EP0515546A4 - Triazole angiotensin ii antagonists incorporating a substituted benzyl element - Google Patents

Triazole angiotensin ii antagonists incorporating a substituted benzyl element

Info

Publication number: EP0515546A4
Authority: EP; European Patent Office
Prior art keywords: substituted benzyl; antagonists incorporating; angiotensin; triazole; benzyl element
Prior art date: 1990-02-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP19910905207

Other languages

English (en)

Other versions

EP0515546A1 (fr

Inventor

William J. Greenlee

Arthur A. Patchett

David Hangauer

Wallace Ashton

Kenneth J. Fitch

Thomas Walsh

Ralph A. Rivero

Daljit S. Dhanoa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-13

Filing date

1991-02-11

Publication date

1993-05-12

1991-02-11 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1992-12-02 Publication of EP0515546A1 publication Critical patent/EP0515546A1/fr

1993-05-12 Publication of EP0515546A4 publication Critical patent/EP0515546A4/en

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP19910905207 1990-02-13 1991-02-11 Triazole angiotensin ii antagonists incorporating a substituted benzyl element Ceased EP0515546A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US479779		1983-03-28
US47977990A	1990-02-13	1990-02-13

Publications (2)

Publication Number	Publication Date
EP0515546A1 EP0515546A1 (fr)	1992-12-02
EP0515546A4 true EP0515546A4 (en)	1993-05-12

Family

ID=23905391

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19910905207 Ceased EP0515546A4 (en)	1990-02-13	1991-02-11	Triazole angiotensin ii antagonists incorporating a substituted benzyl element

Country Status (4)

Country	Link
EP (1)	EP0515546A4 (fr)
JP (1)	JP2726563B2 (fr)
CA (1)	CA2075639A1 (fr)
WO (1)	WO1991011909A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0412594B1 (fr)	1989-07-28	1996-01-03	Merck & Co. Inc.	Triazolinones, triazolinethiones et triazolinimines substituées comme antagonistes d'angiotensine II
US5177095A (en) *	1990-02-13	1993-01-05	Merck & Co., Inc.	Triazole angiotensin II antagonists incorporating a substituted benzyl element
US5183810A (en) *	1990-02-13	1993-02-02	Merck & Co., Inc.	Imidazole angiotensin II antagonists incorporating a substituted benzyl element
US5449682A (en) *	1990-02-13	1995-09-12	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted benzyl element
US5240938A (en) *	1991-02-13	1993-08-31	Merck & Co., Inc.	Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring
US5300668A (en) *	1993-03-10	1994-04-05	Pfizer Inc.	Certain esters of 1-(4-X-methylphenyl)cyclopent-3-ene-1-carboxylic acid, wherein X is a trialkylsilyloxy, bromo or hydroxy group, as intermediates
US6699896B1 (en)	1998-05-12	2004-03-02	Wyeth	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en)	1998-05-12	2001-05-15	American Home Products Corporation	Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
WO1999061410A1 (fr) *	1998-05-12	1999-12-02	American Home Products Corporation	Diphenyles 2,3,5-substitues utiles pour le traitement de la resistance insulinique et de l'hyperglycemie
US6451827B2 (en)	1998-05-12	2002-09-17	Wyeth	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en)	1998-05-12	2000-12-26	American Home Products Corporation	Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6221902B1 (en)	1998-05-12	2001-04-24	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) *	1998-05-12	2000-08-29	American Home Products Corporation	Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6310081B1 (en)	1999-05-10	2001-10-30	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
AR032653A1 (es)	2001-02-09	2003-11-19	Telik Inc	Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2393885T7 (es)	2007-06-04	2014-01-30	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
WO2009149279A2 (fr)	2008-06-04	2009-12-10	Synergy Pharmaceuticals Inc.	Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JPWO2010137336A1 (ja)	2009-05-29	2012-11-12	興和株式会社	新規なα−フェノキシベンゼン酢酸誘導体及びこれを含有する医薬
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
WO2014151206A1 (fr)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonistes de la guanylate cyclase et leurs utilisations
US9486494B2 (en)	2013-03-15	2016-11-08	Synergy Pharmaceuticals, Inc.	Compositions useful for the treatment of gastrointestinal disorders
EP3004138B1 (fr)	2013-06-05	2024-03-13	Bausch Health Ireland Limited	Agonistes ultra-purs de guanylate cyclase c, leur procédé de production et d'utilisation
EA034776B1 (ru)	2015-05-20	2020-03-19	Эмджен Инк.	Триазоловые агонисты рецептора apj
WO2017192485A1 (fr)	2016-05-03	2017-11-09	Amgen Inc.	Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj
US10906890B2 (en)	2016-11-16	2021-02-02	Amgen Inc.	Triazole phenyl compounds as agonists of the APJ receptor
MA46827A (fr)	2016-11-16	2019-09-25	Amgen Inc	Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj
EP3541792B1 (fr)	2016-11-16	2020-12-23	Amgen Inc.	Composés de triazole furane utilisés en tant qu'agonistes du récepteur apj
MA46824A (fr)	2016-11-16	2019-09-25	Amgen Inc	Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
US10689367B2 (en)	2016-11-16	2020-06-23	Amgen Inc.	Triazole pyridyl compounds as agonists of the APJ receptor
WO2018097945A1 (fr)	2016-11-16	2018-05-31	Amgen Inc.	Triazoles substitués par hétéroaryle utilisés en tant qu'agonistes du récepteur apj
US11149040B2 (en)	2017-11-03	2021-10-19	Amgen Inc.	Fused triazole agonists of the APJ receptor
EP3788037A1 (fr)	2018-05-01	2021-03-10	Amgen Inc.	Pyrimidinones substituées en tant qu'agonistes du récepteur apj

