EP1819707A2 - Substituted pteridines for the treatment of inflammatory diseases - Google Patents

Abstract

The invention relates to novel pteridines which are suitable for the treatment of respiratory or gastro-intestinal complaints or diseases, inflammatory diseases of joints, skin or eyes, diseases of the peripheral or central nervous system or cancerous diseases, in addition to pharmaceutical compositions containing said compounds.

Description

 SUBSTITUTED PTERIDINE FOR THE TREATMENT OF INFLAMMATORY DISEASES

The invention relates to novel pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases,

Inflammatory diseases of the joints, the skin or the eyes,

Diseases of the peripheral or central nervous system or

• cancers, as well as pharmaceutical compositions containing these compounds.

STATE OF THE ART

Pteridines are known as drugs with antiproliferative action from the prior art. Merz et al. describe in the Journal of Medicinal Chemistry 1998, 41, 4733-4743 the preparation of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and derivatives thereof, which are free of positional isomers. It has been shown that the compounds produced can inhibit the growth of tumor cells. In DE 3540952 2-piperazino-pteridines are described, which are substituted in the 6-position with a halogen atom selected from a fluorine, chlorine or bromine atom. These compounds were shown to inhibit the activity of tumor cells and human platelets in vitro. DE 3323932 discloses 2-piperazino-pteridines which carry in the 4-position a dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxidothiomorpholino group. These compounds were shown to inhibit the activity of tumor cells and human platelets in vitro. In DE 3445298 pteridines are described with a large number of different substituents in the 2-, 4-, 6- and 7-position, wherein compounds having a 2-piperazino group on the pteridine skeleton are suitable as inhibitors for tumor growth and antithrombotic and metastasis-inhibiting properties exhibit. Tri- and tetrasubstituted pteridine derivatives are disclosed in US Pat. No. 2,940,972, disclosing in general terms that these pteridines have valuable pharmacological properties, namely coronary dilatory, sedative, antipyretic and analgesic effects. The phosphodiesterase 4 inhibitors known in the art are known to induce side effects such as nausea and vomiting (Doherty, 1999, Curr. Op. Chem. Biol., Aug. 3, (4): 466-73). The substances named in this invention are particularly preferably suitable for the treatment of said diseases since they are used in an animal model for nausea and vomiting (S. Murinus, Yamamoto K. et al., Physiol. Behav., 2004, Oct. 30, 83 ( 1), 151-6) do not trigger these side effects.

The object of the present invention is to provide novel compounds which are suitable for the prevention or treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, the skin or the eyes, disorders of the peripheral or central nervous system, or cancers, in particular those compounds characterized by less side effects, especially emesis and nausea.

DESCRIPTION OF THE INVENTION

Surprisingly, it has now been found that pteridines of the formula 1 are suitable for the treatment of inflammatory diseases. The present invention therefore relates to compounds of the formula 1

wherein

R ^{1 is} a heterocyclic ring containing a nitrogen atom;

R ^{2 is} halogen, OR ^{2 1} , SR ^{2 1} , NR ^{2 1} R ^{2 2} or a radical selected from the group consisting of aryl, het and hetaryl, optionally substituted by a radical selected from the group consisting of C _1-6 alkyl , OC _1-6 alkyl, C _3-6 cycloalkyl, C _7- H-aralkyl, and N (C _1- 4-alkyl) _2;

R ^{2 is} H, C _1-4 alkyl, aryl, C _{7 H} - aralkyl; R ^{22 is} H, C _1-4 alkyl, aryl, C _7-11 aralkyl;

Aryl, het, hetaryl or a group of formula 1a,

wherein

A aryl, hetaryl; X NR ³² , S, O;

Y is C _1-4 -alkylene, optionally substituted with one or more R ³³ m, 0.1, 2, 3;

R ^{31 are} each independently C _1-6 alkyl, C _1-6 haloalkyl, C _1-6 alkyl CONR ³¹¹ R ³¹² , C _1-6 alkyl NR ³¹¹ R ³¹² , OR ³¹¹ , OC _{1- 6} -haloalkyl, NHCOR ³¹¹ , SO ₂ R ³¹¹ , aryl; Halogen, CN, OH, CONR ³¹¹ R ³¹² ; or R ³¹ together with two atoms of A forms a 5 or 6 membered carbocyclic ring or a 5 or 6 membered heterocyclic ring which may contain one or more oxygen or nitrogen atoms;

R ³¹¹ H, C _1-6 -alkyl, R ³¹² H, C _1-6 -alkyl,

R ^{32 is} H, C _1-6 alkyl;

Each R ³³ is independently C _1-6 alkyl, C _1-6 alkyl OH, C _3-6 cycloalkyl OH, COOR ³³¹ , CONR ³³¹ R ³³² ; or

R ³³ together with one or two carbon atoms of Y forms a carbocyclic ring having 3, 4, 5 or 6 carbon atoms

R ^{331 is} H, C _1-6 alkyl; R ^{332 is} H, C _1-6 alkyl; R ^{4 is} a radical selected from the group consisting of C _1-6 alkyl, C _2-6 alkenyl, C _2-6 alkynyl, C _3-6 cycloalkyl, C _3-6 cycloalkenyl, OR ^{4 1} , SR ^{4 1} , C _1-6 haloalkyl, NR ^{4 1} R ^{4 2} or a radical selected from the group consisting of aryl, het and hetaryl, optionally substituted by one or more radicals selected from the group consisting of C _1-6 alkyl , C _1-6 -haloalkyl, CN, O-C _1-6 -alkyl,

Halogen,

R ^{4 is} H, C _1-6 alkyl, aryl, C _7-11 aralkyl; R ^{42 is} H, C _1-6 alkyl, aryl, C _7-11 aralkyl;

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof.

Preferred are the above compounds of formula 1 wherein

R ^{1 is} a heterocyclic ring containing a nitrogen atom;

R ^{2 is} halogen, OR ^{2 1} , SR ^{2 1} , NR ^{2 1} R ^{2 2} or a radical selected from the group consisting of aryl, het and hetaryl, optionally substituted by a radical selected from the group consisting of C _1-6 alkyl , OC _1-6 alkyl, C _3-6 cycloalkyl, C ₇ _n aralkyl and N (C _1-4 alkyl) ₂ ;

R ^{2 is} C _1-4 alkyl, aryl, C _7-11 aralkyl; R ^{2 is 2} H, C _1-4 alkyl,

R ^{3 is} aryl, het, hetaryl or a group of the formula 1 a,

wherein

A aryl, hetaryl; X NR ^{3 2} , S, O; YC _1-4 -alkylene, optionally substituted by one or more R ³³ m 0, 1, 2;

R ^{3 1 are} each independently C _1-6 -alkyl, C _1-6 -haloalkyl, C _1-6 -alkyl-CONH ₂ , -C _1-6 -alkyl-NH ₂ , OC _1-6 -alkyl, OC _{1 -6} -haloalkyl, NHCO-C _1-6 -alkyl, SO ₂ -C _1-6 -alkyl, aryl;

Halogen, CN, OH, CONH ₂ ; or

R ^{3 1} forms together with two atoms of A a 5 or 6-membered carbocyclic ring or a 5 or 6-membered heterocyclic ring which may contain one or more oxygen or nitrogen atoms;

R ^{32 is} H, C _1-6 alkyl;

R ^{33 are} each independently C _1-6 -alkyl, C _1-6 -alkyl-OH, C _3-6 -cycloalkyl-OH,

COO-C _1-6 -alkyl, COOH, CONH ₂ ; or R ³³ together with one or two carbon atoms of Y forms a carbocyclic ring having 3, 5 or 6 carbon atoms

R ^{4 is} a radical selected from the group consisting of C _1-6 -alkyl, C _2-6 -alkenyl,

C _2-6 alkynyl, C _3-6 cycloalkyl, C _3-6 cycloalkenyl, OC _1-6 alkyl, SC _1-6 alkyl, C _1-6 haloalkyl, NR ^{4 1} R ^{4 2} or Rest selected from the group consisting of

Aryl, het and hetaryl, optionally substituted by one or more radicals selected from the group consisting of C _1-6 -alkyl, C _1-6 -haloalkyl, CN, OC _1-6 -alkyl, halogen,

R ^{4 is} H, C _1-6 alkyl;

R ^{42 is} C _1-6 alkyl, aryl;

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof.

