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EP0652027A1 - Dispositif d'injection - Google Patents

Dispositif d'injection Download PDF

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Publication number
EP0652027A1
EP0652027A1 EP94116303A EP94116303A EP0652027A1 EP 0652027 A1 EP0652027 A1 EP 0652027A1 EP 94116303 A EP94116303 A EP 94116303A EP 94116303 A EP94116303 A EP 94116303A EP 0652027 A1 EP0652027 A1 EP 0652027A1
Authority
EP
European Patent Office
Prior art keywords
cannula
patient
housing
skin
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP94116303A
Other languages
German (de)
English (en)
Other versions
EP0652027B1 (fr
Inventor
Giorgio Cirelli
Benno Rothenhäusler
Hans Steffen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of EP0652027A1 publication Critical patent/EP0652027A1/fr
Application granted granted Critical
Publication of EP0652027B1 publication Critical patent/EP0652027B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0612—Devices for protecting the needle; Devices to help insertion of the needle, e.g. wings or holders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/1426—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with means for preventing access to the needle after use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1581—Right-angle needle-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1585—Needle inserters

Definitions

  • the invention relates to a device for introducing an active substance solution into a patient with means for fastening the device to the body surface and a cannula for inserting into the skin or into the underlying tissue and for introducing the active substance solution.
  • a venous access is usually created today, to which injection devices can be connected if necessary.
  • this method is often associated with disadvantages, the most serious of which are mentioned.
  • Cannulas can only be inserted by trained medical personnel. In most cases, patients themselves are unable to do this, so self-medication with drugs that are injected is not possible.
  • the insertion of a cannula particularly in long-term therapy, causes an injury with an increased risk of infection. The risk of injury when handling used cannulas represents an additional risk.
  • the disadvantages mentioned mean that the subcutaneous or intradermal injection route is frequently chosen for reasons of cost and safety.
  • EP-A-272 530 describes a portable device for subcutaneous or intradermal injection of a liquid active substance formulation known that consists of a storage container, an injection needle to be connected to this, a pump device for emptying the container through the injection needle and fastening means, the needle being shot into the patient's skin by means of a drive device.
  • Devices of this type which have an active substance reservoir as an integral part have the disadvantage that a separate device is required for each active substance formulation.
  • the limitation of the active substance volume in these devices prevents their use for a number of applications.
  • the invention is therefore based on the object of providing a device which offers high patient comfort and, at the same time, the greatest possible flexibility and safety in intradermal and subcutaneous injections.
  • a device of the type described at the outset which is distinguished by a feed device for shooting the cannula into the skin, a connecting element arranged on the outside of the device for connection to a conveying device for the active substance solution, one in the pierced state Cannula open connecting channel between the connecting element and the cannula, as well as fastening means for fastening the device on the patient's skin.
  • the feed device mentioned is designed such that the cannula can be reset to a protected starting position after the infusion has ended.
  • the device shown in Fig. 1 has an approximately frustoconical housing 1 with a concentric bore 2, which consists of four areas with larger diameters from bottom to top.
  • the base of the housing has a concentric projection 3.
  • the part 3 of the base area surrounding the projection 3 is provided with an adhesive layer 4 for fastening the device to a body part of a patient, the material and thickness of which are selected primarily with regard to the wearing comfort and to ensure that the device is held securely. From this point of view, a so-called adhesive foam was selected for layer 4.
  • the end face of the projection 3 is also provided with an adhesive layer 5, which serves above all to reliably fix the skin.
