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-08-14	REG	Reference to a national code	Ref country code: DE Ref legal event code: R097 Ref document number: 602015090407 Country of ref document: DE
2025-09-09	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20241113
2025-09-19	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
2025-09-19	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
2025-10-10	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: DE Payment date: 20250728 Year of fee payment: 11
2025-10-16	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: GB Payment date: 20250722 Year of fee payment: 11
2025-10-20	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: FR Payment date: 20250725 Year of fee payment: 11
2025-10-22	26N	No opposition filed	Effective date: 20250814