Preferred are the above compounds of formula 1 wherein

R ^{4 is} C _3-6 cycloalkyl, preferably cyclopropyl; and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. Of these, preferred are the above compounds of formula 1, wherein

R ^{3 is} a group of the formula 1 a,

where A is aryl, hetaryl

X NR ^{3 2} , S, O;

Y is C _1-4 -alkylene, optionally substituted with one or more R ^{3 3} m 0, 1, 2;

R ^{3 1 are} each independently of one another C _1-4 -alkyl, C _1-4 -haloalkyl, C _1-4 -alkyl-CONH ₂ ,

C _1-4 alkyl NH ₂ , OC _1-4 alkyl, OC _1-4 haloalkyl, NHCO C _1-4 alkyl, SO ₂ C _1-4 alkyl, aryl; Halogen, CN, OH, CONH ₂ ; or R ^{3 1} forms, together with two atoms of A form a 5 or 6-membered carbocyclic ring or a 5 or 6-membered heterocyclic ring which may contain one or more oxygen or nitrogen atoms;

R ^{3 is 2} H, C _1-4 alkyl;

R ^{3 3 are} each independently of one another C _1-4 -alkyl, C _1-4 -alkyl-OH, C ₃ . ₄ -cycloalkyl-OH, COO-C _1-4 -alkyl, COOH, CONH ₂ ; or

R ^{3 3} together with one or two carbon atoms of Y forms a carbocyclic ring having 3, 5 or 6 carbon atoms

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. Of these, particularly preferred are the compounds of formula 1, wherein a group of the formula 1 a,

wherein A is aryl, hetaryl; X NH, S, O;

YC _1-4 -alkylene, optionally substituted by one or more R ³³ m 0, 1, 2;

R ^{3 1 are} each independently of one another C _1-4 -alkyl, C _1-4 -haloalkyl, C _1-4 -alkyl-CONH ₂ , C _1-4 -alkyl-NH ₂ , OC _1-4 -alkyl, OC _{1- 4} -haloalkyl, NHCO-C _1-4 -alkyl, SO _2- C _1-4 -alkyl, halogen, CN, OH, CONH ₂ ;

Each R ³³ is independently C _1-4 alkyl, C _1-4 alkyl OH, C _3-4 cycloalkyl OH, COO C _1-4 alkyl, COOH, CONH ₂ ; or

R ³³ together with one or two carbon atoms of Y forms a carbocyclic ring having 3, 5 or 6 carbon atoms

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. Of these, most preferred are the above compounds of formula 1 wherein

R ^{3 is} a group of the formula 1a,

wherein

A aryl, hetaryl

X NH, S, O;

YC _1-4 -alkylene, optionally substituted with one or two R ^{3 3} m 0, 1, 2; R ^{3 1 are} each independently C _1-4 alkyl, C _1-4 haloalkyl, OC _1-4 alkyl, OC _1-4 haloalkyl, halogen, CN, OH;

R ^{33 are} each independently C _1-4 alkyl, COOH, CONH ₂ ; or R ³³ together with one or two carbon atoms of Y forms a carbocyclic ring of 3 carbon atoms

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof.

Also preferred are the above compounds of formula 1 wherein

R ^{2 is} halogen, NR ^{2 1} R ²² , Het optionally substituted by a radical selected from the group consisting of C _3-6 cycloalkyl, C _7-11 aralkyl and NMe ₂ ;

R ^{2 1} C _7-11 - aralkyl; R ²² H;

R ³ NR ^{3 1} R ^{3 2} , SR ^{3 1} or Het;

R ^{3 is} C _1-6 -alkylene-C _3-6 -cycloalkyl or C _7-11 -aralkyl, optionally substituted by a radical selected from the group halogen; R ³² is H;

R ^{4 is} a radical selected from the group consisting of C _1-6 -alkyl, C _3-6 -cycloalkyl, OC _1-6 -alkyl, C _1-6 -haloalkyl, NR ^{4 1} R ^{4 2} or a radical selected from among A group consisting of aryl, het and hetaryl, optionally substituted by one or more radicals selected from the group consisting of C _1-6 -alkyl, C _1-6 -haloalkyl, CN, OC _1-6 -alkyl, halogen,

R ^{4 is} H, C _1-6 alkyl;

R ^{42 is} C _1-6 alkyl, aryl; and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof.

Particularly preferred are the above compounds of formula 1 wherein

R ^{2 is} halogen, NR ^{2 1} R ²² , Het optionally substituted by a radical selected from the group consisting of C _3-6 cycloalkyl, C _7-11 aralkyl and NMe ₂ ;

R ^{2 1} C _7-11 - aralkyl; R ² 2H;

R ³ NR ^{3 1} R ^{3 2} , SR ^{3 1} or Het;

R ^{3 is} C _1-4 -alkylene-C _3-6 -cycloalkyl or C _7-11 -aralkyl, optionally substituted by a radical selected from the group halogen; R ³² is H;

R ^{4 is} a radical selected from among C ₁ -C ₄ -alkyl, C ₃ . ₆ -cycloalkyl, OC _1-4 -alkyl, C _1-4 -haloalkyl, NR ^{4 1} R ^{4 2} , Het, hetaryl, aryl, optionally substituted by one or more radicals selected from the group consisting of C _1-4 alkyl , C _1-4 -haloalkyl, CN, OC _1-4 -alkyl, halogen,

R ^{4 is} H, C _1-4 alkyl;

R ^{42 is} C _1-4 -alkyl, aryl;

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof.

Most preferred are the above compounds of formula 1 wherein R ^{2 is} halogen, NH (benzyl), Het, optionally substituted by a radical selected from the group consisting of cyclopropyl, benzyl and NMe ₂ ;

R ³ NR ^{3 1} R ^{3 2} , SR ^{3 1} or Het;

R ^{3 1} methylcyclohexyl or benzyl, optionally substituted by a radical selected from the group of fluorine and chlorine; R ³² is H;

R ^{4 is} a radical selected from the group consisting of methyl, ethyl, propyl, 2-

Methylpropyl, cyclopropyl, cyclohexyl, methoxy, CF ₃ , NR ^{4 1} R ⁴² , het, hetaryl, aryl, optionally substituted by one or more radicals selected from the group consisting of methyl, CF ₃ , CN, methoxy, fluorine, chlorine,

R ^{4 1} H, methyl, ethyl;

R ^{42 is} methyl, ethyl, phenyl;

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof.

