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EP2288911A1 - Cartouche avec capteur à ondes acoustiques de surface (saw) intégré - Google Patents

Cartouche avec capteur à ondes acoustiques de surface (saw) intégré

Info

Publication number
EP2288911A1
EP2288911A1 EP09765769A EP09765769A EP2288911A1 EP 2288911 A1 EP2288911 A1 EP 2288911A1 EP 09765769 A EP09765769 A EP 09765769A EP 09765769 A EP09765769 A EP 09765769A EP 2288911 A1 EP2288911 A1 EP 2288911A1
Authority
EP
European Patent Office
Prior art keywords
sensor
unit according
sensor chip
flow cell
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09765769A
Other languages
German (de)
English (en)
Inventor
Markus Perpeet
Michael Koch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saw Instruments GmbH
Original Assignee
Biosensor GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosensor GmbH filed Critical Biosensor GmbH
Publication of EP2288911A1 publication Critical patent/EP2288911A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/222—Constructional or flow details for analysing fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/24—Probes
    • G01N29/2462—Probes with waveguides, e.g. SAW devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0255—(Bio)chemical reactions, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/025—Change of phase or condition
    • G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0423—Surface waves, e.g. Rayleigh waves, Love waves

Definitions

  • the invention relates to a manageable unit (“cartridge”) comprising a sensor chip for determining an analyte in a fluid, in particular a SAW sensor with a plurality of sensor elements, and a flow cell for guiding the fluid via the sensor surface of the sensor chip that is sensitive to the analyte as well as an analysis system containing such a cartridge.
  • a manageable unit comprising a sensor chip for determining an analyte in a fluid, in particular a SAW sensor with a plurality of sensor elements, and a flow cell for guiding the fluid via the sensor surface of the sensor chip that is sensitive to the analyte as well as an analysis system containing such a cartridge.
  • a sensor unit for use in such systems in particular for use in SAW gas sensor arrays, is known from DE 102 22 068 B4, this is relatively complex and can hardly guarantee easy handling. This sensor unit is unsuitable for production as a "mass-produced article”.
  • the object of the present invention is now to provide a unit of sensor chip and fluidic cell, which are easy and safe to handle and can also be used in a mobile system.
  • it is the object of designing such a unit as a cost-effective and possibly recyclable mass-produced "disposable article" in the form of a regeneratable cartridge.And it is an object of the invention to propose a mobile system for using the cartridge.
  • a particularly important basic idea of the invention resides in the cover part, which is placed directly and sealingly on the sensitive sensor surface, that is to say provided with receptor molecules, and forms the flow cell together with the sensor chip.
  • the cover part does not completely cover the sensor chip, so that the conductor tracks for contacting the sensor surface lead out of the thus formed flow cell, virtually under the edge of the cover part.
  • an easily manageable and self-contained unit in the manner of a cartridge can be realized, which integrates all the components required for analysis.
  • such a cartridge can be incorporated into an overall system with simple steps, so that an analysis can be carried out at any time without any detailed knowledge and experience, even by untrained personnel.
  • the flow cell thus has a cover part to be placed on the sensitive sensor surface, the edge of the cover part sealingly engaging the sensor surface by means of a seal, means being provided for clamping the cover part against the seal and wherein the sensor chip has conductor tracks for contacting the sensor surface, which lead out of the flow cell.
  • a particular advantage of the unit according to the invention is that it can be manufactured as a cost-effective mass product, especially for single use, and it may be particularly advantageous for economic and ecological reasons to provide for recycling.
  • the cartridges according to the invention can thus be used as consumables in mobile systems which can identify and quantify illegal drugs, explosives and possibly also other toxic and hazardous substances by electronic-biochemical means.
  • the lid part is formed as a one-piece flat lid plate, in the surface of which a recess is introduced on one side.
  • the recess which overhangs the sensor chip in the assembled state forms a hollow volume open toward the sensor chip and thus the flow cell.
  • the lid plate in particular as a molded part of a flexible material, such as EPDM or silicone rubber.
  • the edge of the lid plate forms a sealing ring.
  • the sensor chip has a plurality of independent surface elements for the SAW measurement. These are then each assigned the corresponding receptors.
  • the depth of the channel is less than 0.5 mm, in the installed state, in particular about 0.2 mm, with a width between about 0.1 mm and 2 mm, in particular 0.4 mm.
  • the sealing edge is formed by a thin sealing bead and this projects beyond a lowered, in particular extending outside of the sealing bead bearing surface.
  • the sealing bead is pressed together until the contact surface rests flush against the sensor surface.
  • the bearing surface is advantageously at a level which lies above the base surface of the meander-shaped recess by the amount of the intended channel height.
  • the means for clamping have two flat adjoining housing parts which are adapted to the geometry of sensor chip and cover plate and between which the sensor chip and the cover plate are clamped.
