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EP1148878A4 - Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs - Google Patents

Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs

Info

Publication number
EP1148878A4
EP1148878A4 EP00908353A EP00908353A EP1148878A4 EP 1148878 A4 EP1148878 A4 EP 1148878A4 EP 00908353 A EP00908353 A EP 00908353A EP 00908353 A EP00908353 A EP 00908353A EP 1148878 A4 EP1148878 A4 EP 1148878A4
Authority
EP
European Patent Office
Prior art keywords
radior
tumor
resistance
derivatives useful
radiodiagnostic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00908353A
Other languages
German (de)
English (en)
Other versions
EP1148878A1 (fr
Inventor
Donald J Chapman
Richard F Schneider
Edward L Engelhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fox Chase Cancer Center
Original Assignee
Fox Chase Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fox Chase Cancer Center filed Critical Fox Chase Cancer Center
Publication of EP1148878A1 publication Critical patent/EP1148878A1/fr
Publication of EP1148878A4 publication Critical patent/EP1148878A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP00908353A 1999-01-26 2000-01-26 Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs Withdrawn EP1148878A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11725399P 1999-01-26 1999-01-26
US117253P 1999-01-26
PCT/US2000/001754 WO2000043004A1 (fr) 1999-01-26 2000-01-26 Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs

Publications (2)

Publication Number Publication Date
EP1148878A1 EP1148878A1 (fr) 2001-10-31
EP1148878A4 true EP1148878A4 (fr) 2003-04-02

Family

ID=22371814

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00908353A Withdrawn EP1148878A4 (fr) 1999-01-26 2000-01-26 Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs

Country Status (3)

Country Link
EP (1) EP1148878A4 (fr)
CA (1) CA2361115A1 (fr)
WO (1) WO2000043004A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002026748A2 (fr) 2000-09-25 2002-04-04 The Procter & Gamble Company Complexes de metaux a utiliser dans des applications medicales et therapeutiques
WO2005087275A2 (fr) * 2004-03-11 2005-09-22 Board Of Regents, The University Of Texas System Agents d'imagerie tep radiomarques metalliques
US7842278B2 (en) * 2006-10-27 2010-11-30 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
US9408928B2 (en) 2007-03-27 2016-08-09 Radiomedix, Inc. Compositions for targeted imaging and therapy
CN101486707B (zh) * 2009-02-27 2012-08-29 北京师范大学 亲乏氧肿瘤的硝基咪唑类配合物及其制备方法和应用
CN101486708B (zh) * 2009-02-27 2012-08-29 北京师范大学 一类锝-99m标记的肿瘤乏氧显像剂及其制备方法和应用
EP2608785B1 (fr) * 2010-08-26 2016-08-17 Kunyuan Cui Lipomacrocycles et leurs utilisations
CA2843313C (fr) 2011-06-20 2018-02-13 Radiomedix Inc. Compositions, procedes de synthese et utilisation d'agents cibles sur les glucides
CN111356698B (zh) * 2017-09-19 2025-02-25 威奇生物科技公司 用于低氧成像、映射和治疗的标记物、缀合物、组合物和方法
CA3076259A1 (fr) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta Composes actives par bioreduction, leurs promedicaments, produits radiopharmaceutiques, les compositions et leurs applications dans la gestion theranostique multimodale de l'hypoxie, dont le cancer
KR102826887B1 (ko) * 2021-02-26 2025-06-27 씨큐어 타이완 씨오., 엘티디. 티오퓨린계 화합물, 조성물, 제조 방법 및 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654102B1 (fr) * 1989-11-09 1992-01-10 Air Liquide Procede de synthese de derives polyazotes cycliques.
JP2885944B2 (ja) * 1991-02-01 1999-04-26 富士写真フイルム株式会社 複素環基を有するアミン化合物
US5708022A (en) * 1994-10-28 1998-01-13 Procept, Inc. Method for inhibiting immune response
GB9511357D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO0043004A1 *

Also Published As

Publication number Publication date
CA2361115A1 (fr) 2000-07-27
WO2000043004A1 (fr) 2000-07-27
EP1148878A1 (fr) 2001-10-31

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Legal Events

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