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EP1940787A4 - Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisation - Google Patents

Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisation

Info

Publication number
EP1940787A4
EP1940787A4 EP06844228A EP06844228A EP1940787A4 EP 1940787 A4 EP1940787 A4 EP 1940787A4 EP 06844228 A EP06844228 A EP 06844228A EP 06844228 A EP06844228 A EP 06844228A EP 1940787 A4 EP1940787 A4 EP 1940787A4
Authority
EP
European Patent Office
Prior art keywords
methods
ido inhibitors
novel ido
novel
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06844228A
Other languages
German (de)
English (en)
Other versions
EP1940787A1 (fr
Inventor
James B Duhadaway
George C Prendergast
William P Malachowski
Alexander J Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lankenau Institute for Medical Research
Original Assignee
Lankenau Institute for Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lankenau Institute for Medical Research filed Critical Lankenau Institute for Medical Research
Publication of EP1940787A1 publication Critical patent/EP1940787A1/fr
Publication of EP1940787A4 publication Critical patent/EP1940787A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C07C333/20—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
    • C07C333/18—Esters of dithiocarbamic acids
    • C07C333/22—Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP06844228A 2005-10-27 2006-10-27 Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisation Withdrawn EP1940787A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73070605P 2005-10-27 2005-10-27
PCT/US2006/042137 WO2007050963A1 (fr) 2005-10-27 2006-10-27 Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisation

Publications (2)

Publication Number Publication Date
EP1940787A1 EP1940787A1 (fr) 2008-07-09
EP1940787A4 true EP1940787A4 (fr) 2009-07-01

Family

ID=37968157

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06844228A Withdrawn EP1940787A4 (fr) 2005-10-27 2006-10-27 Nouveaux inhibiteurs de l'ido et leurs procedes d'utilisation

Country Status (2)

Country Link
EP (1) EP1940787A4 (fr)
WO (1) WO2007050963A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7705022B2 (en) 2005-10-27 2010-04-27 Lankenau Institute For Medical Research IDO inhibitors and methods of use thereof
EP2227233B1 (fr) 2007-11-30 2013-02-13 Newlink Genetics Inhibiteurs de l'ido
GB0806794D0 (en) * 2008-04-15 2008-05-14 Ludwig Inst Cancer Res Therapeutic compounds
WO2010020676A1 (fr) * 2008-08-20 2010-02-25 Vib Vzw Utilisation d’inhibiteurs de la topoisomérase de type i pour traiter des infections virales
CN102234271B (zh) 2010-04-21 2015-06-10 北京大学 芳杂(烷基)氨基二硫代甲酸酯类化合物、其制备方法和应用
CN102180845B (zh) * 2011-03-29 2013-06-05 郑州大学 含丁烯内酯结构的苄氨基二硫代甲酸酯类化合物、其制备方法及其用途
AU2012282678B2 (en) 2011-07-11 2016-03-03 California Institute Of Technology Akt-specific capture agents, compositions, and methods of using and making
CN103508930B (zh) * 2012-06-25 2016-01-27 北京大学 双(氨基二硫代甲酸)-1,3-丙二酯类化合物及其合成方法、药物组合物和用途
CA2939164A1 (fr) 2014-02-12 2015-08-20 Iteos Therapeutics Derives de 3-(indol-3-yl)piridine, compositions pharmaceutiques et procedes d'utilisation
EP3119763A1 (fr) * 2014-03-18 2017-01-25 Iteos Therapeutics Dérivés substitués par 3-indole, compositions pharmaceutiques et procédés d'utilisation
MD20160118A2 (ro) 2014-05-15 2017-04-30 Iteos Therapeutics Derivaţi ai pirolidin-2,5-dionei, compoziţii farmaceutice şi metode de utilizare ca inhibitori ai IDO1
WO2016100851A1 (fr) 2014-12-18 2016-06-23 Lankenau Institute For Medical Research Procédés et compositions pour le traitement de la rétinopathie et d'autres maladies oculaires
EP3270951B1 (fr) 2015-03-16 2020-09-09 California Institute of Technology Agents de capture spécifiques de la neurotoxine botulique, compositions et méthodes d'utilisation et de préparation associées
KR102013512B1 (ko) * 2015-03-17 2019-08-22 화이자 인코포레이티드 신규 3-인돌 치환 유도체, 제약 조성물 및 사용 방법
CA2994917A1 (fr) 2015-08-10 2017-02-16 Pfizer Inc. Derives substitues par un 3-indole, compositions pharmaceutiques et leurs procedes d'utilisation
US11884707B2 (en) 2016-09-29 2024-01-30 Regeneron Pharmaceuticals, Inc. Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same
CN106966978B (zh) * 2017-03-05 2020-06-26 北京化工大学 一种酰胺类化合物及其制备方法和用途
CN108785322B (zh) * 2017-04-28 2020-11-27 南京葆赫生物技术有限公司 黑骨藤c21甾类在制备ido抑制剂中的用途
CN108785317B (zh) * 2017-04-28 2020-12-01 苏州凯祥生物科技有限公司 香加皮c21甾类化合物在制备ido抑制剂中的用途
CN107226789B (zh) * 2017-05-09 2019-11-08 北京大学 氨基二硫代甲酸酯类化合物、其制备方法以及在制备抗肿瘤药物中的用途
US11719705B2 (en) 2017-06-15 2023-08-08 Indi Molecular, Inc. IL-17F and IL-17A-specific capture agents, compositions, and methods of using and making
US12201679B2 (en) 2019-04-05 2025-01-21 Institute For Systems Biology Epitope-targeted peptide immunostimulants
US12216122B2 (en) 2019-05-20 2025-02-04 Regeneron Pharmaceuticals, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
CN111153850B (zh) * 2020-01-17 2021-08-13 中国药科大学 吲哚类化合物、其制备方法和药物组合物与用途
US12209142B2 (en) 2020-05-29 2025-01-28 Institute For Systems Biology SARS-CoV-2 epitope-targeted peptide immunostimulants
CN111518037B (zh) * 2020-05-31 2021-04-23 湖北工业大学 [2-(5′-氟尿嘧啶)乙酸-乙基苯基二硫代氨基甲酸]酐及在制备抗癌药物中的应用
WO2022098743A1 (fr) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imagerie et procédés thérapeutiques ciblant le récepteur 1 de folate (folr1)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU507567A1 (ru) * 1973-02-02 1976-03-25 Стерлитамакский Опытно-Промышленный Завод По Производству Изопренового Каучука Способ получени замещенных дитиокарбаматов
WO2004093871A1 (fr) * 2003-03-27 2004-11-04 Lankenau Institute For Medical Research Procedes de traitement du cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU507567A1 (ru) * 1973-02-02 1976-03-25 Стерлитамакский Опытно-Промышленный Завод По Производству Изопренового Каучука Способ получени замещенных дитиокарбаматов
WO2004093871A1 (fr) * 2003-03-27 2004-11-04 Lankenau Institute For Medical Research Procedes de traitement du cancer