Especially preferred are the above compounds of formula 1 wherein

R ^{1 is} a five- or six-membered heterocyclic ring containing a nitrogen atom;

R ^{2 is} chlorine, NH (benzyl), a six-membered heterocyclic ring which may contain one or more nitrogen atoms and is optionally substituted by a radical selected from the group consisting of cyclopropyl, benzyl and NMe ₂ ;

R ³ NR ^{3 1} R ^{3 2} , SR ^{3 1} or a six-membered heterocyclic ring which may contain one or more heteroatoms selected from the group consisting of nitrogen and oxygen; R ^{3 1} methylcyclohexyl or benzyl, optionally substituted by a radical selected from the group of fluorine and chlorine; R ³² is H;

R ^{4 is} a radical selected from the group consisting of methyl, ethyl, propyl, 2-methylpropyl, cyclopropyl, cyclohexyl, methoxy, CF ₃ , NR ^{4 1} R ⁴² ,

Aryl, optionally substituted by one or more radicals selected from the group consisting of methyl, CF ₃ , CN, methoxy, fluorine, chlorine,

a five- or six-membered heterocyclic ring which may contain one or more heteroatoms selected from the group consisting of nitrogen and oxygen,

a five-membered heterocyclic aromatic which may contain one or more radicals selected from the group consisting of nitrogen and oxygen,

an aromatic or non-aromatic bicyclic compound which may contain one or more heteroatoms selected from the group consisting of sulfur and oxygen;

R ^{4 1} H, methyl, ethyl;

R ^{42 is} methyl, ethyl, phenyl;

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof.

Most preferred are the above compounds of formula 1 wherein

R ^{1 is} a radical selected from the group consisting of

R ^{2 is} a radical selected from the group consisting of chlorine,

a residue selected from the group consisting of

R ^{4 is} a radical selected from the group consisting of methyl, ethyl, propyl, 2-methylpropyl, methoxy, CF ₃ , NMe ₂ , NEt ₂ ,

and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof.

USED TERMS AND DEFINITIONS

In the context of this application, in the definition of possible substituents, these can also be represented in the form of a structural formula. An asterisk ( ^* ) in the structural formula of the substituent is understood to be the point of attachment to the remainder of the molecule. For example, the residues N-piperidinyl (I), 4-piperidinyl (II), 2-ToIyI (III), 3-ToIyI (IV) and 4-ToIyI (V) are shown as follows:

If there is no star ( ^* ) in the structural formula of the substituent, then each hydrogen atom can be removed from the substituent and the valence liberated thereby serves as a binding site to the remainder of a molecule. For example, VI may have the meaning of 2-ToIyI, 3-ToIyI, 4-ToIyI and benzyl.

By pharmacologically acceptable acid addition salts are meant for example those salts which are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, Hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate, preferably hydrochloride, hydrobromide, hydrosulfate, hydrophosphate, hydrofumarate and hydromethanesulfonate.

The term "C _1-6 -alkyl" (including those which are part of other groups) is understood to mean branched and unbranched alkyl groups having 1 to 6 carbon atoms and branched and unbranched alkyl groups having 1 to 10 by the term "C _1-4 -alkyl" 4 carbon atoms understood. Preferred are alkyl groups having 1 to 4 carbon atoms. Examples include: methyl, ethyl, n-propyl, / so-propyl, n-butyl, / so-butyl, sec-butyl, fe / t-butyl, n-pentyl, / so-pentyl, neo-pentyl or hexyl.

Optionally, the abbreviations Me, Et, n-Pr, / -Pr, n-Bu, / -Bu, t-Bu, etc. are also used for the abovementioned groups. Unless otherwise specified, the definitions of propyl, butyl, pentyl and hexyl include all conceivable isomeric forms of the respective radicals. For example, propyl includes n-propyl and / so-propyl, butyl includes / so-butyl, sec-butyl and terf-butyl, etc.

The term "C _2-6 alkenyl" (including those which are part of other radicals) are branched and unbranched alkenyl groups having 2 to 6 carbon atoms and the term "C _2-4 alkenyl" branched and unbranched alkenyl groups having 2 to 4 Carbon atoms understood, as far as they have at least one double bond. Preferred are alkenyl groups having 2 to 4 carbon atoms. Examples include: ethenyl or vinyl, propenyl, butenyl, pentenyl, or hexenyl. Unless otherwise described, the definitions propenyl, butenyl, pentenyl and hexenyl include all conceivable isomeric forms of the respective radicals. For example, propenyl includes 1-propenyl and 2-propenyl, butenyl includes 1-, 2- and 3-butenyl, 1-methyl-1-propenyl, 1-methyl-2-propenyl, etc.

The term "C _2-6 -alkynyl" (including those which are part of other radicals) are branched and unbranched alkynyl groups having 2 to 6 carbon atoms and the term "C _2-4 -alkynyl" branched and unbranched alkynyl groups having 2 to 4

Carbon atoms understood as far as they have at least one triple bond. Preferred are alkynyl groups having 2 to 4 carbon atoms. Examples include: ethynyl, propynyl, butynyl, pentynyl or hexynyl. Unless otherwise specified, the definitions propynyl, butynyl, pentynyl and hexynyl include all conceivable isomeric forms of the respective radicals. For example, propynyl includes 1-propynyl and 2-propynyl, butinyl includes 1-, 2- and 3-butynyl, 1-methyl-1-propynyl, 1-methyl-2-propynyl, etc.

The term "C _1-4 -alkylene" (including those which are part of other radicals) are understood as meaning branched and unbranched alkylene groups having 1 to 4 carbon atoms. For example: methylene, ethylene, propylene, 1-methylethylene, butylene, 1-methylpropylene, 1, 1-dimethylethylene or 1, 2-dimethylethylene. Unless otherwise stated, the definitions propylene and butylene include all conceivable isomeric forms of the respective radicals of the same carbon number. For example, propyl also includes 1-methylethylene and butylene includes 1-methylpropylene, 1, 1-dimethylethylene, 1, 2-dimethylethylene. Should the carbon chain be substituted by a radical which together with one or two carbon atoms of the alkylene chain forms a carbocyclic ring having 3, 4, 5 or 6 carbon atoms, the following examples of the rings are included:

The term "C _3-6 -cycloalkyl" (including those which are part of other groups) means cyclic alkyl groups having 3 to 6 carbon atoms. Examples include: cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl. Unless otherwise specified, the cyclic alkyl groups may be substituted with one or more radicals selected from the group consisting of methyl, ethyl, iso-propyl, tert-butyl, hydroxy, fluoro, chloro, bromo and iodo.

The term "C _7-11 -aralkyl" (including those which are part of other groups) means branched and unbranched alkyl groups having 1 to 5 carbon atoms which are substituted by an aromatic ring system having 6 carbon atoms. For example: benzyl, 1- or 2-phenylethyl. Unless otherwise stated, the aromatics may be substituted with one or more radicals selected from the group consisting of methyl, ethyl, / so-propyl, tert-butyl, hydroxy, fluorine, chlorine, bromine and iodine. Halogen is in the context of the present invention for fluorine, chlorine, bromine or iodine. Unless otherwise indicated, fluorine, chlorine and bromine are preferred halogens.

The term "C _1-6 -haloalkyl" (including those which are part of other groups) means branched and unbranched alkyl groups having 1 to 6 carbon atoms which are substituted by one or more halogen atoms. By the term "C _1-4 -alkyl" is meant branched and unbranched alkyl groups having from 1 to 4 carbon atoms which are substituted by one or more halogen atoms. Preferred are alkyl groups having 1 to 4 carbon atoms. For example: CF ₃ , CHF ₂ , CH ₂ F, CH ₂ CF ₃ .

The term "aryl" (even if they are part of other radicals) are understood as meaning aromatic ring systems having 6 or 10 carbon atoms. For example: phenyl or naphthyl, more preferably aryl is phenyl. Unless otherwise stated, the aromatics may be substituted with one or more radicals selected from the group consisting of methyl, ethyl, / so-propyl, tert-butyl, hydroxy, fluorine, chlorine, bromine and iodine.

