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EP1748777A1 - Formulations a liberation controlee contenant du vardenafil - Google Patents

Formulations a liberation controlee contenant du vardenafil

Info

Publication number
EP1748777A1
EP1748777A1 EP05739506A EP05739506A EP1748777A1 EP 1748777 A1 EP1748777 A1 EP 1748777A1 EP 05739506 A EP05739506 A EP 05739506A EP 05739506 A EP05739506 A EP 05739506A EP 1748777 A1 EP1748777 A1 EP 1748777A1
Authority
EP
European Patent Office
Prior art keywords
dosage form
pharmaceutical dosage
form according
release
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05739506A
Other languages
German (de)
English (en)
Inventor
Susanne Zuleger
Peter Serno
Helmut Haning
Kerstin Pauli
Roland Heinig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of EP1748777A1 publication Critical patent/EP1748777A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to new pharmaceutical dosage forms with controlled release of active ingredient, which contain the PDE 5 inhibitor vardenafil and / or pharmaceutically acceptable salts, hydrates, solvates and / or polymorphic forms thereof as active ingredient, and their preparation.
  • the invention further relates to the use of these new pharmaceutical dosage forms as pharmaceuticals and their use for the production of pharmaceuticals for the treatment and / or prevention of diseases in humans and animals.
  • the PDE 5 inhibitor vardenafil is the compound of the formula (I) with the systematic name ⁇ 2-ethoxy-5 - [(4-ethyl-1-piperazinyl) sulfonyl] phenyl ⁇ -5-methyl-7- propyl-imidazo [5, l] triazin-4 (3H) -one:
  • the intracellular cGMP level is controlled by the interplay of synthesis by NO-activated guanylate cyclase on the one hand and degradation by phosphodiesterases (PDEs) on the other hand.
  • PDE 5 in the corpus cavemosum tissue of the penis is primarily responsible for controlling the cGMP level that is important for the erection.
  • the NCVcGMP system plays a crucial role in the hemodynamic process of erection. Inhibition of the cGMP-degrading enzyme PDE 5 is particularly effective in situations with increased NO levels, especially with sexual stimulation. Because of this situation, long-lasting plasma levels of a PDE 5 inhibitor can have an effect against sexual dysfunction each time sexual stimulation occurs. Long-term exposure of a PDE 5 inhibitor to other diseases can also lead to an improved therapeutic effect, a reduced fluctuation in plasma levels, a reduction in the dose to be administered and / or reduced side effects.
  • the present invention relates to new pharmaceutical dosage forms of the PDE 5 inhibitor vardenafil, its salts, hydrates, solvates, polymorphic forms and in particular the hydrochloride trihydrate, which are characterized by a controlled release of the active ingredient.
  • Vardenafil and its production and use are described, for example, in WO 99/24433, WO 02/50076, WO 02/089808 and WO 03/011262.
  • Dosage forms with controlled release of active ingredient are basically known in the prior art. Dosage forms with controlled release of active ingredient that contain cGMP PDE 5 inhibitors, on the other hand, are only little known. Although pharmaceutical formulations of PDE 5 inhibitors with controlled release are claimed in WO 00/24383, vardenafil differs from these PDE 5 inhibitors essentially on the basis of special physicochemical and pharmacokinetic properties. Particularly critical is the very low absolute oral bioavailability of vardenafil, which is subject to a much stronger first-pass effect than other cGMP PDE 5 inhibitors, e.g. Sildenafil, and the very pronounced pH dependence of the solubility of Vardenafil.
  • a further principle is represented by flourishing pharmaceutical forms with a very low density, as described, for example, in US Pat. No. 5,626,876, but formulations with a high density are also used to lengthen the stomach residence time, as described, for example, in EP 0526862.
  • success has been achieved such systems have not yet been shown.
  • Such systems do not have the desired effect of prolonged gastric dwell time, especially when fasted, because the drug forms are emptied from the stomach without any noticeable delay due to the strong housekeeper waves.
  • vardenafil its salts, hydrates, solvates, and polymorphic forms that overcome the prior art problems described above.
  • dosage forms with controlled release of the active ingredient of the PDE 5 inhibitor vardenafil are also suitable for the therapy of other, new indications and show significant advantages compared to the rapidly releasing pharmaceutical forms of the prior art.
  • the use of the new drug forms with controlled release of active ingredients has made it possible to achieve much more constant blood levels and to prevent the occurrence of blood level peaks, which, for example, improves the therapeutic effectiveness and reduces the frequency and intensity of undesirable side effects.
  • the Using such dosage forms reduces the frequency of application and thus leads to improved acceptance and compliance in the patient.
  • the invention thus relates to new pharmaceutical dosage forms which contain vardenafil and / or pharmaceutically acceptable salts, hydrates, solvates and / or polymorphic forms thereof as active ingredients and have an average release rate of between 80% in 2 hours and 80% in 24 hours.
  • the active ingredient release from the dosage forms according to the invention is tested in the blade stirrer apparatus "Apparatus 2" of USP 28-NF23 (The United States Pharmaceuticals USP 28 2005).
  • 900 ml of a phosphate buffer pH 6.8 with 0.1% (m / V) sodium lauryl sulfate are used as the release medium (preparation of 1 liter of this medium: 2.747 g disodium hydrogen orthophosphate dihydrate, 0.475 g citric acid monohydrate and 10 g sodium lauryl sulfate solution 10% (m / m) are dissolved in 1000 ml with deionized water (if necessary, the pH is adjusted to 6.8 ⁇ 0.05 with sodium hydroxide or orthophosphoric acid).
  • the release is carried out using sinkers at a temperature of 37 ⁇ 0.5 ° C. and a speed of rotation of the blade stirrer of 75 revolutions per minute (rpm).
  • Samples are taken from the release medium by a filter unit, which must ensure that accompanying substances are removed, and the amount of active substance dissolved therein is determined by HPLC with UV-VIS detection. The amount of active ingredient determined in this way is converted into mass percent of the amount of active ingredient used.
  • the mean release rate in the sense of the present invention is defined over the time until an active ingredient release of 80% is reached, while the initial release describes the percentage active ingredient release after 30 minutes.
  • the dosage forms according to the invention with controlled release of active substance preferably have an average release rate of 80% in the time interval between 3 and 20 hours (80% in 3 hours and 80% in 20 hours).
  • the formulation has a mean release rate of 80% over a period of 3 and 18 hours and an initial release of a maximum of 65% of the active ingredient in the first 30 minutes of the release.
  • the dosage forms according to the invention with controlled release of active ingredient can be formulated in such a way that a relatively low initial release of 0 to 30% in the first 30 minutes or a relatively high initial release of 30 to 60% of the drug is achieved in the first 30 minutes of the drug release.
  • controlled release dosage forms of the present invention with an average release rate of 80% over a period of 4 to 18 hours, this has a relatively low initial release of 0 to 25% in the first 30 minutes of the release.
  • Another preferred embodiment of the pharmaceutical formulations with controlled active ingredient release has an average release rate of 80% in the period from 3 to 16 hours and is characterized by a relatively high initial release of 35 to 60% in the first 30 minutes of the drug release.
  • Dosage forms with controlled active ingredient release of this invention are all formulations in which the active ingredient release is modified in such a way that it takes place at a lower release rate than from rapidly releasing dosage forms, e.g. a conventional tablet or capsule.