  • the adhesive layer 5 consists of a thinner, relatively aggressively adhesive material. However, it is quite possible that the adhesive cloths 4 and 5 are made of the same material.
  • a Luer attachment 6 is arranged at one point of the housing and is used to connect the device to a feed pump for an active ingredient solution and, via this, to a reservoir.
  • a narrow channel 7 leads from the Luer approach to the central bore.
  • O-rings 8 are inserted into corresponding ring grooves in the inner wall of the bore.
  • a thin steel capillary of approximately 200 ⁇ m in diameter with an obliquely ground puncture end serves as cannula 9.
  • the cannula is held in a cannula holder 10.
  • the cannula carrier 10 is a concentrically and axially displaceably arranged in the bore 2 element, which is shown in its upper end position. In its lower end position, the lower end face of the cannula holder rests on the stop, which is formed by the transition from the narrowest region of the bore 2 to its next larger one.
  • the cannula 9 then extends through the narrowest area of the bore 2 serving as a needle passage and through the adhesive layer 5, e.g. into the tissue of a patient's adjacent skin.
  • the end of the cannula 9 opposite the ground tip of the cannula 9 opens into the expansion of the channel 11.
  • the channel 11 is opposite the channel 7 in the housing 1.
  • the cannula holder has a guide flange 12 whose diameter corresponds to the inside diameter of the third bore area.
  • the cannula carrier 10 On its upper surface, the cannula carrier 10 has a hollow cylindrical wall 13, which is provided on its inside directly at its upper end with a circumferential bead. The wall 13 with the bead interacts with the holding and triggering mechanism 14 to be described below.
  • a holding and triggering mechanism 14 is inserted, which holds the cannula carrier 10 in its upper end position in the idle state and enables its displacement into the lower end position by triggering it.
  • a helical spring which presses the cannula holder 10 downwards.
  • the holding and triggering mechanism 14 consists of two axially displaceable parts, of which the lower consists of an annular plate 15 and wall segments 16 which project downward at their central opening and form a substantially hollow cylindrical shape.
  • the plate 15 is firmly connected to the housing, i.e. screwed, welded, etc. It forms the upper abutment of the spring 17 and must therefore be made relatively rigid.
  • the wall segments 16 have a conical shoulder on their outer surfaces, which forms the transition between an upper, smaller to a lower, larger center distance.
  • the bead of the wall 13 rests on this shoulder, as a result of which the cannula carrier 10 is held in its upper end position.
  • the wall segments 16 On its inside, the wall segments 16 also have a shoulder in which an expansion flange 19 to be described below engages.
  • the upper part of the holding and triggering mechanism 14 consists of an approximately mushroom-shaped trigger pusher 18, at the lower end of which the mentioned expansion flange 19 is located.
  • the trigger pusher is held in the upper position shown by a plate spring 20.
  • the expansion flange 19 prevents the inward movement of the elastic wall segments 16 and thus the triggering of the downward movement of the cannula holder 10.
  • the holding and triggering mechanism 14 accordingly represents a snap with a lock.
  • the snap automatically triggers due to the pressure of the spring 17.
  • the device If the device is now attached to a suitable body part of a patient, ie glued on, and with a conveying device for an active ingredient solution is connected and when the injection is to be triggered, the patient presses the pusher 18 against the pressure of the spring 20 downwards. As a result, the expansion flange 19 is pushed out of its seat inside the wall segments 16.
  • the wall segments give way to the inward pressure exerted by the spiral spring 17 via the bead on the shoulder, and the cannula holder 10 together with the cannula 9 is pushed downwards by the spring 17 with high acceleration.
  • the cannula 9 is shot through the adhesive layer 5 into the patient's tissue. Due to the high acceleration, the needle penetrates so quickly that the patient does not feel any pain.
  • FIG. 2 has a number of the same functional elements as that according to FIG. 1. Some elements only have a different shape, while other elements have different or additional functions.