By the term "heterocyclic rings" or "Het" are meant five-, six- or seven-membered, saturated or unsaturated heterocyclic rings or 5-10 membered, bicyclic hetero rings, the one, two or three heteroatoms selected from the group consisting of oxygen, sulfur and In this case, the ring may be linked to the molecule via a carbon atom or, if present, via a nitrogen atom. As examples of five-, six- or seven-membered, saturated or unsaturated heterocyclic rings, mention is made:

Unless otherwise stated, a heterocyclic ring may be provided with a keto group. As an example for this are called.

Examples of 5-10 membered bicyclic heterorings are pyrrolizine, indole, indolizine, isoindole, indazole, purine, quinoline, isoquinoline, benzimidazole, benzofuran, benzopyran, benzothiazole, benzothiazole, benzoisothiazole, pyridopyrimidine, pteridine, pyrimidopyrimidine,

Although included within the term "heterocyclic rings" or "het", the term "heterocyclic aromatics" or "hetaryl" defines five- or six-membered heterocyclic aromatics or 5-10 membered bicyclic heteroaryl rings containing one, two or three heteroatoms selected from the group consisting of: Group containing oxygen, sulfur and nitrogen, and containing as many conjugated double bonds that an aromatic is formed systems. The ring may be linked to the molecule via a carbon atom or, if present, via a nitrogen atom. As examples of five- or six-membered heterocyclic aromatic compounds, there are mentioned:

EXAMPLES

The following general methods can be used to synthesize the examples listed in the table below.

4- (7-Benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl) -piperazine-1-carboxylic acid tert-butyl ester: 1, 02 g (2.40 mmol) of 7-benzylamino 6-chloro-2-piperazino-4-pyrrolidino-pteridine are placed in 10 ml of tetrahydrofuran, added to 1, 05 g (4.80 mmol) of BOC anhydride and 5 ml of saturated sodium bicarbonate solution. It is stirred for 1.5 hours at room temperature, then evaporated in vacuo. The aqueous residue is diluted with water, the precipitate is filtered off with suction, washed and dried. Yield: 1.17 g (= 93% of theory)

EXAMPLE 24

Benzyl- (6-methoxy-2-piperazin-1-yl-4-pyrrolidin-1-yl-pteridin-7-yl) -amine: 100 mg (1.76 mmol) sodium methylate and 300 mg (0.571 mmol) 4 Tert-Butyl (7-Benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl) -piperazine-1-carboxylate are suspended in 5 ml of tetrahydrofuran, then at 120 ° C in the Microwave provided. The reaction mixture is then evaporated, the residue is treated with methanol and filtered with suction. The mother liquor is evaporated, then extracted with water and dichloromethane. The organic phase is dried and evaporated to dryness. The residue is purified by chromatography. Corresponding fractions are evaporated and crystallized from diethyl ether. Yield: 40 mg (= 13% of theory)

The following general methods A, B, C, or D can be used to synthesize the examples given in Table (s.u.):

A) SYNTHESIS OF EXAMPLES 1, 2, 3, 23 AND 30

The N ₂ atmosphere is initially charged with 500 mg (0.952 mmol) of tert.butyl ester of 4- (7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl) -piperazine-1-carboxylate, 19, 0 mg (0.0540 mmol) of iron (III) acetylacetonate and 0.50 ml of N-methylpyrrolidone were added. Under ice-cooling, 1.45 ml (2.90 mmol) of 2 M Istobutylmagnesiumbromidlösung be added dropwise in diethyl ether. It is stirred for 1 hour at room temperature. Subsequently, 30 ml of water are added, then treated with ethyl acetate. The resulting emulsion is filtered, then the phases are separated. The organic phase is washed with saturated sodium chloride solution, dried and evaporated to dryness. The residue is purified by chromatography. Yield: 470 mg (= 90% of theory) The representative cleavage method E was then used to synthesize Examples 1, 2, 3, 23, 30.

B) SYNTHESIS OF EXAMPLES 4,5,6,7,8,9,10,1,12,14,15,16,17,18,20 AND 22

500 mg (0.952 mmol) of 4- (7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl) -piperazine-1-carboxylic acid tert-butyl ester, 122 mg (0.952 mmol) of 2-thiopheneboronic acid and 203 mg (1, 915 mmol) of sodium carbonate are initially charged in 5 ml of toluene, 1 ml of ethanol and 1 ml of water, then heated to 80 ° C. At this temperature, 50 mg (0.0680 mmol) of [1,1'-bis (diphenylphosphino) ferrocene] palladium (II) chloride are added, then stirred for 16 hours. The reaction mixture is then extracted with water and dichloromethane, the aqueous phase separated via separation cartridge and the organic evaporated to dryness. The residue is purified by chromatography. Yield: 504 mg (= 92% of theory). The representative cleavage protocol E was then used to synthesize Examples 4,5,6,7,8,9, 10,11,12,14,15,16,17,18,20,22.

C) SYNTHESIS OF EXAMPLES 13, 19, 21 AND 25

800 mg (1, 524 mmol) of 4- (7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl) -piperazine-1-carboxylic acid tert-butyl ester, 0.15 ml (1, 828 mmol) pyrrolidine, 28 mg (0.0310 mmol) tris (dibenzylideneacetone) dipalladium (0), 29 mg (0.0610 mmol) 2-dicyclohexylphosphino-2'4'6'-tri-iso-propyl-11 ' Biphenyl and 205 mg (2.133 mol) of sodium tert-butoxide are initially charged in 3 ml of toluene, then stirred at 100 ° C. for 80 hours. Then the reaction mixture is extracted with water and ethyl acetate. The organic phase is separated and dried, then grown to extra gel and chromatographed cleaned. The appropriate fractions are evaporated to dryness, the residue is treated with dichloromethane and 1 ml of trifluoromethylacetic added. It is stirred at room temperature until complete Boc cleavage can be seen. Then it is extracted with ethyl acetate and water, the organic phase is dried and evaporated to dryness. The residue is recrystallized from ethyl acetate. Yield: 300 mg (= 43% of theory) The representative cleavage method E was then used to synthesize Examples 13, 19, 21, 25.

D) SYNTHESIS OF EXAMPLES 26 AND 27

In a pressure reaction vessel, 1.50 g (2.86 mmol) of tert-butyl 4- (7-benzylamino-6-chloro-4-pyrrolidin-1-yl-pteridin-2-yl) -piperazine-1-carboxylate Submitted 3 ml of dichloromethane, 20 ml of dimethylamine added under acetone / dry ice cooling. The vessel is closed and heated to 70 ° C. It is stirred under pressure for 48 hours. The reaction mixture is then treated with water and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness. The residue is purified by chromatography. The representative cleavage protocol was then used to synthesize Examples 26 and 27.

E) REPRESENTATIVE SPLITTING REQUIREMENT

460 mg (0.841 mmol) of tert-butyl 4- (7-benzylamino-6-isobutyl-4-pyrrolidin-1-yl -pteridin-2-yl) -piperazine-1-carboxylate are initially introduced in 10 ml of dichloromethane, 1 ml Added trifluoroacetic acid. It is stirred for 16 hours at room temperature. The reaction mixture is then evaporated, the residue extracted with dichloromethane and saturated sodium carbonate solution. The organic phase is dried and evaporated, during which the product crystallizes out. It is filtered off with suction, washed and dried. Yield: 336 mg (= 90% of theory).

