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EP1251834A4 - Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications - Google Patents

Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications

Info

Publication number
EP1251834A4
EP1251834A4 EP01942547A EP01942547A EP1251834A4 EP 1251834 A4 EP1251834 A4 EP 1251834A4 EP 01942547 A EP01942547 A EP 01942547A EP 01942547 A EP01942547 A EP 01942547A EP 1251834 A4 EP1251834 A4 EP 1251834A4
Authority
EP
European Patent Office
Prior art keywords
coenzyme
dosage forms
related applications
reduced form
high bioavailability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01942547A
Other languages
German (de)
French (fr)
Other versions
EP1251834B1 (en
EP1251834A1 (en
Inventor
Raj K Chopra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/488,332 external-priority patent/US6740338B1/en
Application filed by Individual filed Critical Individual
Publication of EP1251834A1 publication Critical patent/EP1251834A1/en
Publication of EP1251834A4 publication Critical patent/EP1251834A4/en
Application granted granted Critical
Publication of EP1251834B1 publication Critical patent/EP1251834B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP01942547.9A 2000-01-20 2001-01-18 Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications Expired - Lifetime EP1251834B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/488,332 US6740338B1 (en) 2000-01-20 2000-01-20 Reduced form of Cenzyme Q in high bioavailability stable oral dosage form
US488332 2000-01-20
US637559 2000-08-11
US09/637,559 US8753675B1 (en) 2000-01-20 2000-08-11 Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications
PCT/US2001/001997 WO2001052822A1 (en) 2000-01-20 2001-01-18 Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications

Publications (3)

Publication Number Publication Date
EP1251834A1 EP1251834A1 (en) 2002-10-30
EP1251834A4 true EP1251834A4 (en) 2008-11-05
EP1251834B1 EP1251834B1 (en) 2014-05-28

Family

ID=27049313

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01942547.9A Expired - Lifetime EP1251834B1 (en) 2000-01-20 2001-01-18 Reduced form of coenzyme q in high bioavailability stable dosage forms and related applications

Country Status (5)

Country Link
US (1) US8753675B1 (en)
EP (1) EP1251834B1 (en)
AU (1) AU2001229679A1 (en)
CA (1) CA2397447C (en)
WO (1) WO2001052822A1 (en)

