EP1474076A1 - Device that facilitates the handling of an animal cornea and, in particular, a human cornea - Google Patents
Device that facilitates the handling of an animal cornea and, in particular, a human corneaInfo
- Publication number
- EP1474076A1 EP1474076A1 EP03718833A EP03718833A EP1474076A1 EP 1474076 A1 EP1474076 A1 EP 1474076A1 EP 03718833 A EP03718833 A EP 03718833A EP 03718833 A EP03718833 A EP 03718833A EP 1474076 A1 EP1474076 A1 EP 1474076A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cornea
- support
- handling
- pull tab
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000004087 cornea Anatomy 0.000 title claims abstract description 40
- 241001465754 Metazoa Species 0.000 title abstract description 4
- 238000004321 preservation Methods 0.000 claims abstract description 4
- 238000007431 microscopic evaluation Methods 0.000 claims description 3
- 239000003599 detergent Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 241000282412 Homo Species 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0095—Packages or dispensers for prostheses or other implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
Definitions
- the present invention relates to a device for aiding the manipulation of animal corneas, in particular human corneas, and aims to optimize the preservation of corneal cells until the graft.
- the device according to the invention is introduced into the different flasks containing the liquid media used before a corneal transplant.
- the transplant of a cornea to a patient first requires its removal from a deceased person.
- the harvested cornea is then introduced by the surgeon into a first bottle containing a sample medium. It is then monitored under a microscope and then introduced into a second bottle containing a preservative liquid. Finally, a few hours before the transplant, a third bottle, containing a detergent medium, that is to say reducing the swelling of the cornea, is used.
- the cornea is freely deposited in the solution.
- the technique is to hold the cornea in suspension at the end of a thread that is attached to the periphery of the cornea by piercing it with a needle. This current technique has many disadvantages:
- EP-0262 766 discloses a corneal support device formed on the stopper of a vial. This device requires the use of modified specific bottles, the standard bottles are not adaptable to this system.
- the present invention aims to provide a device that does not reproduce the disadvantages of the prior art.
- the present invention is intended to provide such a device that is simple and inexpensive to manufacture, assemble and use, while allowing the use of unmodified standard bottles.
- the subject of the present invention is therefore a device for aiding human cornea manipulation with a view to optimizing the conservation of corneal cells in different flasks and media used prior to corneal transplantation, characterized in that it comprises a support on which the cornea and a pull tab are deposited to hold and extract said support from the different flasks and media.
- said device is entirely independent of the bottles and / or their plugs.
- the cornea without being compressed, remains contained in a minimized space.
- the surfaces in contact with the cornea are minimized.
- the support is held by the pull tab so that the cornea is positioned above the bottom of the bottle, where stagnant degenerate cells, via support elements, such as feet.
- the support has at least one orifice which allows the light to pass directly on the cornea during the microscopic analysis.
- FIG. 1a is a top view of the cornea support according to one embodiment of the present invention
- FIG. 1b is a sectional view along the line AA of FIG.
- FIG. 1a shows a sectional view along the line SS of FIG.
- FIG. 2a represents a view from above of the corresponding pull tab
- FIG. 2b represents a sectional view along line B-B of line 2a
- FIG. 2c represents a sectional view along line X-X of FIG. 2a
- FIG. 3 shows a sectional view of the assembled device.
- the device comprises a support 1, having the shape of a wheel with spokes 2, and pierced at its center.
- the spokes 2 are inclined downwards (in the position of Figures 1b and 3) so as to center the cornea 11, and they preferably have a rounded profile to minimize the contact surface.
- the height of the support 1 is preferably Umite by that transparent sterile boxes in which it is introduced with the cornea during microscopic analysis, so as not to touch the cornea.
- the central hole 3 of the support 1 passes the light of the microscope and allows a direct sight on the cornea.
- a pull tab is provided to manipulate the support 1.
- This pull tab 9 can be removably attached to said support 1.
- two fastening clips 4 can be used to hold the support 1 on the pull tab 9.
- Other fastening means are also possible.
- the pull tab advantageously has feet 5 which are slid into notches 6 of the support 1, so as not to hinder the grip of the support. The feet are advantageously long enough to hold the support 1 above the bottom of the bottle, where stagnant degenerate cells.
