EP0672171A4 - Formation de complexes a triple helice d'adn double brin a l'aide d'oligomeres de nucleosides qui comprennent des analogues a base de purine. - Google Patents

Formation de complexes a triple helice d'adn double brin a l'aide d'oligomeres de nucleosides qui comprennent des analogues a base de purine.

Info

Publication number: EP0672171A4
Authority: EP; European Patent Office
Prior art keywords: nucleotidoligomers; analogue; constructed; double; formation
Prior art date: 1991-08-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP92919326A

Other languages

German (de)

English (en)

Other versions

EP0672171A1 (fr

Inventor

Paul S Miller

Purshotam Bhan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Johns Hopkins University

Original Assignee

Johns Hopkins University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-30

Filing date

1992-08-27

Publication date

1997-04-09

1992-08-27 Application filed by Johns Hopkins University filed Critical Johns Hopkins University

1995-09-20 Publication of EP0672171A1 publication Critical patent/EP0672171A1/fr

1997-04-09 Publication of EP0672171A4 publication Critical patent/EP0672171A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/333—Modified A
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Public Health (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Analytical Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

EP92919326A 1991-08-30 1992-08-27 Formation de complexes a triple helice d'adn double brin a l'aide d'oligomeres de nucleosides qui comprennent des analogues a base de purine. Withdrawn EP0672171A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US75181391A	1991-08-30	1991-08-30
PCT/US1992/007246 WO1993005180A1 (fr)	1991-08-30	1992-08-27	Formation de complexes a triple helice d'adn double brin a l'aide d'oligomeres de nucleosides qui comprennent des analogues a base de purine
US751813		2000-12-29

Publications (2)

Publication Number	Publication Date
EP0672171A1 EP0672171A1 (fr)	1995-09-20
EP0672171A4 true EP0672171A4 (fr)	1997-04-09

Family

ID=25023590

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92919326A Withdrawn EP0672171A4 (fr)	1991-08-30	1992-08-27	Formation de complexes a triple helice d'adn double brin a l'aide d'oligomeres de nucleosides qui comprennent des analogues a base de purine.

Country Status (8)

Country	Link
EP (1)	EP0672171A4 (fr)
JP (1)	JPH06510203A (fr)
AU (1)	AU668886B2 (fr)
CA (1)	CA2116343A1 (fr)
FI (1)	FI940922L (fr)
IL (1)	IL102983A (fr)
NZ (1)	NZ244125A (fr)
WO (1)	WO1993005180A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992009705A1 (fr) *	1990-11-23	1992-06-11	Gilead Sciences, Inc.	Oligomeres formant un triplex et contenant des bases modifiees
US6451968B1 (en)	1991-05-24	2002-09-17	Isis Pharmaceuticals, Inc.	Peptide nucleic acids
US7223833B1 (en)	1991-05-24	2007-05-29	Isis Pharmaceuticals, Inc.	Peptide nucleic acid conjugates
US6441130B1 (en)	1991-05-24	2002-08-27	Isis Pharmaceuticals, Inc.	Linked peptide nucleic acids
US6713602B1 (en)	1991-05-24	2004-03-30	Ole Buchardt	Synthetic procedures for peptide nucleic acids
AU2696897A (en) *	1996-04-26	1997-11-19	Novartis Ag	Modified oligonucleotides
TR200000547T2 (tr)	1997-08-27	2001-05-21	Pioneer Hi-Bred International, Inc.	Lignin biyosentezi için enzimleri kodlayan genler ve bunların kullanımı.
WO2001032924A1 (fr) *	1999-10-29	2001-05-10	Cygene, Inc.	Compositions, procedes de syntese et utilisation de nouvelles structures d'acides nucleiques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990015884A1 (fr) *	1989-06-19	1990-12-27	The Johns Hopkins University	Formation de complexes a triple helice d'adn a double brin par utilisation d'oligomeres de nucleosides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2006008C (fr) *	1988-12-20	2000-02-15	Donald J. Kessler	Methode pour obtenir des oligonucleotides synthetiques qui se lient specifiquement a des sites cibles sur des molecules d'adn double brin, en formant un triplex colineaire; methode d'utilisation de ces oligonucleotides synthetiques

1992
- 1992-08-27 EP EP92919326A patent/EP0672171A4/fr not_active Withdrawn
- 1992-08-27 AU AU25544/92A patent/AU668886B2/en not_active Ceased
- 1992-08-27 WO PCT/US1992/007246 patent/WO1993005180A1/fr not_active Ceased
- 1992-08-27 CA CA002116343A patent/CA2116343A1/fr not_active Abandoned
- 1992-08-27 FI FI940922A patent/FI940922L/fi not_active Application Discontinuation
- 1992-08-27 JP JP5505283A patent/JPH06510203A/ja active Pending
- 1992-08-28 IL IL102983A patent/IL102983A/en not_active IP Right Cessation
- 1992-08-28 NZ NZ244125A patent/NZ244125A/en unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990015884A1 (fr) *	1989-06-19	1990-12-27	The Johns Hopkins University	Formation de complexes a triple helice d'adn a double brin par utilisation d'oligomeres de nucleosides