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4061488A (en) *	1972-11-13	1977-12-06	Hershey Foods Corporation	Plant treating mixtures and methods utilizing spores of Bacillus uniflagellatus
WO1987003303A1 (fr) *	1985-11-20	1987-06-04	Crop Genetics International, N.V.	Micro-organismes endosymbiotiques fabricant des produits chimiques agricoles, et leur procede de preparation et d'utilisation
US5015651A (en) *	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
JPH02117321A (ja) *	1988-10-26	1990-05-01	Shoichi Ishimoto	栽培植物の育成方法

1991
- 1991-02-11 JP JP3505096A patent/JP2726563B2/ja not_active Expired - Lifetime
- 1991-02-11 CA CA002075639A patent/CA2075639A1/fr not_active Abandoned
- 1991-02-11 EP EP19910905207 patent/EP0515546A4/en not_active Ceased
- 1991-02-11 WO PCT/US1991/000963 patent/WO1991011909A1/fr not_active Ceased

Also Published As

Publication number	Publication date
CA2075639A1 (fr)	1991-08-14
JP2726563B2 (ja)	1998-03-11
EP0515546A1 (fr)	1992-12-02
JPH05503533A (ja)	1993-06-10
WO1991011909A1 (fr)	1991-08-22

Publication	Publication Date	Title
EP0515546A4 (en)	1993-05-12	Triazole angiotensin ii antagonists incorporating a substituted benzyl element
EP0515535A4 (en)	1996-01-17	Angiotensin ii antagonists incorporating a substituted benzyl element
EP0475206A3 (en)	1992-08-05	Angiotensin ii receptor antagonists
IL105877A0 (en)	1993-10-20	Angiotensin ii antagonists
EP0409332A3 (en)	1991-08-07	Substituted triazoles as angiotensin ii antagonists
AP9000237A0 (en)	1991-01-31	Triazole antifungal agents
ZA912656B (en)	1992-03-25	Substituted benzimidazoles having angiotensin 11 receptor antagonisn
EG18737A (en)	1993-12-30	Herbicidal triazolinones
EP0543491A3 (en)	1993-07-14	Angiotensin ii antagonists having a substituted 1,3-benzodioxolering or 1,3-benzodithiolering
AU3276293A (en)	1993-07-28	Angiotensin II receptor antagonists
EP0586613A4 (en)	1994-08-24	Bradykinin antagonists
ZA943690B (en)	1995-11-27	Imidazole 5-position substituted angiotensin II antagonists
ZA948720B (en)	1995-07-03	Herbicidal substituted phenylaminosulphonylureas
GB9317760D0 (en)	1993-10-13	Angiotensin ii antagonist
EP0515548A4 (en)	1993-03-10	Imidazole angiotensin ii antagonists incorporating a substituted benzyl element
EP0505111A3 (en)	1992-09-30	Angiotensin ii antagonists incorporating a substituted imidazo (1,2-b)(1,2,4) triazole
GB9317758D0 (en)	1993-10-13	Angiotensin ii antagonist
GB9107055D0 (en)	1991-05-22	Triazole antifungal agents
GB9110858D0 (en)	1991-07-10	Herbicidal compounds
PL297750A1 (en)	1993-11-02	Herbicidal n-cyanopyridazinones
EP0546449A3 (en)	1993-07-14	Benzofuranderivatives as angiotensin ii antagonists
IL110239A0 (en)	1994-10-21	Azacyclic - heterocyclic compounds as angiotensin II receptor antagonists
HU9300076D0 (en)	1993-04-28	New herbicidal preparatives
GB9217034D0 (en)	1992-09-23	Triazole angiotensin ii antagonists incorporating a substituted benzyl element
GB9217033D0 (en)	1992-09-23	Angiotensin ii antagonists incorporating a substituted benzyl element

Legal Events

Date	Code	Title	Description
1992-10-16	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1992-12-02	17P	Request for examination filed	Effective date: 19920808
1992-12-02	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): CH DE FR GB IT LI NL
1993-05-12	A4	Supplementary search report drawn up and despatched	Effective date: 19930326
1993-05-12	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): CH DE FR GB IT LI NL
1996-06-27	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
1996-08-14	17Q	First examination report despatched	Effective date: 19960701
1997-03-21	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
1997-05-07	18R	Application refused	Effective date: 19961221