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ITMI20010129A1 (en) 2001-01-25 2002-07-25 Pharmacia & Upjohn Spa ESSENTIAL FATTY ACIDS IN THE THERAPY OF HEART INSUFFICIENCY AND HEART FAILURE
JP3742602B2 (en) * 2001-05-09 2006-02-08 株式会社カネカ Stable solution of reduced coenzyme Q
JP2003026567A (en) * 2001-05-10 2003-01-29 Kanegafuchi Chem Ind Co Ltd Composition for administration to mucosa and containing coenzyme q as active ingredient
EP1388340B1 (en) 2001-05-10 2010-09-08 Kaneka Corporation Compositions for transmucosal administration containing coenzyme q as the active ingredient
DE10133305B4 (en) 2001-07-12 2004-06-03 Aquanova German Solubilisate Technologies (Agt) Gmbh Ubiquinone concentrate
TWI310029B (en) * 2001-07-13 2009-05-21 Kaneka Corp
TWI235146B (en) 2001-07-16 2005-07-01 Kaneka Corp Method of stabilizing reduced coenzyme q10 and method of acidic crystallization
US20030044474A1 (en) * 2001-08-03 2003-03-06 Shaklee Corporation High molecular weight, lipophilic, orally ingestible bioactive agents in formulations having improved bioavailability
JP3822479B2 (en) 2001-10-10 2006-09-20 株式会社カネカ Stabilized composition of reduced coenzyme Q aqueous solution
TWI329510B (en) 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
TW200302056A (en) * 2002-01-18 2003-08-01 Kaneka Corp Method for stabilizing reduced coenzyme Q10 and composition therefor
TW200304372A (en) * 2002-03-20 2003-10-01 Kanegafuchi Chemical Ind Compositions for diabetes
TWI322008B (en) * 2003-01-31 2010-03-21 Kaneka Corp Fatigue improving agent including reduced coenzyme q10
US8105583B2 (en) 2003-09-29 2012-01-31 Soft Gel Technologies, Inc. Solubilized CoQ-10
US8124072B2 (en) 2003-09-29 2012-02-28 Soft Gel Technologies, Inc. Solubilized CoQ-10
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US7708990B2 (en) 2004-03-23 2010-05-04 Kaneka Corporation Coenzyme Q compositions persisting in blood
ATE555674T1 (en) * 2004-04-09 2012-05-15 Kaneka Corp COMPOSITION WITH THE REDUCED FORM OF COENZYME Q10 AND CAROTENOID COMPOUND
TW200603786A (en) * 2004-05-11 2006-02-01 Kaneka Corp Anti-fatigue composition
JP2006070016A (en) * 2004-08-02 2006-03-16 Kaneka Corp Whitening composition containing reduced coenzyme q
ES2563929T3 (en) * 2004-12-24 2016-03-16 Kaneka Corporation Solid preparation comprising reduced coenzyme Q10 and process for the production thereof
US8067217B2 (en) 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
US20080254016A1 (en) * 2005-03-29 2008-10-16 Kaneka Corporation Composition For Increasing Anti-Oxidation Activity In Blood
CN1853728A (en) * 2005-04-19 2006-11-01 上海天博生物科技有限公司 Method prescription and use for improving medicine or nutrient oral absorption
ES2714900T3 (en) 2005-06-01 2019-05-30 Bioelectron Tech Corp Active redox therapeutic products for the treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
TW200726460A (en) * 2005-06-24 2007-07-16 Kaneka Corp Anti-fatigue composition
DE102005032352A1 (en) * 2005-07-08 2007-01-11 Aquanova German Solubilisate Technologies (Agt) Gmbh Solubilizer for an active ingredient concentrate in the food industry comprises a St. John's wort extract, a roseda extract or a tarragon extract, a polysorbate emulsifier and water
WO2007035496A1 (en) 2005-09-15 2007-03-29 Edison Pharmaceuticals, Inc. Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
JPWO2007034852A1 (en) * 2005-09-22 2009-03-26 株式会社カネカ Life prolonging composition and method for extending life
JP5015548B2 (en) * 2005-10-31 2012-08-29 株式会社カネカ Method for stabilizing reduced coenzyme Q10
US8506956B2 (en) 2005-10-31 2013-08-13 Kaneka Corporation Method for stabilizing reduced coenzyme Q10
WO2007100652A2 (en) 2006-02-22 2007-09-07 Edison Pharmaceuticals, Inc. Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
AU2007244232B2 (en) 2006-04-28 2012-07-19 Kaneka Corporation Method for stabilization of reduced coenzyme Q10
CA2666688C (en) 2006-06-22 2016-01-19 Kaneka Corporation Reduced coenzyme q10-containing composition and method for producing the same
US8642030B2 (en) * 2006-08-25 2014-02-04 Epc Europe Gmbh Compositions containing coenzyme Q-10 and dihydrolipoic acid
US8343541B2 (en) * 2007-03-15 2013-01-01 Soft Gel Technologies, Inc. Ubiquinol and alpha lipoic acid compositions
WO2008119605A1 (en) * 2007-04-02 2008-10-09 Unilever Plc Toothpaste composition
WO2009025277A1 (en) 2007-08-22 2009-02-26 Kaneka Corporation Method of producing reduced coenzyme q10 and method of stabilizing the same
WO2009044852A1 (en) * 2007-10-05 2009-04-09 Kaneka Corporation Method of producing reduced coenzyme q10
CN101307338B (en) 2008-07-17 2012-04-25 任雷 Preparation method of reduced coenzyme Q10
JP2012502064A (en) 2008-09-10 2012-01-26 エジソン ファーマシューティカルズ， インコーポレイテッド Treatment of pervasive developmental disorders with redox-active therapeutic agents
CN101514148B (en) * 2009-03-27 2015-05-13 玉溪健坤生物药业有限公司 Method for preparing reduced coenzyme Q10
WO2011045934A1 (en) 2009-10-16 2011-04-21 株式会社カネカ Method for producing reduced coenzyme q10, method for stabilizing same, and composition comprising same
US8557236B2 (en) 2010-02-09 2013-10-15 Vascure Natural LLC Cardiovascular support supplement and compositions and methods thereof
PL2544663T3 (en) 2010-03-12 2018-09-28 Berg Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
JP5546935B2 (en) * 2010-04-20 2014-07-09 株式会社カネカ Reduced coenzyme Q10-containing composition and method for producing the same
IT1400695B1 (en) * 2010-06-21 2013-06-28 Labomar S R L PHARMACEUTICAL AND / OR NUTRACEUTICAL COMPOSITIONS CONTAINING ACTIVE INSOLUBLES IN WATER AND PROCEDURE TO OBTAIN THEM.
JP5344768B2 (en) * 2010-08-11 2013-11-20 クラシエフーズ株式会社 Coenzyme Q10 photodegradation inhibitor and oral composition
US9655849B2 (en) 2011-03-18 2017-05-23 Particle Dynamics International, Llc Solid particulate compositions comprising coenzyme Q10
KR102058256B1 (en) 2011-06-17 2020-01-22 버그 엘엘씨 Inhalable pharmaceutical compositions
US20140107223A1 (en) * 2012-10-12 2014-04-17 Whitehill Oral Technologies, Inc. Topical ubiquinol supplement skin care compositions
EP3389646A1 (en) 2015-12-17 2018-10-24 BioElectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
ES2685329B1 (en) * 2017-03-30 2019-07-22 Phidinut S L Oral composition for deep mouth cleaning
ES2645028B2 (en) * 2017-10-13 2018-06-04 Maria D. GÓMEZ GARRE Single and stable pharmaceutical preparation containing berberine, in slow-release formulation, a statin and ubiquinol for the treatment of cardiovascular disease and associated risk factors
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof
DE102019218240A1 (en) * 2019-11-26 2021-05-27 Beiersdorf Ag Active ingredient combinations of ubiquinol and glyceryl stearate citrate and cosmetic or dermatological preparations containing such active ingredient combinations
US20240245628A1 (en) * 2023-01-03 2024-07-25 Bausch + Lomb Ireland Limited Compositions and methods for health comprising co-enzyme q10