- the pull tab 9 of the device of the invention may also have a wheel 7 with spokes 8 with a rounded profile to minimize the contact surface.
- the pull tab may comprise a rod 10 T-shaped, of suitable length and width standard bottles to allow to center the device at the neck of said bottle.
- the device of the invention is therefore advantageously completely independent of the bottles and / or their plugs, which allows the use of existing standard vials and usually used without the device of the invention. This is very profitable, since the use of modified specific bottles is avoided.
- the device is preferably made of plastic and can be manufactured in a single press injection molding operation.
- a metal device, or other materials, such as ceramics, are also conceivable.
- the device is preferably sterilized and disposable.
- the device according to the invention is particularly suitable for handling human corneas before transplantation.
- the device according to the invention facilitates handling, reduces the contact surfaces with the cornea and eliminates the tactile contacts. It allows in particular:
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Prostheses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Dispositif d'aide à la manipulation de cornée animale, notamment humaine Device for assisting the handling of animal corneas, in particular human
La présente invention concerne un dispositif d'aide à la manipulation des cornées animales, notamment humaines, et vise à optimiser la conservation des cellules cornéennes jusqu'à la greffe. Le dispositif selon l'invention est introduit dans les différents flacons contenant les milieux liquides utilisés avant une greffe de cornée.The present invention relates to a device for aiding the manipulation of animal corneas, in particular human corneas, and aims to optimize the preservation of corneal cells until the graft. The device according to the invention is introduced into the different flasks containing the liquid media used before a corneal transplant.
Dans le cas des humains, la greffe d'une cornée sur un patient nécessite tout d'abord son prélèvement sur une personne décédée. La cornée prélevée est ensuite introduite par le chirurgien dans un premier flacon contenant un milieu dit de prélèvement. Elle est ensuite contrôlée au microscope puis introduite dans un second flacon contenant un liquide de conservation. Enfin, quelques heures avant la greffe, un troisième flacon, contenant un milieu déturgescent, c'est-à-dire réduisant le gonflement de la cornée, est utilisé.In the case of humans, the transplant of a cornea to a patient first requires its removal from a deceased person. The harvested cornea is then introduced by the surgeon into a first bottle containing a sample medium. It is then monitored under a microscope and then introduced into a second bottle containing a preservative liquid. Finally, a few hours before the transplant, a third bottle, containing a detergent medium, that is to say reducing the swelling of the cornea, is used.
Actuellement, dans le flacon de prélèvement, la cornée est déposée librement dans la solution. Dans le flacon de conservation et de déturgescence, la technique est de maintenir la cornée en suspension au bout d'un fil que l'on fixe sur la périphérie de la cornée en la perçant à l'aide d'une aiguille. Cette technique actuelle présente de nombreux inconvénients :Currently, in the sampling bottle, the cornea is freely deposited in the solution. In the preservative and detergent vial, the technique is to hold the cornea in suspension at the end of a thread that is attached to the periphery of the cornea by piercing it with a needle. This current technique has many disadvantages:
- la manipulation est peu pratique,- the manipulation is impractical,
- la manipulation de la cornée doit être réalisée avec des instruments stérilisés ou à usage unique,the manipulation of the cornea must be performed with sterilized or single-use instruments,
- le risque de contamination et/ou d'infection est important,- the risk of contamination and / or infection is important,
- les contacts multiples contre les parois des flacons peuvent altérer les cellules cornéennes,multiple contacts against the walls of the flasks can alter the corneal cells,
- la stagnation de la cornée au fond du flacon de prélèvement forme un risque d'adhérence de la cornée sur les parois du flacon, et implique un contact avec les cellules dégénérées qui stagnent au fond d'un flacon. Le document EP-0262 766 divulgue un dispositif de support de cornée formé sur le bouchon d'un flacon. Ce dispositif impose l'utilisation de flacons spécifiques modifiés, les flacons standards n'étant pas adaptables à ce système.stagnation of the cornea at the bottom of the sampling flask constitutes a risk of adhesion of the cornea to the walls of the flask, and involves contact with the degenerate cells which stagnate at the bottom of a flask. EP-0262 766 discloses a corneal support device formed on the stopper of a vial. This device requires the use of modified specific bottles, the standard bottles are not adaptable to this system.