  • a housing 21 has a bore 22, which in the present case has only a gradation of its diameter, namely the narrowing at its lower end to a passage opening for an injection cannula 29.
  • the housing is also provided on its underside with an adhesive layer 24, which is continuous here is trained.
  • a Luer extension 26 is arranged in a laterally attached extension 23 of the housing and is connected to the bore 22 via a channel 27. Above and below the mouth of the channel 27 in the bore 22 there are two O-rings 28 in corresponding ring grooves.
  • the cannula 29 is seated in a cannula carrier 30 which is essentially cylindrical and has a channel 31 for connecting the rear of the cannula to the bore 22. Its lateral surface has a conical heel formed by an increase in cross section.
  • the cannula support 30 is fixedly connected via an annular, crystal-clear viewing element 33 to a cap 38 encompassing the entire mechanism, which can be moved downward from the upper position shown in the figure and serves as a release head.
  • the cap 38 has a viewing window 39 in its center.
  • the housing surface there are arranged around the edge of the bore 22 wall segments 36, which are provided on their upper edge with projections directed towards the axis, which engage under the conical shoulder of the cannula carrier 30.
  • the wall segments 36 are elastic and together with the conical shoulder of the cannula holder form a holding and triggering mechanism 34.
  • By pressing the finger on the cap 38 they are bent outwards until they release the cannula holder 30 when there is sufficient pressure. Due to the finger pressure required to overcome the holding force, the needle is pressed into the patient's skin when the cannula carrier 30 is released.
  • the upper end of the cannula carrier 30 is tapered and is designed such that the elastic wall elements 36 exert a downward pressure on the cannula carrier, which holds the needle in the lower puncture position after being pushed in.
  • the outer surface of the cap 38 is shaped so that it can be gripped with the fingers and pulled back into its starting position.
  • the cap is provided with an inwardly directed projection 37 which, together with a corresponding shoulder 35 of the housing, prevents the cap from being pulled off beyond the starting position. This ensures that the cannula can be fully retracted into the housing after the infusion has ended.
  • the projections of the wall segments 36 are at the height of the viewing element 33 and rest against it.
  • the wall segments 36 are highlighted in color so that they are clearly visible through the viewing window 39 in this position and thereby indicate that the cannula 29 is inserted. Such a visual inspection is often advantageous because the patient does not feel the puncture.
  • Fig. 3a shows a device in which the housing 41 is very similar to that in Fig. 1 with bore 42, projection 43, adhesive layers 44 and 45, and with Luer approach 46, channel 47 and O-rings 48 in the Wall of the bore 42.
  • the cannula carrier 50 with cannula 49 and connecting channel 51 and the wall segments 56 holding it are the same as in the device according to FIG. 2.
  • the cap 57 which here also has a viewing window 59, is provided with a toggle 58, through which it can be rotated. It also has a plurality of fingers 60 projecting downward from its underside, which in turn are provided with cams 61 directed radially outwards.
  • cams 61 slide in grooves which are provided in the wall of the upper bore region and one of which is shown in FIG. 3b.
  • the groove has a leg 62 and which runs vertically downwards a ramp-shaped oblique leg 63.
  • the two legs are connected at the bottom by a short horizontal piece 64.
  • a horizontal groove piece 65, 66 is connected at its upper ends.
  • the horizontal groove piece 65 on the right in the drawing, which is located at the top of the vertical leg 62, defines the rest position before the device is used.
  • the other horizontal groove piece 66 on top of the inclined leg 63 defines the position after use of the device.
  • the cannula holder 50 and injection cannula 49 are withdrawn into this position by turning the toggle 58 before the device is removed from the patient. This withdrawal of the cannula prevents possible injury to the patient by tilting the cannula when it is removed, as well as injuries and thus infections of the medical aids by the above cannula.
  • the device shown in FIG. 4 does not have manual triggering of the cannula advance by the patient.