  • Dosage forms with controlled release of the active substance of the present invention also contain formulations with delayed release, in which the release of the active substance is modified in such a way that the release begins at a later point in time than with a conventional rapid-release dosage form.
  • the subsequent release from a delayed-release pharmaceutical form can also take place in a controlled manner, with a reduced release rate.
  • the dosage forms according to the invention with controlled release of active substance comprise formulations with pulsatile release, in which the active substance is released in batches at different times or at certain locations in the gastrointestinal tract, and formulations in which different principles of controlled release of active substance are combined.
  • the dosage forms of this invention also include pharmaceutical formulations which contain part of the active ingredient in a quick-release form and another part of the active ingredient in a controlled-release form.
  • a particular aspect of the present invention are dosage forms with controlled release of active ingredients, which contain acids, bases, buffer substances and / or substances with pH-dependent solubility, such as enteric polymers, as additives.
  • the new formulations with controlled release behavior can be administered in different ways. Oral application is particularly preferred, but other application routes are also possible, e.g. buccal, sublingual, inhalation, ocular, transdermal or rectal administration or use in the form of an implant.
  • Solid, semi-solid or liquid formulations with controlled release behavior can be used. Fixed dosage forms are preferred.
  • the pharmaceutical formulations according to the invention can contain the active substance in dissolved, suspended and / or solid, amorphous or crystalline form.
  • the active ingredient can be in various grain sizes, e.g. in unground, ground or in micronized form.
  • the dosage forms described above with controlled release of active substance are, for example, in the form of particles containing active substance such as pellets, granules, microcapsules, tablets, extrudates or active substance crystals which are coated with a diffusion-controlling membrane.
  • active substance such as pellets, granules, microcapsules, tablets, extrudates or active substance crystals which are coated with a diffusion-controlling membrane.
  • diffusion-controlled systems are preferably multiparticulate, ie they preferably consist of a large number of coated cores, such as, for example, neutral pellets, onto which a mixture of the active ingredient with a customary binder and thickener, optionally together with customary auxiliaries and carriers, as defined below, for example. is applied and then coated with a diffusion lacquer, which may contain plasticizers and other auxiliaries.
  • the diffusion-controlled systems according to the invention can also consist of homogeneous drug-containing cores, 'extrusion, if necessary, be prepared by spheronisation for example, by granulation, rotor granulation, fluidized bed agglomeration, tableting, moist extrusion or melt, and with a diffusion lacquer which can contain plasticizers and other excipients, are coated.
  • the active substance-containing particles contain auxiliary substances such as acids or buffer substances, which modify the pH and thereby contribute to reducing the dependence of the active substance release on the pH value of the release medium.
  • the diffusion-controlled membrane contains auxiliaries which, due to their pH-dependent solubility, contribute to the permeability of the membrane influence different pH values and thus help to minimize the pH dependence of the active ingredient release.
  • Hydroxypropyl methyl celluloses HPMC
  • polyvinyl pyrrolidone PVP
  • binders and thickeners in the production of coated neutral pellets (e.g. consisting of sucrose, microcrystalline cellulose, citric acid).
  • coated neutral pellets e.g. consisting of sucrose, microcrystalline cellulose, citric acid.
  • Other natural, synthetic or partially synthetic polymers such as methyl cellulose (MC), hydroxypropyl cellulose (HPC), other hydroxyalkyl celluloses and hydroxyalkylmethyl celluloses, carboxymethyl celluloses and their salts, polyacrylic acids, polymethacrylates, gelatin, starch or starch derivatives can also be used.
  • active ingredient pellets active ingredient-containing particles and (mini) tablets by granulation, fluidized bed agglomeration, moisture extrusion, tableting, e.g. Cellulose, microcrystalline cellulose, cellulose derivatives such as e.g. HMPC, HPC and low substituted hydroxypropyl cellulose (L-HPC), dicalcium phosphate, lactose, PVP and sucrose are used as binders and fillers.
  • active ingredient-containing particles and (mini) tablets by granulation, fluidized bed agglomeration, moisture extrusion, tableting, e.g. Cellulose, microcrystalline cellulose, cellulose derivatives such as e.g. HMPC, HPC and low substituted hydroxypropyl cellulose (L-HPC), dicalcium phosphate, lactose, PVP and sucrose are used as binders and fillers.
  • HMPC microcrystalline cellulose
  • L-HPC low substituted hydroxypropyl cellulose
  • dicalcium phosphate lac
  • Melt extrusion pellets are made by embedding the active ingredient in thermoplastic auxiliaries such as HPC, HPMC, ethyl cellulose, Hydroxypropymethylcelluloseacetatsuccinat (HPMCAS), PVP, vinylpyrrolidone vinyl acetate copolymer, acrylates of polyethylene glycol, polyethylene oxide, polymethacrylate, polyvinyl alcohols (PVA), partially saponified polyvinyl acetate (PVAc), polysaccharides (eg, alginic acid, alginates, galactomannans) waxes, fats and fatty acid derivatives manufactured.
  • thermoplastic auxiliaries such as HPC, HPMC, ethyl cellulose, Hydroxypropymethylcelluloseacetatsuccinat (HPMCAS), PVP, vinylpyrrolidone vinyl acetate copolymer, acrylates of polyethylene glycol, polyethylene oxide, polymethacrylate, polyvinyl alcohols (PVA), partially saponified polyvinyl a
  • pH-modifying substances such as e.g. Acids, bases and buffer substances, incorporated in the active substance-containing core.
  • auxiliaries which modify the pH in the cores containing the active ingredient are: adipic acid, malic acid, L-arginine, ascorbic acid, aspartic acid, benzenesulfonic acid, benzoic acid, succinic acid, citric acid, ethanesulfonic acid, 2-hydroxyethanesulfonic acid, fumaric acid, gluconic acid, Glucuronic acid, glutamic acid, potassium hydrogen tartrate, maleic acid, malonic acid, methanesulfonic acid, toluenesulfonic acid, trometamol, tartaric acid.
  • Citric acid, succinic acid, tartaric acid, potassium hydrogen tartrate are preferably used.
  • Ethyl celluloses for example as an aqueous dispersion commercially available under the name Aquacoat ® or Surelease ®
  • polymethacrylates such as Eudragit ® NE, Eudragit ® RS and RL
  • Eudragit ® NE, Eudragit ® RS and RL are particularly suitable for producing the diffusion lacquer.
  • other materials such as cellulose acetate and cellulose acetate butyrate can be used as film-forming diffusion-controlling polymers.
  • the diffusion coating in addition to the diffusion-controlling polymer also contains excipients with pH-dependent solubility, such as enteric polymers such as cellulose phthalates, in particular cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate, Cellulosesuccinate, in particular cellulose acetate succinate and hydroxypropylmethylcellulose acetate succinate or polymethacrylates (eg Eudragit ® L).
  • enteric polymers such as cellulose phthalates, in particular cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate, Cellulosesuccinate, in particular cellulose acetate succinate and hydroxypropylmethylcellulose acetate succinate or polymethacrylates (eg Eudragit ® L).