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DE3405581A1 (en) * 1983-02-16 1984-10-18 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A., Rom/Roma PHARMACEUTICAL COMPOSITION WITH METABOLIC AND ENERGY EFFECTIVENESS FOR USE IN HEART AND VESSEL THERAPY
EP0383432A1 (en) * 1989-01-18 1990-08-22 Merck & Co. Inc. Coenzyme Q10 with HMG-COA reductase inhibitors
WO1998003170A1 (en) * 1996-07-24 1998-01-29 Biosytes Usa, Inc. Method for enhancing dissolution properties of relatively insoluble dietary supplements and product incorporating same
EP0882450A2 (en) * 1997-05-27 1998-12-09 Kaneka Corporation Cholesterol-lowering composition comprising coenzyme Q
EP0956854A1 (en) * 1996-08-16 1999-11-17 Kaneka Corporation Pharmaceutical composition comprising coenzyme q 10

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US5316765A (en) 1989-09-07 1994-05-31 Karl Folkers Foundation For Biomedical And Clinical Research Use of coenzyme Q10 in combination with HMG-CoA reductase inhibitor therapies
US5082650A (en) 1989-09-07 1992-01-21 Folkers Karl A Amelioration of reductions of coenzyme Q10 in cardiomyopathy patients receiving lovastatin
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US5908613A (en) * 1997-09-08 1999-06-01 Bozzacco; Craig Composition for the treatment and prevention of periodontal disease
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US6805880B1 (en) * 1999-08-20 2004-10-19 Ferrosan A/S Pharmaceutical delivery system for vitamin C and vitamin E and use of a combination of vitamin C and E for preventing or treating conditions involving oxidative stress
US6998501B1 (en) * 1999-08-30 2006-02-14 Ocean Nutrition Canada Limited Nutritional supplement for lowering serum triglyceride and cholesterol levels
US6441050B1 (en) * 2000-08-29 2002-08-27 Raj K. Chopra Palatable oral coenzyme Q liquid
US6300377B1 (en) * 2001-02-22 2001-10-09 Raj K. Chopra Coenzyme Q products exhibiting high dissolution qualities

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DE3405581A1 (en) * 1983-02-16 1984-10-18 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A., Rom/Roma PHARMACEUTICAL COMPOSITION WITH METABOLIC AND ENERGY EFFECTIVENESS FOR USE IN HEART AND VESSEL THERAPY
EP0383432A1 (en) * 1989-01-18 1990-08-22 Merck & Co. Inc. Coenzyme Q10 with HMG-COA reductase inhibitors
WO1998003170A1 (en) * 1996-07-24 1998-01-29 Biosytes Usa, Inc. Method for enhancing dissolution properties of relatively insoluble dietary supplements and product incorporating same
EP0956854A1 (en) * 1996-08-16 1999-11-17 Kaneka Corporation Pharmaceutical composition comprising coenzyme q 10
EP0882450A2 (en) * 1997-05-27 1998-12-09 Kaneka Corporation Cholesterol-lowering composition comprising coenzyme Q

Non-Patent Citations (1)

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Title
See also references of WO0152822A1 *

Also Published As

Publication number Publication date
WO2001052822A1 (en) 2001-07-26
US8753675B1 (en) 2014-06-17
CA2397447A1 (en) 2001-07-26
EP1251834B1 (en) 2014-05-28
CA2397447C (en) 2009-08-11
EP1251834A1 (en) 2002-10-30
AU2001229679A1 (en) 2001-07-31

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