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EP1446167A2 - Traitement d'aphtes au moyen de patchs permettant de guerir et de soulager la douleur rapidement - Google Patents

Traitement d'aphtes au moyen de patchs permettant de guerir et de soulager la douleur rapidement

Info

Publication number
EP1446167A2
EP1446167A2 EP02791205A EP02791205A EP1446167A2 EP 1446167 A2 EP1446167 A2 EP 1446167A2 EP 02791205 A EP02791205 A EP 02791205A EP 02791205 A EP02791205 A EP 02791205A EP 1446167 A2 EP1446167 A2 EP 1446167A2
Authority
EP
European Patent Office
Prior art keywords
gum
medication
patch
patches
dgl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02791205A
Other languages
German (de)
English (en)
Other versions
EP1446167A4 (fr
Inventor
Jeffrey T. Haley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orahealth LLC
Original Assignee
Orahealth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orahealth LLC filed Critical Orahealth LLC
Priority to EP10192668A priority Critical patent/EP2338475A3/fr
Publication of EP1446167A2 publication Critical patent/EP1446167A2/fr
Publication of EP1446167A4 publication Critical patent/EP1446167A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Definitions

  • an oral patch as used herein and other forms of medicinal preparations is that an oral patch is designed to release medication into the mouth over a relatively long period of time, such as 30 minutes or more, restrict local flow of saliva so that the medication can reach high concentrations along side the patch, and remain in the mouth as a single item that will not spread to be in a plurality of locations in the mouth at one time.
  • the mixture is deposited as an array of hot, viscous drops onto a sheet of high temperature plastic or coated paper.
  • the drops are allowed to cool and then the sheets of plastic or coated paper with the drops on them are dried in a drying room or oven till the water activity level less than 0.8.
  • the product is sold still adhered to the plastic or paper and the user pulls it off the plastic or paper.
  • Pain relief Using a DGL patch for 10-15 minutes before a meal relieves pain of the canker sore, and, if used up to commencement of a meal, the pain relief lasts through a typical meal. There is no numbing effect on surrounding tissues.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Insects & Arthropods (AREA)
  • Anesthesiology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Animal Husbandry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une méthode de traitement des aphtes au moyen de patchs oraux permettant de guérir et de soulager la douleur rapidement. Si certains médicaments sont appliqués sur un aphte au moyen d'un patch oral qui restreint l'écoulement local de salive et qui délivre le médicament durant au moins 30 minutes, les patchs étant utilisés durant au moins deux heures par jour, la méthode réduit le temps de guérison des aphtes des 10 à 14 jours classiques à 2 jours. La méthode de l'invention peut être utilisée avec divers agents antimicrobiens qui accélèrent la guérison des aphtes, notamment la pénicilline et l'amoxicilline. Elle peut également être utilisée avec de l'amlexanoxe et de l'extrait de réglisse déglycyrrhiziné (DGL) qui fonctionnent grâce à une méthode inconnue. Lorsqu'elle est utilisée avec du DGL, la méthode permet également de soulager rapidement la douleur d'un aphte et, si elle est utilisée avant le début d'un repas, elle soulage la douleur durant tout le repas. L'invention concerne également un patch oral soluble avec du DGL.
EP02791205A 2001-11-05 2002-11-05 Traitement d'aphtes au moyen de patchs permettant de guerir et de soulager la douleur rapidement Withdrawn EP1446167A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10192668A EP2338475A3 (fr) 2001-11-05 2002-11-05 Traitement d'aphtes au moyen de patchs permettant de guérir et de soulager la douleur rapidement

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US33291601P 2001-11-05 2001-11-05
US332916P 2001-11-05
US34457701P 2001-12-28 2001-12-28
US344577P 2001-12-28
US23628902A 2002-09-04 2002-09-04
US236289 2002-09-04
PCT/US2002/035399 WO2003039465A2 (fr) 2001-11-05 2002-11-05 Traitement d'aphtes au moyen de patchs permettant de guerir et de soulager la douleur rapidement

Publications (2)

Publication Number Publication Date
EP1446167A2 true EP1446167A2 (fr) 2004-08-18
EP1446167A4 EP1446167A4 (fr) 2010-09-29

Family

ID=27398834

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10192668A Withdrawn EP2338475A3 (fr) 2001-11-05 2002-11-05 Traitement d'aphtes au moyen de patchs permettant de guérir et de soulager la douleur rapidement
EP02791205A Withdrawn EP1446167A4 (fr) 2001-11-05 2002-11-05 Traitement d'aphtes au moyen de patchs permettant de guerir et de soulager la douleur rapidement

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10192668A Withdrawn EP2338475A3 (fr) 2001-11-05 2002-11-05 Traitement d'aphtes au moyen de patchs permettant de guérir et de soulager la douleur rapidement

Country Status (6)

Country Link
EP (2) EP2338475A3 (fr)
JP (2) JP2005508980A (fr)
CN (1) CN1309425C (fr)
AU (2) AU2009217365A1 (fr)
CA (1) CA2466061A1 (fr)
WO (1) WO2003039465A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107802641A (zh) * 2016-09-09 2018-03-16 李明典 口腔软组织(牙龈、粘膜)抗发炎酸痛剂