  • enteric polymers such as cellulose phthalates, in particular cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate, Cellulosesuccinate, in particular cellulose acetate succinate and hydroxypropylmethylcellulose acetate succinate
  • citric acid derivatives for example, triethyl citrate, tributyl citrate, acetyl triethyl citrate
  • phthalic acid derivatives for example (for example, dimethyl phthalate, diethyl phthalate, dibutyl lat)
  • benzoic acid and benzoic acid esters other aromatic Carbon
  • trimellitic klareester aliphatic dicarboxylic acid esters (eg, dialkyl adipates, sebacic acid esters , in particular diethyl sebacate, tartaric acid ester), glycerol mono-, glycerol di- or glycerol triacetate, polyols (e.g. glycerol, 1, 2-propanediol, polyethylene glycol of different chain lengths), fatty acids and derivatives (e.g. glycerol monostearates, acetylated fatty acid glycerides, castor oil and other native oils and miglyol) Fatty acid alcohols (e.g.
  • cetyl alcohol cetylstearyl alcohol
  • type and amount of plasticizer are selected so that the above-defined release according to the invention and the required stability of the pharmaceutical forms are achieved.
  • the proportion of the plasticizer is advantageously from 0 to 50% (m / m), preferably from 0 to 35% (m / m), particularly preferably from 0 to 25% (m / m), based on the mass of the film.
  • anti-adhesive agents can be added to the paint, e.g. Talc, magnesium stearate, glycerol monostearate and Aerosil.
  • the proportion of these anti-adhesives is dependent on the polymer and plasticizer or plasticizer content used and is usually from 0 to 50% (m m) of the total mass of the coating film.
  • the release rate according to the invention is controlled by the paint composition and the thickness of the paint layer.
  • so-called "pore formers” can be added to the lacquer or to the particle to be coated.
  • Soluble polymers such as, for example, polyethylene glycols, PVP, PVA, HPMC, HPC, Hydroxyethyl celluloses (HEC), MC, carboxymethyl celluloses or their salts, dextrins, maltodextrins, cyclodextrins, dextrans or other soluble substances such as urea, salts (sodium chloride, potassium chloride, ammonium chloride, etc.), sugar (sucrose, lactose, glucose, fructose, Maltose, etc.), sugar alcohols (mannitol, sorbitol, xylitol, lactitol, etc.).
  • Based on the mass of the diffusion film 0 to 50% (m / m), preferably
  • Bind example enteric polymers such as cellulose phthalates, in particular cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate, Cellulosesuccinate, in particular cellulose acetate succinate and Hydroxypropylmethylcellulosacetatsuccinat and polymethacrylates (for example Eudragit ® L).
  • the diffusion-controlled dosage forms described consist of 0.5 to 50% (m / m), preferably 2 to 40% (m / m) of active ingredient (calculated as vardenafil), 10 to 95% (m / m) of binding agent.
  • / Filler or thermoplastic auxiliary in the case of melt extrusion pellets and 5 to 50% (m / m), preferably 5 to 40% (m / m), particularly preferably 5 to 30% (m / m) diffusion lacquer and they can contain further additives (pH-modifying substances, other common pharmaceutical auxiliary substances).
  • the diffusion lacquer or the diffusion layer contains, based on the amount of lacquer, 40 to 100% (m / m), preferably 50 to 100% (m / m) of film-forming agent (film-forming diffusion-controlling polymers and, if appropriate, enteric polymers), 0 to 50% (m / m m), preferably 0 to 35% (m / m), particularly preferably 0 to 25% plasticizer and 0 to 50% (m / m), preferably 0 to 35% (m / m), particularly preferably 0 to 20% ( m / m) contains pore formers (water-soluble polymers and other water-soluble substances).
  • film-forming agent film-forming diffusion-controlling polymers and, if appropriate, enteric polymers
  • the paint may contain anti-adhesive, referring to 0 to 50% (m / m) based on the film mass, and other additives (pigments, dyes, surfactants, emulsifiers, other common pharmaceutical auxiliaries).
  • coated dosage forms which contain one or more swellable excipients which, when liquid penetrates through the
  • These formulations can contain, for example, polyvinylpyrrolidones, crospovidones, crosslinked sodium carboxymethyl cellulose, crosslinked sodium carboxymethyl starch, polyethylene oxides, polymethacrylates, low-substituted hydroxypropyl methyl cellulose (L-HPC) as swellable auxiliaries.
  • Suitable coating materials are, for example, cellulose acetate, ethyl cellulose and polymethacrylates.
  • various coated formulations can also be combined with one another in a pharmaceutical form, and an initial dose can be administered, for example, by combination with rapidly releasing formulation particles, for example unpainted pellets, granules or powder.
  • formulations which comprise the active ingredient in a matrix.
  • matrix formulations release the active ingredient through diffusion and / or erosion.
  • These formulations are preferably in the form of a tablet or in the form of several tablets, e.g. can be encapsulated.
  • the tablets can be coated or varnished.
  • Such matrix formulations are produced, for example, by mixing the constituents and direct tableting, or by dry or wet granulation with subsequent tableting.
  • the mass ratio of active ingredient to the total mass of the matrix formulation in these new formulations is in the range from 1: 1 to 1: 200, preferably in the range from 1: 2 to 1:40.
  • the amount of the matrix former is preferably in the range from 10 to 70% (m m) of the mass of the formulation.
  • Water-soluble, water-swellable or water-insoluble substances can be used as matrix formers.
  • the novel formulations preferably contain one or more water-swellable polymers.
  • medicinal preparations for the purposes of this invention which contain water-soluble, hydrogel-forming polymers, these polymers having a nominal viscosity of at least 15 cP, preferably at least 50 cP (measured as a 2% strength aqueous solution at 20 ° C.).
  • Preferred water-soluble or water-swellable matrix-forming polymers are hydroxypropylmethylcelluloses (HPMC), hydroxyethylmethylcelluloses, hydroxypropylcelluloses (HPC), hydroxyethylcelluloses, methylcelluloses (MC), ethylcelluloses, other alkylcelluloses, hydroxyalkylcelluloses and hydroxylalkylmethylcelluloses, sodium carboxamines, sodium carboxamines, sodium carboxamino cellulose Guar and locust bean gum, xanthans, polyethylene oxides, polyacrylic acids, polymethyacrylic acids, polymethacrylic acid derivatives, poly vinyl alcohols (PVA), partially saponified polyvinyl acetate (PVAc), polyvinyl pyrrolidone (PVP), agar, pectin, gum arabic, tragacanth, gelatin, starch or starch derivatives and mixtures of these substances are used.
  • HPMC hydroxypropylmethylcelluloses
  • HPC
  • HPMC HPMC is particularly preferred.
  • the matrix formulations according to the invention should preferably contain at least 10% of a hydroxypropylmethyl cellulose type whose nominal viscosity (measured as a 2% aqueous solution at 20 ° C.) is at least 15 cP, preferably at least 50 cP.
  • HPMC types with a degree of substitution of the methoxy groups of 16.5-30%, particularly preferably 19-30%, and a degree of substitution of the hydroxypropoxy groups of 4-32%, particularly preferably 4-12%, are preferably used.
  • Substances are used as scaffolders in the matrix formulations according to the invention, e.g. unsaturated or saturated / hydrogenated fatty acids and their salts, esters or amides, fatty acid mono-, di- or triglycerides, waxes, ceramides, cholesterol derivatives and mixtures of these substances.