F) SYNTHESIS OF EXAMPLES 32-38, EXEMPLARY TO EXAMPLE 32 a) 6-Trifluoromethyl-pteridine-2,4,7-triol: 10.00 g (41, 63 mmol) of diaminouracil and 5.75 g (41, 63 mmol) of potassium carbonate are initially charged in 300 ml of water, then to 100 ° C heated. After completion of gas evolution, the suspension is cooled to 60 ° C and 4.25 ml (41, 63 mmol) of 3,3,3-Trifluorbrenztraubensäuremethylester added. The reaction mixture is stirred for 16 hours at 60 ° C and 24 hours at 100 ° C, then filtered hot. The filtrate is evaporated, and the resulting precipitate is filtered off with suction. This is purified by chromatography. Yield: 3.50 g (= 94% of theory)

b) 2,4,7-Trichloro-6-trifluoromethyl-pteridine: 3.00 g (12.09 mmol) of 6-trifluoromethyl-pteridine-2,4,7-triol are initially charged, with 35 ml (228.27 mmol ) Phosphorus oxychloride and 16

Hours at 9O ° C stirred. Subsequently, the excess phosphorus oxychloride is distilled off, the residue is treated with 100 ml of dichloromethane and stirred for 1 hour at room temperature. It is filtered through silica gel, the solution evaporated to dryness. Yield: 1.80 g (= 49% of theory)

c) 2,7-Dichloro-4-pyrrolidin-1-yl-6-trifluoromethyl-pteridine: 1.10 g (3.63 mmol) of 2,4,7-trichloro-6-trifluoromethyl-pteridine are dissolved in 50 ml of dichloromethane submitted, then cooled to -78 ⁰ C. 0.30 ml (3.63 mmol) of pyrrolidine are dissolved in 10 ml of dichloromethane, slowly added dropwise. The reaction mixture is stirred for 16 hours at room temperature, then evaporated. The residue is purified by chromatography. Yield: 750 mg (= 61% of theory)

d) Benzyl- (2-chloro-4-pyrrolidin-1-yl-6-trifluoromethyl-pteridin-7-yl) -amine: 750 mg (2.22 mmol) 2,7-dichloro-4-pyrrolidin-1 - yl-6-trifluoromethyl-furan pteridine is dissolved in 35 ml of tetrahydro- and cooled to -78 ⁰ C. 0.24 ml (2.22 mmol) of benzylamine are placed under an atmosphere of nitrogen in 15 ml of tetrahydrofuran, and slowly added 1.39 ml (2.22 mmol) of butyl lithium. This solution is dripped to the first one. Subsequently, the reaction mixture is stirred for 16 hours at room temperature, then evaporated. The residue is purified by chromatography. Yield: 650 mg (= 72% of theory)

e) Benzyl- (2-piperazin-1-yl-4-pyrrolidin-1-yl-6-trifluoromethyl-pteridin-7-yl) -amine (Example 32): 700 mg (7.95 mmol) of piperazine are dissolved in 24 submitted dioxane and heated to 8O ° C. 650 mg (1, 59 mmol) of benzyl (2-chloro-4-pyrrolidin-1-yl-6-trifluoromethyl-pteridin-7-yl) -amine are dissolved in 25 ml of dioxane and added within 0.5 hours to the Dropped piperazine solution. The reaction mixture is then added dropwise to 200 ml of ice-water, and the resulting precipitate is filtered off with suction and dried. The still contaminated product is purified by chromatography. Yield: 210 mg (= 29% of theory)

Below are exemplified compounds that can be represented by one of the synthetic routes shown above. Melting points (m _p ) are given in ° C.

INDICATIONS

As has been found, the compounds of formula 1 are characterized by a variety of possible applications in the therapeutic field. Worth mentioning are those applications for which the compounds of formula 1 according to the invention can preferably be used as a PDE4 inhibitor due to their pharmaceutical activity. Examples include his respiratory or gastrointestinal diseases or disorders, inflammatory diseases of the joints, the skin or the eyes, cancers, as well as diseases of the peripheral or central nervous system.

Preference is given here to the prevention and treatment of respiratory or lung diseases, which are associated with increased mucus production, inflammation and / or obstructive diseases of the respiratory tract. Examples include his, acute, allergic or chronic bronchitis, chronic obstructive pulmonary disease (COPD), cough, pulmonary emphysema, allergic or non-allergic rhinitis or sinusitis, chronic rhinitis or sinusitis, asthma, alveolitis, Farmers ^' disease, hyperrespiratory airways, infectious bronchitis or pneumonitis, pediatric asthma, bronchiectasis, pulmonary fibrosis, ARDS (adult respiratory distress syndrome), Bronchial edema, pulmonary edema, bronchitis, pneumonia or interstitial pneumonia triggered by various causes such as aspiration, inhalation of toxic gases or bronchitis, pneumonia or interstitial pneumonia triggered by congestive heart failure, radiation, chemotherapy cystic fibrosis or cystic fibrosis, alphai-antitrypsin deficiency.

Likewise preferred is the treatment of inflammatory diseases of the gastrointestinal tract. Examples thereof include its, acute or chronic inflammatory changes in gallbladder inflammation, Crohn's disease, ulcerative colitis, inflammatory pseudopolyps, juvenile polyps, colitis cystica profunda, interstinal pneumatosis cystoides, diseases of the bile ducts and gallbladder, e.g. Gallstones and conglomerates for the treatment of inflammatory diseases of the joints such as rheumatoid arthritis or inflammatory diseases of the skin and eyes.

Likewise preferred is the treatment of cancer. Exemplary of this are called all forms of acute and chronic leukemias such as, acute lymphoblastic and acute myeloid leukemia, chronic lymphocytic and chronic myeloid leukemia, as well as bone tumors such as osteosarcoma and as well as all types of gliomas such as oligodendroglioma and glioblastoma.

Preference is furthermore given to the prevention and treatment of diseases of the peripheral or central nervous system. Examples include depression, bipolar or manic depression, acute and chronic anxiety, schizophrenia, Alzheimer's disease, Parkinson's disease, acute and chronic multiple sclerosis or acute and chronic pain, and brain damage caused by stroke, hypoxia, or skull injury. Brain trauma.

More particularly, the present invention relates to the use of compounds of formula 1 for the manufacture of a medicament for the treatment of inflammatory or obstructive diseases of the upper and lower respiratory organs, including the lung, such as allergic rhinitis, chronic rhinitis, bronchiectasis, cystic fibrosis, idiopathic pulmonary fibrosis, fibrosing alveolitis, COPD, chronic bronchitis, chronic sinusitis, asthma, Crohn's disease, ulcerative colitis, especially COPD, chronic bronchitis and asthma.

Most preferred is the use of the compounds of formula 1 for the treatment of inflammatory and obstructive diseases such as COPD, chronic bronchitis, chronic sinusitis, asthma, Crohn's disease, ulcerative colitis, especially COPD, chronic bronchitis and asthma.

Also preferred is the use of the compounds of formula 1 for the treatment of diseases of the peripheral or central nervous system such as depression, bipolar or manic depression, acute and chronic anxiety, schizophrenia, Alzheimer's disease, Parkinson's disease, acute and chronic multiple sclerosis or acute and chronic pain as well as brain damage caused by stroke, hypoxia or craniocerebral trauma.

An outstanding aspect of the present invention is the reduced profile of side effects. In the context of the invention, this is understood as being able to administer a dose of a pharmaceutical composition without inducing vomiting in the patient, preferably nausea, particularly preferably malaise. Most preferably, administration of a therapeutically effective amount of substance without inducing emesis or nausea is at any stage of the disease process.