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7201930B2 (en) 2001-11-05 2007-04-10 Haley Jeffrey T Licorice root extract oral patch for treating canker sores
CN1309425C (zh) * 2001-11-05 2007-04-11 奥拉黑尔斯公司 用贴片治疗口腔溃疡以加速痊愈和缓解疼痛的方法
JP2006096728A (ja) * 2004-09-30 2006-04-13 Kobayashi Pharmaceut Co Ltd 口腔内定着型固形製剤
US20070243238A1 (en) * 2006-04-13 2007-10-18 Haley Jeffrey T Treating mouth sores with patches adhered to teeth
CN1850059B (zh) * 2006-05-29 2010-05-12 王法平 氨来呫诺口腔膜剂及其制备方法
CN101138541B (zh) * 2006-09-06 2010-10-06 上海医药工业研究院 氨来占诺局部成膜凝胶组合物及其应用
EP1917982B1 (fr) * 2006-11-06 2010-04-21 Lohmann & Rauscher GmbH & Co. KG Produit de traitement de l'inflammation, les contusions et/ou les aphtes pour les soins buccaux et utilisation d'un tel produit
JP2008208088A (ja) * 2007-02-27 2008-09-11 Ehime Univ 口内炎処置用組成物
EP3673902B1 (fr) * 2012-02-19 2022-01-05 Quest Products, LLC Adhésif de gomme d'acacia alcalinisé pour disques d'adhérence orale
US20150320676A1 (en) * 2012-12-13 2015-11-12 Lts Lohmann Therapie-Systeme Ag Topical drug for treating aphthae

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US3046195A (en) 1957-03-14 1962-07-24 Gerardus Van Loon Process for deglycyrrhizinating licorice
IL65184A0 (en) * 1982-03-05 1982-05-31 Yissum Res Dev Co Preparation for the treatment of oral diseases,comprising glycyrrhizin
US5362737A (en) * 1991-04-09 1994-11-08 Chemex Pharmaceuticals, Inc. Methods of treating aphthous ulcers and other mucocutaneous disorders with amlexanox
JP2609564B2 (ja) * 1991-05-31 1997-05-14 政夫 斎藤 アレルギー性皮膚炎用クリーム及びその製造方法
US5198217A (en) * 1991-09-24 1993-03-30 Choice Pharmaceuticals Topical demulcent for viral and inflammatory diseases of the skin
JP3350678B2 (ja) * 1992-02-27 2002-11-25 株式会社ダイゾー 口腔用エアゾール製品
US5409703A (en) * 1993-06-24 1995-04-25 Carrington Laboratories, Inc. Dried hydrogel from hydrophilic-hygroscopic polymer
US5713852A (en) * 1995-06-07 1998-02-03 Alza Corporation Oral dosage and method for treating painful conditions of the oral cavity
US5849322A (en) * 1995-10-23 1998-12-15 Theratech, Inc. Compositions and methods for buccal delivery of pharmaceutical agents
TW452494B (en) * 1996-03-12 2001-09-01 Jang De Shan Herbal composition for stimulating blood circulation
BR9811478A (pt) * 1997-07-23 2000-08-15 Perio Prod Ltd Composições de polìmero-ácido tânico para a liberação controlada de agentes farmacêuticos particularmente na cavidade oral
JPH11197217A (ja) * 1998-01-12 1999-07-27 Kanae Kagawa:Kk 速溶性ディスポ口腔用材
US6117446A (en) * 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
US6248718B1 (en) 1999-08-18 2001-06-19 Atlantic Biomed Corporation Lesion-directed dry dosage forms of antibacterial agents for the treatment of acute mucosal infections of the oral cavity
JP2001089346A (ja) * 1999-09-24 2001-04-03 We'll Corporation:Kk 口腔用組成物
DE10038571A1 (de) * 2000-08-03 2002-02-14 Knoll Ag Zusammensetzungen und Dosierungsformen zur Anwendung in der Mundhöhle bei der Bhandlung von Mykosen
CN1309425C (zh) * 2001-11-05 2007-04-11 奥拉黑尔斯公司 用贴片治疗口腔溃疡以加速痊愈和缓解疼痛的方法
US20070048369A1 (en) * 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107802641A (zh) * 2016-09-09 2018-03-16 李明典 口腔软组织(牙龈、粘膜)抗发炎酸痛剂

Also Published As

Publication number Publication date
CA2466061A1 (fr) 2003-05-15
JP2005508980A (ja) 2005-04-07
AU2009217365A1 (en) 2009-10-08
WO2003039465A2 (fr) 2003-05-15
JP2010163451A (ja) 2010-07-29
EP2338475A2 (fr) 2011-06-29
CN1582172A (zh) 2005-02-16
EP1446167A4 (fr) 2010-09-29
AU2009217366A1 (en) 2009-10-08
CN1309425C (zh) 2007-04-11
EP2338475A3 (fr) 2012-08-08
WO2003039465A3 (fr) 2003-11-20
HK1073802A1 (en) 2005-10-21

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