  • the formulations of the present invention may contain customary tableting aids such as colloidal silicon dioxide (Aerosil ®), magnesium stearate, talc, PVP, lactose or microcrystalline cellulose.
  • customary tableting aids such as colloidal silicon dioxide (Aerosil ®), magnesium stearate, talc, PVP, lactose or microcrystalline cellulose.
  • these are usually in an amount of 10 to 50%, in the case of Mg stearate, in an amount of 0.5 to 3%, and in the case of Aerosil, in an amount of 0.1 to 2% based on the tablet mass.
  • substances are incorporated into the matrix which control the pH in the matrix.
  • pH-modifying auxiliaries and / or by the addition of substances which dissolve or rise out of the matrix with increasing pH and thus increase the porosity or permeability of the matrix and / or promote erosion of the matrix it is possible to achieve an almost pH-independent release for these preferred embodiments of the present invention.
  • auxiliaries which can be added to the matrix formulations according to the invention in order to achieve a pH-independent release: adipic acid, malic acid, L-arginine, ascorbic acid, aspartic acid, benzenesulfonic acid, benzoic acid, succinic acid, cellulose phthalates, especially cellulose acetate phthalate and hydroxypropylmethyl cellulose phthalate, cellulose succinates, especially cellulose Acetate succinate and HPMCAS, citric acid, ethanesulfonic acid, 2-hydroxyethanesulfonic acid, fumaric acid, gluconic acid, glucuronic acid, glutamic acid, potassium hydrogen tartrate, maleic acid, malonic acid, methanesulfonic acid, polymethacrylates (e.g.
  • Eudragit ® types toluenesulfonic acid, tromic acid metamol.
  • Citric acid, succinic acid, tartaric acid, HPMCAS and polymethacrylates are preferably used. If these auxiliaries are contained in the matrix formulations according to the invention, they are typically added in a proportion of 10 to 50% (mm) based on the total mass of the matrix.
  • the active substance-containing matrix can also be in special geometric shapes in which the release is influenced by the special geometry and matrix surface.
  • the matrix and release surface can be checked, for example, by pressing into special formats (e.g. ring tablets) and / or by painting partial areas or applying barrier layers using a multi-layer press.
  • Formulations with different release properties can e.g. in multi-layer or coated-core tablets to form a pharmaceutical form.
  • the controlled releases according to the invention with a high initial active ingredient release are achieved by multi-layer tablets which comprise a rapidly releasing layer or shell-core tablets with a fast-releasing shell, while a final acceleration is accelerated by shell-core tablets with a fast-releasing core Release (later burst) can achieve.
  • Another embodiment of the dosage forms according to the invention with controlled release of active substance is characterized in that the active substance is embedded in a matrix consisting of one or more physiologically acceptable excipients by means of a melting process.
  • the active ingredient is released from these so-called melt extrudates by diffusion and / or erosion.
  • These formulations are preferably in the form of granules, pellets or tablets.
  • the forms obtained by melt extrusion, in particular pellets and granules, can be processed further into other dosage forms, e.g. by encapsulation or tableting, optionally with the addition of pharmaceutically customary ones
  • melt extrudates according to the invention can be ground and then used in this comminuted form for the production of other dosage forms, such as, for example, matrix tablets. Further processing also includes the combination of formulations with different drug releases, such as, for example, slow-release and fast-releasing particles, into one dosage form.
  • the melt extrudates and / or the dosage forms which are produced from melt extrudates can be coated or lacquered.
  • the melt extrudates are produced by mixing the active ingredient with at least one meltable physiologically acceptable auxiliary (carrier) and, if appropriate, other customary pharmaceutical additives, melting at a temperature in the range from 50 to 250 ° C., preferably 60 to 200 ° C., injection molding or extrusion and molding.
  • the components can be mixed either before melting or during melting, or some of the components are melted and the other components of this melt are mixed.
  • the mixture of the carrier, the active ingredient and any additives present is thermoplastic after melting and can therefore be extruded.
  • Numerous methods are available for shaping the mixture, for example hot granulation, cold granulation, calendering with two shaping rollers, extrusion and deformation of the still plastic strand, for example between two belts or rollers, or rounding, for example in an air granulation unit after cutting the strand.
  • the mass ratio of active ingredient to the total mass of the melt extrudate in these new formulations is in the range from 1: 3 to 1: 200, preferably in the range from 1: 4 to 1: 100.
  • thermoplastic carriers which are preferably swellable or soluble in physiological media are: polyvinylpyrrolidone (PVP), copolymers of N-vinylpyrrolidone (NVP) and vinyl esters, in particular vinyl acetate, copolymers of vinyl acetate and crotonic acid, partially saponified polyvinyl acetate, polyvinyl alcohol, Celluloseester, cellulose ethers, in particular methylcellulose and ethylcellulose, hydroxyalkylcelluloses, in particular hydroxypropylcellulose, Hydroxyalkylmethylcellulosen, in particular hydroxypropylmethylcellulose, and hydroxyethylmethylcellulose, carboxymethylcelluloses, cellulose phthalates, in particular cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate, Cellulosesuccinate, in particular cellulose acetate succinate and hydroxypropyl methylcellulose acetate succinate, polyhydroxy alkyl acrylates, polyhydroxyalkyl methacrylates,
  • thermoplastic excipients for the preparation of the invention Pharmaceutical form with controlled release of active ingredient are HPC, PVP, vinylpyrrolidone / vinyl acetate copolymers, polymethacrylates, in particular Eudragit ® L and RS PO, HPMCAS, polyethylene glycols, polyethylene oxides and mixtures thereof.
  • Plasticizing auxiliaries for reducing the glass transition temperature of the mixture include, for example, propylene glycol, glycerol, triethylene glycol, butanediols, pentanols, such as pentaerythritol, hexanols, long-chain alcohols, polyethylene glycols, polypropylene glycols, polyethylene propylene glycols, silicones, phthalic acid dibutyl derivatives, (eg dimethyl phthalate dibutyl derivatives, for example dimethyl phthalate dibutyl derivatives, such as dimethyl phthalate dibutyl derivatives, such as dimethyl phthalate dibutyl derivatives, such as dimethyl phthalate dibutyl derivatives (eg dimethyl phthalate dibutyl derivatives) z phthalate), benzoic acid and benzoic acid esters, other aromatic Carbonklareester (.
  • phthalic acid dibutyl derivatives eg dimethyl phthalate dibutyl derivatives
  • B. trimellitic acid citric acid derivatives (for example, triethyl citrate, tributyl citrate, Acetyltriethyl- citrate), aliphatic dicarboxylic acid esters (eg, dialkyl adipates, sebacic acid esters, in particular diethyl sebacate, Weinchureester), glycerol mono-, di- or Glycerol triacetate, fatty acids and derivatives (e.g. glycerol monostearates, acetylated fatty acid glycerides, castor oil and other native oils, miglyol), fatty acid alcohols (e.g.
  • cetyl alcohol cetylstearyl alcohol
  • sugar sugar alcohols and sugar derivatives (e.g. erythritol, isoma lt, lactitol, mannitol, maltitol, maltodextrin, xylitol)
  • concentration of plasticizer is usually 0 to 30% (m / m), preferably 0 to 20% (m / m) based on the total mass of the melt extrudate.