COMBINATIONS

The compounds of the formula 1 can be used alone or in combination with other active compounds of the formula 1 according to the invention. Optionally, the compounds of formula 1 can also be used in combination with other pharmacologically active ingredients. Preferred active substances are those which are selected, for example, from the group consisting of betamimetics, anticholinergics, corticosteroids, further PDE4 inhibitors, LTD4 antagonists, EGFR inhibitors, dopamine agonists, H1 antihistamines, PAF antagonists and PI3 Kinase inhibitors or two or three combinations thereof, such as combinations of Betamimetics with corticosteroids, PDE4 inhibitors, EGFR inhibitors or LTD4 antagonists,

Anticholinergics with betamimetics, corticosteroids, PDE4 inhibitors, EGFR inhibitors or LTD4 antagonists, - corticosteroids with PDE4 inhibitors, EGFR inhibitors or LTD4 antagonists PDE4 inhibitors with EGFR inhibitors or LTD4 antagonists EGFR inhibitors with LTD4 antagonists ,

Also, the combinations of three active ingredients each one of the o.g. Is connection classes

Component of the invention.

PRESENTATIONS

A further aspect of the invention is medicaments for the treatment of respiratory diseases which comprise one or more of the abovementioned pteridines of the

Formula 1, which is preferred in combination with one or more additional active ingredients selected from the group of betamimetics, anticholinergics, corticosteroids, PI3-kinase inhibitors, LTD4 antagonists, EGFR inhibitors, dopamine agonists, H1 - antihistamines or PAF antagonists Betamimetics, anticholinergics or corticosteroids can be used together or sequentially, for simultaneous, sequential or separate administration.

Suitable application forms are, for example, tablets, capsules, solutions, juices, emulsions or inhalable powders or aerosols. In this case, the proportion of the pharmaceutically active compound (s) in each case in the range of 0.1 to 90 wt .-%, preferably 0.5 to 50 wt .-% of the total composition, i. in amounts sufficient to reach the dosage range given below.

Oral administration may be in the form of a tablet, as a powder, as a powder in a capsule (eg hard gelatin capsule), as a solution or suspension. In the case of an inhalative administration, the active substance combination can be carried out as a powder, as an aqueous or aqueous-ethanolic solution or by means of a propellant gas formulation. Therefore, pharmaceutical formulations are preferably characterized by the content of one or more compounds of formula 1 according to the above preferred embodiments.

It is particularly preferred if the compounds of the formula 1 are administered orally, it is particularly preferred if the administration takes place once or twice daily. Corresponding tablets can be prepared, for example, by mixing the active substance (s) with known excipients, for example inert diluents such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants, such as

Magnesium stearate or talc, and / or agents for obtaining the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate are obtained. The tablets can also consist of several layers.

Coated tablets can accordingly be produced by coating cores produced analogously to the tablets with agents customarily used in tablet coatings, for example collidone or shellac, gum arabic, talc, titanium dioxide or sugar. To achieve a depot effect or to avoid incompatibilities, the core can also consist of several layers. Similarly, the dragee sheath to achieve a depot effect of several layers may consist of the above mentioned in the tablets excipients can be used.

Juices of the active compounds or active compound combinations according to the invention may additionally contain a sweetening agent, such as saccharin, cyclamate, glycerol or sugar, and a taste-improving agent, e.g. Flavorings such as vanillin or orange extract. They may also contain suspending aids or thickening agents, such as sodium carboxymethylcellulose, wetting agents, for example condensation products of fatty alcohols with ethylene oxide, or protective agents, such as p-hydroxybenzoates.

The capsules containing one or more active ingredients or combinations of active substances can be prepared, for example, by mixing the active ingredients with inert carriers, such as lactose or sorbitol, and encapsulating them in gelatine capsules. Suitable suppositories can be prepared, for example, by mixing with suitable carriers, such as neutral fats or polyethylene glycol or its derivatives.

As adjuvants there may be mentioned, for example, water, pharmaceutically acceptable organic solvents such as paraffins (e.g., petroleum fractions), oils of vegetable origin (e.g., peanut or sesame oil), mono- or polyfunctional alcohols (e.g., ethanol or glycerin), excipients such as e.g. ground natural minerals (e.g., kaolins, clays, talc, chalk), ground synthetic minerals (e.g., fumed silica and silicates), sugars (e.g., cane, milk and dextrose), emulsifying agents (e.g., lignin, liquor liquors,

Methyl cellulose, starch and polyvinyl pyrrolidone) and lubricants (e.g., magnesium stearate, talc, stearic acid and sodium lauryl sulfate).

In the case of oral administration, of course, the tablets may also contain additives other than those mentioned. Sodium citrate, calcium carbonate and dicalcium phosphate together with various additives such as starch, preferably potato starch, gelatin and the like. Further, lubricants such as magnesium stearate, sodium lauryl sulfate and talc may be used for tableting. In the case of aqueous suspensions, the active ingredients may be added to the abovementioned excipients with various flavor enhancers or dyes.

It is likewise preferred if the compounds of the formula 1 are administered by inhalation, it being particularly preferred if the administration is carried out once or twice daily. For this purpose, the compounds of formula 1 in inhalable

Dosage forms are provided. Suitable inhalable dosage forms are inhalable powders, propellant-containing metered-dose inhalers or propellant-free inhalable solutions which, if appropriate, are present in admixture with conventional physiologically compatible excipients.

In the context of the present invention, the term propellant-free inhalable solutions also includes concentrates or sterile, ready-to-use inhalable solutions. The administration forms which can be used in the context of the present invention will be described in detail in the following part of the description. inhalation powder

If the compounds of the formula 1 are contained in a mixture with physiologically acceptable excipients, the following physiologically acceptable excipients can be used to prepare the inhalable powders according to the invention:

Monosaccharides (e.g., glucose or arabinose), disaccharides (e.g., lactose, sucrose, maltose), oligo- and polysaccharides (e.g., dextrans), polyalcohols (e.g., sorbitol, mannitol, xylitol), salts (e.g., sodium chloride, calcium carbonate) or mixtures of these excipients with each other. Preferably, mono- or disaccharides are used, wherein the use of lactose or glucose, in particular, but not exclusively in the form of their hydrates, is preferred. Lactose, most preferably lactose monohydrate, is used as adjuvant for the purposes of the invention. Methods for producing the inhalable powders according to the invention by grinding and micronizing as well as by final mixing of the constituents are known from the prior art.

Propellant-containing inhalation aerosols

The propellant-containing inhalable aerosols which can be used in the context of the use according to the invention can be dissolved in the propellant gas or in dispersed form. The propellant gases which can be used for the preparation of the inhalation aerosols are known from the prior art. Suitable propellant gases are selected from the group consisting of hydrocarbons such as n-propane, n-butane or isobutane and halohydrocarbons such as preferably fluorinated derivatives of methane, ethane, propane, butane, cyclopropane or cyclobutane. The abovementioned propellant gases can be used alone or in mixtures thereof. Particularly preferred propellant gases are fluorinated alkane derivatives selected from TG134a (1,1,1,2-tetrafluoroethane), TG227 (1,1,1,3,3,3,3-heptafluoropropane) and mixtures thereof. The propellant-containing inhalation aerosols which can be used in the context of the use according to the invention can also contain further constituents, such as co-solvents, stabilizers, surfactants, antioxidants, lubricants and agents for adjusting the pH. All of these ingredients are known in the art.

LPG-free inhalation solutions The use according to the invention of compounds of the formula 1 is preferably carried out for the preparation of propellant-free inhalable solutions and inhalable suspensions. Suitable solvents for this purpose are aqueous or alcoholic, preferably ethanolic solutions. The solvent may be water only or it may be a mixture of water and ethanol. The solutions or suspensions are adjusted to a pH of from 2 to 7, preferably from 2 to 5, with suitable acids. To adjust this pH, acids selected from inorganic or organic acids can be used. Examples of particularly suitable inorganic acids are hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid and / or phosphoric acid. Examples of particularly suitable organic acids are:

Ascorbic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, fumaric acid, acetic acid, formic acid and / or propionic acid and others. Preferred inorganic acids are hydrochloric acid, sulfuric acid. It is also possible to use the acids which already form an acid addition salt with one of the active substances. Among the organic acids, ascorbic acid, fumaric acid and citric acid are preferable. Optionally, mixtures of said acids may also be employed, particularly in the case of acids which, in addition to their acidification properties, also possess other properties, e.g. as flavorants, antioxidants or complexing agents, such as citric acid or ascorbic acid. Hydrochloric acid is particularly preferably used according to the invention for adjusting the pH.

