EP0672171A4 - FORMATION OF TRIPLE HELIX COMPLEXES FROM DOUBLE-STRANDED DNA BY MEANS OF NUCLEOTIDOLIGOMERS CONSTRUCTED FROM ANALOGUE PURINE BASES. - Google Patents

FORMATION OF TRIPLE HELIX COMPLEXES FROM DOUBLE-STRANDED DNA BY MEANS OF NUCLEOTIDOLIGOMERS CONSTRUCTED FROM ANALOGUE PURINE BASES.

Info

Publication number: EP0672171A4
Authority: EP; European Patent Office
Prior art keywords: nucleotidoligomers; analogue; constructed; double; formation
Prior art date: 1991-08-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP92919326A

Other languages

German (de)

French (fr)

Other versions

EP0672171A1 (en

Inventor

Paul S Miller

Purshotam Bhan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Johns Hopkins University

Original Assignee

Johns Hopkins University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-30

Filing date

1992-08-27

Publication date

1997-04-09

1992-08-27 Application filed by Johns Hopkins University filed Critical Johns Hopkins University

1995-09-20 Publication of EP0672171A1 publication Critical patent/EP0672171A1/en

1997-04-09 Publication of EP0672171A4 publication Critical patent/EP0672171A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/333—Modified A
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Plant Pathology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

EP92919326A 1991-08-30 1992-08-27 FORMATION OF TRIPLE HELIX COMPLEXES FROM DOUBLE-STRANDED DNA BY MEANS OF NUCLEOTIDOLIGOMERS CONSTRUCTED FROM ANALOGUE PURINE BASES. Withdrawn EP0672171A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US75181391A	1991-08-30	1991-08-30
US751813		1991-08-30
PCT/US1992/007246 WO1993005180A1 (en)	1991-08-30	1992-08-27	Formation of triple helix complexes of double stranded dna using nucleoside oligomers which comprise purine base analogs

Publications (2)

Publication Number	Publication Date
EP0672171A1 EP0672171A1 (en)	1995-09-20
EP0672171A4 true EP0672171A4 (en)	1997-04-09

Family

ID=25023590

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92919326A Withdrawn EP0672171A4 (en)	1991-08-30	1992-08-27	FORMATION OF TRIPLE HELIX COMPLEXES FROM DOUBLE-STRANDED DNA BY MEANS OF NUCLEOTIDOLIGOMERS CONSTRUCTED FROM ANALOGUE PURINE BASES.

Country Status (8)

Country	Link
EP (1)	EP0672171A4 (en)
JP (1)	JPH06510203A (en)
AU (1)	AU668886B2 (en)
CA (1)	CA2116343A1 (en)
FI (1)	FI940922L (en)
IL (1)	IL102983A (en)
NZ (1)	NZ244125A (en)
WO (1)	WO1993005180A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0558634A4 (en) *	1990-11-23	1995-06-28	Gilead Sciences Inc	Triplex-forming oligomers containing modified bases
US6713602B1 (en)	1991-05-24	2004-03-30	Ole Buchardt	Synthetic procedures for peptide nucleic acids
US7223833B1 (en)	1991-05-24	2007-05-29	Isis Pharmaceuticals, Inc.	Peptide nucleic acid conjugates
US6441130B1 (en)	1991-05-24	2002-08-27	Isis Pharmaceuticals, Inc.	Linked peptide nucleic acids
US6451968B1 (en)	1991-05-24	2002-09-17	Isis Pharmaceuticals, Inc.	Peptide nucleic acids
AU2696897A (en) *	1996-04-26	1997-11-19	Novartis Ag	Modified oligonucleotides
WO1999010498A2 (en)	1997-08-27	1999-03-04	Pioneer Hi-Bred International, Inc.	Genes encoding enzymes for lignin biosynthesis and uses thereof
WO2001032924A1 (en) *	1999-10-29	2001-05-10	Cygene, Inc.	Compositions and methods of synthesis and use of novel nucleic acid structures

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990015884A1 (en) *	1989-06-19	1990-12-27	The Johns Hopkins University	Formation of triple helix complexes of double stranded dna using nucleoside oligomers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2006008C (en) *	1988-12-20	2000-02-15	Donald J. Kessler	Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use

1992
- 1992-08-27 WO PCT/US1992/007246 patent/WO1993005180A1/en not_active Ceased
- 1992-08-27 FI FI940922A patent/FI940922L/en not_active Application Discontinuation
- 1992-08-27 CA CA002116343A patent/CA2116343A1/en not_active Abandoned
- 1992-08-27 EP EP92919326A patent/EP0672171A4/en not_active Withdrawn
- 1992-08-27 AU AU25544/92A patent/AU668886B2/en not_active Ceased
- 1992-08-27 JP JP5505283A patent/JPH06510203A/en active Pending
- 1992-08-28 NZ NZ244125A patent/NZ244125A/en unknown
- 1992-08-28 IL IL102983A patent/IL102983A/en not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990015884A1 (en) *	1989-06-19	1990-12-27	The Johns Hopkins University	Formation of triple helix complexes of double stranded dna using nucleoside oligomers

Also Published As

Publication number	Publication date
NZ244125A (en)	1995-04-27
FI940922A7 (en)	1994-04-07
IL102983A (en)	1998-02-08
WO1993005180A1 (en)	1993-03-18
FI940922A0 (en)	1994-02-25
JPH06510203A (en)	1994-11-17
EP0672171A1 (en)	1995-09-20
AU2554492A (en)	1993-04-05
FI940922L (en)	1994-04-07
AU668886B2 (en)	1996-05-23
CA2116343A1 (en)	1993-03-18
IL102983A0 (en)	1993-01-31