  • the extrudable mixture can also contain other pharmaceutically customary additives, for example lubricants and mold release agents, lubricants and flow agents, fillers and adsorbents, stabilizers, radical scavengers, complexing agents, antioxidants, photostabilizers, blowing agents, surfactants, preservatives, Coloring, sweetening and flavoring agents.
  • other pharmaceutically customary additives for example lubricants and mold release agents, lubricants and flow agents, fillers and adsorbents, stabilizers, radical scavengers, complexing agents, antioxidants, photostabilizers, blowing agents, surfactants, preservatives, Coloring, sweetening and flavoring agents.
  • the proportion of additives can be up to 60% (m / m) of the total mass of the extrudate.
  • Lubricants and mold release agents can, for example, stearic acid and stearates, in particular aluminum, calcium and magnesium stearate, calcium behenate, sodium stearyl fumarate, talc, silicones, waxes, as well as mono-, di- and tri-glycerides, e.g. Glycerol monostearate, glycerol distearate, glycerol dibehenate, glyceromonooleate, glyceryl palmitostearate, in an amount of 0 to 10% (m / m), preferably 0.5 to 5% (m / m), based on the total mass of the melt extrudate.
  • stearic acid and stearates in particular aluminum, calcium and magnesium stearate, calcium behenate, sodium stearyl fumarate, talc, silicones, waxes, as well as mono-, di- and tri-glycerides, e.g. Glycerol monostearate
  • the flow agents used are, for example, animal and vegetable fats, preferably in hydrogenated form and with a melting point of at least 50 ° C., waxes (for example camauba wax), mono-, di- and triglycerides (for example glycerol monostearate, glycerol distearates, glycerol dibehenate, glyceromonooleate, glyceryl palmitostearate), phosphatides , in particular lecithin, in a total amount of 0 to 30% (mm), preferably 0 to 10% (m / m), based on the total mass of the extrudate.
  • waxes for example camauba wax
  • mono-, di- and triglycerides for example glycerol monostearate, glycerol distearates, glycerol dibehenate, glyceromonooleate, glyceryl palmitostearate
  • phosphatides in particular lecithin,
  • Fillers include substances such as titanium dioxide, aluminum oxide, magnesium oxide, silica and silicates, stearic acid and stearates, cellulose derivatives (eg methyl cellulose), starch and starch derivatives, sugar, sugar alcohols and sugar derivatives, usually in a proportion of 0 to 30% (m / m) , preferably 0 to 20% (m / m), based on the total mass of the extrudate.
  • substances such as titanium dioxide, aluminum oxide, magnesium oxide, silica and silicates, stearic acid and stearates, cellulose derivatives (eg methyl cellulose), starch and starch derivatives, sugar, sugar alcohols and sugar derivatives, usually in a proportion of 0 to 30% (m / m) , preferably 0 to 20% (m / m), based on the total mass of the extrudate.
  • a preferred embodiment of the dosage forms according to the invention with controlled release of active ingredients are melt extrudates which contain auxiliaries with pH-modifying properties and / or pH-dependent solubility.
  • auxiliaries for example the acids, bases, buffer substances and enteric-resistant polymers described several times above
  • solid solutions can be formed in which the active substance is present in the matrix in a molecularly dispersed manner.
  • a further embodiment of the dosage forms according to the invention with controlled active ingredient release are osmotic drug release systems.
  • osmotic systems are known in the prior art.
  • the drug delivery from the drug form is generally based on an osmotic pressure as the driving force.
  • a detailed description of the osmotic systems is e.g. in Verma R.K. et. al. "Osmotic pumps in drug delivery", Critical Reviews TM in Therapeutic Drug Carrier Systems, 21 (2004) 477-520 and Santus G. et al. "Osmotic drug delivery: a review of the patent literature", Journal of Controlled Release 35 (1995) 1-21.
  • a shell that consists of a water-permeable material that is impermeable to the components of the active substance-containing core and has at least one opening through which components present in the core can be released.
  • the material from which the shell of these dosage forms according to the invention with controlled active ingredient release is formed is semipermeable, ie permeable to water, aqueous media and biological liquids and not or very little permeable to the components of the core, and suitable for film formation.
  • the selective semi-permeable coating material is insoluble in body fluids, does not erode, is not broken down in the GI tract and is excreted unchanged, or it only shows bioerosion towards the end of the release period.
  • Typical materials for the production of the casing are known from the literature and are described, for example, in the patents US 3916899, US 3977404 and EP 0277092.
  • acylated cellulose derivatives which are substituted by acetyl groups once to three times or by acetyl groups once to twice and another acyl radical other than acetyl
  • cellulose esters which are substituted by acetyl groups once to three times or by acetyl groups once to twice and another acyl radical other than acetyl
  • cellulose acetate cellulose triacetate, cellulose acetate methyl carbamate, cellulose acetate phthalate, cellulose acetate, cellulose acetate, cellulose acetate, Celluloseacetatdimethylamino- acetate, Celluloseacetatdiethylaminoacetat Celluloseaceatethylcarbonat, Celluloseacetatchloracetat, Celluloseacetatethyloxalat, Celluloseacetatmethylsulfonat, Celluloseacetatbutylsulfonat, cellulose acetate propionate, Celluloseacetatoct
  • ethyl cellulose also suitable as semipermeable membrane material are ethyl cellulose, copolymers of alkylene oxide and alkyglycidyl ether, polymeric epoxies, polyglycols and polylactic acid derivatives. Mixtures of per se water-insoluble acrylates, for example a copolymer of ethyl acrylate and methyl methacrylate, can be used. If necessary, the casing can also contain plasticizers, such as the plasticizing substances already mentioned above, and other additives, such as pore formers.
  • a light-protection lacquer can be applied to the semipermeable shell, which can consist, for example, of HPMC or HPC, and a suitable plasticizer (for example polyethylene glycol) and pigments (for example titanium dioxide, iron oxides).
  • a suitable plasticizer for example polyethylene glycol
  • pigments for example titanium dioxide, iron oxides.
  • the osmotic system can also be provided with a coating containing the active ingredient, from which the active ingredient is released rapidly upon contact with the release medium before the osmotically controlled release of active ingredient from the core begins.
  • Suitable as water-swellable polymers which may be contained in the core include polyethylene oxides substi having molecular weights of 100,000 to 8,000,000 (eg, Polyox ®), xanthan gum, copolymers of vinylpyrrolidone and vinyl acetate, polyvinylpyrrolidones, crospovidones, cross-linked sodium carboxymethylcellulose, cross-linked sodium carboxymethyl starch, low - Tuated hydroxypropylmethyl cellulose (L-HPC), poly (hydroxyalkyl methacrylate), alginates and galactomannans as well as further hydrophilic polymeric swelling agents and mixtures thereof mentioned in the patents US 3865108, US 4002173, US 4207893, EP 0052917, EP 0277092 and WO 96/40080.
  • polyethylene oxides substi having molecular weights of 100,000 to 8,000,000 eg, Polyox ®
  • xanthan gum copolymers of vinylpyrrolidone and vinyl acetate
  • water-soluble, physiologically harmless substances are suitable as osmotically active substances which can be added to the core for inducing osmosis, such as eg the water-soluble substances mentioned in the Pharmocopoeia and in "Remingtons Pharmaceutical Science”.