  • the very flat, only approx. 10 mm high housing 71 is closed at the top and has a concentric chamber 72 which is open at the bottom. It is also in two parts and has a part 73 inserted into the base area, which at the same time has a projecting part of the base area surrounding the passage opening forms. Between the main part of the housing 71 and the inserted part 73, a protective film 74 is arranged which encloses the chamber formed between the two parts. In the upper part of the housing, a Luer extension 76 is arranged, which is connected to the chamber 72 by a channel 77.
  • An O-ring 78 is inserted into a corresponding circumferential groove on a concentric projection protruding into the chamber from above.
  • a channel 79 is seated in a cannula carrier 80, which is essentially adapted to the shape of the chamber 72.
  • the cannula carrier 80 At its lower edge, the cannula carrier 80 has a circumferential projection which engages in a corresponding annular groove in the housing and which together with the groove forms a catch 81. In the idle state, this holds the cannula holder in the position shown.
  • the cannula carrier Near the upper edge of its cylindrical outer surface, the cannula carrier has a circumferential annular groove in which an O-ring 82 is inserted.
  • the two O-rings 78 and 82 create between the cannula holder and the upper end face of the chamber an annular closed space, which is connected to the Luer approach 76 only by the channel 77.
  • the cannula carrier also has two radially outwardly projecting pins 83.
  • the end pieces of two leg springs 84 engage on these. These are pre-tensioned so that they move the cannula holder down as soon as it is released.
  • the function of this embodiment is as follows: If the device is attached to a body part of the patient, the connection to the delivery device for the active substance solution (not shown) is established via the Luer approach.
  • the feed pump generates a pressure in the upper region of the chamber 72.
  • the sprout thereby acting on the cannula carrier 80 is added to the force of the springs 84.
  • the cannula carrier moves downwards.
  • the springs 84 now take over the propulsion of the cannula holder. After a first short distance, the inner upper edge of the cannula holder comes under the O-ring 78 and thus clears the way for the active substance solution to the upper end of the cannula 79.
  • the active substance solution can reach the patient's skin through the cannula 79.
  • the device shown in Figure 5 is shown in two mutually perpendicular cross sections in order to make the details clearer. The aim of this device was to reduce the overall height even further.
  • the housing 91 is very flat, i.e. it has a height of less than 10 mm.
  • a chamber 92 arranged centrally in the housing is in turn open from below and closed at the top.
  • the housing has two parts for assembly.
  • the lower part 93 forms a central, concentric projection which projects beyond the base of the housing.
  • Protective foils 94 are arranged between the lower part 93 and the main part of the housing 91 and seal the cavity that is formed between the two housing parts.
  • In the upper housing part 91 there is again a Luer attachment 96 which is connected to the chamber 92 by a channel 97.
  • a cannula 99 is inserted in a cannula holder 100 and otherwise moves freely in an elastic seal 101 located in the lower part of the chamber.
  • the cannula carrier 100 consists essentially of only a U-shaped element, at the upper leg ends of which there are attachment points for the force transmission of leg spring 102.
  • the springs 102 are biased so that they drive the cannula holder down with the cannula 99 as soon as they are released.
  • the cannula holder 100 is held in the upper rest position shown in FIG. 5 by a slide 103. If the slider 103 is pushed to the right, it releases the cannula holder 100, and the spring 102 can move the cannula holder 100 together with the cannula 99 downward and thus pierce the cannula 99 into the patient's skin.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Polarising Elements (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
EP94116303A 1993-10-22 1994-10-17 Dispositif d'injection Expired - Lifetime EP0652027B1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CH320093 1993-10-22
CH3200/93 1993-10-22
CH320093 1993-10-22
US32753494A 1994-10-21 1994-10-21
US57409295A 1995-12-11 1995-12-11
US70126896A 1996-08-22 1996-08-22
US08/911,198 US5848990A (en) 1993-10-22 1997-08-14 Device for introducing active substance into a patient

