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EP1156759A4 - Spirales a base de polymere/proteine biodegradable, pour implants endoluminaux - Google Patents

Spirales a base de polymere/proteine biodegradable, pour implants endoluminaux

Info

Publication number
EP1156759A4
EP1156759A4 EP99951622A EP99951622A EP1156759A4 EP 1156759 A4 EP1156759 A4 EP 1156759A4 EP 99951622 A EP99951622 A EP 99951622A EP 99951622 A EP99951622 A EP 99951622A EP 1156759 A4 EP1156759 A4 EP 1156759A4
Authority
EP
European Patent Office
Prior art keywords
coil
protein
biocompatible
growth factor
providing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP99951622A
Other languages
German (de)
English (en)
Other versions
EP1156759A1 (fr
Inventor
Yuichi Murayama
Fernando Vinuela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1999/001790 external-priority patent/WO1999044538A1/fr
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of EP1156759A1 publication Critical patent/EP1156759A1/fr
Publication of EP1156759A4 publication Critical patent/EP1156759A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Definitions

  • the invention relates generally to the field of surgical and endovascular interventional instruments and specially to Intraluminal implants for occlusion of vessels or aneurysms.
  • Brain aneurysms are the commonest cause of nontraumatic subarachnoid hemorrhage (SAH) which is a significant life-threatening disease in adults. Annually in North America, the rupture of saccular aneurysms accounts for 25000 new cases of SAH. Microsurgical clipping of an aneurysm has been considered the gold standard for the treatment of this disease. Recently, intravascular treatment of aneurysms has become an accepted alternative technique. With the availability of microcatheters capable of accessing the intracranial circulation it has become possible to obliterate an aneurysm by filling it with soft platinum detachable coils (Guglielmi Detachable Coils; GDC).
  • GDC Global System for Delivery and detachment of platinum coils within an aneurysm.
  • Recent advances in endovascular techniques have proved valuable in the treatment of cerebral saccular aneurysms.
  • GDCs have contributed especially to improvements in the endovascular management of cerebral aneurysms.
  • the size of an aneurysm neck has an important effect on the anatomic results of aneurysm obliteration. It has been reported that in one study complete obliteration of aneurysms was achieved in 85% of small-necked aneurysms and 15% of wide-necked aneurysms.
  • GDCs Guglielmi detachable coils
  • Occlusion coils are used to occlude a site within a body lumen, such as a blood vessel, brain aneurysm, or vascular malformation.
  • the coils are typically placed at a desired site within the lumen by means of a microcatheter.
  • the coils are normally made of a radioopaque, biocompatible metals such as platinum, gold, or tungsten.
  • the coils occlude the aneurysm by posing a physical barrier to blood flow and by promoting thrombus formation.
  • the formation of the neo-endothelium and mature intra-aneurysmal thrombus is necessary prior to subsequent organization and scar formation that, in turn, yields a permanently occluded aneurysm.
  • metallic coils can be insufficiently thrombogenic to promote the establishment of firm and mature thrombus within the aneurysm. They have difficulty in promoting endothelialization across the wide neck of an aneurysm. Therefore, it is advantageous to tightly pack the aneurysm with coils for complete cure of the aneurysms. This may cause a mass effect on adjacent the brain parenchyma or cranial nerves.
  • Bioabsorbable polymers such as polyglycolic acid and polyglycolic/poly-L-lactic acid copolymers, or bioabsorbable proteins, such as collagen and gelatins, have been used to make Intraluminal implants. These bioabsorbable polymers or proteins are also used to provide a the drug delivery vehicle (such as for continuous local delivery of growth factors). It is necessary to modify biological cellular response in preparation for acceleration of wound healing.
  • Coil thrombogenicity was enhanced previously by increasing the surface area of the coils with fabric strands, such as Dacron, and by placing such coils into a thrombin solution. More recently, some investigators have modified the surfaces of platinum coils by coating them with collagen or polyurethane. This has resulted in some advantages, such as an increase in thrombogenicity of these coils.
  • protein coatings on platinum surfaces are usually weak and may be removed easily during the delivery of the coils. Additionally, weakly coated proteins may be washed off by high-velocity arterial flow and may be a potential source of distal thromboemboli.
  • polyurethane coatings in particular also have the disadvantage of producing unfavorable changes in GDC performance, affecting their softness, thinness, smoothness,
  • GDCs and surrounding thrombus within an aneurysm are continuously exposed to and interact with circulating blood at the neck of the aneurysm.
  • Coil compaction resulting from the force of pulsatile arterial blood flow is one of the reasons for incomplete obliteration of aneurysms. When this occurs, there is a potential risk of aneurysm recanalization and (re)rupture.
  • Re- endothelialization and the promotion of wound healing in the aneurysmal sac and across its neck are necessary for complete aneurysm cure.
  • the invention is an intravascular device that modifies either accelerating or decreasing biological cellular response comprising a separable tip or coil comprised at least in part of at least one biocompatible and absorbable polymer or protein, and a placement device associated with the separable coil adapted to dispose the coil into a selected body lumen.
  • the biocompatible and absorbable polymer or protein promotes an intra-aneurysmal inflammatory response and healing of the aneurysms.
  • This device may carry growth factors, such as a vascular endothelial growth factor, a basic fibroblast growth factor or a mixture of several growth factors or cytokines.
  • the separable tip which also need not be a coil, need not be comprised of a polymer or protein, but may be comprised of any material now known or later devised which is biocompatible, absorbable and which promotes an intra-aneurysmal inflammatory response and promotes healing of the aneurysm.