  • fastening means in particular by snap closures, firmly but detachably.
  • fastening means are provided which can only be opened with special tools available to the specialist personnel without causing any visible damage.
  • a hollow volume which is open toward the sensor chip spans over the latter, the so-called flow cell.
  • the sensor surfaces and the flow cell thus form a closed channel through which the liquid to be analyzed flows.
  • the flow cell is firmly integrated into the surrounding housing.
  • the housing fixes sensor chip and fluidic cell in the required arrangement for the overall function.
  • the surrounding housing releases the sensor chip with its contacts in the required areas. Channels are integrated in the housing which direct the fluid to and from the flow cell.
  • the flow cell is accurately inserted into a recess provided in the cartridge cover. The tightness against both the sensor chip and against the cartridge cover is accomplished mechanically by the contact pressure realized in the assembly. Adhesives or other adhesion promoters are not used.
  • FIG. 2 a cartridge
  • Figure 3 a section through the cartridge in height of the sensor chip.
  • a mobile system (not shown) advantageously has a dispensing module for easy administration of the analyte, and for rapid and uncomplicated analyzes, wipers are particularly suitable for this, which in particular absorb samples of body fluids such as perspiration.
  • the fluidic module is for conducting the fluid loaded with analyte with corresponding Provided channels.
  • a drive and analysis unit for automatically performing the measurement is available.
  • This has in particular a microcomputer, which controls the sensor chip with signal frequencies and evaluates the measurement results. Via output means, such as a display and / or a printer, the measurement results are output to the user.
  • housing parts 2 and 4 are provided as injection-molded parts made of solid plastic, which are adapted to the geometry of sensor chip 1 and cover plate 3.
  • the size of the housing parts, in particular of the housing part 2 is measured on a good handling. Overall, the dimensioning of the housing parts is on the order of less than 3 cm.
  • the first housing part 2 has a recess 5 for receiving the cover plate 3 forming the flow cell in conjunction with the sensor chip, wherein the second housing part 4 has a recess 6 for receiving the sensor chip 1.
  • the depth of the recesses 5 and 6 are each dimensioned so that the flat covering of the housing parts 2 and 3 causes the seal between the cover part and the sensor surface.
  • channels 7 are provided, which open in the assembled state in the flow cell and via which the fluid to the sensor chip back and is led away again.
  • the connection of the cartridge is done via two flange-like cap pieces 8, which are placed by means of sealing rings 9 on nozzle 10 of the housing part 4.
  • the two housing parts 2 and 4 lie against one another via bearing surfaces, wherein the bearing surface 11 of the first housing part 2 is larger and serves as an abutment of the conductor tracks 12 protruding under the seal.
  • the interconnects form a comb-like conductor structure, which rests on the support surface 11 of the housing part 2 and is freely accessible for electrical contact. This can be provided with corresponding mating contacts in the mobile system interact.
  • the geometry of the housing parts is dimensioned so that the housing can be positively inserted into a corresponding receptacle in the mobile system.
  • the two housing parts 2 and 4 are connected by means of peg-like snap fasteners 13.
  • FIG. 3 a horizontal section through the cartridge in height of the sensor chip 14 is first shown in FIG. Evident is the outer comb-like structure of the contact points 15 of the conductor tracks, which continue in the interior of the flow cell as SAW surface elements 16.
  • the cover plate 17 is placed from EPDM, in which a meandering channel structure 18 is introduced. It can be seen that the meanders are designed so that all surface elements 16 fluid is supplied.
  • the lid plate 17 also has two openings 19, through which the fluid is added and discharged again.
  • FIG. 3b A cross section through the flow cell formed by sensor chip 14 and cover plate 17 is shown in FIG. 3b.
  • the cover plate 17 initially has the recess 19 forming the flow cell with an edge 20.
  • the edge 20 is increased as a sealing bead 21 against a support surface 22.
  • the sealing bead 21 compresses and the sensor chip 14 lies flat against the bearing surface 22.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne une unité maniable présentant une puce d'analyse (1) destinée à déterminer la présence d'un analyte dans un fluide, en particulier un capteur SAW comportant plusieurs éléments capteurs, et une cuve de circulation pour guider le fluide sur la surface de la puce d'analyse (1) sensible à l'analyte. La cuve de circulation présente une partie couvercle (3) qui est placée sur la surface sensible du capteur; le bord de la partie couvercle (3) s'appuie sur la surface du capteur de manière étanche par au moyen d'un joint. Il est prévu des moyens pour contraindre la partie couvercle (3) contre le joint et la puce d'analyse (1) présente des pistes conductrices qui sont destinées à faire contact avec la surface sensible et mènent hors de la cuve de circulation.
EP09765769A 2008-06-17 2009-06-09 Cartouche avec capteur à ondes acoustiques de surface (saw) intégré Withdrawn EP2288911A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200810028404 DE102008028404B4 (de) 2008-06-17 2008-06-17 Kartusche mit integriertem SAW Sensor
PCT/EP2009/057075 WO2009153189A1 (fr) 2008-06-17 2009-06-09 Cartouche avec capteur à ondes acoustiques de surface (saw) intégré