Publications (2)

Publication Number Publication Date
EP0652027A1 true EP0652027A1 (fr) 1995-05-10
EP0652027B1 EP0652027B1 (fr) 2003-05-07

Family

ID=27509120

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94116303A Expired - Lifetime EP0652027B1 (fr) 1993-10-22 1994-10-17 Dispositif d'injection

Country Status (12)

Country Link
US (1) US5848990A (fr)
EP (1) EP0652027B1 (fr)
JP (1) JP3544715B2 (fr)
AT (1) ATE239522T1 (fr)
AU (1) AU696522B2 (fr)
CA (1) CA2132277C (fr)
DE (1) DE59410282D1 (fr)
DK (1) DK0652027T3 (fr)
IL (1) IL111316A (fr)
NZ (1) NZ264719A (fr)
SG (1) SG54173A1 (fr)
ZA (1) ZA948095B (fr)

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US5997501A (en) * 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
WO2007093051A1 (fr) * 2006-02-16 2007-08-23 Pka Softtouch Corp. Appareil pour dé livrer un médicament
WO2009050584A3 (fr) * 2007-10-16 2009-06-04 Cequr Aps Dispositif d'insertion de canule et procédés associés
WO2009101130A1 (fr) * 2008-02-13 2009-08-20 Unomedical A/S Joint d'étanchéité entre une partie canule et un trajet de fluide
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
US8012126B2 (en) 2006-10-31 2011-09-06 Unomedical A/S Infusion set
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
US8221355B2 (en) 2004-03-26 2012-07-17 Unomedical A/S Injection device for infusion set
US8303549B2 (en) 2005-12-23 2012-11-06 Unomedical A/S Injection device
US8430850B2 (en) 2007-07-03 2013-04-30 Unomedical A/S Inserter having bistable equilibrium states
US8439838B2 (en) 2006-06-07 2013-05-14 Unomedical A/S Inserter for transcutaneous sensor
US8486003B2 (en) 2007-07-10 2013-07-16 Unomedical A/S Inserter having two springs
US8562567B2 (en) 2009-07-30 2013-10-22 Unomedical A/S Inserter device with horizontal moving part
US8790311B2 (en) 2006-06-09 2014-07-29 Unomedical A/S Mounting pad
US8945057B2 (en) 2006-08-02 2015-02-03 Unomedical A/S Cannula and delivery device
US9186480B2 (en) 2007-06-20 2015-11-17 Unomedical A/S Apparatus for making a catheter
US9211379B2 (en) 2006-02-28 2015-12-15 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
US9254373B2 (en) 2008-12-22 2016-02-09 Unomedical A/S Medical device comprising adhesive pad
US9415159B2 (en) 2010-03-30 2016-08-16 Unomedical A/S Medical device
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
US9533092B2 (en) 2009-08-07 2017-01-03 Unomedical A/S Base part for a medication delivery device
US9566384B2 (en) 2008-02-20 2017-02-14 Unomedical A/S Insertion device with horizontally moving part
US9724127B2 (en) 2010-09-27 2017-08-08 Unomedical A/S Insertion system and insertion kit
EP3395396A1 (fr) * 2003-08-12 2018-10-31 Becton, Dickinson and Company Dispositif d'injection sous forme de patch
US10369277B2 (en) 2005-09-12 2019-08-06 Unomedical A/S Invisible needle
US11020526B2 (en) 2010-10-04 2021-06-01 Unomedical A/S Sprinkler cannula
US11110261B2 (en) 2011-10-19 2021-09-07 Unomedical A/S Infusion tube system and method for manufacture
US11197689B2 (en) 2011-10-05 2021-12-14 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
US11865321B2 (en) 2016-12-15 2024-01-09 Pka Softtouch Corp. Fluid delivery device

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JPH0526849A (ja) * 1991-07-17 1993-02-02 Hitachi Building Syst Eng & Service Co Ltd 磁気探傷装置
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20020198509A1 (en) 1999-10-14 2002-12-26 Mikszta John A. Intradermal delivery of vaccines and gene therapeutic agents via microcannula
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Also Published As

Publication number Publication date
ZA948095B (en) 1995-06-05
US5848990A (en) 1998-12-15
JP3544715B2 (ja) 2004-07-21
EP0652027B1 (fr) 2003-05-07
CA2132277C (fr) 2005-05-10
HK1012590A1 (en) 1999-08-06
IL111316A0 (en) 1994-12-29
AU7586994A (en) 1995-05-11
SG54173A1 (en) 1998-11-16
CA2132277A1 (fr) 1995-04-23
IL111316A (en) 1999-11-30
AU696522B2 (en) 1998-09-10
DE59410282D1 (de) 2003-06-12
ATE239522T1 (de) 2003-05-15
DK0652027T3 (da) 2003-08-25
NZ264719A (en) 1998-02-26
JPH07178170A (ja) 1995-07-18

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