  • the biocompatible and absorbable polymer is in the illustrated embodiment at least one polymer selected from the group consisting of polyglycolic acid, poly ⁇ glycolic acid/poly-L-lactic acid copolymers, polycaprolactive, polyhydroxybutyrate/hydroxyvalerate copolymers, poly-L- lactide, polydioxanone, polycarbonates, and polyanhydrides.
  • the biocompatible and absorbable protein is at least one protein selected from the group consisting of collagen, fibrinogen, fibronectin, vitronectin, laminin, and gelatin.
  • the coil is composed of the biocompatible and absorbable polymer or protein with a radio-opaque material is disposed thereon.
  • the coil is composed of a radio-opaque material, and the biocompatible and absorbable polymer or protein is disposed thereon.
  • the invention is also characterized as a method for forming a thrombus comprising the steps of providing a separable coil comprised at least in part of at least one biocompatible and absorbable polymer or protein and disposing the separable coil into a body lumen including the various combinations and examples described above.
  • the method further of comprises the step of providing the coil with a growth factor, and in particular a vascular endothelial growth factor (VEGF), a basic fibroblast growth factor (bFGF), or other growth factors.
  • a growth factor and in particular a vascular endothelial growth factor (VEGF), a basic fibroblast growth factor (bFGF), or other growth factors.
  • VEGF vascular endothelial growth factor
  • bFGF basic fibroblast growth factor
  • a biodegradable polymer (or protein) coils are used to control thrombosis or accelerate wound healing of the brain aneurysms for which platinum coils sometimes have often proven unsatisfactory.
  • Another aspect of the invention is a method of drug delivery system using biodegradable polymer (or proteins) in the combination with growth factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) or other growth factors which promote long lasting effect of the wound healing
  • growth factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) or other growth factors which promote long lasting effect of the wound healing
  • biodegradable coils are useful for treating giant brain aneurysms to prevent the mass effect on the brain parenchyma or cranial nerves by shrinkage of scaring aneurysm.
  • the implants of the invention may be placed within body lumens, e.g., blood vessels, Fallopian tubes, etc., of any mammalian species, including humans.
  • the implant coils are made of biocompatible and absorbable polymers or proteins.
  • bioabsorbable polymers that have been used in the illustrated embodiment to make Intraluminal implants include but are not limited to polyglycolic acid, poly ⁇ gycolic/poly-L-lactic acid copolymers, polycaprolactive, polyhydroxybutyrate /hydroxyvalerate copolymers, poly-L-lactide, polydioxanone, polycarbonates, and polyanhydrides.
  • bioabsorbable proteins that have been used in the illustrated embodiment to make Intraluminal implants include but are not limited to collagen, fibrinogen, fibronectin, vitronectin, laminin and gelatin.
  • the bioabsorbable polymer coils may be coated or mixed with radioopaque materials such as tantalum or platinum.
  • the bioabsorbable polymer or protein itself may be mounted or coated onto coils or wires of metals such as platinum or nitonol.
  • Preferred growth factors for use in the invention are the naturally occurring mammalian angiogenic growth such as VEGF, or b-FGF. Mixtures of such growth factors may also be used if desired.
  • the biodegradable polymer coils of the invention can be placed within the body lumen, vascular system or vessels using procedures well known in the art.
  • the desired site within the vessel is accessed with a catheter.
  • the catheter may be guided to the site by the use of guide wires.
  • the catheter lumen is cleared by removing guide wire.
  • the coils are loaded by means of a pusher wire.
  • the coils may be attached to the distal end of the pusher via a cleavable joint (e.g., a joint that is severable by heat, electrolysis, electrodynamic activation or other means) or a mechanical joint that permits the coil to be detached from the distal end of the pusher wire by mechanical manipulation.
  • the coils may be free and detached from the pusher wire, simply pushed through the catheter and expelled from the distal end of the catheter.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Medical Informatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une spirale séparable, constituée en partie d'un polymère ou d'une protéine absorbable et de facteurs de croissance, à implanter dans un compartiment vasculaire ou tout emplacement intraluminal, permettant une manipulation cellulaire endovasculaire et l'induction d'une réponse inflammatoire. Généralement, on utilise un cathéter associé à la spirale séparable pour placer cette dernière dans une lumière du corps sélectionnée. La protéine ou le polymère biocompatible et absorbable est thrombogène. La spirale se compose au moins en partie d'un facteur de croissance, notamment d'un facteur de croissance endothéliale, d'un facteur de croissance des fibroplastes de base ou de tout autre facteur de croissance. Le polymère biocompatible et absorbable est, dans le mode de réalisation présenté, au moins un polymère choisi dans le groupe formé d'acide polyglycolique, de copolymères d'acide poly-L-lactique/poly∩glycolique, de polycaprolactide, de copolymères de polyhydroxybutyrate/hydroxyvalérate, de poly-L-lactide, de polydioxynone, de polycarbonates et de polyanhydrides. La protéine biocompatible et absorbable est au moins une protéine choisie dans le groupe formé de collagène, fibrinogène, fibronectine, vitronectine, laminine et gélatine. Dans un mode de réalisation, la spirale se compose du polymère ou de la protéine biocompatible et absorbable revêtu(e) d'une substance radio-opaque. Ledit appareil peut être positionné dans des anévrismes intracrâniens ou autre ainsi que dans d'autres cavités du corps.
EP99951622A 1999-01-27 1999-09-27 Spirales a base de polymere/proteine biodegradable, pour implants endoluminaux Ceased EP1156759A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/US99/01790 1999-01-27
PCT/US1999/001790 WO1999044538A1 (fr) 1998-01-27 1999-01-27 Serpentins biodegradables a base de polymeres/proteines pour implants endoluminaux
PCT/US1999/022420 WO2000044306A1 (fr) 1999-01-27 1999-09-27 Spirales a base de polymere/proteine biodegradable, pour implants endoluminaux