Also Published As

Publication number	Publication date
CA2116343A1 (fr)	1993-03-18
AU668886B2 (en)	1996-05-23
FI940922A7 (fi)	1994-04-07
EP0672171A1 (fr)	1995-09-20
FI940922L (fi)	1994-04-07
IL102983A0 (en)	1993-01-31
AU2554492A (en)	1993-04-05
WO1993005180A1 (fr)	1993-03-18
NZ244125A (en)	1995-04-27
FI940922A0 (fi)	1994-02-25
JPH06510203A (ja)	1994-11-17
IL102983A (en)	1998-02-08

Publication	Publication Date	Title
FI922812L (fi)	1992-06-17	Stabil oeverfoering av dna till bakteriernas arvanslag.
TR24372A (tr)	1991-09-20	Org.peroksi asit agartma oen-maddelerine dayanan aktivatoer bilesimleri
FI880131A7 (fi)	1988-07-15	T7-dna-polymeras.
FI893930A0 (fi)	1989-08-22	Foerfarande foer framstaellning av vaxbeklaedda, foerdroejt frigjorda partiklar innehaollande tuggummi.
FI884373A0 (fi)	1988-09-23	Saett att lufta mellanoerat medelst en i oerats trumhinna applicerbar ventilationstub, ventilationstub foer utfoerande av saettet jaemte anvaendning av en dylik ventilationstub.
FI885380A0 (fi)	1988-11-18	Luftledningslaoda foer stabilisering av loepet av en varubana, saerskilt en pappersbana.
FI883763L (fi)	1989-02-13	Frigoering av vaerdens foersvarsmediatorer i biologiska vaetskor genom systematisk behandling med dubbelstraengat rna.
DE3868184D1 (de)	1992-03-12	Pigment aus aluminiumschueppchen.
EP0672171A4 (fr)	1997-04-09	Formation de complexes a triple helice d'adn double brin a l'aide d'oligomeres de nucleosides qui comprennent des analogues a base de purine.
FI880916A0 (fi)	1988-02-26	Anordning foer stabilisering av en materialbana, isynnerhet foer stabilisering av en pappersbana i torkpartiet i en pappersmaskin.
FI883063A7 (fi)	1988-12-27	Kaolinitaggregation genom anvaendning av organokiselfoereningar.
FI882604L (fi)	1988-12-07	Foerbaettrande av utnyttjande av foer vaexter anvaendbart kvaeve genom bringande av odlingsvaexter att uttrycka glutaminsyntetas i oeverskott.
FI880454A0 (fi)	1988-02-01	Laosanordning, saerskilt foer en lucka till en dammsugare.
FI883223A7 (fi)	1989-01-14	Sjaelvreglerande anordning foer fastlaosning av tvao foeremaol, i vilken anordning distansen mellan faestningsstaellena fraon det ena foeremaolet till det andra kan variera.
FI883005L (fi)	1988-12-25	Promotorer foer expression av fraemmande dna i metylotrofiska bakterier, deras tillvaratagande och deras anvaendning.
FI880588L (fi)	1989-01-03	Interpolymerkompositioner och membraner av eten-akrylsyratyp, vilka har foerbaettrad glidbarhet och foerminskad faestfoermaoga.
FI884857A7 (fi)	1989-04-22	Anordning foer framstaellning av portabla, roerformiga paket av tryckalster.
DE3870891D1 (de)	1992-06-17	Strangpressmatrize.
NO940658L (no)	1994-02-25	Nukleinsyre-polymerase-forökning
FI885517L (fi)	1989-05-31	Benavlaegsningsanordning, saerskilt foer avlaegsning av revben fraon en buk.
FI880851A7 (fi)	1988-08-25	Anordning foer hopsaettning av skurna aemnen, saerskilt foer aostadkommande av foerpackningar.
FI892769L (fi)	1989-06-06	Foerfarande foer inaktivering av den rekombinanta dna:n.
FI884819L (fi)	1988-10-19	Foerfarande foer framstaellning av en elektriskt halvledande, lossnande plastblandning.
DE68914551D1 (de)	1994-05-19	Verfahren zur Produktion von O-silyl O,N-Keten-Acetalen.
FI880073A0 (fi)	1988-01-08	Ramspaennanordning, saerskilt foer girfogning av ramar.

Legal Events

Date	Code	Title	Description
1995-08-04	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-09-20	17P	Request for examination filed	Effective date: 19940301
1995-09-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
1997-04-09	A4	Supplementary search report drawn up and despatched	Effective date: 19970224
1997-04-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
1998-06-03	17Q	First examination report despatched	Effective date: 19980422
1999-01-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1999-03-03	18D	Application deemed to be withdrawn	Effective date: 19980903