Co-solvents and / or further auxiliaries can be added to the propellant-free inhalable solutions which can be used in the context of the inventive use. Preferred co-solvents are those which contain hydroxyl groups or other polar groups, for example alcohols - in particular isopropyl alcohol, glycols - in particular propylene glycol, polyethylene glycol, polypropylene glycol, glycol ethers, glycerol, polyoxyethylene alcohols and polyoxyethylene fatty acid esters. In this context, auxiliaries and additives are understood as meaning any pharmacologically acceptable substance which is not an active substance but together with the substance (s).

Active ingredient (s) can be formulated in the pharmacologically suitable solvent to improve the qualitative properties of the drug formulation. These substances preferably do not develop any appreciable or at least no undesirable pharmacological effect in the context of the intended therapy. To the Auxiliaries and additives include, for example, surfactants such as soybean lecithin, oleic acid, sorbitan esters such as polysorbates, polyvinylpyrrolidone other stabilizers, complexing agents, antioxidants and / or preservatives that ensure or prolong the useful life of the finished drug formulation, flavorings, vitamins and / or other dem Known in the art

Additives. The additives also include pharmacologically acceptable salts such as sodium chloride as isotonants. Preferred excipients include antioxidants, such as ascorbic acid, if not already used for pH adjustment, vitamin A, vitamin E, tocopherols, and similar vitamins or provitamins found in the human organism. Preservatives may be used to protect the formulation from contamination by germs. Suitable preservatives are those known in the art, in particular cetylpyridinium chloride, benzalkonium chloride or benzoic acid or benzoates such as sodium benzoate in the concentration known from the prior art.

For the above-described forms of treatment, ready-to-use packs of a medicament for the treatment of respiratory disorders, including an enclosed description containing, for example, the words respiratory disease, COPD or asthma, a pteridine and one or more combination partners selected from the group described above, are provided.