La présente invention a pour but de fournir un dispositif qui ne reproduit pas les inconvénients de l'art antérieur.The present invention aims to provide a device that does not reproduce the disadvantages of the prior art.
La présente invention a notamment pour but de fournir un tel dispositif qui soit simple et peu coûteux à fabriquer, à assembler et à utiliser, tout en permettant l'utilisation des flacons standards non modifiés.The present invention is intended to provide such a device that is simple and inexpensive to manufacture, assemble and use, while allowing the use of unmodified standard bottles.
La présente invention a donc pour objet un dispositif d'aide à la manipulation de cornée humaine visant à optimiser la conservation des cellules cornéennes dans différents flacons et milieux utilisés avant la greffe de la cornée, caractérisé en ce qu'il comporte un support sur lequel est déposé la cornée et une tirette pour mamtenir et extraire ledit support des différents flacons et milieux.The subject of the present invention is therefore a device for aiding human cornea manipulation with a view to optimizing the conservation of corneal cells in different flasks and media used prior to corneal transplantation, characterized in that it comprises a support on which the cornea and a pull tab are deposited to hold and extract said support from the different flasks and media.
Avantageusement, ledit dispositif est entièrement indépendant des flacons et/ou de leurs bouchons.Advantageously, said device is entirely independent of the bottles and / or their plugs.
Avantageusement, la cornée, sans être comprimée, reste contenue dans un espace réduit au minimum.Advantageously, the cornea, without being compressed, remains contained in a minimized space.
Avantageusement, les surfaces en contact avec la cornée sont minimisées. Avantageusement, le support est maintenu par la tirette de façon à ce que la cornée soit positionnée au-dessus du fond du flacon, où stagnent des cellules dégénérées, par l'intermédiaire d'éléments de supports, tels que des pieds.Advantageously, the surfaces in contact with the cornea are minimized. Advantageously, the support is held by the pull tab so that the cornea is positioned above the bottom of the bottle, where stagnant degenerate cells, via support elements, such as feet.
Avantageusement, le support présente au moins un orifice qui laisse passer la lumière directement sur la cornée lors de l'analyse microscopique.Advantageously, the support has at least one orifice which allows the light to pass directly on the cornea during the microscopic analysis.
D'autres caractéristiques et avantages de la présente invention apparaîtront plus clairement dans la description détaillée suivante d'un mode de réalisation particulier de l'invention, faite en référence aux dessins joints, donnés à titre d'exemples non limitatifs, et sur lesquels :Other features and advantages of the present invention will appear more clearly in the following detailed description of a particular embodiment of the invention, with reference to the accompanying drawings, given by way of non-limiting examples, and in which:
- la figure la représente une vue de dessus du support de cornée selon un mode de réalisation de la présente invention, - la figure 1b représente une vue en coupe selon la ligne A-A de la figure la, - la figure le représente une vue en coupe selon la ligne S-S de la figure la,FIG. 1a is a top view of the cornea support according to one embodiment of the present invention; FIG. 1b is a sectional view along the line AA of FIG. FIG. 1a shows a sectional view along the line SS of FIG.
- la figure 2a représente une vue de dessus de la tirette correspondante,FIG. 2a represents a view from above of the corresponding pull tab,
- la figure 2b représente une vue en coupe selon la ligne B-B de la ligne 2a,FIG. 2b represents a sectional view along line B-B of line 2a,
- la figure 2c représente une vue en coupe selon la ligne X-X de la figure 2a, etFIG. 2c represents a sectional view along line X-X of FIG. 2a, and
- la figure 3 représente une vue en coupe du dispositif assemblé.- Figure 3 shows a sectional view of the assembled device.
En référence à ces dessins et selon un mode de réalisation avantageux de la présente invention, le dispositif comporte un support 1, ayant environ la forme d'une roue avec des rayons 2, et percée en son centre.Referring to these drawings and according to an advantageous embodiment of the present invention, the device comprises a support 1, having the shape of a wheel with spokes 2, and pierced at its center.
