PL2558462T3 - Pyridyl-vinyl-pyrazolo-chinolines as PAR1 inhibitors - Google Patents

Pyridyl-vinyl-pyrazolo-chinolines as PAR1 inhibitors

Info

Publication number: PL2558462T3
Authority: PL; Poland
Prior art keywords: chinolines; pyrazolo; pyridyl; vinyl; par1 inhibitors
Prior art date: 2010-04-16

Application number

PL11714317T

Other languages

Polish (pl)

Inventor

Karl Schoenafinger

Henning Steinhagen

Bodo Scheiper

Uwe Heinelt

Volkmar Wehner

Matthias Herrmann

Jacques Mauger

Pavel Safar

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-04-16

Filing date

2011-04-14

Publication date

2015-03-31

2011-04-14 Application filed by Sanofi Sa filed Critical Sanofi Sa

2015-03-31 Publication of PL2558462T3 publication Critical patent/PL2558462T3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL11714317T 2010-04-16 2011-04-14 Pyridyl-vinyl-pyrazolo-chinolines as PAR1 inhibitors PL2558462T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP10305395		2010-04-16
PCT/EP2011/055964 WO2011128420A1 (en)	2010-04-16	2011-04-14	Pyridyl-vinyl pyrazoloquinolines as par1 inhibitors
EP11714317.2A EP2558462B1 (en)	2010-04-16	2011-04-14	Pyridyl-vinyl-pyrazolo-chinolines as PAR1 inhibitors

Publications (1)

Publication Number	Publication Date
PL2558462T3 true PL2558462T3 (en)	2015-03-31

Family

ID=42246248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL11714317T PL2558462T3 (en)	2010-04-16	2011-04-14	Pyridyl-vinyl-pyrazolo-chinolines as PAR1 inhibitors

Country Status (5)

Country	Link
US (1)	US8791133B2 (en)
EP (1)	EP2558462B1 (en)
ES (1)	ES2527535T3 (en)
PL (1)	PL2558462T3 (en)
WO (1)	WO2011128420A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP4242213A4 (en)	2020-12-10	2024-05-08	Lg Chem, Ltd.	BORIC ACID COMPOUND

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6063847A (en)	1997-11-25	2000-05-16	Schering Corporation	Thrombin receptor antagonists
ES2219919T3 (en)	1997-11-25	2004-12-01	Schering Corporation	ANTAGONISTS OF THE THROMBINE RECEIVER.
TWI302913B (en)	2000-06-15	2008-11-11	Schering Corp	Thrombin receptor antagonists
US7235567B2 (en)	2000-06-15	2007-06-26	Schering Corporation	Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US7488742B2 (en)	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
US20040192753A1 (en)	2000-06-15	2004-09-30	Samuel Chackalamannil	Methods of use of thrombin receptor antagonists
JP3795458B2 (en)	2001-04-19	2006-07-12	エーザイ株式会社	2-Iminopyrrolidine derivatives
JPWO2002096875A1 (en)	2001-05-25	2004-09-09	持田製薬株式会社	4-hydroxypiperidine derivative having analgesic action
PT1495018E (en)	2002-04-16	2008-02-19	Schering Corp	Tricyclic thrombin receptor antagonists
EP1607436B2 (en)	2003-03-25	2019-06-12	Sekisui Plastics Co., Ltd.	Expandable resin beads of styrene-modified linear low-density polyethylene
EP1751144B1 (en)	2004-05-28	2008-08-27	Schering Corporation	Constrained himbacine analogs as thrombin receptor antagonists
EP2075250B1 (en)	2004-10-08	2015-03-04	Merck Sharp & Dohme Corp.	Thrombin receptor antagonists
PT1853592E (en)	2005-01-14	2011-05-10	Schering Corp	Synthesis of himbacine analogs
EP1863778B1 (en)	2005-03-31	2015-12-30	Merck Sharp & Dohme Corp.	Spirocyclic thrombin receptor antagonists
CA2634907A1 (en)	2005-12-22	2007-07-05	Schering Corporation	Oxazoloisoquinoline derivatives as thrombin receptor antagonists
EP1999111B1 (en)	2006-03-29	2013-12-18	Merck Sharp & Dohme Corp.	Monocyclic and bicyclic himbacine derivatives useful as thrombin receptor antagonists
WO2008042422A2 (en)	2006-10-04	2008-04-10	Schering Corporation	Bicyclic and tricyclic derivatives as thrombin receptor antagonists
WO2009124103A2 (en) *	2008-04-02	2009-10-08	Schering Corporation	Combination therapies comprising par1 antagonists with par4 antagonists

2011
- 2011-04-14 PL PL11714317T patent/PL2558462T3/en unknown
- 2011-04-14 EP EP11714317.2A patent/EP2558462B1/en not_active Not-in-force
- 2011-04-14 ES ES11714317.2T patent/ES2527535T3/en active Active
- 2011-04-14 WO PCT/EP2011/055964 patent/WO2011128420A1/en not_active Ceased
2012
- 2012-10-16 US US13/652,893 patent/US8791133B2/en active Active

Also Published As

Publication number	Publication date
US20130040981A1 (en)	2013-02-14
EP2558462A1 (en)	2013-02-20
ES2527535T3 (en)	2015-01-26
WO2011128420A1 (en)	2011-10-20
EP2558462B1 (en)	2014-10-22
US8791133B2 (en)	2014-07-29

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PL2640893T5 (en)	2021-06-28	Compositions
GB201002983D0 (en)	2010-04-07	Nutritinal composition
GB201009549D0 (en)	2010-07-21	Compositions
EP2552214A4 (en)	2013-10-16	Pyrazolyl-pyrimidines as kinase inhibitors
EP2552211A4 (en)	2013-10-23	Indazolyl-pyrimidines as kinase inhibitors
GB201009546D0 (en)	2010-07-21	Compositions
ZA201206456B (en)	2013-05-29	Uses of dgati inhibitors
GB201010954D0 (en)	2010-08-11	Compositions
GB201009853D0 (en)	2010-07-21	HSP90 inhibitors
EP2625231A4 (en)	2014-04-16	Ink-printable compositions
GB201002861D0 (en)	2010-04-07	Compositions
IL221959A (en)	2016-11-30	Propynylaminoindan transdermal compositions
EP2632903A4 (en)	2014-11-26	Metalloenzyme inhibitor compounds
EP2651905A4 (en)	2014-05-07	Metalloenzyme inhibitor compounds
IL225952A0 (en)	2013-07-31	Pharmaceitucal compositions
GB201014591D0 (en)	2010-10-13	Compositions
PL2558465T3 (en)	2015-05-29	Tricyclic pyridyl-vinyl-pyroles as par1 inhibitors
GB201007790D0 (en)	2010-06-23	Compositions
ZA201208111B (en)	2014-03-26	Cytokine inhibitors
GB201004717D0 (en)	2010-05-05	Composition
PL2558462T3 (en)	2015-03-31	Pyridyl-vinyl-pyrazolo-chinolines as PAR1 inhibitors
GB201019606D0 (en)	2010-12-29	Compositions
GB201008043D0 (en)	2010-06-30	Compositions