  • water-soluble salts of inorganic and organic acids or non-ionic organic substances with high water solubility, such as carbohydrates, especially sugar, or amino acids can be used.
  • inorganic salts such as chorides, sulfates, sulfites, carbonates, bicarbonates, phosphates, hydrogen phosphates and dihydrogen phosphates of the alkali and alkaline earth metals, such as Sodium, lithium, potassium, calcium or magnesium
  • organic acids such as adipic acid, ascorbic acid, succinic acid, citric acid, fumaric acid, maleic acid, tartaric acid, benzoic acid and their alkali or alkaline earth metal salts, acetates
  • pentoses such as arabinose, ribose or xylose
  • hexoses such as Glucose, fructose, galactose or mannose
  • disaccharides such as sucrose, maltose or lactose
  • trisaccharides such as raffinose
  • sugar alcohols such as mannitol
  • Sodium chloride and sodium bicarbonate are particularly preferably used.
  • the osmotic system can contain other pharmaceutically common additives, e.g. Contain lubricants and mold release agents, lubricants, binders, dyes, thickeners, protective colloids, stabilizers and surfactants.
  • other pharmaceutically common additives e.g. Contain lubricants and mold release agents, lubricants, binders, dyes, thickeners, protective colloids, stabilizers and surfactants.
  • the osmotic release system according to the invention is produced with the aid of standard techniques such as wet granulation or dry compaction and tableting to produce the active ingredient-containing core and subsequent organic coating.
  • the shell of the osmotic system has at least one outlet opening through which the active substance, possibly together with other components of the core, is released.
  • the opening can be made in the envelope in various ways, e.g. by punching, mechanical drilling or using a laser drill.
  • the term “opening” also includes bioerodible materials which, when using this dosage form according to the invention, detach from the casing and thus lead to the formation of outlet openings in situ.
  • the nature and manufacture of the openings are known in the art and e.g. in the patents US 3485770, US 3916899, US 4063064 and US 4088864.
  • the release rate according to the invention is primarily set by the composition and thickness of the semipermeable sheath, by the type and amount of any polymeric swelling agent present and by the type and amount of any osmotic active substance present which serves to induce osmosis.
  • it can be a formulation in which the active ingredient is present as an ion exchanger complex.
  • particles of the formulation principles mentioned above can be present together in one dosage form (e.g. capsule filled with several active substance-containing matrices).
  • several of the different embodiments e.g. pellets with diffusion lacquer and matrix tablet
  • the present invention furthermore relates to the combination of formulations with different release properties, e.g. quick release and slow release, in a dosage form.
  • the pharmaceutical forms according to the invention can be coated and lacquered, e.g. to achieve light protection, to achieve taste masking or to control the place or time of the start of drug release.
  • the dosage form according to the invention with controlled release of active substance is preferably a formulation in which the maximum blood level (C max ) after application is reduced compared to a rapidly releasing dosage form of the same dosage and in which the mean residence time (MRT) of the drug in the body is extended compared to a quick-release dosage form.
  • C max maximum blood level
  • MRT mean residence time
  • the present invention also encompasses the use of the new pharmaceutical dosage forms for the production of medicaments which are intended for the treatment and / or prevention of diseases in humans and animals.
  • the dosage of the new dosage forms can also be creeping in, ie over a longer period (for example 2-10 days) with a progressively increasing dose.
  • the treatment with the new formulation can also be carried out on several consecutive days, for example daily or in another fixed time rhythm.
  • the new dosage forms according to the invention are suitable for the prophylaxis and / or treatment of diseases in which an increase in the cGMP concentration is beneficial, ie diseases which are related to cGMP-regulated processes (usually simply called 'cGMP-related diseases' in English). designated).
  • the new dosage forms of the PDE 5 inhibitor vardenafil with controlled release can be used in medicaments for the treatment of cardiovascular diseases, for example for the treatment and / or prophylaxis of hypertension, neuronal hypertension, stable and unstable angina, peripheral and cardiac vascular diseases, of arrhythmias, for the treatment of thromboembolic disorders and ischemia such as myocardial infarction, cerebral ischemia, transient ischemic attacks, angina pectoris, primary pulmonary hypertension, secondary pulmonary hypertension, pulmonary arterial hypertension, portopulmonary hypertension, hepatopulmonary syndrome, caused by medications such as amphetaminal hypotension, , pulmonary hypertension with HIV, thromboembolic pulmonary hypertension, pulmonary hypertension in children and newborns, pulmonary hypertension (altitude sickness) caused by atmospheric hypoxia, CO PD, emphysema, chronic asthma, mucoviscidosis-related pulmonary hypertension, right ventricular insufficiency, left ventricular insufficiency and
  • a further embodiment of the invention relates to the use of the new dosage form of the PDE 5 inhibitor vardenafil with controlled release of active ingredient for the manufacture of a medicament for the treatment and / or prophylaxis of disorders of perception, concentration, learning and / or memory, especially if the disorder is a Is the result of dementia.
  • the new formulations according to the invention are particularly suitable for improving perception, concentration, learning performance or memory performance after cognitive disorders, such as occur in particular in situations / diseases / syndromes such as "mild cognitive impairment", age-associated learning and memory disorders, age-associated memory losses, vascular Dementia, traumatic brain injury, stroke, post-stroke dementia (post-stroke dementia), post-traumatic traumatic brain injury, general concentration disorders, concentration Disorders in children with learning and memory problems, Alzheimer's disease, dementia with Lewy bodies, dementia with degeneration of the frontal lobes including Pick's syndrome, Parkinson's disease, progressive nuclear palsy, dementia with corticobasal degeneration, amyolateral sclerosis (ALS) , Huntington's disease, multiple sclerosis, thalamic degeneration, Creutzfeld-Jacob dementia, HIV dementia, schizophrenia with dementia or Korsakoff psychosis.
  • ALS amyolateral sclerosis
  • the new dosage forms of the PDE 5 inhibitor vardenafil can also be used for the treatment and / or prophylaxis of psoriasis, cancer, bladder disorders, nitrate-induced tolerance, preeclampsia, alopecia, pain, hearing loss, tinnitus or the renal syndrome.
  • the new formulations of the PDE 5 inhibitor vardenafil can also be used for the treatment and / or prophylaxis of eye diseases such as glaucoma, of central retinal or posterior ciliary artery occlusion, central retinal venous occlusion, optical neuropathy such as anterior ischemic optical neuropathy and glaucomatous degeneration of macular and neoplastic disease ,
  • the new formulations of the PDE 5 inhibitor vardenafil can also be used to prepare medicaments for the treatment and / or prophylaxis of coronary heart disease, diabetes, insulin resistance, hyperglycaemia, pancreatitis, diabetic gastroparesis, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic Gangrene, diabetic glomeralosclerosis, diabetic dermatopathy, diabetic arthropathy, diabetic cataract, for the treatment of gastric and esophageal peristalsis, osteoporosis, female infertility, premature labor, liver cirrhosis, acute and chronic kidney failure, cystitis and allergic bronchitis be used.
  • the new formulations of the PDE 5 inhibitor vardenafil can also be used to treat and / or prevent cardiac ischemia, to achieve or improve a "preconditioning" effect, to treat an acute myocardial infarction and to reperfusion damage, especially after a myocardial infarction, for the treatment of male infertility , Raynaud's syndrome, intermittent claudication, Peyronie's disease, for the treatment of fibrotic diseases, atherosclerosis, for the improvement of sperm motility, for the treatment of depression, leukemia (e.g.