Publication	Publication Date	Title
FI922812L (en)	1992-06-17	STABIL OEVERFOERING AV DNA TILL BACTERIERNAS ARVANSLAG.
TR24372A (en)	1991-09-20	ACTIVATOER COMPOUNDS BASED ON ORG.PEROXY ACID AGARTMENT OEN-SUBSTANCES
ITTO920136A1 (en)	1993-08-20	ORGANOPOLISILOSSANI PRODUCTION PROCESS.
FI893930L (en)	1989-08-22	FOERFARANDE FOER FRAMSTAELLNING AV VAXBEKLAEDDA, FOERDROEJT FRIGJORDA PARTIKLAR INNEHAOLLANDE TUGGUMMI.
FI884373A0 (en)	1988-09-23	SAETT ATT LUFTA MELLANOERAT MEDELST EN I OERATS TRUMHINNA APPLICERBAR VENTILATIONSTUB, VENTILATIONSTUB FOER UTFOERANDE AV SAETTET JAEMTE ANVAENDNING AV EN DYLIK VENTILATIONSTUB.
FI885380A0 (en)	1988-11-18	LUFTLEDNINGSLAODA FOER STABILIZERING AV LOEPET AV EN VARUBANA, SAERSKILT EN PAPPERSBANA.
DE3868184D1 (en)	1992-03-12	PIGMENT FROM ALUMINUM SHOES.
EP0672171A4 (en)	1997-04-09	FORMATION OF TRIPLE HELIX COMPLEXES FROM DOUBLE-STRANDED DNA BY MEANS OF NUCLEOTIDOLIGOMERS CONSTRUCTED FROM ANALOGUE PURINE BASES.
FI880916A0 (en)	1988-02-26	ANORDNING FOER STABILIZERING AV EN MATERIALBANA, ISYNNERHET FOER STABILIZERING AV EN PAPPERSBANA I TORKPARTIET I EN PAPPERSMASKIN.
FI883063A7 (en)	1988-12-27	KAOLINITAGGREGATION GENOM ANVAENDNING AV ORGANOKISELFOERENINGAR.
FI882604L (en)	1988-12-07	FOERBAETTRANDE AV UTNYTTJANDE AV FOER VAEXTER ANVAENDBART KVAEVE GENOM BRINGANDE AV ODLINGSVAEXTER ATT UTTRYCKA GLUTAMINSYNTETAS I OEVERSKOTT.
FI883223A7 (en)	1989-01-14	SJAELVREGLERANDE ANORDNING FOER FASTLAOSNING AV TVAO FOEREMAOL, I VILKEN ANORDNING DISTANSEN MELLAN FAESTNINGSSTAELLENA FRAON DET ENA FOEREMAOLET TILL DET ANDRA KAN VARIERA.
FI883005L (en)	1988-12-25	PROMOTORER FOER EXPRESSION AV FRAEMMANDE DNA I METYLOTROPHISKA BAKTERIER, DERAS TILLVARATAGANDE OCH DERAS ANVAENDNING.
FI880588L (en)	1989-01-03	INTERPOLYMERKOMPOSITIONER OCH MEMBRANER AV ETEN-AKRYLSYRATYP, VILKA HAR FOERBAETTRAD GLIDBARHET OCH FOERMINSKAD FAESTFOERMAOGA.
FI884857A7 (en)	1989-04-22	ANORDNING FOER FRAMSTAELLNING AV PORTABLA, ROERFORMIGA PAKET AV TRYCKALSTER.
DE3870891D1 (en)	1992-06-17	Extrusion die.
NO940658D0 (en)	1994-02-25	Nucleic acid polymerase amplification
FI892769L (en)	1989-06-06	FOERFARANDE FOER INACTIVERING AV DEN RECOMBINANTA DNA.
FI884819L (en)	1988-10-19	FOERFARANDE FOER FRAMSTAELLNING AV EN ELEKTRISKT HALVLEDANDE, LOSSNANDE PLASTBLANDNING.
FI880073A0 (en)	1988-01-08	RAMSPAENNANORDNING, SAERSKILT FOER GIRFOGNING AV RAMAR.
ATA208286A (en)	1987-06-15	STAIRS, STAEGE O.DGL.
NO882949D0 (en)	1988-07-01	DOUBLE WIRED NUCLEIC ACID DERIVATIVES.
FI893184L (en)	1989-06-29	BEHAOLLARE FOER TRANSPORT AV LAONGSTRAECKTA FOEREMAOL, I SYNNERHET VALSAR TILL PAPERMASKINER.
FI875468A0 (en)	1987-12-14	FOERFARANDE FOER REPARERING AV AVLOPPSBRUNNAR EL.DYL.GENOM BETONERING.
FI880628L (en)	1988-08-13	NUCLEOTIDE DANALOGER, DERAS FRAMSTAELLNING OCH ANVAENDNING.

Legal Events

Date	Code	Title	Description
1995-08-04	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-09-20	17P	Request for examination filed	Effective date: 19940301
1995-09-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
1997-04-09	A4	Supplementary search report drawn up and despatched	Effective date: 19970224
1997-04-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
1998-06-03	17Q	First examination report despatched	Effective date: 19980422
1999-01-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1999-03-03	18D	Application deemed to be withdrawn	Effective date: 19980903