Les rayons 2 sont inclinés vers le bas (dans la position des figures lb et 3) de façon à centrer la cornée 11, et ils présentent de préférence un profil arrondi afin de minimiser la surface de contact. La hauteur du support 1 est de préférence Umitée par celle des boites stériles transparentes dans lesquelles il est introduit avec la cornée lors de l'analyse microscopique, ceci afin de ne pas toucher la cornée. Le trou central 3 du support 1 laisse passer la lumière du microscope et autorise une visée directe sur la cornée. Une tirette est prévue pour manipuler le support 1. Cette tirette 9 peut être fixée de manière amovible audit support 1. Par exemple, deux clips de fixation 4 peuvent être utilisés pour maintenir le support 1 sur la tirette 9. D'autres moyens de fixation sont aussi envisageables. La tirette comporte avantageusement des pieds 5 qui viennent se glisser dans des encoches 6 du support 1, de façon à ne pas gêner la préhension du support. Les pieds sont avantageusement suffisamment longs pour mamtenir le support 1 au-dessus du fond du flacon, où stagnent des cellules dégénérées.The spokes 2 are inclined downwards (in the position of Figures 1b and 3) so as to center the cornea 11, and they preferably have a rounded profile to minimize the contact surface. The height of the support 1 is preferably Umite by that transparent sterile boxes in which it is introduced with the cornea during microscopic analysis, so as not to touch the cornea. The central hole 3 of the support 1 passes the light of the microscope and allows a direct sight on the cornea. A pull tab is provided to manipulate the support 1. This pull tab 9 can be removably attached to said support 1. For example, two fastening clips 4 can be used to hold the support 1 on the pull tab 9. Other fastening means are also possible. The pull tab advantageously has feet 5 which are slid into notches 6 of the support 1, so as not to hinder the grip of the support. The feet are advantageously long enough to hold the support 1 above the bottom of the bottle, where stagnant degenerate cells.
La tirette 9 du dispositif de l'invention peut aussi présenter une roue 7 avec des rayons 8 à profil arrondi pour minimiser la surface de contact. La tirette peut comporter une tige 10 en forme de T, de longueur et de largeur adaptées aux flacons standards pour permettre de centrer le dispositif au niveau du col dudit flacon.The pull tab 9 of the device of the invention may also have a wheel 7 with spokes 8 with a rounded profile to minimize the contact surface. The pull tab may comprise a rod 10 T-shaped, of suitable length and width standard bottles to allow to center the device at the neck of said bottle.
Le dispositif de l'invention est donc avantageusement complètement indépendant des flacons et/ou de leurs bouchons, ce qui permet l'utilisation des flacons standards existant et utilisés habituellement sans le dispositif de l'invention. Ceci est très rentable, puisque l'utilisation de flacons spécifiques modifiés est évitée.The device of the invention is therefore advantageously completely independent of the bottles and / or their plugs, which allows the use of existing standard vials and usually used without the device of the invention. This is very profitable, since the use of modified specific bottles is avoided.
Le dispositif est de préférence constitué de matière plastique et peut être fabriqué en une seule opération de moulage par injection sur presse. Un dispositif métallique, ou d'autres matériaux, tels que les céramiques, sont aussi envisageables.The device is preferably made of plastic and can be manufactured in a single press injection molding operation. A metal device, or other materials, such as ceramics, are also conceivable.
Le dispositif est de préférence stérilisé et à usage unique.The device is preferably sterilized and disposable.
Le dispositif selon l'invention est particulièrement adapté à la manipulation des cornées humaines avant une greffe. Ainsi, le dispositif selon l'invention facilite la manipulation, réduit les surfaces de contacts avec la cornée et élimine les contacts tactiles. Il permet notamment :The device according to the invention is particularly suitable for handling human corneas before transplantation. Thus, the device according to the invention facilitates handling, reduces the contact surfaces with the cornea and eliminates the tactile contacts. It allows in particular:
- de maintenir le support à une hauteur déterminée,to maintain the support at a determined height,
- de centrer le dispositif dans le flacon, - d'introduire et d'extraire sainement le support du flacon, sans risquer d'abîmer la cornée.- To center the device in the bottle, - to introduce and extract the support of the bottle, without risk of damaging the cornea.
Bien que la présente invention a été décrite en référence à un mode de réalisation particulier de celle-ci, il est entendu qu'elle ne se limite pas à cette mise en œuvre. Ainsi, la forme en roue à rayons pourrait être modifiée. D'autres modifications sont aussi envisageables par l'homme du métier sans sortir du cadre de la présente invention défini par les revendications annexées. Although the present invention has been described with reference to a particular embodiment thereof, it is understood that it is not limited to this implementation. Thus, the spoke wheel shape could be modified. Other modifications are also conceivable by those skilled in the art without departing from the scope of the present invention defined by the appended claims.