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A. S. FISYUK AND B. V+ UNKOVSKII: "SYNTHESIS OF 6-HYDROXYTETRAHYDRO-1,3-THIAZINE-2-THIONES AND METHYL ESTERS OF 3-OXOALKYLDITHIOCARBAMIC ACIDS FROM 1,3-ISOTHIOCYANATO KETONES", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 27, 1991, pages 339 - 341, XP002526364 *
A. S. FISYUK, E. A. RYZHOVA, AND B. V. UNKOVSKII: "INTERACTION OF METHYL N-(3-OXOALKYL)CARBAMATES, S-METHYL -CARBAMATES, AND -DITHIOCARBAMATES WITH SODIUM BOROHYDRIDE. SYNTHESIS OF TETRAHYDRO- 1,3-OXAZIN-2-ONES AND -THIONES", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 37, 2001, pages 597 - 609, XP002526363 *
BERNABE M ET AL: "Dérivés du cyclopropane. V. Préparation d'acides amino-1 aryl-2 cyclopropanecarboxyliques et résultats préliminaires de leur interaction ave la dopadécarboxylase", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 14, 1 January 1979 (1979-01-01), pages 33 - 45, XP009116425, ISSN: 0223-5234 *
BRAUN J V: "Mittheilungen über Dithiourethane", CHEMISCHE BERICHTE, VERLAG CHEMIE GMBH. WEINHEIM, DE, vol. 35, no. 3, 1 October 1902 (1902-10-01), pages 3368, XP009116291, ISSN: 0009-2940 *
MARTIN ONSLOW FORSTER ET AL: "Studies in the Comphane Series. Part XXIV. Camphoryldithiocarbamic Acid and Camphorylthiocarbimide", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LETCHWORTH., GB, vol. 91, 1 January 1907 (1907-01-01), pages 1877 - 1890, XP009116317, ISSN: 0368-1769 *
MOHANTA P K ET AL: "1-(Methyldithiocarbonyl)imidazole: a Useful Thiocarbonyl Transfer Reagent for Synthesis of Substituted Thioureas", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 56, no. 4, 1 January 2000 (2000-01-01), pages 629 - 637, XP004186122, ISSN: 0040-4020 *
MONTANARI L ET AL: "Sull'attività antifungina di diesteri del 2-mercapto benzenmetantiolo", FARMACO, EDIZIONE SCIENTIFICA, SOCIETA CHIMICA ITALIANA, PAVIA, vol. 37, 1 January 1982 (1982-01-01), pages 759 - 763, XP009116424, ISSN: 0430-0920 *
R. E. ORTH AND J. W. JONES: "Preparation of some 1-substituted 1,2,3,4-tetrazole-5-thiones", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 51, 1962, pages 862 - 864, XP002526362 *
SALVATORE R N ET AL: "Mild and efficient synthesis of thiocarbonates and thiocarbamates via a three-component coupling utilizing Cs2CO3 and TBAI", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 42, no. 11, 11 March 2001 (2001-03-11), pages 2055 - 2058, XP004229200, ISSN: 0040-4039 *
See also references of WO2007050963A1 *

Also Published As

Publication number Publication date
WO2007050963A1 (fr) 2007-05-03
EP1940787A1 (fr) 2008-07-09

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PRENDERGAST, GEORGE, C.

Inventor name: DUHADAWAY, JAMES, B.

Inventor name: MULLER, ALEXANDER, J.

Inventor name: MALACHOWSKI, WILLIAM, P.

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 401/12 20060101ALI20090520BHEP

Ipc: C07D 417/06 20060101ALI20090520BHEP

Ipc: A61K 31/27 20060101ALI20090520BHEP

Ipc: A61P 35/00 20060101ALI20090520BHEP

Ipc: A61P 31/12 20060101ALI20090520BHEP

Ipc: C07C 333/20 20060101ALI20090520BHEP

Ipc: C07C 333/22 20060101ALI20090520BHEP

Ipc: C07D 209/14 20060101AFI20090520BHEP

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A4 Supplementary search report drawn up and despatched

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