  • chronic lymphocytic leukemia for the treatment of priapism, for Treatment of platelet adhesion and aggregation in renal ischemia, to support and promote liver regeneration after surgical liver resection or liver cancer, to inhibit the contraction of the esophageal muscles (e.g.
  • liver diseases such as liver cirrhosis
  • lupus hypertensive systemic lupus erythematosus
  • scleroderma for the treatment of multiple sclerosis, rheumatoid arthritis, allergies, autoimmune Osteoporosis, cachexia, polycystic ovary syndrome, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, hyperlipidemia and dyslipidemia, to promote growth and improve survival of oocytes, zygotes, embryos or fetuses, to increase the weight in premature births, to increase milk production, especially in the case of mammals, to increase milk production People, for the treatment of migraines, incontinence, acute and chronic kidney failure, glomeral disease, nephritis, tubulointerstitial diseases,
  • the use of the new formulations according to the invention increases the action of substances, such as EDRF (endothelium derived relaxing factor), ANP (atrial natriuretic peptide), nitrovasodilators and all other substances which, in a way other than phosphodiesterase inhibitors, reduce the cGMP concentration increase.
  • substances such as EDRF (endothelium derived relaxing factor), ANP (atrial natriuretic peptide), nitrovasodilators and all other substances which, in a way other than phosphodiesterase inhibitors, reduce the cGMP concentration increase.
  • the new dosage forms of the PDE 5 inhibitor vardenafil can also be used in combination with other active pharmaceutical ingredients.
  • active pharmaceutical ingredients eg simvastatin, atorvastatin, fluvastatin, rosuvastatin, pravastatin, itavastatin
  • CETP inhibitors eg torcetrapib, JTT-705
  • ACE inhibitors eg enalapril, captopril, benazpril , Fosinopril, quinapril, lisinopril, ramipril
  • PPARalpha agonists e.g.
  • PPARgamma agonists e.g. rosiglitazone
  • aldose reductase inhibitors ezetimibe
  • thrombocyte aggregation inhibitor e.g. aspirin, clopidolamidophenin, e.g. aspirin, clopidylamine , Thrombin inhibitors (eg ximelagatran, melagatran, bivalirudin, Clexane), beta-blockers (eg propanolol, atenolol), diuretics (eg furomide), insulin and insulin derivatives as well as orally active hypoglycemic active substances.
  • Insulin and insulin derivatives include both insulins of animal, human or biotechnological origin as well as mixtures thereof.
  • the new dosage forms of the PDE 5 inhibitor vardenafil can also be used in combination with sulphonylureas (e.g. tolbutamide, gliblamide, glimepiride, glipizide or gliclazide), biguanide derivatives (e.g. metformin), alpha-glucosidase inhibitors (e.g. miglitol or acarbose) , Meglitinides (e.g. repaglinide, nateglinide), active substances against obesitas (e.g.
  • GP ⁇ b-IIIa antagonists e.g. tirofiban, abciximab
  • factor Xa inhibitors e.g. DX 9065a, DPC 906, JTV 803, BAY 597939
  • Calcium antagonists e.g. nifedipine, amlodipine, verapamil, diltiazem
  • antagonists of the alphal receptors e.g. candesartan, losartan, valsartan, telmisartan
  • PDE 5 inhibitors e.g. sildenafil, tadalafil
  • active ingredients for the treatment of erectile dysfunction e.g. apomorphine.
  • physiologically acceptable salts of vardenafil and vardenafil can be used to produce the new formulations of the PDE 5 inhibitor vardenafil.
  • physiologically acceptable salts can be salts of vardenafil with inorganic or organic acids.
  • organic carboxylic or sulfonic acids such as acetic acid, maleic acid, fumaric acid, malic acid, citric acid, tartaric acid, lactic acid, benzoic acid, or methanesulfonic acid, ethanesulfonic acid, phenylsulfonic acid, toluenesulfonic acid or naphthalenedisulfonic acid.
  • vardenafil and its salts can also be present as hydrates.
  • hydrates are understood to mean those compounds which contain water in the crystal. Such compounds can contain one or more, typically one to six equivalents of water. Hydrates can be prepared, for example, by crystallizing the compound in question from water or a water-containing solvent.
  • vardenafil and its salts can also be present as solvates.
  • solvates are understood to mean those compounds which contain physiologically compatible solvents in the crystal.
  • Example 1 Diffusion pellets a) Production of the active ingredient-coated pellets
  • the neutral pellets are coated with a dispersion consisting of the micronized active ingredient, HPMC, potassium hydrogen tartrate and water in a fluidized bed granulator with Wurster insert. b) painting the pellets
  • the active ingredient-loaded pellets are coated by spraying on a dispersion consisting of ethyl cellulose dispersion, HPMCAS, TEC and water in a fluidized bed system (with Wurster insert).
  • the coated pellets are then at temperatures of 40- 90 ° C annealed to improve the storage stability of the pellet formulation.
  • the coated pellets are then encapsulated.
  • the components of the single-layer matrix tablets with the exception of magnesium stearate and possibly silicon dioxide are mixed. Magnesium stearate and possibly silicon dioxide are mixed in as an aftermix.
  • the powder mixture is then directly tableted (format: around 8 mm).
  • the tablets obtained can be lacquered or coated, for example to ensure light protection or to delay or delay the release.
  • the components of the single-layer matrix tablets with the exception of magnesium stearate and possibly silicon dioxide are mixed.
  • the mixture is then dry granulated by roller compacting and tabletted after admixing silicon dioxide and magnesium stearate.
  • the tablets obtained can be lacquered or coated, for example to ensure light protection or to delay or delay the release. Examples 20 to 25: 2-layer tablets
  • the components of the quick-release layer with the exception of the post-mixing (silicon dioxide, microcrystalline cellulose (approx. 15% of the total) and magnesium stearate) are mixed and granulated by roller compaction.
  • the components of the sustained release layer are also mixed and compacted, with the exception of the post-mixing components (silicon dioxide and magnesium stearate).
  • both granules are tabletted on a 2-layer tablet press (format: edge 10 mm in Example 20 to 22 and edge 9 mm in Example 23 to 25).
  • the 2-layer tablets can be painted or coated, for example to provide light protection. Examples 26 to 31: melt extrudates
  • the active ingredient is mixed with the auxiliary materials for the extrudate.
  • This mixture is extruded in the extruder at a suitable temperature (eg 120-190 ° C).
  • Pellets are formed by cutting the extradate strand into pieces of suitable length (approx. 2-3 mm). These melt extrusion pellets can then be rounded off.
  • the pellets can be coated with a dispersion, for example consisting of an ethyl acrylate, methyl methacrylate copolymer dispersion, HPMC, polysorbate, magnesium stearate and water in a fluidized bed granulator with Wurster insert.
  • the extrudates can be encapsulated. Examples 32 to 34: Osmotic systems (two layers)
  • Active ingredient amount corresponding to 22 mg vardenafil; incl. 10% excess, which remains in pharmaceutical form after complete release
  • the components of the active ingredient and osmotic layer are used to produce 2-layer tablets by dry granulation and tableting (format: around 8 mm). These tablets are coated with a mixture of cellulose acetate and polyethylene glycol in an acetone solution.