Claims
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0201260 | 2002-02-04 | ||
| FR0201260A FR2835423B1 (en) | 2002-02-04 | 2002-02-04 | DEVICE FOR HANDLING HUMAN HUMAN BEFORE TRANSPLANT |
| PCT/FR2003/000339 WO2003065937A1 (en) | 2002-02-04 | 2003-02-04 | Device that facilitates the handling of an animal cornea and, in particular, a human cornea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1474076A1 true EP1474076A1 (en) | 2004-11-10 |
Family
ID=27619848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP03718833A Withdrawn EP1474076A1 (en) | 2002-02-04 | 2003-02-04 | Device that facilitates the handling of an animal cornea and, in particular, a human cornea |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050149055A1 (en) |
| EP (1) | EP1474076A1 (en) |
| JP (1) | JP2005516671A (en) |
| CN (1) | CN1627925A (en) |
| AU (1) | AU2003222878A1 (en) |
| BR (1) | BR0307445A (en) |
| FR (1) | FR2835423B1 (en) |
| RU (1) | RU2296545C2 (en) |
| WO (1) | WO2003065937A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1634497A1 (en) * | 2004-09-14 | 2006-03-15 | Medical Technology Transfer Holding B.V. | Suspension device for donor corneal tissue storage |
| JP2008518034A (en) * | 2004-10-26 | 2008-05-29 | サージカル スペシャリティーズ コーポレイション | Apparatus and method for preserving the cornea in vitro |
| US20100120013A1 (en) * | 2008-11-07 | 2010-05-13 | Mb Research Laboratories, Inc. | Procedure for long term corneal culture |
| CN105286778B (en) * | 2015-09-30 | 2017-02-22 | 深圳艾尼尔角膜工程有限公司 | Cornea location system and location method |
| CN105342749B (en) * | 2015-09-30 | 2017-08-25 | 深圳艾尼尔角膜工程有限公司 | A kind of cornea automatic station-keeping system and method |
| US11154052B2 (en) | 2018-09-14 | 2021-10-26 | University Of Miami | Dual-chamber vial for corneal graft preservation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3139097A (en) * | 1962-11-28 | 1964-06-30 | Barnes Hind International Inc | Cleansing device for contact lenses |
| US3314533A (en) * | 1965-11-15 | 1967-04-18 | Kopfle John Arnold | Lens containing and dispensing device |
| US4423809A (en) * | 1982-02-05 | 1984-01-03 | Staar Surgical Company, Inc. | Packaging system for intraocular lens structures |
| US4824066A (en) * | 1983-04-11 | 1989-04-25 | Smith S Gregory | Apparatus for aiding in the storing and preserving of donor corneas |
| US5019084A (en) * | 1986-08-06 | 1991-05-28 | Minnesota Mining And Manufacturing Company | Corneal holder |
| US4844242A (en) * | 1987-09-02 | 1989-07-04 | The Johns Hopkins University | Cornea retainer |
| US4981657A (en) * | 1988-09-09 | 1991-01-01 | Ryder International Corporation | Contact lens case with raised, protective ribs |
| US5817075A (en) * | 1989-08-14 | 1998-10-06 | Photogenesis, Inc. | Method for preparation and transplantation of planar implants and surgical instrument therefor |
| US5167323A (en) * | 1990-08-09 | 1992-12-01 | Tomei Sangyo Co., Ltd. | Lens treating device for treating contact lens |
| US5407241A (en) * | 1994-07-21 | 1995-04-18 | Harrison; Kenneth | Contact lens applicator |
| RU2097009C1 (en) * | 1994-10-06 | 1997-11-27 | Уфимский научно-исследовательский институт глазных болезней | Method for preparing transplant |
| JP2995548B2 (en) * | 1997-03-06 | 1999-12-27 | ジャパンフォ−カス株式会社 | Corneal collapse prevention device that can be used for surgery with high suction pressure |
| US6256089B1 (en) * | 1999-12-16 | 2001-07-03 | Eyetech Vision, Inc. | Optical donor tissue cell |
| US6543610B1 (en) * | 2000-09-12 | 2003-04-08 | Alok Nigam | System for packaging and handling an implant and method of use |
-
2002
- 2002-02-04 FR FR0201260A patent/FR2835423B1/en not_active Expired - Fee Related
