EP2560489A4 - Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof - Google Patents

Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof

Info

Publication number: EP2560489A4
Authority: EP; European Patent Office
Prior art keywords: inhibitors; enzyme; compositions; opioid prodrugs; cleavable
Prior art date: 2010-04-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP20100850371

Other languages

German (de)

French (fr)

Other versions

EP2560489A1 (en

Inventor

Thomas E Jenkins

Craig O Husfeld

Julie D Seroogy

Jonathan W Wray

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Signature Therapeutics Inc

Original Assignee

Signature Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-04-21

Filing date

2010-04-21

Publication date

2014-01-22

2010-04-21 Application filed by Signature Therapeutics Inc filed Critical Signature Therapeutics Inc

2013-02-27 Publication of EP2560489A1 publication Critical patent/EP2560489A1/en

2014-01-22 Publication of EP2560489A4 publication Critical patent/EP2560489A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

EP20100850371 2010-04-21 2010-04-21 Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof Withdrawn EP2560489A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2010/031953 WO2011133149A1 (en)	2010-04-21	2010-04-21	Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof

Publications (2)

Publication Number	Publication Date
EP2560489A1 EP2560489A1 (en)	2013-02-27
EP2560489A4 true EP2560489A4 (en)	2014-01-22

Family

ID=44834413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP20100850371 Withdrawn EP2560489A4 (en)	2010-04-21	2010-04-21	Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof

Country Status (9)

Country	Link
EP (1)	EP2560489A4 (en)
JP (1)	JP2013525348A (en)
CN (1)	CN102917589A (en)
AU (1)	AU2010351605C1 (en)
BR (1)	BR112012026768A2 (en)
CA (1)	CA2795222A1 (en)
IL (1)	IL222354A0 (en)
RU (1)	RU2012149438A (en)
WO (1)	WO2011133149A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2013503862A (en) *	2009-09-08	2013-02-04	シグネーチャーセラピューティクス，インク．	Composition comprising an enzyme-cleavable ketone-modified opioid prodrug and an optional inhibitor thereof
WO2012096887A2 (en) *	2011-01-11	2012-07-19	Signature Therapeutics, Inc.	Compositions comprising enzyme-cleavable oxycodone prodrug
US11634384B2 (en)	2014-11-25	2023-04-25	Concentric Analgesics, Inc.	Prodrugs of phenolic TRPV1 agonists
US20170056352A1 (en)	2015-08-25	2017-03-02	Rgenix, Inc.	PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
JP2019516773A (en)	2016-05-25	2019-06-20	コンセントリックアナルジジックス，インク．	Prodrugs of phenol TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
WO2018160178A1 (en)	2017-03-01	2018-09-07	Rgenix, Inc.	Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof
WO2019058367A1 (en) *	2017-09-19	2019-03-28	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.	Lipophilic peptide prodrugs
US11965041B2 (en)	2017-09-19	2024-04-23	Technische Universitaet Muenchen	N-methylated cyclic peptides and their prodrugs
TW202019887A (en)	2018-07-27	2020-06-01	美商同心止痛劑股份有限公司	Pegylated prodrugs of phenolic trpv1 agonists
AU2020402994A1 (en)	2019-12-11	2022-06-23	Inspirna, Inc.	Methods of treating cancer
US11806405B1 (en)	2021-07-19	2023-11-07	Zeno Management, Inc.	Immunoconjugates and methods
MX2024003466A (en)	2021-09-29	2024-06-04	Ensysce Biosciences Inc	Enzyme-cleavable methadone prodrugs and methods of use thereof.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007140272A2 (en) *	2006-05-26	2007-12-06	Pharmacofore, Inc.	Controlled release of phenolic opioids
WO2008101187A2 (en) *	2007-02-16	2008-08-21	Pharmacofore, Inc.	Pro-drugs of peripheral phenolic opioid antagonists
WO2010045599A1 (en) *	2008-10-17	2010-04-22	Pharmacofore, Inc.	Pharmaceutical compositions with attenuated release of phenolic opioids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2353872C (en) *	1998-12-15	2011-05-03	Tropix, Inc.	Multiple enzyme assays
US7060708B2 (en) *	1999-03-10	2006-06-13	New River Pharmaceuticals Inc.	Active agent delivery systems and methods for protecting and administering active agents
WO2007022535A2 (en) *	2005-08-19	2007-02-22	Pharmacofore, Inc.	Prodrugs of active agents
CN101309917B (en) *	2005-10-06	2013-09-11	奥斯拜客斯制药有限公司	Deuterated inhibitor of gastric H+, K+-ATPase with enhanced therapeutic properties
CN101528264B (en) *	2006-05-26	2014-02-26	特色疗法股份有限公司	Controlled release of phenolic opioids
JP2013503862A (en) *	2009-09-08	2013-02-04	シグネーチャーセラピューティクス，インク．	Composition comprising an enzyme-cleavable ketone-modified opioid prodrug and an optional inhibitor thereof