Publications (2)

Publication Number Publication Date
EP1156759A1 EP1156759A1 (fr) 2001-11-28
EP1156759A4 true EP1156759A4 (fr) 2002-11-20

Family

ID=22272061

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99951622A Ceased EP1156759A4 (fr) 1999-01-27 1999-09-27 Spirales a base de polymere/proteine biodegradable, pour implants endoluminaux

Country Status (5)

Country Link
EP (1) EP1156759A4 (fr)
JP (3) JP2003524456A (fr)
AU (1) AU6402699A (fr)
CA (1) CA2323151C (fr)
WO (1) WO2000044306A1 (fr)

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US8864790B2 (en) 2006-04-17 2014-10-21 Covidien Lp System and method for mechanically positioning intravascular implants
EP3034046B1 (fr) 2006-10-22 2018-01-17 IDEV Technologies, INC. Procédés de fixation d'extrémités de brins et dispositifs résultants
MX2009004292A (es) 2006-10-22 2009-08-12 Idev Technologies Inc Dispositivos y metodos para el avance de stent.
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US9023095B2 (en) 2010-05-27 2015-05-05 Idev Technologies, Inc. Stent delivery system with pusher assembly
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US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
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JP2003524456A (ja) 2003-08-19
WO2000044306A1 (fr) 2000-08-03
JP4751661B2 (ja) 2011-08-17
CA2323151A1 (fr) 2000-08-03
JP2006021052A (ja) 2006-01-26
JP2004223268A (ja) 2004-08-12
AU6402699A (en) 2000-08-18
CA2323151C (fr) 2007-04-10
EP1156759A1 (fr) 2001-11-28

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