Publications (1)

Publication Number Publication Date
EP2288911A1 true EP2288911A1 (fr) 2011-03-02

Family

ID=41050408

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09765769A Withdrawn EP2288911A1 (fr) 2008-06-17 2009-06-09 Cartouche avec capteur à ondes acoustiques de surface (saw) intégré

Country Status (3)

Country Link
EP (1) EP2288911A1 (fr)
DE (1) DE102008028404B4 (fr)
WO (1) WO2009153189A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
EP2413128A1 (fr) 2010-07-30 2012-02-01 SAW instruments GmbH Unités de capteur microfluidiques améliorés pour la détection de la présence d'un analyte dans un échantillon liquide
GB2483858A (en) * 2010-09-21 2012-03-28 Univ Hull Amplifying nucleic acids using microfluidic device to perform PRC
FR2968766B1 (fr) 2010-12-10 2016-12-09 Univ De Tech De Troyes Systeme de procede de detection d'especes biologiques ou chimiques bases sur un qcm structure
EP2515111A1 (fr) 2011-04-19 2012-10-24 SAW instruments GmbH Procédé analytique permettant d'étudier la liaison des ligands analytes aux cellules
EP2556887A1 (fr) 2011-08-08 2013-02-13 SAW instruments GmbH Dispositifs microfluidiques améliorés utiles pour l'exposition sélective d'un ou plusieurs échantillons liquides sur une ou plusieurs régions d'échantillon
DE102012218052A1 (de) 2012-10-02 2014-04-03 Panasonic Corporation Biosensor mit auswechselbarer Sensorplatte
EP4431933A1 (fr) * 2023-03-16 2024-09-18 Bio Saw GmbH Module de capteur saw
DE102023126570A1 (de) * 2023-09-28 2025-04-03 Bürkert Werke GmbH & Co. KG Sensorelementhalter, Sensoreinheit, Einweg-Fluidführungsbaugruppe mit Sensoreinheit sowie Proteindefektdiagnosevorrichtung mit Einweg-Fluidführungsbaugruppe und Sensoreinheit

Citations (1)

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Publication number Priority date Publication date Assignee Title
DE10222068A1 (de) * 2002-05-15 2003-11-27 Karlsruhe Forschzent Sensor auf der Basis von Oberflächenwellen-Bauelementen

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US4735906A (en) * 1984-11-28 1988-04-05 Texas A&M University Sensor having piezoelectric crystal for microgravimetric immunoassays
JP2647194B2 (ja) * 1989-04-17 1997-08-27 住友電気工業株式会社 半導体用パッケージの封止方法
DE4334834A1 (de) * 1993-10-13 1995-04-20 Andrzej Dr Ing Grzegorzewski Biosensor zum Messen von Viskositäts- und/oder Dichteänderungen
DE20320482U1 (de) * 2003-05-16 2004-09-09 Sitronic Gesellschaft für elektrotechnische Ausrüstung mbH. & Co. KG Sensoreinheit
EP1510254A3 (fr) * 2003-08-30 2005-09-28 Roche Diagnostics GmbH dispositif et procédé de détection d'un analyte dans un fluide
JP4824580B2 (ja) * 2003-12-30 2011-11-30 スリーエム イノベイティブ プロパティズ カンパニー 検出カートリッジ
US20090115004A1 (en) * 2003-12-30 2009-05-07 3M Innovative Properties Company Surface acoustic wave sensor assemblies
DE102004006823B4 (de) * 2004-02-11 2013-04-11 Saw Instruments Gmbh Verfahren zur Bestimmung der Massebelegung auf der Oberfläche von Oberflächenwellensensoren
CA2566962A1 (fr) * 2004-05-21 2005-12-01 Atonomics A/S Capteur d'ondes acoustiques de surface comprenant un hydrogel

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10222068A1 (de) * 2002-05-15 2003-11-27 Karlsruhe Forschzent Sensor auf der Basis von Oberflächenwellen-Bauelementen

Non-Patent Citations (2)

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Title
HOFFMANN W ET AL: "Integrated microanalytical system with electrochemical detection", SENSORS AND ACTUATORS B: CHEMICAL: INTERNATIONAL JOURNAL DEVOTED TO RESEARCH AND DEVELOPMENT OF PHYSICAL AND CHEMICAL TRANSDUCERS, ELSEVIER S.A, SWITZERLAND, vol. 34, no. 1-3, 1 August 1996 (1996-08-01), pages 471 - 475, XP004078026, ISSN: 0925-4005, DOI: 10.1016/S0925-4005(96)01853-9 *
See also references of WO2009153189A1 *

Also Published As

Publication number Publication date
WO2009153189A1 (fr) 2009-12-23
DE102008028404B4 (de) 2013-07-18
DE102008028404A1 (de) 2010-03-25

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