2010
- 2010-04-21 BR BR112012026768A patent/BR112012026768A2/en not_active IP Right Cessation
- 2010-04-21 RU RU2012149438/15A patent/RU2012149438A/en not_active Application Discontinuation
- 2010-04-21 EP EP20100850371 patent/EP2560489A4/en not_active Withdrawn
- 2010-04-21 WO PCT/US2010/031953 patent/WO2011133149A1/en not_active Ceased
- 2010-04-21 AU AU2010351605A patent/AU2010351605C1/en not_active Ceased
- 2010-04-21 CN CN2010800671025A patent/CN102917589A/en active Pending
- 2010-04-21 CA CA2795222A patent/CA2795222A1/en not_active Abandoned
- 2010-04-21 JP JP2013506120A patent/JP2013525348A/en active Pending
2012
- 2012-10-11 IL IL222354A patent/IL222354A0/en unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007140272A2 (en) *	2006-05-26	2007-12-06	Pharmacofore, Inc.	Controlled release of phenolic opioids
WO2008101187A2 (en) *	2007-02-16	2008-08-21	Pharmacofore, Inc.	Pro-drugs of peripheral phenolic opioid antagonists
WO2010045599A1 (en) *	2008-10-17	2010-04-22	Pharmacofore, Inc.	Pharmaceutical compositions with attenuated release of phenolic opioids

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
INTERNET CITATION, 25 October 2005 (2005-10-25), XP002350634, Retrieved from the Internet <URL:http://onlineethics.org/reseth/helsinki.html> [retrieved on 20051025] *
KATRAGADDA S ET AL: "Simultaneous modulation of transport and metabolism of acyclovir prodrugs across rabbit cornea: An approach involving enzyme inhibitors", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 320, no. 1-2, 31 August 2006 (2006-08-31), pages 104 - 113, XP027972848, ISSN: 0378-5173, [retrieved on 20060831] *
PAULETTI GIOVANNI M ET AL: "Esterase-sensitive cyclic prodrugs of peptides: Evaluation of a phenylpropionic acid promoiety in a model hexapeptide", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS, NEW YORK, NY, US, vol. 14, no. 1, 1 January 1997 (1997-01-01), pages 11 - 17, XP002496921, ISSN: 0724-8741, DOI: 10.1023/A:1012091014242 *
See also references of WO2011133149A1 *
SONG XIAOPING ET AL: "Synthesis of a novel cyclic prodrug of RGD peptidomimetic to improve its cell membrane permeation.", BIOORGANIC CHEMISTRY AUG 2002, vol. 30, no. 4, August 2002 (2002-08-01), pages 285 - 301, XP002717776, ISSN: 0045-2068 *
VESELL E S ED - TAYLOR J B: "PHARMACOGENETICS", COMPREHENSIVE MEDICINAL CHEMISTRY. BIOPHARMACEUTICALS; [COMPREHENSIVE MEDICINAL CHEMISTRY : RATIONAL DESIGN, MECHANISTIC STUDY AND THERAPEUTIC APPLICATION OF CHEMICAL COMPOUNDS], OXFORD, PERGAMON PRESS, GB, vol. 5, 1 January 1990 (1990-01-01), pages 248 - 278, XP008054499 *

Also Published As

Publication number	Publication date
AU2010351605A1 (en)	2012-11-22
AU2010351605B2 (en)	2015-01-29
CN102917589A (en)	2013-02-06
EP2560489A1 (en)	2013-02-27
IL222354A0 (en)	2012-12-31
WO2011133149A1 (en)	2011-10-27
CA2795222A1 (en)	2011-10-27
BR112012026768A2 (en)	2015-09-29
AU2010351605C1 (en)	2015-08-06
JP2013525348A (en)	2013-06-20
RU2012149438A (en)	2014-05-27

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IL222354A0 (en)	2012-12-31	Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
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HUE051133T2 (en)	2021-03-01	Pharmaceutical compositions
EP2560678A4 (en)	2013-09-18	Pharmaceutical compositions
HK1180899A (en)	2013-11-01	Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
IL215486A0 (en)	2011-12-29	Compositions of cholinesterase inhibitors
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GB201009767D0 (en)	2010-07-21	Compositions and methods
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GB201018651D0 (en)	2010-12-22	Methods and compositions
GB201018597D0 (en)	2010-12-22	Inhibitors
GB201008590D0 (en)	2010-07-07	Pharmaceutical compositions

Legal Events

Date	Code	Title	Description
2013-01-25	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2013-02-27	17P	Request for examination filed	Effective date: 20121116
2013-02-27	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
2013-02-27	AX	Request for extension of the european patent	Extension state: AL BA ME RS
2013-04-03	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: SIGNATURE THERAPEUTICS, INC.
2013-11-01	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1180899 Country of ref document: HK
2014-01-22	A4	Supplementary search report drawn up and despatched	Effective date: 20140103
2014-01-22	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/44 20060101ALI20131216BHEP Ipc: A01N 43/42 20060101AFI20131216BHEP
2015-06-03	17Q	First examination report despatched	Effective date: 20150506
2016-03-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2016-04-27	18D	Application deemed to be withdrawn	Effective date: 20151117
2019-11-29	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1180899 Country of ref document: HK