-
2003
- 2003-02-04 JP JP2003565367A patent/JP2005516671A/en active Pending
- 2003-02-04 BR BR0307445-5A patent/BR0307445A/en not_active IP Right Cessation
- 2003-02-04 WO PCT/FR2003/000339 patent/WO2003065937A1/en not_active Ceased
- 2003-02-04 CN CNA038032457A patent/CN1627925A/en active Pending
- 2003-02-04 RU RU2004126694/14A patent/RU2296545C2/en not_active IP Right Cessation
- 2003-02-04 US US10/503,474 patent/US20050149055A1/en not_active Abandoned
- 2003-02-04 AU AU2003222878A patent/AU2003222878A1/en not_active Abandoned
- 2003-02-04 EP EP03718833A patent/EP1474076A1/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| See references of WO03065937A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1627925A (en) | 2005-06-15 |
| JP2005516671A (en) | 2005-06-09 |
| BR0307445A (en) | 2004-12-28 |
| FR2835423B1 (en) | 2004-11-05 |
| WO2003065937A1 (en) | 2003-08-14 |
| RU2004126694A (en) | 2005-06-27 |
| AU2003222878A1 (en) | 2003-09-02 |
| US20050149055A1 (en) | 2005-07-07 |
| RU2296545C2 (en) | 2007-04-10 |
| FR2835423A1 (en) | 2003-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2751251B1 (en) | Methods for inoculating culture media on petri dishes by means of vibration frequencies | |
| WO2002080661A1 (en) | Ear tag for marking animals with organic substance sampling system | |
| EP2217058A1 (en) | Marking device for identifying and marking animals, and male portion of such device | |
| EP3283043B1 (en) | Sealing device for making it possible to collect a composition, packaging assembly comprising such a sealing device, collection and packaging methods | |
| WO2003065937A1 (en) | Device that facilitates the handling of an animal cornea and, in particular, a human cornea | |
| EP1241998B1 (en) | Device for handling and identifying small implants | |
| WO2017081412A1 (en) | Adapter for tube rack | |
| FR2612297A1 (en) | Laboratory device for analysis requiring transient contact of a solid phase with a liquid phase | |
| FR2621048A1 (en) | APPARATUS FOR MAINTAINING IN CONTACT WITH A LIQUID MEDIUM A BIOLOGICAL SAMPLE ON A SUPPORT | |
| FR3023614A1 (en) | SYSTEM FOR COLLECTING SAMPLES OF FECAL MATERIAL | |
| FR2586426A1 (en) | DEVICE FOR CULTURING MICROORGANISMS ON TWO SEPARATE MEDIA | |
| WO2008104710A2 (en) | Tray for carrying a plurality of bottles | |
| EP2085949A1 (en) | Information device | |
| WO2006037897A1 (en) | Air sampling method, device and system for microbiological analysis | |
| FR2726202A1 (en) | SINGLE USE RACK FOR TEST TUBES | |
| FR2591101A1 (en) | Flattenable and flexible container for sampling and/or administering biological liquids comprising means for identification of the source and/or destination of the aforesaid liquids | |
| FR2785033A1 (en) | Identified holder for manipulation and identification of small surgical implant | |
| CH555889A (en) | Growing separate bacteria colonies from one dip - which is wiped in traces across solid culture medium | |
| EP2934339B1 (en) | Device for preserving a biological sample | |
| FR3138610A1 (en) | DEVICE FOR PRESERVING A PLANT ALIVE ON A PAINTING AND PAINTING OF LIVING NATURE COMPRISING SUCH A DEVICE | |
| WO2001078901A1 (en) | Device for centrifuging a fatty tissue sample | |
| WO1998038095A1 (en) | Flask specifically designed for packaging biological analysis reagents and method for packaging biological analysis reagents | |
| WO2023208902A1 (en) | Aseptic sampling device | |
| EP4327946A1 (en) | Test tube racks | |
| VOLCKRICK | Légitimation et communication |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20040901 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20130903 |