  • Tablets are drilled in a suitable way.
  • the tablets can then be overcoated, for example with a light protection lacquer.
  • Examples 35 to 37 Osmotic Systems (Single Layer)
  • Active ingredient amount corresponding to 24 mg vardenafil; incl. 20% excess, which remains in pharmaceutical form after complete release
  • Xanthan gum, sodium chloride, sodium bicarbonate and sodium carboxymethyl starch and copovidones are mixed and then granulated with an aqueous dispersion of the active ingredient with HPMC and sodium lauryl sulfate.
  • the granulate is mixed with magnesium stearate and colloidal silicon dioxide and tabletted (format: 8 mm edge). These tablets are coated with a mixture of cellulose acetate and polyethylene glycol in an acetone solution. The ⁇ tablets are drilled in a suitable manner. The tablets can then be overcoated, for example with a light protection lacquer.
  • acetate buffer pH 4.5 according to USP (preparation of 1 liter of this buffer: 2.99 g of sodium acetate trihydrate and 14 ml of 2 N acetic acid become 1000 as release media ml dissolved in demineralized water, if necessary the pH is adjusted to 4.5 ⁇ 0.05 with sodium hydroxide or 2 N acetic acid) and phosphate buffer pH 6.8 with 0.1% (m / V) sodium lauryl sulfate (preparation of 1 Liters of this medium: 2.747 g disodium hydrogen orthophosphate dihydrate, 0.475 g citric acid monohydrate and 10 g sodium lauryl sulfate solution 10% (m / m) are dissolved in 1000 ml with deionized water and the pH is adjusted to 6.8 with sodium hydroxide or orthophosphoric acid ⁇ 0.05 set) is used.
  • Samples are taken from the release medium by a filter unit, which must ensure that accompanying substances are removed, and the amount of active substance dissolved therein is determined by HPLC with UV-VIS detection. The amount of active ingredient determined in this way is converted into mass percent of the amount of active ingredient used.
  • both formulas are dosage forms with controlled release of active ingredients, in which the release according to the invention defined above is achieved.
  • the formulation from Example 13, the release of which is shown in FIG. 2, represents a preferred embodiment of the present invention, since in this dosage form, by adding an acid, the pH dependence on the formulation from Example 5 without pH-modifying additives , the release of which is shown in Fig. 1, is significantly reduced.
  • the ingredients of the matrix tablets with the exception of silicon dioxide and magnesium stearate are mixed. Silicon dioxide and magnesium stearate are mixed in as a mixture. The powder mixture is then directly tableted (format: 8 mm edge).
  • Comparative Examples 1 and 2 are formulations which have an average release rate of 80% in less than 2 hours (Comparative Example 1) or an average release rate of 80% in more than 24 hours (Comparative Example 2).
  • these formulations not according to the invention are not suitable for overcoming the problems of the prior art.
  • the excessively high average release rate of Comparative Example 1 does not significantly increase the exposure and duration of action compared to formulations of the prior art.
  • Comparative Examples 3 and 4 Pharmacokinetic Parameters of Vardenafil after Oral Application of a Fast-Release Tablet According to the Prior Art
  • Examples 39 to 41 Pharmacokinetic parameters of vardenafil after oral administration of formulations according to the invention with controlled release and a low initial release (dose 20 mg)
  • Examples 42 to 44 Pharmacokinetic parameters of vardenafil after oral administration of formulations according to the invention with controlled release and a high initial release (dose 30 mg)

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Abstract

L'invention concerne de nouvelles formes galéniques à libération contrôlée contenant, comme principe actif, l'inhibiteur de PDE 5 vardénafil et/ou ses sels, hydrates, solvates pharmaceutiquement compatibles et/ou ses formes polymorphes. L'invention concerne également la production de ces formes galéniques, leur utilisation comme médicament ainsi que leur utilisation pour produire des médicaments servant à traiter et/ou à prévenir des maladies chez l'homme et l'animal.
EP05739506A 2004-05-11 2005-05-10 Formulations a liberation controlee contenant du vardenafil Withdrawn EP1748777A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004023069A DE102004023069A1 (de) 2004-05-11 2004-05-11 Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
PCT/EP2005/005023 WO2005110420A1 (fr) 2004-05-11 2005-05-10 Formulations a liberation controlee contenant du vardenafil

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EP1748777A1 true EP1748777A1 (fr) 2007-02-07

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EP11156648A Withdrawn EP2335691A1 (fr) 2004-05-11 2005-04-29 Formules dotées comprenant du vardenafil d'une libération contrôlée d'agent actif
EP05744781A Withdrawn EP1748778A1 (fr) 2004-05-11 2005-04-29 Formulations a liberation controlee contenant du vardenafil
EP05739506A Withdrawn EP1748777A1 (fr) 2004-05-11 2005-05-10 Formulations a liberation controlee contenant du vardenafil

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EP11156648A Withdrawn EP2335691A1 (fr) 2004-05-11 2005-04-29 Formules dotées comprenant du vardenafil d'une libération contrôlée d'agent actif
EP05744781A Withdrawn EP1748778A1 (fr) 2004-05-11 2005-04-29 Formulations a liberation controlee contenant du vardenafil

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US (2) US20080268046A1 (fr)
EP (3) EP2335691A1 (fr)
JP (3) JP2007537175A (fr)
CN (1) CN1984661A (fr)
AU (1) AU2005244488A1 (fr)
BR (1) BRPI0510936A (fr)
CA (2) CA2566278A1 (fr)
DE (1) DE102004023069A1 (fr)
EC (1) ECSP066990A (fr)
IL (1) IL179097A0 (fr)
MA (1) MA28610B1 (fr)
MX (1) MXPA06013134A (fr)
NO (1) NO20065638L (fr)
NZ (1) NZ551166A (fr)
RU (1) RU2006143540A (fr)
UA (1) UA90858C2 (fr)
WO (2) WO2005110419A1 (fr)
ZA (1) ZA200609293B (fr)

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US12364701B2 (en) 2013-12-09 2025-07-22 Respira Therapeutics, Inc. PDE5 inhibitor powder formulations and methods relating thereto

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EP2335691A1 (fr) 2011-06-22
RU2006143540A (ru) 2008-06-20
MA28610B1 (fr) 2007-05-02
ECSP066990A (es) 2006-12-29
JP2007537175A (ja) 2007-12-20
JP2012254993A (ja) 2012-12-27
US20080187588A1 (en) 2008-08-07
CN1984661A (zh) 2007-06-20
NO20065638L (no) 2007-02-12
WO2005110419A1 (fr) 2005-11-24
CA2566278A1 (fr) 2005-11-24
JP2007537183A (ja) 2007-12-20
WO2005110420A1 (fr) 2005-11-24
ZA200609293B (en) 2008-04-30
IL179097A0 (en) 2007-03-08
NZ551166A (en) 2010-07-30
CA2566185A1 (fr) 2005-11-24
UA90858C2 (ru) 2010-06-10
EP1748778A1 (fr) 2007-02-07
BRPI0510936A (pt) 2007-11-20
DE102004023069A1 (de) 2005-12-08
MXPA06013134A (es) 2007-02-14
AU2005244488A1 (en) 2005-11-24
US20080268046A1 (en) 2008-10-30

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