Claims

1 . Compounds of the formula 1 wherein R ^{1 is} a heterocyclic ring containing a nitrogen atom; R ^{2 is} halogen, OR ^{2 1} , SR ^{2 1} , NR ^{2 1} R ^{2 2} or a radical selected from the group consisting of aryl, het and hetaryl, optionally substituted with one Residue selected from the group consisting of C _1-6 alkyl, OC _1-6 alkyl, C _3-6 cycloalkyl, C _7- n aralkyl and N (C _1-4 alkyl) ₂ ; R ^{2 is} H, C 1-4 alkyl, aryl, C _7-11 aralkyl; R ^{22 is} H, C _1-4 alkyl, aryl, C _7-11 aralkyl; R ^{3 is} aryl, het, hetaryl or a group of the formula 1a, wherein A aryl, hetaryl X NR ^{3 2} , S, O; Y is C _1-4 -alkylene, optionally substituted with one or more R ³³ m 0, 1, 2, 3; R ^{3 1 are} each independently C _1-6 -alkyl, C ₁ . ₆ -haloalkyl, C _1-6 -alkyl-CONR ^{3 1 1} R ^{3 1 2} , - C _1-6 -alkyl-NR ^{3 1 1} R ^{3 1 2} , OR ^{3 1 1} , OC _1-6 -haloalkyl, NHCOR ^{3 1 1} , SO ₂ R ^{3 1 1} , aryl; Halogen, CN, OH, CONR ^{3 1 1} R ^{3 1 2} ; or R ^{3 1} forms together with two atoms of A a 5 or 6-membered carbocyclic ring or a 5 or 6-membered heterocyclic ring which may contain one or more oxygen or nitrogen atoms; R ^{3 1 1} H, C _1-6 -alkyl, R ^{3 1 2} H, C _1-6 -alkyl, R ³² H, C _1-6 alkyl; R ^{33 are} each independently C _1-6 alkyl, C _1-6 alkyl OH, C _3-6 cycloalkyl OH, COOR ^{33 1} , CONR ^{3 3 1} R ^{3 32} ; or R ³³ together with one or two carbon atoms of Y forms a carbocyclic ring having 3, 4, 5 or 6 carbon atoms R ^{3 3} H, C _1-6 alkyl; R ^{3 is 32} H, C _1-6 -alkyl; R ^{4 is} a radical selected from the group consisting of C _1-6 alkyl, C _2-6 alkenyl, C _2-6 alkynyl, C _3-6 cycloalkyl, C _3-6 cycloalkenyl, OR ^{4 1} , SR ^{4 1} , C _1-6 haloalkyl, NR ^{4 1} R ^{4 2} or a radical selected from the group consisting of aryl, het and hetaryl, optionally substituted by one or more radicals selected from the group consisting of C _1-6 alkyl , C _1-6 -haloalkyl, CN, O-C _1-6 -alkyl, halogen, R ^{4 is} H, C _1-6 alkyl, aryl, C _7-11 aralkyl; R ^{42 is} H, C _1-6 alkyl, aryl, C _7-11 aralkyl; and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. 2. Compounds of formula 1, according to claim 1, wherein Aryl, het, hetaryl or a group of formula 1a, wherein A aryl, hetaryl X NR ^{3 2} , S, O; YC _1-4 -alkylene, optionally substituted by one or more R ³³ m 0, 1, 2; R ^{3 1 are} each independently C _1-6 -alkyl, C _1-6 -haloalkyl, C _1-6 -alkyl-CONH ₂ , -C _1-6 -alkyl-NH _2l OC _1-6 -alkyl, OC _{1- 6} haloalkyl, -NHCO-C _1- 8 alkyl, SO ₂ C _1-6 alkyl, aryl; Halogen, CN, OH, CONH ₂ ; or R ^{3 1} forms, together with two atoms of A form a 5 or 6-membered carbocyclic ring or a 5 or 6-membered hetero- cyclic ring which may contain one or more oxygen or nitrogen atoms; R ^{32 is} H, C _1-6 alkyl; R ^{33 are} each independently C _1-6 alkyl, C _1-6 alkyl OH, C _3-6 cycloalkyl OH, COO C _1-6 alkyl, COOH, CONH ₂ ; or R ³³ together with one or two carbon atoms of Y forms a carbocyclic ring having 3, 5 or 6 carbon atoms a radical selected from the group consisting of C _1-6 -alkyl, C _2-6 alkenyl, C _2-6 alkynyl, C _3-6 cycloalkyl, C _3-6 cycloalkenyl, OC _1-6 alkyl, SC _1-6 alkyl, C _1-6 haloalkyl, NR ^{4 1} R ⁴² or a radical selected from the group consisting of aryl, het and hetaryl, optionally substituted by one or more radicals selected from the group consisting of C _1-8 alkyl, C _1-6 haloalkyl, CN, OC _{1 -6-} alkyl, halogen, R ^{4 is} H, C _1-6 alkyl; R ^{42 is} C _1-6 alkyl, aryl; and pharmacologically acceptable salt, diastereomers, enantiomers, Racemates, hydrates or solvates thereof. 3. Compounds of formula 1 according to any one of claims 1 or 2, wherein R ^{4 is} C _3-6 cycloalkyl; and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. 4. Compounds of formula 1 according to any one of claims 1 to 3, wherein R ^{3 is} a group of the formula 1a, wherein A aryl, hetaryl X NH, S, O; Y is C _1-4 -alkylene, optionally substituted with one or more R ³³ m 0, 1, 2; R ^{3 1 are} each independently of one another C _1-4 -alkyl, C _1-4 -haloalkyl, C _1-4 -alkyl-CONH ₂ , C _1-4 -alkyl-NH ₂ , OC _1-4 -alkyl, OC _{1- 4} -haloalkyl, NHCO-C _1-4 -alkyl, SO _2- C _1-4 -alkyl, halogen, CN, OH, CONH ₂ ; Each R ³³ is independently C _1-4 alkyl, C _1-4 alkyl OH, C _3-4 cycloalkyl OH, COO C _1-4 alkyl, COOH, CONH ₂ ; or R ³³ together with one or two carbon atoms of Y forms a carbocyclic ring having 3, 5 or 6 carbon atoms and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. 5. Compounds of formula 1 according to any one of claims 1 to 4, wherein R ^{3 is} a group of the formula 1 a, wherein A aryl, hetaryl X NH, S, O; YC _1-4 -alkylene, optionally substituted with one or two R ^{3 3} m 0, 1, 2; R ^{3 1 are} each independently of one another C _1-4 -alkyl, C _1-4 -haloalkyl, OC _1-4 -alkyl, OC _1-4 -haloalkyl, halogen, CN, OH; R ^{33 are} each independently C _1-4 alkyl, COOH, CONH ₂ ; or R ³³ together with one or two carbon atoms of Y forms a carbocyclic ring of 3 carbon atoms and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. 6. Compounds of formula 1 according to any one of claims 1 or 2, wherein R ^{2 is} halogen, NR ^{2 1} R ²² , Het optionally substituted by a radical selected from the group consisting of C _3-6 cycloalkyl, C _7-11 aralkyl and NMe ₂ ; R ^{2 1} C _7-11 - aralkyl; R ²² H; R ³ NR ^{3 1} R ^{3 2} , SR ^{3 1} or Het; R ^{3 is} C _1-6 -alkylene-C _3-6 -cycloalkyl or C _7-11 -aralkyl, optionally substituted by a radical selected from the group halogen; R ³² is H; R ^{4 is} a radical selected from the group consisting of C _1-6 -alkyl, C _3-6 -cycloalkyl, OC _1-6 -alkyl, C _1-6 -haloalkyl, NR ^{4 1} R ⁴² or a radical selected from the group consisting of aryl, het and hetaryl, optionally substituted by one or more radicals selected from the group consisting of C _1-6 -alkyl, C _1-6 -haloalkyl, CN, O-C _1-6 -alkyl, halogen, R ^{4 is} H, C _1-6 alkyl; R ^{42 is} C _1-6 alkyl, aryl; and pharmacologically acceptable salt, diastereomers, enantiomers, Racemates, hydrates or solvates thereof. 7. Compounds of formula 1 according to any one of claims 1 to 3 or 6, wherein R ^{2 is} halogen, NH (benzyl), Het, optionally substituted by a radical selected from the group consisting of cyclopropyl, benzyl and NMe ₂ ; R ³ NR ^{3 1} R ^{3 2} , SR ^{3 1} or Het; R ^{3 1} methylcyclohexyl or benzyl, optionally substituted by a radical selected from the group of fluorine and chlorine; R ³² is H; R ^{4 is} a radical selected from the group consisting of methyl, ethyl, propyl, 2-methylpropyl, cyclopropyl, cyclohexyl, methoxy, CF ₃ , NR ^{4 1} R ⁴² , Het, hetaryl, aryl, optionally substituted with one or more radicals selected from the group consisting of methyl, CF ₃ , CN, methoxy, fluorine, chlorine, R ^{4 1} H, methyl, ethyl; R ^{42 is} methyl, ethyl, phenyl; and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. Compounds of formula 1 according to any one of claims 1 to 3, 6 or 7, wherein R ^{1 is} a five- or six-membered heterocyclic ring containing one nitrogen atom; R ^{2 is} chlorine, NH (benzyl), a six-membered heterocyclic ring which may contain one or more nitrogen atoms and is optionally substituted by a radical selected from the group consisting of cyclopropyl, benzyl and NMe ₂ ; R ³ NR ^{3 1} R ^{3 2} , SR ^{3 1} or a six-membered heterocyclic ring which may contain one or more heteroatoms selected from the group consisting of nitrogen and oxygen; R ^{3 1} methylcyclohexyl or benzyl, optionally substituted by a radical selected from the group of fluorine and chlorine; R ³² is H; R ^{4 is} a radical selected from the group consisting of methyl, ethyl, propyl, 2-methylpropyl, cyclopropyl, cyclohexyl, methoxy, CF ₃ , NR ^{4 1} R ⁴² , Aryl, optionally substituted by one or more radicals selected from the group consisting of methyl, CF ₃ , CN, methoxy, fluorine, chlorine, a five- or six-membered heterocyclic ring which may contain one or more heteroatoms selected from the group consisting of nitrogen and oxygen, a five-membered heterocyclic aromatic which may contain one or more radicals selected from the group consisting of nitrogen and oxygen, an aromatic or non-aromatic bicyclic one or more Heteroatoms selected from the group consisting of sulfur and oxygen may contain; R ^{4 1} H, methyl, ethyl; R ^{42 is} methyl, ethyl, phenyl; and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. 9. Compounds of formula 1 according to any one of claims 1 to 3 or 6 to 8, wherein R ^{1 is} a radical selected from the group consisting of a radical selected from the group consisting of chlorine, a residue selected from the group consisting of a radical selected from the group consisting of methyl, ethyl, propyl, 2-methylpropyl, methoxy, CF ₃ , NMe ₂ , NEt ₂ , and pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof. 10. Compounds according to any one of claims 1 to 9 as a medicament. 1 1. Use of compounds according to one of claims 1 to 9, to Preparation of a medicament for the treatment of diseases which can be treated by inhibition of the PDE4 enzyme. 12. Use of compounds according to any one of claims 1 to 9 for the manufacture of a medicament for the treatment of respiratory or gastrointestinal disorders or diseases, as well as inflammatory diseases of the joints, the skin or the eyes, cancers, as well as diseases of the peripheral or central nervous system , 13. Use of compounds according to any one of claims 1 to 9 for the manufacture of a medicament for the prevention and treatment of respiratory or pulmonary diseases associated with increased mucus production, inflammation and / or obstructive respiratory diseases. 14. Use of compounds according to any one of claims 1 to 9 for the manufacture of a medicament for the treatment of inflammatory diseases of the gastrointestinal tract. 15. Use of compounds according to any one of claims 1 to 9 for the manufacture of a medicament for the treatment of inflammatory and obstructive diseases such as COPD, chronic sinusitis, asthma, Crohn's disease, ulcerative colitis. Use of compounds according to any one of claims 1 to 9 for the manufacture of a medicament for the prevention and treatment of diseases of the peripheral or central nervous system such as depression, bipolar or manic depression, acute and chronic anxiety, schizophrenia, Alzheimer's Disease, Parkinson's disease, acute and chronic multiple sclerosis or acute and chronic pain, and brain damage caused by stroke, hypoxia or traumatic brain injury. 17. Use of compounds according to one of claims 1 to 9 for the manufacture of a medicament for the treatment of cancers such as acute and chronic leukemias, acute lymphoblastic and acute myeloid leukemia, chronic lymphocytic and chronic myeloid leukemia, as well as bone tumors such as osteosarcoma and all kinds of Gliomas like Oligodendroglioma and glioblastoma. 18. Use according to any one of claims 10 to 17, wherein side effects of the treatment are reduced. Use according to any one of claims 10 to 18, wherein the reduced side effects are selected from the group of emesis and nausea.